iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-046287

UUCD1 version

UUC-HoS-01188

Ensembl Protein ID

ENSP00000344259.4

UniProt Accession

P68036; B2R4A7; B4DDG1; B4DSZ4; E7EWS7; P51966; P70653; Q9HAV1; UB2L3_HUMAN

Genbank Protein ID

AAB36017.1; CAA63538.1; CAA04156.1; AAG17922.1; CAG30492.1; BAG56722.1; BAG61806.1; BAG34704.1; EAW59459.1; AAH53368.1

Protein Name

Ubiquitin-conjugating enzyme E2 L3; E2 ubiquitin-conjugating enzyme L3; L-UBC; UbcH7; Ubiquitin carrier protein L3; Ubiquitin-conjugating enzyme E2-F1; Ubiquitin-protein ligase L3

Genbank Nucleotide ID

S81003; X92962; AJ000519; AF300336; CR456606; AK293179; AK299985; AK311761; AP000553; BC053368

Gene Name

UBE2L3; UBCE7; UBCH7

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000185651.14	ENST00000342192.8	ENSP00000344259.4
ENSG00000185651.14	ENST00000545681.2	ENSP00000445931.1
ENSG00000185651.14	ENST00000458578.6	ENSP00000400906.2

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
miRWalk	TargetScan	RepTar	SomamiR
miRcode	RAID2
Protein-protein Interaction
IID	PINA	HINT	Mentha
InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	UniProt	PHOSIDA	BioGRID
mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E2/UBC	E2_UBC	16061177; 20553626; 19664228; 19592251; 16709802; 14684739; 12612082

Classification

Family	E-value	Score	Start	End
E2/UBC	2.70e-43	148.7	6	141

Active Site

Position(s)	Description	Evidence
86	Glycyl thioester intermediate	{ECO:0000255\|PROSITE-ProRule:PRU00388, ECO:0000255\|PROSITE-ProRule:PRU10133}

Domain Profile

E2/UBC

   S: 1    RlkkelkelekdppegisakpvdesdltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltkifhPnvyenGkvClsilkeeekW 92
           Rl+kel+e++k  +++++  +vde++l +w+ li+ p++ pY++g+F++ei+fp +YPfkPPk++f tki+hPn++e+G+vCl ++ ++e+W
   Q: 6    RLMKELEEIRKCGMKNFRNIQVDEANLLTWQGLIV-PDNPPYDKGAFRIEINFPAEYPFKPPKITFKTKIYHPNIDEKGQVCLPVI-SAENW 95
           9**********************************.**************************************************.5**** PP
   S: 93   spalsvesvllsiqsllaepnpesplneeaaellkknreeykkkvr 138
           +pa++  +v+ s+++l+++p+pe+pl+++ ae+++k+r+++ k+++
   Q: 96   KPATKTDQVIQSLIALVNDPQPEHPLRADLAEEYSKDRKKFCKNAE 141
           ******************************************9986 PP

Organism

Homo sapiens

Functional Description
(View)

Ubiquitin-conjugating enzyme E2 that specifically acts with HECT-type and RBR family E3 ubiquitin-protein ligases. Does not function with most RING-containing E3 ubiquitin-protein ligases because it lacks intrinsic E3-independent reactivity with lysine: in contrast, it has activity with the RBR family E3 enzymes, such as PARK2 and ARIH1, that function like function like RING-HECT hybrids. Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'-linked polyubiquitination. Involved in the selective degradation of short-lived and abnormal proteins. Down-regulated during the S-phase it is involved in progression through the cell cycle. Regulates nuclear hormone receptors transcriptional activity. May play a role in myelopoiesis.

Protein Sequence
(Fasta)

MAASRRLMKE LEEIRKCGMK NFRNIQVDEA NLLTWQGLIV PDNPPYDKGA FRIEINFPAE 60
YPFKPPKITF KTKIYHPNID EKGQVCLPVI SAENWKPATK TDQVIQSLIA LVNDPQPEHP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGTATGCAGG TCGCTGCAGG GACCCGAGGC GACACGCGCC TGCAGGAGGT GGCACTCCTG 60
CCGCAGCTCT TCGATCTGCT TGTCCTTGGC CAGCGGCGCG CTCGCCTGCT CCGACAGGTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0903--Direct protein sequencing
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway

Interpro

IPR000608--UBQ-conjugat_E2
IPR023313--UBQ-conjugating_AS
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS00183--UBIQUITIN_CONJUGAT_1
PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00179--UQ_con

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0000151--C:ubiquitin ligase complex
GO:0005524--F:ATP binding
GO:0019899--F:enzyme binding
GO:0003723--F:RNA binding
GO:0003713--F:transcription coactivator activity
GO:0061631--F:ubiquitin conjugating enzyme activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0097027--F:ubiquitin-protein transferase activator activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0044770--P:cell cycle phase transition
GO:0008283--P:cell proliferation
GO:0006464--P:cellular protein modification process
GO:0071385--P:cellular response to glucocorticoid stimulus
GO:0071383--P:cellular response to steroid hormone stimulus
GO:1903955--P:positive regulation of protein targeting to mitochondrion
GO:0031398--P:positive regulation of protein ubiquitination
GO:0051443--P:positive regulation of ubiquitin-protein transferase activity
GO:0070979--P:protein K11-linked ubiquitination
GO:0000209--P:protein polyubiquitination
GO:0016567--P:protein ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

hsa:7332

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001446	Ailuropoda melanoleuca	100.00	8.00e-53	198.00
IUUC-Apl-003318	Anas platyrhynchos	94.81	5.00e-73	266.00
IUUC-Aca-005234	Anolis carolinensis	98.65	1.00e-73	268.00
IUUC-Ame-011452	Astyanax mexicanus	93.92	8.00e-69	252.00
IUUC-Bta-012693	Bos taurus	99.32	1.00e-72	264.00
IUUC-Cel-018332	Caenorhabditis elegans	59.21	3.00e-58	217.00
IUUC-Cja-019062	Callithrix jacchus	100.00	4.00e-78	283.00
IUUC-Cfa-020027	Canis familiaris	100.00	4.00e-78	283.00
IUUC-Cpo-022341	Cavia porcellus	100.00	4.00e-78	283.00
IUUC-Cho-024916	Choloepus hoffmanni	93.14	7.00e-43	164.00
IUUC-Cin-025130	Ciona intestinalis	66.88	2.00e-47	181.00
IUUC-Csv-026183	Ciona savignyi	65.56	2.00e-47	181.00
IUUC-Dre-027710	Danio rerio	94.81	2.00e-73	268.00
IUUC-Dno-029371	Dasypus novemcinctus	100.00	9.00e-55	204.00
IUUC-Dor-031017	Dipodomys ordii	94.81	4.00e-71	259.00
IUUC-Dme-031814	Drosophila melanogaster	74.03	2.00e-68	251.00
IUUC-Ete-032754	Echinops telfairi	100.00	4.00e-78	283.00
IUUC-Eca-034056	Equus caballus	96.75	9.00e-76	275.00
IUUC-Eeu-034942	Erinaceus europaeus	98.70	4.00e-77	280.00
IUUC-Fca-036173	Felis catus	100.00	4.00e-78	283.00
IUUC-Fal-036820	Ficedula albicollis	100.00	5.00e-73	266.00
IUUC-Gmo-038480	Gadus morhua	91.03	4.00e-65	239.00
IUUC-Gga-041039	Gallus gallus	100.00	4.00e-78	283.00
IUUC-Gac-041571	Gasterosteus aculeatus	77.48	2.00e-56	211.00
IUUC-Ggo-044482	Gorilla gorilla	100.00	1.00e-73	268.00
IUUC-Itr-049057	Ictidomys tridecemlineatus	100.00	5.00e-67	246.00
IUUC-Lch-049699	Latimeria chalumnae	81.90	1.00e-43	168.00
IUUC-Loc-052000	Lepisosteus oculatus	92.95	2.00e-71	261.00
IUUC-Laf-053833	Loxodonta africana	99.32	2.00e-72	264.00
IUUC-Meu-056738	Macropus eugenii	100.00	1.00e-47	181.00
IUUC-Mga-060134	Meleagris gallopavo	97.37	3.00e-73	267.00
IUUC-Mmr-060627	Microcebus murinus	96.10	7.00e-84	302.00
IUUC-Mdo-062043	Monodelphis domestica	82.35	3.00e-73	267.00
IUUC-Mmu-063615	Mus musculus	100.00	4.00e-78	283.00
IUUC-Mlu-067987	Myotis lucifugus	98.05	2.00e-87	313.00
IUUC-Opr-070315	Ochotona princeps	100.00	4.00e-78	283.00
IUUC-Ont-072036	Oreochromis niloticus	92.86	2.00e-71	261.00
IUUC-Ocu-074565	Oryctolagus cuniculus	96.15	6.00e-74	269.00
IUUC-Ola-086994	Oryzias latipes	82.47	5.00e-73	266.00
IUUC-Oga-088085	Otolemur garnettii	94.16	1.00e-83	301.00
IUUC-Oar-089520	Ovis aries	99.32	1.00e-72	265.00
IUUC-Ptr-090890	Pan troglodytes	99.35	4.00e-88	316.00
IUUC-Pan-092445	Papio anubis	100.00	1.00e-73	268.00
IUUC-Psi-093376	Pelodiscus sinensis	96.05	7.00e-73	265.00
IUUC-Pma-094445	Petromyzon marinus	79.86	7.00e-55	205.00
IUUC-Pfo-096258	Poecilia formosa	92.86	4.00e-71	260.00
IUUC-Pab-097654	Pongo abelii	100.00	4.00e-78	283.00
IUUC-Pca-100712	Procavia capensis	79.22	3.00e-55	207.00
IUUC-Pva-103113	Pteropus vampyrus	100.00	2.00e-72	264.00
IUUC-Sha-106823	Sarcophilus harrisii	100.00	3.00e-70	256.00
IUUC-Sar-113240	Sorex araneus	100.00	2.00e-72	264.00
IUUC-Ssc-115442	Sus scrofa	100.00	4.00e-78	283.00
IUUC-Tgu-117352	Taeniopygia guttata	99.32	1.00e-72	264.00
IUUC-Tru-117653	Takifugu rubripes	92.86	7.00e-72	262.00
IUUC-Tsy-119345	Tarsius syrichta	79.22	4.00e-54	203.00
IUUC-Tni-119709	Tetraodon nigroviridis	92.86	7.00e-72	262.00
IUUC-Tbe-127451	Tupaia belangeri	94.16	3.00e-83	300.00
IUUC-Ttr-128840	Tursiops truncatus	100.00	4.00e-78	283.00
IUUC-Xtr-132650	Xenopus tropicalis	97.40	5.00e-76	276.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence