iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	CircNet	miRTarBase	microRNA
TRANSFAC	miRWalk	TargetScan	miRecords
RepTar	miRNAMap	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Information
ClinVar	GWASdb	OMIM
Drug and target
TTD
Post-translational Modifications (PTMs)
PhosphositePlus	BioGRID
DNA Methylation
MethyCancer	TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	SOCS	16616006; 12228220; 19339690; 17183367; 10747851; 15021916

Classification

Family	E-value	Score	Start	End
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	5.00e-13	50.4	163	210

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box

   S: 3    klwllrseprSLqhLCRlaIrrclgsqrlkaidkLPLPksLkdYLlyedyq 53
            ++l+++++r+Lq+LCR +I+ ++g+++l    ++PL+++L+dYL+++++q
   Q: 163  GAPLRQRRVRPLQELCRQRIVATVGRENL---ARIPLNPVLRDYLSSFPFQ 210
           6789*************************...***************9986 PP

Organism

Homo sapiens

Functional Description
(View)

SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway. Through binding to JAKs, inhibits their kinase activity. In vitro, also suppresses Tec protein-tyrosine activity. Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor (LIF). Regulates interferon-gamma mediated sensory neuron survival (By similarity). Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize JAK2. SOCS1 appears to be a negative regulator in IGF1R signaling pathway.

Protein Sequence
(Fasta)

MVAHNQVAAD NAVSTAAEPR RRPEPSSSSS SSPAAPARPR PCPAVPAPAP GDTHFRTFRS 60
HADYRRITRA SALLDACGFY WGPLSVHGAH ERLRAEPVGT FLVRDSRQRN CFFALSVKMA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGCTGCACGG CTCCTGGCCC CGGAGCATGC GCGAGAGCCG CCCCGGAGCG CCCCGGAGCC 60
CCCCGCCGTC CCGCCCGCGG CGTCCCGCGC CCCGCCGCCA GGTGAGCCGG GCCCTGGGCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0968--Cytoplasmic vesicle
KW-0341--Growth regulation
KW-0539--Nucleus
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0727--SH2 domain
KW-0734--Signal transduction inhibitor
KW-0833--Ubl conjugation pathway

Interpro

IPR000980--SH2
IPR028411--SOCS1
IPR001496--SOCS_box

PROSITE

PS50001--SH2
PS50225--SOCS

Pfam

PF00017--SH2
PF07525--SOCS_box

SMART

SM00252--SH2
SM00253--SOCS
SM00969--SOCS_box

Gene Ontology

GO:0005737--C:cytoplasm
GO:0031410--C:cytoplasmic vesicle
GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:0000932--C:P-body
GO:0005159--F:insulin-like growth factor receptor binding
GO:0019210--F:kinase inhibitor activity
GO:0019901--F:protein kinase binding
GO:0004860--F:protein kinase inhibitor activity
GO:0071230--P:cellular response to amino acid stimulus
GO:0019221--P:cytokine-mediated signaling pathway
GO:0045444--P:fat cell differentiation
GO:0007259--P:JAK-STAT cascade
GO:0046627--P:negative regulation of insulin receptor signaling pathway
GO:0046426--P:negative regulation of JAK-STAT cascade
GO:0042512--P:negative regulation of tyrosine phosphorylation of Stat1 protein
GO:0042518--P:negative regulation of tyrosine phosphorylation of Stat3 protein
GO:0016567--P:protein ubiquitination
GO:0010534--P:regulation of activation of JAK2 kinase activity
GO:0050707--P:regulation of cytokine secretion
GO:0040008--P:regulation of growth
GO:0060334--P:regulation of interferon-gamma-mediated signaling pathway
GO:0001932--P:regulation of protein phosphorylation

KEGG

hsa:8651

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001204	Ailuropoda melanoleuca	91.88	7.00e-80	289.00
IUUC-Apl-003313	Anas platyrhynchos	60.66	1.00e-72	265.00
IUUC-Aca-005109	Anolis carolinensis	68.35	3.00e-63	234.00
IUUC-Ame-011550	Astyanax mexicanus	50.00	7.00e-49	186.00
IUUC-Bta-013411	Bos taurus	85.65	5.00e-94	337.00
IUUC-Cja-019595	Callithrix jacchus	98.10	3.00e-97	347.00
IUUC-Cfa-020563	Canis familiaris	97.52	2.00e-90	324.00
IUUC-Cpo-021374	Cavia porcellus	94.01	2.00e-95	341.00
IUUC-Csa-023333	Chlorocebus sabaeus	98.12	2.00e-95	341.00
IUUC-Dre-028507	Danio rerio	46.79	1.00e-44	172.00
IUUC-Dno-029406	Dasypus novemcinctus	91.47	3.00e-94	337.00
IUUC-Ete-032399	Echinops telfairi	95.26	2.00e-93	334.00
IUUC-Eca-033519	Equus caballus	83.89	3.00e-91	327.00
IUUC-Fal-036726	Ficedula albicollis	60.66	5.00e-74	270.00
IUUC-Gmo-039667	Gadus morhua	50.44	9.00e-27	113.00
IUUC-Gga-040970	Gallus gallus	61.14	2.00e-72	265.00
IUUC-Gac-041838	Gasterosteus aculeatus	45.00	1.00e-35	142.00
IUUC-Ggo-045569	Gorilla gorilla	90.52	2.00e-96	344.00
IUUC-Itr-047995	Ictidomys tridecemlineatus	92.89	9.00e-93	332.00
IUUC-Lch-050219	Latimeria chalumnae	62.66	2.00e-62	231.00
IUUC-Loc-052494	Lepisosteus oculatus	57.86	9.00e-55	206.00
IUUC-Laf-054219	Loxodonta africana	96.32	2.00e-72	264.00
IUUC-Mcc-054830	Macaca mulatta	97.67	3.00e-95	340.00
IUUC-Meu-056565	Macropus eugenii	70.14	2.00e-81	294.00
IUUC-Mga-060153	Meleagris gallopavo	61.14	6.00e-72	263.00
IUUC-Mmr-061365	Microcebus murinus	89.95	3.00e-93	334.00
IUUC-Mdo-062824	Monodelphis domestica	70.09	7.00e-79	286.00
IUUC-Mmu-064120	Mus musculus	87.74	5.00e-92	330.00
IUUC-Mpu-066839	Mustela putorius furo	90.74	3.00e-95	340.00
IUUC-Mlu-067829	Myotis lucifugus	88.15	9.00e-92	329.00
IUUC-Nle-069592	Nomascus leucogenys	89.57	7.00e-91	326.00
IUUC-Ont-072173	Oreochromis niloticus	45.00	7.00e-38	150.00
IUUC-Oan-073586	Ornithorhynchus anatinus	54.21	3.00e-26	110.00
IUUC-Ocu-073996	Oryctolagus cuniculus	98.76	6.00e-92	329.00
IUUC-Oba-075150	Oryza barthii	30.59	3.50e-02	31.20
IUUC-Ola-087158	Oryzias latipes	46.25	2.00e-39	155.00
IUUC-Oga-088076	Otolemur garnettii	91.04	2.00e-93	334.00
IUUC-Ptr-091241	Pan troglodytes	99.53	2.00e-97	347.00
IUUC-Pan-091836	Papio anubis	91.00	4.00e-96	343.00
IUUC-Psi-093628	Pelodiscus sinensis	63.98	2.00e-74	271.00
IUUC-Pfo-097501	Poecilia formosa	45.28	7.00e-37	147.00
IUUC-Pab-098170	Pongo abelii	98.12	2.00e-94	338.00
IUUC-Pop-100072	Populus trichocarpa	32.69	1.00e-02	34.30
IUUC-Pva-102796	Pteropus vampyrus	97.65	6.00e-94	336.00
IUUC-Rno-105319	Rattus norvegicus	88.21	5.00e-92	330.00
IUUC-Sha-107201	Sarcophilus harrisii	81.17	2.00e-74	270.00
IUUC-Ssc-116004	Sus scrofa	90.91	1.00e-95	342.00
IUUC-Tgu-116836	Taeniopygia guttata	73.29	4.00e-73	267.00
IUUC-Tru-118090	Takifugu rubripes	43.12	4.00e-36	144.00
IUUC-Tni-120719	Tetraodon nigroviridis	43.75	4.00e-32	130.00
IUUC-Vpa-130235	Vicugna pacos	92.09	4.00e-94	337.00
IUUC-Xtr-132610	Xenopus tropicalis	58.29	4.00e-67	247.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence