iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000185658.13	ENST00000333229.6	ENSP00000330753.2
ENSG00000185658.13	ENST00000446924.5	ENSP00000391014.1
ENSG00000185658.13	ENST00000342449.7	ENSP00000344333.3
ENSG00000185658.13	ENST00000380800.7	ENSP00000370178.3
ENSG00000185658.13	ENST00000424441.1	ENSP00000415066.1
ENSG00000185658.13	ENST00000445668.5	ENSP00000395575.1
ENSG00000185658.13	ENST00000430093.5	ENSP00000393702.1
ENSG00000185658.13	ENST00000445245.5	ENSP00000390684.1
ENSG00000185658.13	ENST00000455867.5	ENSP00000389882.1
ENSG00000185658.13	ENST00000412604.1	ENSP00000398900.1
ENSG00000185658.13	ENST00000341322.4	ENSP00000342106.4

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
TargetScan	RepTar	miRNAMap	SomamiR
miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
GWASdb
Drug and target
GRAC
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	UniProt	PHOSIDA	BioGRID
mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/DCX/DWD	WD_repeat	17588513

Classification

Family	E-value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	8.40e-35	118.9	184	221
UBD/Beta-Prp	2.80e-54	186.0	286	543

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvll 36
           gH + v+c+af  + +++ +GsdD+ +k+W+++ g+ll
   Q: 184  GHLSAVYCVAFdRTgHRIFTGSDDCLVKIWSTHNGRLL 221
           8**********955599***************999987 PP

UBD/Beta-Prp

   S: 22   ksllatgsrdgtikvwdvttgkl......lrslsgheaevtavk..fspdgkilvtgseDrtikvw..dlstgkcvhtlkghedsvlslsfs 103
           +++++++++dgt+  w+++ ++l      l+  ++  ++v+ ++  fs  g +l+tgs+D++i+ +   +++++ +  l+ h+d+v s++f+
   Q: 286  QRYMVSTGADGTVCFWQWDLESLkfsprpLKFTEKPRPGVQMLCssFSVGGMFLATGSTDHVIRMYflGFEAPEKIAELESHTDKVDSIQFC 377
           689*****************99999988777778888888755522888888**************99999********************* PP
   S: 104  psgdklvsGshdrtirvwdletgqclee...............tlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgght 180
            +gd+++sGs+d t+r+w  e+ ++ +                 ++  +  v++++++++++++v++ +D ++++W++ tg+ll+ l g h 
   Q: 378  NNGDRFLSGSRDGTARIWRFEQLEWRSIlldmatrisgdlsseEERFMKPKVTMIAWNQNDSIVVTAVNDHVLKVWNSYTGQLLHNLMG-HA 468
           ***********************99998999********998877777888*************************************9.** PP
   S: 181  dsvysls...fdsngkelvsgsldgtvklwdlqtgecvrtlnght.....dnvksvrfspnderlvsgssDgsiriW 249
           d v  l+   fds  + ++s+++dg++ +wd+ +g+ ++ + +         v + +fs+++++++++ s+g + i+
   Q: 469  DEVFVLEthpFDS--RIMLSAGHDGSIFIWDITKGTKMKHYFNMIegqghGAVFDCKFSQDGQHFACTDSHGHLLIF 543
           *******555555..99****************999977766544444456677789999*****999999998886 PP

Organism

Homo sapiens

Functional Description
(View)

May be a transcriptional activator. May be involved in chromatin remodeling (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape.

Protein Sequence
(Fasta)

MAEPSSARRP VPLIESELYF LIARYLSAGP CRRAAQVLVQ ELEQYQLLPK RLDWEGNEHN 60
RSYEELVLSN KHVAPDHLLQ ICQRIGPMLD KEIPPSISRV TSLLGAGRQS LLRTAKDCRH 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGAGAGGCCA GATCGTGTGG ACTTGGCCTT TTCCTCTGGG TCTGATGGGA GCCTCTGGAG 60
GATTTTGAGA GAGGAAGGAC AAGTCCGTCT TTAGTTTGTT TTTTTTTTTT TCTTGAGATG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0010--Activator
KW-0025--Alternative splicing
KW-0103--Bromodomain
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0853--WD repeat

Interpro

IPR001487--Bromodomain
IPR018359--Bromodomain_CS
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00633--BROMODOMAIN_1
PS50014--BROMODOMAIN_2
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00439--Bromodomain
PF00400--WD40

PRINTS

PR00503--BROMODOMAIN

SMART

SM00297--BROMO
SM00320--WD40

Gene Ontology

GO:0005829--C:cytosol
GO:0005730--C:nucleolus
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0006325--P:chromatin organization
GO:0007010--P:cytoskeleton organization
GO:0008360--P:regulation of cell shape
GO:0006357--P:regulation of transcription from RNA polymerase II promoter
GO:0006351--P:transcription, DNA-templated

KEGG

hsa:54014

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002332	Ailuropoda melanoleuca	84.56	0.00e+00	3316.00
IUUC-Apl-004083	Anas platyrhynchos	69.45	0.00e+00	1964.00
IUUC-Aca-004348	Anolis carolinensis	72.67	0.00e+00	1954.00
IUUC-Aly-006517	Arabidopsis lyrata	30.58	3.00e-73	271.00
IUUC-Ame-010718	Astyanax mexicanus	71.21	0.00e+00	1175.00
IUUC-Bta-013217	Bos taurus	88.76	0.00e+00	3713.00
IUUC-Bdi-014797	Brachypodium distachyon	29.25	3.00e-59	224.00
IUUC-Bol-015737	Brassica oleracea	30.00	6.00e-74	273.00
IUUC-Bra-017961	Brassica rapa	29.96	3.00e-73	271.00
IUUC-Cja-019966	Callithrix jacchus	95.17	0.00e+00	4004.00
IUUC-Cfa-021037	Canis familiaris	88.25	0.00e+00	3627.00
IUUC-Cpo-021934	Cavia porcellus	92.14	0.00e+00	2781.00
IUUC-Cre-023003	Chlamydomonas reinhardtii	34.15	9.00e-35	142.00
IUUC-Csa-023352	Chlorocebus sabaeus	97.62	0.00e+00	3847.00
IUUC-Cho-024690	Choloepus hoffmanni	80.34	0.00e+00	1381.00
IUUC-Dno-028938	Dasypus novemcinctus	85.01	0.00e+00	3576.00
IUUC-Dme-031752	Drosophila melanogaster	49.84	0.00e+00	671.00
IUUC-Eca-034349	Equus caballus	89.48	0.00e+00	3552.00
IUUC-Fca-035485	Felis catus	82.67	0.00e+00	3099.00
IUUC-Fal-037307	Ficedula albicollis	77.67	0.00e+00	2298.00
IUUC-Gma-043340	Glycine max	30.36	6.00e-71	263.00
IUUC-Ggo-045500	Gorilla gorilla	99.05	0.00e+00	4145.00
IUUC-Itr-047962	Ictidomys tridecemlineatus	95.71	0.00e+00	1173.00
IUUC-Lch-049662	Latimeria chalumnae	57.91	0.00e+00	2115.00
IUUC-Lpe-051619	Leersia perrieri	31.23	1.00e-70	262.00
IUUC-Laf-053848	Loxodonta africana	87.28	0.00e+00	3565.00
IUUC-Mcc-054638	Macaca mulatta	97.89	0.00e+00	4116.00
IUUC-Meu-056739	Macropus eugenii	79.91	0.00e+00	1117.00
IUUC-Mga-060165	Meleagris gallopavo	77.82	0.00e+00	2306.00
IUUC-Mmr-061227	Microcebus murinus	92.21	0.00e+00	3848.00
IUUC-Mdo-062074	Monodelphis domestica	70.44	0.00e+00	2795.00
IUUC-Mmu-064075	Mus musculus	82.83	0.00e+00	3020.00
IUUC-Mac-065343	Musa acuminata	31.02	2.00e-75	278.00
IUUC-Mpu-066643	Mustela putorius furo	90.31	0.00e+00	3011.00
IUUC-Mlu-067735	Myotis lucifugus	86.48	0.00e+00	3506.00
IUUC-Nle-069402	Nomascus leucogenys	96.14	0.00e+00	3148.00
IUUC-Oan-072954	Ornithorhynchus anatinus	69.87	0.00e+00	2859.00
IUUC-Ocu-074456	Oryctolagus cuniculus	88.38	0.00e+00	3700.00
IUUC-Oba-075709	Oryza barthii	30.17	1.00e-60	229.00
IUUC-Oru-085195	Oryza rufipogon	30.17	1.00e-60	229.00
IUUC-Olu-087745	Ostreococcus lucimarinus	28.57	2.00e-56	214.00
IUUC-Oga-087938	Otolemur garnettii	82.97	0.00e+00	3282.00
IUUC-Oar-090214	Ovis aries	87.78	0.00e+00	3566.00
IUUC-Ptr-091213	Pan troglodytes	99.35	0.00e+00	4135.00
IUUC-Pan-092444	Papio anubis	97.16	0.00e+00	4084.00
IUUC-Psi-093271	Pelodiscus sinensis	60.60	0.00e+00	2216.00
IUUC-Pma-094427	Petromyzon marinus	66.98	4.00e-133	467.00
IUUC-Ppa-095793	Physcomitrella patens	29.84	2.00e-74	275.00
IUUC-Pfo-097318	Poecilia formosa	62.84	0.00e+00	1792.00
IUUC-Pab-097573	Pongo abelii	97.61	0.00e+00	4012.00
IUUC-Pop-099672	Populus trichocarpa	31.03	8.00e-73	269.00
IUUC-Pca-100759	Procavia capensis	70.97	0.00e+00	1162.00
IUUC-Pva-102782	Pteropus vampyrus	88.13	0.00e+00	3591.00
IUUC-Rno-105687	Rattus norvegicus	79.01	0.00e+00	3301.00
IUUC-Sly-111348	Solanum lycopersicum	30.56	7.00e-76	280.00
IUUC-Sar-113519	Sorex araneus	80.54	0.00e+00	1787.00
IUUC-Tgu-116513	Taeniopygia guttata	77.55	0.00e+00	2311.00
IUUC-Tsy-118921	Tarsius syrichta	90.27	0.00e+00	2043.00
IUUC-Tca-121615	Theobroma cacao	29.89	7.00e-68	253.00
IUUC-Tbe-127663	Tupaia belangeri	80.20	0.00e+00	1361.00
IUUC-Ttr-128561	Tursiops truncatus	86.95	0.00e+00	3467.00
IUUC-Vpa-130444	Vicugna pacos	85.78	0.00e+00	3351.00
IUUC-Vvi-131362	Vitis vinifera	30.99	6.00e-74	273.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence