iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000185359.12	ENST00000329138.8	ENSP00000331201.4
ENSG00000185359.12	ENST00000572392.1	ENSP00000458987.1
ENSG00000185359.12	ENST00000571237.1	ENSP00000458775.1
ENSG00000185359.12	ENST00000575078.5	ENSP00000460130.1
ENSG00000185359.12	ENST00000573320.1	ENSP00000458789.1
ENSG00000185359.12	ENST00000570652.1	ENSP00000460165.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	circBase	circRNADb	CircNet
miRTarBase	microRNA	TRANSFAC	miRWalk
TargetScan	miRecords	RepTar	miRNAMap
SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
OMIM
Drug and target
DrugBank
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	PHOSIDA
BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
UBD/Alpha-Helix/UIM	UIM	11919637; 12230472; 12750381; 15640163
UBD/Alpha-Helix/DUIM	DUIM	16462748
UBD/Alpha-Helix/VHS	VHS	22493438

Classification

Family	E-value	Score	Start	End
UBD/Alpha-Helix/VHS	7.70e-51	173.2	15	143
UBD/Alpha-Helix/DUIM	8.60e-05	9.1	258	276

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/VHS

   S: 1    atselvtsedwelileicdliqetkegakdalralrkrinnknphvalraLtlLdscvsnCgkkfhvevaskdlleelrellknenepkvie 92
           ats+l+ ++dwe+il+icdli++ +++ak+a+++++k++n+knphval+aL++++s+v+nCg+++h+eva+k+++eel++llk+++e++v++
   Q: 15   ATSQLLLETDWESILQICDLIRQGDTQAKYAVNSIKKKVNDKNPHVALYALEVMESVVKNCGQTVHDEVANKQTMEELKDLLKRQVEVNVRN 106
           799***************************************************************************************** PP
   S: 93   KlkalivsWadelknepalslivaliktlkeeGlefp 129
           K+++li++Wa++++nep++++++++++ +k eG++fp
   Q: 107  KILYLIQAWAHAFRNEPKYKVVQDTYQIMKVEGHVFP 143
           ************************************8 PP

UBD/Alpha-Helix/DUIM

   S: 1    dEdeeLqlAlalSlqEeee 19
           +E+eeLqlAlalS +E+ee
   Q: 258  QEEEELQLALALSQSEAEE 276
           69***************97 PP

Organism

Homo sapiens

Functional Description
(View)

Interacts with TRAK1. Interacts with TRAK2 (By similarity). Interacts with TRAK1. Component of the ESCRT-0 complex composed of STAM or STAM2 and HGS. Part of a complex at least composed of HSG, STAM2 (or probably STAM) and EPS15. Interacts with STAM. Interacts with STAM2. Interacts with EPS15; the interaction is direct, calcium-dependent and inhibited by SNAP25. Interacts with NF2; the interaction is direct. Interacts with ubiquitin; the interaction is direct. Interacts with VPS37C. Interacts with SMAD1, SMAD2 and SMAD3. Interacts with TSG101; the interaction mediates the association with the ESCRT-I complex. Interacts with SNAP25; the interaction is direct and decreases with addition of increasing concentrations of free calcium. Interacts with SNX1; the interaction is direct. Component of a 550 kDa membrane complex at least composed of HGS and SNX1 but excluding EGFR. Component of the CART complex, at least composed of ACTN4, HGS/HRS, MYO5B and TRIM3. Interacts (via UIM domain) with UBQLN1 (via ubiquitin-like domain) (By similarity). Interacts with ARRDC3 (PubMed:23208550). Identified in a complex containing at least ARRDC4, V2R and HGS (PubMed:23236378).

Protein Sequence
(Fasta)

MGRGSGTFER LLDKATSQLL LETDWESILQ ICDLIRQGDT QAKYAVNSIK KKVNDKNPHV 60
ALYALEVMES VVKNCGQTVH DEVANKQTME ELKDLLKRQV EVNVRNKILY LIQAWAHAFR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCGAGGGGAG AGGAAGTGCC CGTGGAGGGC GGCAGGCCCC CTCATCCCGC GCCAATTATC 60
CTCAGCTCGG GCCGTCCCCC GCTCCCGAAG GCTGGCCTTA AGTCACGACC TGACCCGCTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0967--Endosome
KW-0472--Membrane
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0813--Transport
KW-0832--Ubl conjugation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR008942--ENTH_VHS
IPR024641--HRS_helical
IPR017073--Ubi-bd_Hrs_VPS27
IPR003903--UIM_dom
IPR002014--VHS_dom
IPR000306--Znf_FYVE
IPR017455--Znf_FYVE-rel
IPR011011--Znf_FYVE_PHD
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50330--UIM
PS50179--VHS
PS50178--ZF_FYVE

Pfam

PF01363--FYVE
PF12210--Hrs_helical
PF00790--VHS

SMART

SM00064--FYVE
SM00288--VHS

Gene Ontology

GO:0005829--C:cytosol
GO:0005769--C:early endosome
GO:0031901--C:early endosome membrane
GO:0005768--C:endosome
GO:0033565--C:ESCRT-0 complex
GO:0070062--C:extracellular exosome
GO:0043231--C:intracellular membrane-bounded organelle
GO:0005764--C:lysosome
GO:0032585--C:multivesicular body membrane
GO:0046872--F:metal ion binding
GO:0019904--F:protein domain specific binding
GO:0016197--P:endosomal transport
GO:0016236--P:macroautophagy
GO:0010324--P:membrane invagination
GO:0061024--P:membrane organization
GO:0036258--P:multivesicular body assembly
GO:0008285--P:negative regulation of cell proliferation
GO:0042059--P:negative regulation of epidermal growth factor receptor signaling pathway
GO:0046426--P:negative regulation of JAK-STAT cascade
GO:1903543--P:positive regulation of exosomal secretion
GO:0010628--P:positive regulation of gene expression
GO:0016579--P:protein deubiquitination
GO:0072657--P:protein localization to membrane
GO:0006622--P:protein targeting to lysosome
GO:0043405--P:regulation of MAP kinase activity
GO:0042176--P:regulation of protein catabolic process
GO:0007165--P:signal transduction

KEGG

hsa:9146

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001518	Ailuropoda melanoleuca	87.90	0.00e+00	1011.00
IUUC-Apl-003662	Anas platyrhynchos	81.79	0.00e+00	958.00
IUUC-Aca-004940	Anolis carolinensis	83.04	0.00e+00	1138.00
IUUC-Ago-007931	Ashbya gossypii	30.43	8.00e-27	115.00
IUUC-Acl-008274	Aspergillus clavatus	31.41	3.00e-40	160.00
IUUC-Afl-008521	Aspergillus flavus	33.98	6.00e-41	162.00
IUUC-Afu-008774	Aspergillus fumigatus	33.33	7.00e-41	162.00
IUUC-Ani-009445	Aspergillus nidulans	32.96	2.00e-41	164.00
IUUC-Ang-009863	Aspergillus niger	33.57	1.00e-42	168.00
IUUC-Ate-010444	Aspergillus terreus	35.53	7.00e-43	168.00
IUUC-Ame-011111	Astyanax mexicanus	77.73	0.00e+00	951.00
IUUC-Bgr-012087	Blumeria graminis	33.57	5.00e-43	169.00
IUUC-Bta-012506	Bos taurus	92.85	0.00e+00	1184.00
IUUC-Bci-013782	Botrytis cinerea	34.57	1.00e-41	164.00
IUUC-Cel-018493	Caenorhabditis elegans	52.61	3.00e-68	253.00
IUUC-Cja-019998	Callithrix jacchus	95.63	0.00e+00	1172.00
IUUC-Cfa-020615	Canis familiaris	89.66	0.00e+00	1098.00
IUUC-Cpo-022019	Cavia porcellus	93.37	0.00e+00	1250.00
IUUC-Csa-023596	Chlorocebus sabaeus	98.71	0.00e+00	1164.00
IUUC-Cin-025488	Ciona intestinalis	45.91	6.00e-127	448.00
IUUC-Csv-025802	Ciona savignyi	49.91	1.00e-112	400.00
IUUC-Cgl-026560	Colletotrichum gloeosporioides	35.42	3.00e-40	160.00
IUUC-Cne-026847	Cryptococcus neoformans	31.89	3.00e-38	153.00
IUUC-Dre-028353	Danio rerio	77.59	0.00e+00	929.00
IUUC-Dno-029005	Dasypus novemcinctus	86.62	0.00e+00	1143.00
IUUC-Dor-030280	Dipodomys ordii	92.15	0.00e+00	1181.00
IUUC-Dse-031238	Dothistroma septosporum	38.71	8.00e-43	168.00
IUUC-Dme-031952	Drosophila melanogaster	48.24	4.00e-79	289.00
IUUC-Ete-032235	Echinops telfairi	96.36	2.00e-132	466.00
IUUC-Eca-033873	Equus caballus	93.88	0.00e+00	1182.00
IUUC-Eeu-034652	Erinaceus europaeus	95.53	1.00e-104	374.00
IUUC-Fca-036563	Felis catus	91.15	0.00e+00	1141.00
IUUC-Fal-036649	Ficedula albicollis	83.05	0.00e+00	1030.00
IUUC-Fox-037962	Fusarium oxysporum	32.86	1.00e-39	158.00
IUUC-Fso-038396	Fusarium solani	33.57	3.00e-40	160.00
IUUC-Gmo-039510	Gadus morhua	74.43	0.00e+00	954.00
IUUC-Ggr-039938	Gaeumannomyces graminis	31.91	9.00e-38	152.00
IUUC-Gga-040201	Gallus gallus	82.33	0.00e+00	1095.00
IUUC-Gac-041459	Gasterosteus aculeatus	74.65	0.00e+00	956.00
IUUC-Ggo-044573	Gorilla gorilla	99.36	0.00e+00	1279.00
IUUC-Itr-049065	Ictidomys tridecemlineatus	94.72	0.00e+00	1250.00
IUUC-Kpa-049327	Komagataella pastoris	31.42	6.00e-33	135.00
IUUC-Lch-049944	Latimeria chalumnae	73.11	4.00e-157	548.00
IUUC-Loc-051850	Lepisosteus oculatus	79.59	0.00e+00	1015.00
IUUC-Lma-053252	Leptosphaeria maculans	35.65	4.00e-41	163.00
IUUC-Laf-053346	Loxodonta africana	83.97	0.00e+00	1047.00
IUUC-Mcc-055789	Macaca mulatta	98.92	0.00e+00	1233.00
IUUC-Meu-056329	Macropus eugenii	73.13	1.00e-159	557.00
IUUC-Mor-057205	Magnaporthe oryzae	33.56	9.00e-39	155.00
IUUC-Mpo-057295	Magnaporthe poae	31.56	3.00e-39	156.00
IUUC-Mla-058849	Melampsora laricipopulina	33.03	6.00e-32	132.00
IUUC-Mga-059361	Meleagris gallopavo	81.82	0.00e+00	1023.00
IUUC-Mvi-060561	Microbotryum violaceum	32.33	3.00e-40	160.00
IUUC-Mmr-061122	Microcebus murinus	95.37	0.00e+00	1047.00
IUUC-Mdo-062171	Monodelphis domestica	89.59	0.00e+00	1194.00
IUUC-Mmu-063952	Mus musculus	93.44	0.00e+00	1280.00
IUUC-Mpu-065852	Mustela putorius furo	91.17	0.00e+00	1105.00
IUUC-Mlu-066996	Myotis lucifugus	84.18	9.00e-148	516.00
IUUC-Nfi-068539	Neosartorya fischeri	33.33	4.00e-41	163.00
IUUC-Ncr-068726	Neurospora crassa	39.19	6.00e-40	159.00
IUUC-Nle-070148	Nomascus leucogenys	93.05	0.00e+00	1144.00
IUUC-Opr-070833	Ochotona princeps	72.51	0.00e+00	798.00
IUUC-Ont-071261	Oreochromis niloticus	77.33	0.00e+00	963.00
IUUC-Oan-073684	Ornithorhynchus anatinus	70.59	2.00e-154	538.00
IUUC-Ola-087570	Oryzias latipes	74.41	0.00e+00	972.00
IUUC-Oga-089087	Otolemur garnettii	88.67	0.00e+00	1099.00
IUUC-Oar-089534	Ovis aries	92.44	0.00e+00	1181.00
IUUC-Ptr-091654	Pan troglodytes	93.95	0.00e+00	1170.00
IUUC-Pan-092652	Papio anubis	98.97	0.00e+00	1238.00
IUUC-Pno-095125	Phaeosphaeria nodorum	37.39	2.00e-42	167.00
IUUC-Pfo-096757	Poecilia formosa	75.84	0.00e+00	936.00
IUUC-Pab-097788	Pongo abelii	99.79	0.00e+00	886.00
IUUC-Pca-100145	Procavia capensis	79.02	0.00e+00	915.00
IUUC-Pva-102965	Pteropus vampyrus	86.79	0.00e+00	1113.00
IUUC-Pgr-103609	Puccinia graminis	34.69	2.00e-33	137.00
IUUC-Ptt-103865	Puccinia triticina	35.71	4.00e-34	140.00
IUUC-Pte-104095	Pyrenophora teres	35.24	8.00e-42	165.00
IUUC-Pyt-104668	Pyrenophora triticirepentis	35.87	2.00e-41	164.00
IUUC-Rno-105125	Rattus norvegicus	93.79	0.00e+00	1210.00
IUUC-Sce-106192	Saccharomyces cerevisiae	28.00	7.00e-27	115.00
IUUC-Sha-107066	Sarcophilus harrisii	90.18	0.00e+00	1156.00
IUUC-Sja-107931	Schizosaccharomyces japonicus	33.42	1.00e-41	164.00
IUUC-Spo-108220	Schizosaccharomyces pombe	36.41	1.00e-36	147.00
IUUC-Stu-112464	Solanum tuberosum	45.90	4.00e-13	70.90
IUUC-Sar-113393	Sorex araneus	91.58	3.00e-106	379.00
IUUC-Sre-114986	Sporisorium reilianum	38.12	2.00e-42	168.00
IUUC-Tgu-117505	Taeniopygia guttata	81.99	0.00e+00	1045.00
IUUC-Tru-118494	Takifugu rubripes	77.32	0.00e+00	994.00
IUUC-Tsy-119626	Tarsius syrichta	100.00	3.00e-54	206.00
IUUC-Tni-120174	Tetraodon nigroviridis	73.18	0.00e+00	998.00
IUUC-Tre-122191	Trichoderma reesei	33.82	1.00e-40	161.00
IUUC-Tvi-122318	Trichoderma virens	33.33	8.00e-42	165.00
IUUC-Tme-126914	Tuber melanosporum	34.40	6.00e-44	172.00
IUUC-Ttr-129095	Tursiops truncatus	92.98	0.00e+00	1226.00
IUUC-Uma-129475	Ustilago maydis	36.61	3.00e-39	157.00
IUUC-Vda-129908	Verticillium dahliae	32.87	2.00e-35	144.00
IUUC-Xtr-131900	Xenopus tropicalis	76.14	0.00e+00	1028.00
IUUC-Xma-133124	Xiphophorus maculatus	75.81	0.00e+00	976.00
IUUC-Yli-134682	Yarrowia lipolytica	35.27	1.00e-32	134.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence