iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Bta-012506

Ensembl Protein ID

ENSBTAP00000000527.4

UniProt Accession

Q0V8S0; Q2NKZ6; HGS_BOVIN

Genbank Protein ID

ABG66987.1; AAI11314.1

Protein Name

Hepatocyte growth factor-regulated tyrosine kinase substrate

Genbank Nucleotide ID

BT026148; BC111313

Gene Name

HGS

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSBTAG00000000411.4	ENSBTAT00000000527.4	ENSBTAP00000000527.4

Status

Reviewed

Details

Family	Domain	References (PMIDs)
UBD/Alpha-Helix/UIM	UIM	20054405

Classification

Family	E-value	Score	Start	End
UBD/Alpha-Helix/VHS	6.50e-51	171.9	15	143

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/VHS

   S: 1    atselvtsedwelileicdliqetkegakdalralrkrinnknphvalraLtlLdscvsnCgkkfhvevaskdlleelrellknenepk 89
           ats+l+ ++dwe+il+icdli++ +++ak+a+ +++k++n+knphval+aL++++s+v+nCg+++h+eva+k+++eel++llk+++e++
   Q: 15   ATSQLLLETDWESILQICDLIRQGDTQAKYAVSSIKKKVNDKNPHVALYALEVMESVVKNCGQTVHDEVANKQTMEELKDLLKRQVEVN 103
           799************************************************************************************** PP
   S: 90   vieKlkalivsWadelknepalslivaliktlkeeGlefp 129
           v++K+++li++Wa++++nep++++++++++ +k eG++fp
   Q: 104  VRNKILYLIQAWAHAFRNEPKYKVVQDTYQIMKVEGHVFP 143
           ***************************************8 PP

Organism

Bos taurus

Functional Description
(View)

Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. May contribute to the efficient recruitment of SMADs to the activin receptor complex. Involved in receptor recycling via its association with the CART complex, a multiprotein complex required for efficient transferrin receptor recycling but not for EGFR degradation (By similarity).

Protein Sequence
(Fasta)

MGRGSGTFER LLDKATSQLL LETDWESILQ ICDLIRQGDT QAKYAVSSIK KKVNDKNPHV 60
ALYALEVMES VVKNCGQTVH DEVANKQTME ELKDLLKRQV EVNVRNKILY LIQAWAHAFR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGTGGGGATC GCCGCGGCGT CTGGTTGGGG TCCCGGGTCG CCATGGGGCG TGGCAGTGGC 60
ACCTTCGAGC GTCTCCTAGG TAACGCTGCC CCCGCTCCCC GGTGGGAAAG ACCCCCGCCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0967--Endosome
KW-0472--Membrane
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0813--Transport
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR008942--ENTH_VHS
IPR024641--HRS_helical
IPR017073--Ubi-bd_Hrs_VPS27
IPR003903--UIM_dom
IPR002014--VHS_dom
IPR000306--Znf_FYVE
IPR017455--Znf_FYVE-rel
IPR011011--Znf_FYVE_PHD
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50330--UIM
PS50179--VHS
PS50178--ZF_FYVE

Pfam

PF01363--FYVE
PF12210--Hrs_helical
PF00790--VHS

SMART

SM00064--FYVE
SM00288--VHS

Gene Ontology

GO:0005829--C:cytosol
GO:0031901--C:early endosome membrane
GO:0070062--C:extracellular exosome
GO:0005764--C:lysosome
GO:0032585--C:multivesicular body membrane
GO:0046872--F:metal ion binding
GO:0010324--P:membrane invagination
GO:0046426--P:negative regulation of JAK-STAT cascade
GO:1903543--P:positive regulation of exosomal secretion
GO:0010628--P:positive regulation of gene expression
GO:0072657--P:protein localization to membrane
GO:0006622--P:protein targeting to lysosome
GO:0043405--P:regulation of MAP kinase activity

KEGG

bta:511582

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001518	Ailuropoda melanoleuca	88.65	0.00e+00	1022.00
IUUC-Apl-003662	Anas platyrhynchos	82.33	0.00e+00	991.00
IUUC-Aca-004940	Anolis carolinensis	83.49	0.00e+00	1162.00
IUUC-Ago-007931	Ashbya gossypii	29.86	2.00e-26	114.00
IUUC-Acl-008274	Aspergillus clavatus	31.27	6.00e-40	159.00
IUUC-Afl-008521	Aspergillus flavus	28.82	2.00e-41	164.00
IUUC-Afu-008774	Aspergillus fumigatus	32.96	1.00e-40	161.00
IUUC-Ani-009445	Aspergillus nidulans	33.09	2.00e-41	164.00
IUUC-Ang-009863	Aspergillus niger	33.21	1.00e-42	168.00
IUUC-Ate-010444	Aspergillus terreus	34.12	5.00e-43	168.00
IUUC-Ame-011111	Astyanax mexicanus	78.93	0.00e+00	954.00
IUUC-Bgr-012087	Blumeria graminis	33.21	1.00e-42	167.00
IUUC-Bci-013782	Botrytis cinerea	30.86	7.00e-42	165.00
IUUC-Cel-018493	Caenorhabditis elegans	52.13	4.00e-68	252.00
IUUC-Cja-019998	Callithrix jacchus	89.23	0.00e+00	1081.00
IUUC-Cfa-020615	Canis familiaris	90.41	0.00e+00	1111.00
IUUC-Cpo-022019	Cavia porcellus	91.35	0.00e+00	1226.00
IUUC-Cre-022770	Chlamydomonas reinhardtii	42.65	1.00e-10	61.60
IUUC-Csa-023596	Chlorocebus sabaeus	92.04	0.00e+00	1095.00
IUUC-Cin-025488	Ciona intestinalis	46.40	5.00e-128	451.00
IUUC-Csv-025802	Ciona savignyi	49.45	2.00e-114	405.00
IUUC-Cgl-026560	Colletotrichum gloeosporioides	35.07	2.00e-40	160.00
IUUC-Cne-026847	Cryptococcus neoformans	31.56	1.00e-37	151.00
IUUC-Dre-028353	Danio rerio	78.51	0.00e+00	929.00
IUUC-Dno-029005	Dasypus novemcinctus	86.63	0.00e+00	1130.00
IUUC-Dor-030280	Dipodomys ordii	89.19	0.00e+00	1141.00
IUUC-Dse-031238	Dothistroma septosporum	38.25	1.00e-42	167.00
IUUC-Dme-031952	Drosophila melanogaster	43.74	4.00e-100	359.00
IUUC-Ete-032235	Echinops telfairi	96.36	5.00e-133	468.00
IUUC-Eca-033873	Equus caballus	94.92	0.00e+00	1198.00
IUUC-Eeu-034652	Erinaceus europaeus	96.09	2.00e-105	376.00
IUUC-Fca-036563	Felis catus	92.43	0.00e+00	1156.00
IUUC-Fal-036649	Ficedula albicollis	83.99	0.00e+00	1038.00
IUUC-Fox-037962	Fusarium oxysporum	32.51	2.00e-39	157.00
IUUC-Fso-038396	Fusarium solani	33.22	4.00e-40	159.00
IUUC-Gmo-039510	Gadus morhua	74.78	0.00e+00	961.00
IUUC-Ggr-039938	Gaeumannomyces graminis	32.70	6.00e-39	155.00
IUUC-Gga-040201	Gallus gallus	82.67	0.00e+00	1115.00
IUUC-Gac-041459	Gasterosteus aculeatus	77.49	0.00e+00	966.00
IUUC-Ggo-044573	Gorilla gorilla	92.68	0.00e+00	1177.00
IUUC-Hsa-046009	Homo sapiens	92.94	0.00e+00	1224.00
IUUC-Itr-049065	Ictidomys tridecemlineatus	91.78	0.00e+00	1224.00
IUUC-Kpa-049327	Komagataella pastoris	30.97	1.00e-32	134.00
IUUC-Lch-049944	Latimeria chalumnae	77.38	1.00e-157	549.00
IUUC-Loc-051850	Lepisosteus oculatus	79.40	0.00e+00	1033.00
IUUC-Lma-053252	Leptosphaeria maculans	35.22	5.00e-41	162.00
IUUC-Laf-053346	Loxodonta africana	82.61	0.00e+00	1021.00
IUUC-Mcc-055789	Macaca mulatta	92.04	0.00e+00	1158.00
IUUC-Meu-056329	Macropus eugenii	72.97	2.00e-160	559.00
IUUC-Mor-057205	Magnaporthe oryzae	33.22	2.00e-38	154.00
IUUC-Mpo-057295	Magnaporthe poae	33.44	3.00e-40	160.00
IUUC-Mla-058849	Melampsora laricipopulina	33.19	7.00e-32	132.00
IUUC-Mga-059361	Meleagris gallopavo	82.16	0.00e+00	1049.00
IUUC-Mvi-060561	Microbotryum violaceum	32.91	5.00e-41	162.00
IUUC-Mmr-061122	Microcebus murinus	93.30	0.00e+00	1009.00
IUUC-Mdo-062171	Monodelphis domestica	90.00	0.00e+00	1194.00
IUUC-Mmu-063952	Mus musculus	91.26	0.00e+00	1262.00
IUUC-Mpu-065852	Mustela putorius furo	92.05	0.00e+00	1123.00
IUUC-Mlu-066996	Myotis lucifugus	84.57	2.00e-150	525.00
IUUC-Nfi-068539	Neosartorya fischeri	32.96	7.00e-41	162.00
IUUC-Ncr-068726	Neurospora crassa	38.74	9.00e-40	158.00
IUUC-Nle-070148	Nomascus leucogenys	87.55	0.00e+00	1058.00
IUUC-Opr-070833	Ochotona princeps	72.35	0.00e+00	794.00
IUUC-Ont-071261	Oreochromis niloticus	77.97	0.00e+00	970.00
IUUC-Oan-073684	Ornithorhynchus anatinus	71.82	1.00e-161	562.00
IUUC-Ola-087570	Oryzias latipes	75.66	0.00e+00	978.00
IUUC-Oga-089087	Otolemur garnettii	87.48	0.00e+00	1056.00
IUUC-Oar-089534	Ovis aries	98.65	0.00e+00	1274.00
IUUC-Ptr-091654	Pan troglodytes	87.29	0.00e+00	1066.00
IUUC-Pan-092652	Papio anubis	92.17	0.00e+00	1163.00
IUUC-Pno-095125	Phaeosphaeria nodorum	38.53	3.00e-42	166.00
IUUC-Pfo-096757	Poecilia formosa	76.29	0.00e+00	948.00
IUUC-Pab-097788	Pongo abelii	94.00	0.00e+00	824.00
IUUC-Pca-100145	Procavia capensis	78.15	0.00e+00	901.00
IUUC-Pva-102965	Pteropus vampyrus	90.44	0.00e+00	1127.00
IUUC-Pgr-103609	Puccinia graminis	34.69	2.00e-33	136.00
IUUC-Ptt-103865	Puccinia triticina	35.71	4.00e-34	140.00
IUUC-Pte-104095	Pyrenophora teres	35.40	9.00e-42	165.00
IUUC-Pyt-104668	Pyrenophora triticirepentis	35.87	2.00e-41	164.00
IUUC-Rno-105125	Rattus norvegicus	91.24	0.00e+00	1170.00
IUUC-Sce-106192	Saccharomyces cerevisiae	28.44	2.00e-27	117.00
IUUC-Sha-107066	Sarcophilus harrisii	90.32	0.00e+00	1152.00
IUUC-Sja-107931	Schizosaccharomyces japonicus	33.70	3.00e-42	166.00
IUUC-Spo-108220	Schizosaccharomyces pombe	32.48	2.00e-36	147.00
IUUC-Stu-112464	Solanum tuberosum	45.90	2.00e-13	71.20
IUUC-Sar-113393	Sorex araneus	92.11	7.00e-107	381.00
IUUC-Sre-114986	Sporisorium reilianum	37.67	3.00e-42	167.00
IUUC-Tgu-117505	Taeniopygia guttata	82.86	0.00e+00	1050.00
IUUC-Tru-118494	Takifugu rubripes	78.04	0.00e+00	1016.00
IUUC-Tsy-119626	Tarsius syrichta	98.97	6.00e-54	205.00
IUUC-Tni-120174	Tetraodon nigroviridis	72.66	0.00e+00	994.00
IUUC-Tre-122191	Trichoderma reesei	33.45	2.00e-40	160.00
IUUC-Tvi-122318	Trichoderma virens	32.98	3.00e-41	163.00
IUUC-Tme-126914	Tuber melanosporum	35.11	8.00e-45	175.00
IUUC-Ttr-129095	Tursiops truncatus	96.49	0.00e+00	1274.00
IUUC-Uma-129475	Ustilago maydis	36.61	4.00e-39	156.00
IUUC-Vda-129908	Verticillium dahliae	33.22	3.00e-36	146.00
IUUC-Xtr-131900	Xenopus tropicalis	74.87	0.00e+00	1041.00
IUUC-Xma-133124	Xiphophorus maculatus	76.84	0.00e+00	992.00
IUUC-Yli-134682	Yarrowia lipolytica	36.16	2.00e-33	137.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence