iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mcc-055789

Ensembl Protein ID

ENSMMUP00000011578.2

UniProt Accession

F7EWU7; F7EWU7_MACMU

Genbank Protein ID

AFH34589.1; AFI38732.1

Protein Name

Hepatocyte growth factor-regulated tyrosine kinase substrate

Genbank Nucleotide ID

JSUE03017635; JV048661

Gene Name

HGS

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMMUG00000008833.3	ENSMMUT00000012345.3	ENSMMUP00000011578.2
ENSMMUG00000008833.3	ENSMMUT00000054189.1	ENSMMUP00000052426.1
ENSMMUG00000008833.3	ENSMMUT00000073770.1	ENSMMUP00000055453.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/Alpha-Helix/VHS	5.20e-51	173.2	15	143

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/VHS

   S: 1    atselvtsedwelileicdliqetkegakdalralrkrinnknphvalraLtlLdscvsnCgkkfhvevaskdlleelrellknenepk 89
           ats+l+ ++dwe+il+icdli++ +++ak+a+++++k++n+knphval+aL++++s+v+nCg+++h+eva+k+++eel++llk+++e++
   Q: 15   ATSQLLLETDWESILQICDLIRQGDTQAKYAVNSIKKKVNDKNPHVALYALEVMESVVKNCGQTVHDEVANKQTMEELKDLLKRQVEVN 103
           799************************************************************************************** PP
   S: 90   vieKlkalivsWadelknepalslivaliktlkeeGlefp 129
           v++K+++li++Wa++++nep++++++++++ +k eG++fp
   Q: 104  VRNKILYLIQAWAHAFRNEPKYKVVQDTYQIMKVEGHVFP 143
           ***************************************8 PP

Organism

Macaca mulatta

Protein Sequence
(Fasta)

MGRGSGTFER LLDKATSQLL LETDWESILQ ICDLIRQGDT QAKYAVNSIK KKVNDKNPHV 60
ALYALEVMES VVKNCGQTVH DEVANKQTME ELKDLLKRQV EVNVRNKILY LIQAWAHAFR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGCGGAAGTC GGGGGGCGCG CCAGCTGGGA TCAGGGGAGC GCCCGCGGCG ACGGGTCTGT 60
GCTGGAGGTC GCCATGGGGC GAGGTAGCGG CACCTTCGAG CGTCTTCTAG GTAACGCATC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0418--Kinase
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0808--Transferase
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR008942--ENTH_VHS
IPR024641--HRS_helical
IPR017073--Ubi-bd_Hrs_VPS27
IPR003903--UIM_dom
IPR002014--VHS_dom
IPR000306--Znf_FYVE
IPR017455--Znf_FYVE-rel
IPR011011--Znf_FYVE_PHD
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50330--UIM
PS50179--VHS
PS50178--ZF_FYVE

Pfam

PF01363--FYVE
PF12210--Hrs_helical
PF00790--VHS

SMART

SM00064--FYVE
SM00288--VHS

Gene Ontology

GO:0005829--C:cytosol
GO:0005769--C:early endosome
GO:0070062--C:extracellular exosome
GO:0005764--C:lysosome
GO:0016301--F:kinase activity
GO:0046872--F:metal ion binding
GO:0010324--P:membrane invagination
GO:0046426--P:negative regulation of JAK-STAT cascade
GO:1903543--P:positive regulation of exosomal secretion
GO:0010628--P:positive regulation of gene expression
GO:0072657--P:protein localization to membrane
GO:0006622--P:protein targeting to lysosome
GO:0043405--P:regulation of MAP kinase activity

KEGG

mcc:714385

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001518	Ailuropoda melanoleuca	87.64	0.00e+00	1007.00
IUUC-Apl-003662	Anas platyrhynchos	81.79	0.00e+00	957.00
IUUC-Aca-004940	Anolis carolinensis	82.78	0.00e+00	1135.00
IUUC-Ago-007931	Ashbya gossypii	30.43	7.00e-27	115.00
IUUC-Acl-008274	Aspergillus clavatus	31.41	3.00e-40	160.00
IUUC-Afl-008521	Aspergillus flavus	33.98	5.00e-41	162.00
IUUC-Afu-008774	Aspergillus fumigatus	33.33	6.00e-41	162.00
IUUC-Ani-009445	Aspergillus nidulans	32.96	1.00e-41	164.00
IUUC-Ang-009863	Aspergillus niger	33.57	8.00e-43	168.00
IUUC-Ate-010444	Aspergillus terreus	35.53	6.00e-43	168.00
IUUC-Ame-011111	Astyanax mexicanus	77.73	0.00e+00	947.00
IUUC-Bgr-012087	Blumeria graminis	33.57	5.00e-43	169.00
IUUC-Bta-012506	Bos taurus	92.44	0.00e+00	1177.00
IUUC-Bci-013782	Botrytis cinerea	34.57	1.00e-41	164.00
IUUC-Cel-018493	Caenorhabditis elegans	52.61	2.00e-68	253.00
IUUC-Cja-019998	Callithrix jacchus	95.12	0.00e+00	1169.00
IUUC-Cfa-020615	Canis familiaris	89.40	0.00e+00	1093.00
IUUC-Cpo-022019	Cavia porcellus	92.96	0.00e+00	1244.00
IUUC-Csa-023596	Chlorocebus sabaeus	99.49	0.00e+00	1173.00
IUUC-Cin-025488	Ciona intestinalis	45.91	7.00e-127	447.00
IUUC-Csv-025802	Ciona savignyi	49.72	8.00e-113	400.00
IUUC-Cgl-026560	Colletotrichum gloeosporioides	35.42	2.00e-40	160.00
IUUC-Cne-026847	Cryptococcus neoformans	31.89	3.00e-38	153.00
IUUC-Dre-028353	Danio rerio	77.53	0.00e+00	924.00
IUUC-Dno-029005	Dasypus novemcinctus	86.87	0.00e+00	1140.00
IUUC-Dor-030280	Dipodomys ordii	92.02	0.00e+00	1179.00
IUUC-Dse-031238	Dothistroma septosporum	38.71	9.00e-43	168.00
IUUC-Dme-031952	Drosophila melanogaster	48.24	4.00e-79	289.00
IUUC-Ete-032235	Echinops telfairi	96.36	2.00e-132	466.00
IUUC-Eca-033873	Equus caballus	93.62	0.00e+00	1179.00
IUUC-Eeu-034652	Erinaceus europaeus	95.53	1.00e-104	374.00
IUUC-Fca-036563	Felis catus	90.77	0.00e+00	1137.00
IUUC-Fal-036649	Ficedula albicollis	82.82	0.00e+00	1028.00
IUUC-Fox-037962	Fusarium oxysporum	32.86	1.00e-39	158.00
IUUC-Fso-038396	Fusarium solani	33.57	3.00e-40	160.00
IUUC-Gmo-039510	Gadus morhua	74.05	0.00e+00	951.00
IUUC-Ggr-039938	Gaeumannomyces graminis	31.91	9.00e-38	152.00
IUUC-Gga-040201	Gallus gallus	82.07	0.00e+00	1095.00
IUUC-Gac-041459	Gasterosteus aculeatus	74.65	0.00e+00	954.00
IUUC-Ggo-044573	Gorilla gorilla	98.97	0.00e+00	1271.00
IUUC-Hsa-046009	Homo sapiens	98.84	0.00e+00	1315.00
IUUC-Itr-049065	Ictidomys tridecemlineatus	94.47	0.00e+00	1252.00
IUUC-Kpa-049327	Komagataella pastoris	30.13	5.00e-33	136.00
IUUC-Lch-049944	Latimeria chalumnae	73.71	1.00e-155	542.00
IUUC-Loc-051850	Lepisosteus oculatus	79.32	0.00e+00	1010.00
IUUC-Lma-053252	Leptosphaeria maculans	35.65	4.00e-41	163.00
IUUC-Laf-053346	Loxodonta africana	83.85	0.00e+00	1043.00
IUUC-Meu-056329	Macropus eugenii	72.47	8.00e-158	550.00
IUUC-Mor-057205	Magnaporthe oryzae	33.56	1.00e-38	155.00
IUUC-Mpo-057295	Magnaporthe poae	31.56	3.00e-39	157.00
IUUC-Mla-058849	Melampsora laricipopulina	33.03	6.00e-32	132.00
IUUC-Mga-059361	Meleagris gallopavo	81.43	0.00e+00	1024.00
IUUC-Mvi-060561	Microbotryum violaceum	38.14	1.00e-39	158.00
IUUC-Mmr-061122	Microcebus murinus	95.53	0.00e+00	1043.00
IUUC-Mdo-062171	Monodelphis domestica	89.19	0.00e+00	1185.00
IUUC-Mmu-063952	Mus musculus	93.05	0.00e+00	1273.00
IUUC-Mpu-065852	Mustela putorius furo	91.04	0.00e+00	1102.00
IUUC-Mlu-066996	Myotis lucifugus	84.18	2.00e-147	515.00
IUUC-Nfi-068539	Neosartorya fischeri	33.33	3.00e-41	163.00
IUUC-Ncr-068726	Neurospora crassa	39.19	5.00e-40	159.00
IUUC-Nle-070148	Nomascus leucogenys	92.66	0.00e+00	1135.00
IUUC-Opr-070833	Ochotona princeps	72.20	0.00e+00	793.00
IUUC-Ont-071261	Oreochromis niloticus	77.33	0.00e+00	962.00
IUUC-Oan-073684	Ornithorhynchus anatinus	70.59	2.00e-154	538.00
IUUC-Ola-087570	Oryzias latipes	74.54	0.00e+00	975.00
IUUC-Oga-089087	Otolemur garnettii	89.20	0.00e+00	1097.00
IUUC-Oar-089534	Ovis aries	92.04	0.00e+00	1175.00
IUUC-Ptr-091654	Pan troglodytes	93.56	0.00e+00	1161.00
IUUC-Pan-092652	Papio anubis	99.87	0.00e+00	1249.00
IUUC-Pno-095125	Phaeosphaeria nodorum	38.53	2.00e-42	167.00
IUUC-Pfo-096757	Poecilia formosa	76.11	0.00e+00	938.00
IUUC-Pab-097788	Pongo abelii	99.36	0.00e+00	880.00
IUUC-Pca-100145	Procavia capensis	79.15	0.00e+00	910.00
IUUC-Pva-102965	Pteropus vampyrus	86.39	0.00e+00	1106.00
IUUC-Pgr-103609	Puccinia graminis	34.69	2.00e-33	137.00
IUUC-Ptt-103865	Puccinia triticina	35.71	3.00e-34	140.00
IUUC-Pte-104095	Pyrenophora teres	35.24	7.00e-42	165.00
IUUC-Pyt-104668	Pyrenophora triticirepentis	35.87	2.00e-41	164.00
IUUC-Rno-105125	Rattus norvegicus	93.39	0.00e+00	1203.00
IUUC-Sce-106192	Saccharomyces cerevisiae	28.00	7.00e-27	115.00
IUUC-Sha-107066	Sarcophilus harrisii	90.04	0.00e+00	1152.00
IUUC-Sja-107931	Schizosaccharomyces japonicus	33.42	1.00e-41	164.00
IUUC-Spo-108220	Schizosaccharomyces pombe	36.41	1.00e-36	147.00
IUUC-Stu-112464	Solanum tuberosum	45.90	3.00e-13	70.90
IUUC-Sar-113393	Sorex araneus	91.58	3.00e-106	379.00
IUUC-Sre-114986	Sporisorium reilianum	38.12	1.00e-42	168.00
IUUC-Tgu-117505	Taeniopygia guttata	81.18	0.00e+00	1043.00
IUUC-Tru-118494	Takifugu rubripes	77.19	0.00e+00	991.00
IUUC-Tsy-119626	Tarsius syrichta	100.00	3.00e-54	206.00
IUUC-Tni-120174	Tetraodon nigroviridis	73.24	0.00e+00	996.00
IUUC-Tre-122191	Trichoderma reesei	33.82	1.00e-40	161.00
IUUC-Tvi-122318	Trichoderma virens	33.33	1.00e-41	165.00
IUUC-Tme-126914	Tuber melanosporum	34.40	5.00e-44	172.00
IUUC-Ttr-129095	Tursiops truncatus	92.71	0.00e+00	1221.00
IUUC-Uma-129475	Ustilago maydis	36.61	2.00e-39	157.00
IUUC-Vda-129908	Verticillium dahliae	32.87	1.00e-35	144.00
IUUC-Xtr-131900	Xenopus tropicalis	76.26	0.00e+00	1028.00
IUUC-Xma-133124	Xiphophorus maculatus	75.81	0.00e+00	977.00
IUUC-Yli-134682	Yarrowia lipolytica	35.27	9.00e-33	135.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence