iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
miRTarBase	microRNA	TRANSFAC	TargetScan
RepTar	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB	4.50e-13	51.0	29	93

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_Other: BTB

   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmeleesksklmveikdvqpevfrallkFlYtgkld 66
           +Dv+l+ +g+ef+ah++ La sS++F+alf+++  es+    ++++  ++  ++ ll+F+Yt  l+
   Q: 29   CDVTLETEGSEFPAHRSLLACSSDYFRALFKSHTQESR-ARVIHLHVPSAAGLQRLLDFIYTAWLS 93
           9************************************9.9******99**************8766 PP

Organism

Homo sapiens

Protein Sequence
(Fasta)

MSYFLSYCKA HGGALLTGYQ ALRAEGFLCD VTLETEGSEF PAHRSLLACS SDYFRALFKS 60
HTQESRARVI HLHVPSAAGL QRLLDFIYTA WLSLSMDTVE DTLEAASYLQ VTEALGLCGR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGTTGTCCCC GGCCTTCGCG GGTGCCCGCA GAACCCGTCC TCCTCGTCCA CCCCGGAGAG 60
GTCAGAGTCC TCGCCCTGCA CTCCCGGGAC GCCGCATCTG CGCCGTCGGA CATCCAGCAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0880--Kelch repeat
KW-1185--Reference proteome
KW-0677--Repeat

Interpro

IPR011705--BACK
IPR017096--BTB-kelch_protein
IPR000210--BTB/POZ_dom
IPR015915--Kelch-typ_b-propeller
IPR006652--Kelch_1
IPR011333--SKP1/BTB/POZ

PROSITE

PS50097--BTB

Pfam

PF07707--BACK
PF00651--BTB
PF01344--Kelch_1

SMART

SM00875--BACK
SM00225--BTB
SM00612--Kelch

Gene Ontology

GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0005615--C:extracellular space
GO:0016567--P:protein ubiquitination

KEGG

hsa:257240

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001332	Ailuropoda melanoleuca	85.12	0.00e+00	958.00
IUUC-Apl-003397	Anas platyrhynchos	52.58	1.00e-164	573.00
IUUC-Aca-005046	Anolis carolinensis	50.08	3.00e-161	561.00
IUUC-Ame-010614	Astyanax mexicanus	40.56	3.00e-116	412.00
IUUC-Bta-012398	Bos taurus	88.77	0.00e+00	916.00
IUUC-Cja-019513	Callithrix jacchus	87.75	0.00e+00	934.00
IUUC-Cfa-020271	Canis familiaris	87.96	0.00e+00	921.00
IUUC-Cpo-021570	Cavia porcellus	82.34	0.00e+00	954.00
IUUC-Csa-023939	Chlorocebus sabaeus	95.96	0.00e+00	1035.00
IUUC-Dre-027419	Danio rerio	38.57	7.00e-117	414.00
IUUC-Dno-029912	Dasypus novemcinctus	87.35	0.00e+00	999.00
IUUC-Dor-030827	Dipodomys ordii	81.50	0.00e+00	926.00
IUUC-Eeu-035056	Erinaceus europaeus	81.45	0.00e+00	905.00
IUUC-Fca-036382	Felis catus	78.63	0.00e+00	883.00
IUUC-Fal-037567	Ficedula albicollis	51.54	4.00e-169	588.00
IUUC-Gga-040307	Gallus gallus	52.86	2.00e-167	582.00
IUUC-Gac-041818	Gasterosteus aculeatus	37.22	1.00e-89	323.00
IUUC-Ggo-045460	Gorilla gorilla	93.16	0.00e+00	953.00
IUUC-Itr-048321	Ictidomys tridecemlineatus	83.03	0.00e+00	859.00
IUUC-Lch-050093	Latimeria chalumnae	44.80	1.00e-150	526.00
IUUC-Loc-052133	Lepisosteus oculatus	43.62	6.00e-127	447.00
IUUC-Laf-053511	Loxodonta africana	88.10	2.00e-135	475.00
IUUC-Mcc-055396	Macaca mulatta	95.96	0.00e+00	1008.00
IUUC-Mmr-060664	Microcebus murinus	89.64	0.00e+00	917.00
IUUC-Mdo-062058	Monodelphis domestica	72.27	0.00e+00	836.00
IUUC-Mmu-064318	Mus musculus	82.66	0.00e+00	884.00
IUUC-Mpu-065754	Mustela putorius furo	85.71	0.00e+00	956.00
IUUC-Opr-070464	Ochotona princeps	81.13	0.00e+00	699.00
IUUC-Ont-071463	Oreochromis niloticus	35.68	7.00e-92	331.00
IUUC-Ocu-074434	Oryctolagus cuniculus	84.22	0.00e+00	920.00
IUUC-Ola-086467	Oryzias latipes	37.24	6.00e-95	341.00
IUUC-Oga-089092	Otolemur garnettii	85.20	0.00e+00	894.00
IUUC-Ptr-090457	Pan troglodytes	91.93	0.00e+00	954.00
IUUC-Pan-092610	Papio anubis	95.96	0.00e+00	1016.00
IUUC-Psi-093009	Pelodiscus sinensis	49.44	9.00e-170	590.00
IUUC-Pfo-097358	Poecilia formosa	35.93	7.00e-91	328.00
IUUC-Pab-097741	Pongo abelii	96.96	0.00e+00	1008.00
IUUC-Pva-102251	Pteropus vampyrus	88.25	0.00e+00	976.00
IUUC-Rno-105869	Rattus norvegicus	82.92	0.00e+00	876.00
IUUC-Sha-107242	Sarcophilus harrisii	70.02	0.00e+00	777.00
IUUC-Tgu-116693	Taeniopygia guttata	50.97	1.00e-171	596.00
IUUC-Tru-117864	Takifugu rubripes	34.64	4.00e-85	309.00
IUUC-Tsy-118840	Tarsius syrichta	89.74	0.00e+00	1002.00
IUUC-Tbe-128143	Tupaia belangeri	86.99	4.00e-175	608.00
IUUC-Xtr-132958	Xenopus tropicalis	46.76	2.00e-155	542.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence