iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Nle-070148

Ensembl Protein ID

ENSNLEP00000016808.1

UniProt Accession

G1RU83; G1RU83_NOMLE

Genbank Protein ID

ENSNLEP00000016808

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

ADFV01083999

Gene Name

HGS

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSNLEG00000013843.2	ENSNLET00000017660.2	ENSNLEP00000016808.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/Alpha-Helix/VHS	2.30e-51	173.2	15	143

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/VHS

   S: 1    atselvtsedwelileicdliqetkegakdalralrkrinnknphvalraLtlLdscvsnCgkkfhvevaskdlleelrellknenepk 89
           ats+l+ ++dwe+il+icdli++ +++ak+a+++++k++n+knphval+aL++++s+v+nCg+++h+eva+k+++eel++llk+++e++
   Q: 15   ATSQLLLETDWESILQICDLIRQGDTQAKYAVNSIKKKVNDKNPHVALYALEVMESVVKNCGQTVHDEVANKQTMEELKDLLKRQVEVN 103
           799************************************************************************************** PP
   S: 90   vieKlkalivsWadelknepalslivaliktlkeeGlefp 129
           v++K+++li++Wa++++nep++++++++++ +k eG++fp
   Q: 104  VRNKILYLIQAWAHAFRNEPKYKVVQDTYQIMKVEGHVFP 143
           ***************************************8 PP

Organism

Nomascus leucogenys

Protein Sequence
(Fasta)

MGRGSGTFER LLDKATSQLL LETDWESILQ ICDLIRQGDT QAKYAVNSIK KKVNDKNPHV 60
ALYALEVMES VVKNCGQTVH DEVANKQTME ELKDLLKRQV EVNVRNKILY LIQAWAHAFR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TCTTCCCGAC GCCCGTGGCC CCCAGCAGGA GACACATTCC GTGCTTCGCT CTACCCGGCA 60
CCCGTAGCTC GGCGCCGCGG AGCAAGGCCC GCCCACCGCC CACTCTCACT GGATAGTTCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR008942--ENTH_VHS
IPR024641--HRS_helical
IPR017073--Ubi-bd_Hrs_VPS27
IPR003903--UIM_dom
IPR002014--VHS_dom
IPR000306--Znf_FYVE
IPR017455--Znf_FYVE-rel
IPR011011--Znf_FYVE_PHD
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50330--UIM
PS50179--VHS
PS50178--ZF_FYVE

Pfam

PF12210--Hrs_helical
PF00790--VHS

SMART

SM00064--FYVE
SM00288--VHS

Gene Ontology

GO:0005829--C:cytosol
GO:0005769--C:early endosome
GO:0070062--C:extracellular exosome
GO:0005764--C:lysosome
GO:0046872--F:metal ion binding
GO:0010324--P:membrane invagination
GO:0046426--P:negative regulation of JAK-STAT cascade
GO:1903543--P:positive regulation of exosomal secretion
GO:0010628--P:positive regulation of gene expression
GO:0072657--P:protein localization to membrane
GO:0006622--P:protein targeting to lysosome
GO:0043405--P:regulation of MAP kinase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001518	Ailuropoda melanoleuca	82.47	0.00e+00	888.00
IUUC-Apl-003662	Anas platyrhynchos	77.20	0.00e+00	863.00
IUUC-Aca-004940	Anolis carolinensis	78.83	0.00e+00	1029.00
IUUC-Ago-007931	Ashbya gossypii	27.05	3.00e-18	86.70
IUUC-Acl-008274	Aspergillus clavatus	28.52	8.00e-31	128.00
IUUC-Afl-008521	Aspergillus flavus	30.86	2.00e-31	130.00
IUUC-Afu-008774	Aspergillus fumigatus	30.43	1.00e-31	131.00
IUUC-Ani-009445	Aspergillus nidulans	30.00	4.00e-32	133.00
IUUC-Ang-009863	Aspergillus niger	31.41	2.00e-33	137.00
IUUC-Ate-010444	Aspergillus terreus	32.60	7.00e-34	138.00
IUUC-Ame-011111	Astyanax mexicanus	72.68	0.00e+00	848.00
IUUC-Bgr-012087	Blumeria graminis	30.71	4.00e-34	139.00
IUUC-Bta-012506	Bos taurus	87.08	0.00e+00	1071.00
IUUC-Bci-013782	Botrytis cinerea	31.60	1.00e-32	134.00
IUUC-Cel-018493	Caenorhabditis elegans	46.70	4.00e-55	209.00
IUUC-Cja-019998	Callithrix jacchus	89.46	0.00e+00	1066.00
IUUC-Cfa-020615	Canis familiaris	84.42	0.00e+00	999.00
IUUC-Cpo-022019	Cavia porcellus	87.14	0.00e+00	1120.00
IUUC-Csa-023596	Chlorocebus sabaeus	92.54	0.00e+00	1043.00
IUUC-Cin-025488	Ciona intestinalis	43.57	8.00e-113	401.00
IUUC-Csv-025802	Ciona savignyi	47.25	1.00e-98	353.00
IUUC-Cgl-026560	Colletotrichum gloeosporioides	32.99	6.00e-32	132.00
IUUC-Cne-026847	Cryptococcus neoformans	29.24	5.00e-29	122.00
IUUC-Dre-028353	Danio rerio	72.19	0.00e+00	829.00
IUUC-Dno-029005	Dasypus novemcinctus	82.26	0.00e+00	1030.00
IUUC-Dor-030280	Dipodomys ordii	86.87	0.00e+00	1095.00
IUUC-Dse-031238	Dothistroma septosporum	34.10	3.00e-31	130.00
IUUC-Dme-031952	Drosophila melanogaster	44.57	2.00e-65	243.00
IUUC-Ete-032235	Echinops telfairi	87.73	6.00e-115	408.00
IUUC-Eca-033873	Equus caballus	87.92	0.00e+00	1069.00
IUUC-Eeu-034652	Erinaceus europaeus	95.53	3.00e-104	372.00
IUUC-Fca-036563	Felis catus	86.17	0.00e+00	1033.00
IUUC-Fal-036649	Ficedula albicollis	78.07	0.00e+00	919.00
IUUC-Fox-037962	Fusarium oxysporum	30.04	6.00e-30	125.00
IUUC-Fso-038396	Fusarium solani	30.45	1.00e-30	128.00
IUUC-Gmo-039510	Gadus morhua	70.10	0.00e+00	856.00
IUUC-Ggr-039938	Gaeumannomyces graminis	30.05	5.00e-29	122.00
IUUC-Gga-040201	Gallus gallus	76.50	0.00e+00	985.00
IUUC-Gac-041459	Gasterosteus aculeatus	69.88	0.00e+00	861.00
IUUC-Ggo-044573	Gorilla gorilla	93.05	0.00e+00	1139.00
IUUC-Hsa-046009	Homo sapiens	93.05	0.00e+00	1185.00
IUUC-Itr-049065	Ictidomys tridecemlineatus	88.80	0.00e+00	1152.00
IUUC-Kpa-049327	Komagataella pastoris	25.81	1.00e-21	98.20
IUUC-Lch-049944	Latimeria chalumnae	70.72	3.00e-141	495.00
IUUC-Loc-051850	Lepisosteus oculatus	75.00	0.00e+00	908.00
IUUC-Lma-053252	Leptosphaeria maculans	31.30	1.00e-29	125.00
IUUC-Laf-053346	Loxodonta africana	78.80	0.00e+00	923.00
IUUC-Mcc-055789	Macaca mulatta	92.42	0.00e+00	1098.00
IUUC-Meu-056329	Macropus eugenii	69.82	1.00e-144	506.00
IUUC-Mor-057205	Magnaporthe oryzae	30.82	1.00e-29	124.00
IUUC-Mpo-057295	Magnaporthe poae	29.33	2.00e-30	127.00
IUUC-Mla-058849	Melampsora laricipopulina	30.32	1.00e-22	102.00
IUUC-Mga-059361	Meleagris gallopavo	75.52	0.00e+00	926.00
IUUC-Mvi-060561	Microbotryum violaceum	31.32	3.00e-31	130.00
IUUC-Mmr-061122	Microcebus murinus	88.59	0.00e+00	927.00
IUUC-Mdo-062171	Monodelphis domestica	84.86	0.00e+00	1081.00
IUUC-Mmu-063952	Mus musculus	87.77	0.00e+00	1152.00
IUUC-Mac-064432	Musa acuminata	36.62	2.00e-23	104.00
IUUC-Mpu-065852	Mustela putorius furo	85.92	0.00e+00	987.00
IUUC-Mlu-066996	Myotis lucifugus	80.04	4.00e-132	464.00
IUUC-Nfi-068539	Neosartorya fischeri	30.43	1.00e-31	131.00
IUUC-Ncr-068726	Neurospora crassa	35.59	8.00e-31	128.00
IUUC-Opr-070833	Ochotona princeps	66.25	0.00e+00	679.00
IUUC-Ont-071261	Oreochromis niloticus	73.28	0.00e+00	862.00
IUUC-Oan-073684	Ornithorhynchus anatinus	70.00	7.00e-152	530.00
IUUC-Ola-087570	Oryzias latipes	70.58	0.00e+00	881.00
IUUC-Oga-089087	Otolemur garnettii	83.53	0.00e+00	978.00
IUUC-Oar-089534	Ovis aries	86.68	0.00e+00	1069.00
IUUC-Ptr-091654	Pan troglodytes	87.64	0.00e+00	1028.00
IUUC-Pan-092652	Papio anubis	92.79	0.00e+00	1105.00
IUUC-Pno-095125	Phaeosphaeria nodorum	33.04	8.00e-31	128.00
IUUC-Pfo-096757	Poecilia formosa	70.99	0.00e+00	848.00
IUUC-Pab-097788	Pongo abelii	95.07	0.00e+00	819.00
IUUC-Pca-100145	Procavia capensis	74.00	0.00e+00	799.00
IUUC-Pva-102965	Pteropus vampyrus	82.51	0.00e+00	1017.00
IUUC-Pgr-103609	Puccinia graminis	30.61	1.00e-22	101.00
IUUC-Ptt-103865	Puccinia triticina	31.63	1.00e-22	102.00
IUUC-Pte-104095	Pyrenophora teres	30.84	4.00e-30	126.00
IUUC-Pyt-104668	Pyrenophora triticirepentis	30.84	9.00e-30	125.00
IUUC-Rno-105125	Rattus norvegicus	87.85	0.00e+00	1081.00
IUUC-Sce-106192	Saccharomyces cerevisiae	24.89	4.00e-19	89.70
IUUC-Sha-107066	Sarcophilus harrisii	85.13	0.00e+00	1044.00
IUUC-Sja-107931	Schizosaccharomyces japonicus	30.14	2.00e-28	120.00
IUUC-Spo-108220	Schizosaccharomyces pombe	31.80	2.00e-24	107.00
IUUC-Smo-109345	Selaginella moellendorffii	37.76	2.00e-20	92.80
IUUC-Sar-113393	Sorex araneus	87.15	3.00e-92	332.00
IUUC-Sre-114986	Sporisorium reilianum	33.62	7.00e-32	132.00
IUUC-Tgu-117505	Taeniopygia guttata	77.69	0.00e+00	951.00
IUUC-Tru-118494	Takifugu rubripes	72.46	0.00e+00	890.00
IUUC-Tsy-119626	Tarsius syrichta	100.00	3.00e-54	206.00
IUUC-Tni-120174	Tetraodon nigroviridis	69.30	0.00e+00	895.00
IUUC-Tre-122191	Trichoderma reesei	30.91	1.00e-31	131.00
IUUC-Tvi-122318	Trichoderma virens	30.10	3.00e-32	133.00
IUUC-Tme-126914	Tuber melanosporum	30.85	4.00e-32	133.00
IUUC-Ttr-129095	Tursiops truncatus	87.31	0.00e+00	1101.00
IUUC-Uma-129475	Ustilago maydis	32.89	2.00e-29	124.00
IUUC-Vda-129908	Verticillium dahliae	29.89	1.00e-26	115.00
IUUC-Xtr-131900	Xenopus tropicalis	72.29	0.00e+00	928.00
IUUC-Xma-133124	Xiphophorus maculatus	71.49	0.00e+00	872.00
IUUC-Yli-134682	Yarrowia lipolytica	32.14	3.00e-23	103.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence