iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	CircNet	miRTarBase
microRNA	TRANSFAC	TargetScan	RepTar
SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Variation
OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	UniProt
BioGRID
DNA Methylation
TCGA	ICGC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB	9.10e-07	30.8	33	95

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_Other: BTB

   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmeleesksklmveikdvqpevfrallkFlYtgklde 67
           +Dv ++++++ef+ hk++Laa+S ++++ fl  l +sk + +++i   ++ev r ll  +Ytg l+ 
   Q: 33   CDVSIYINDTEFQGHKVILAACSTFMRDQFL--LTQSK-HVRITIL-QSAEVGRKLLLSCYTGALEV 95
           8*****************************5..56777.7788888.89999999999999999876 PP

Organism

Homo sapiens

Functional Description
(View)

Widely expressed with highest levels in brain.

Protein Sequence
(Fasta)

MAAESDVLHF QFEQQGDVVL QKMNLLRQQN LFCDVSIYIN DTEFQGHKVI LAACSTFMRD 60
QFLLTQSKHV RITILQSAEV GRKLLLSCYT GALEVKRKEL LKYLTAASYL QMVHIVEKCT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTGTTTTCTT CCAGGCTAAG TCCATCTTCC GGCTTGGGCA GACGCTGCCG CGGAATCCTT 60
GACTCTAGTT TTCTGAGTCG GTGAGTGAGT GCAAAGTAGA TTCCTCAGGT GGAGGGTGCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0238--DNA-binding
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR000210--BTB/POZ_dom
IPR011333--SKP1/BTB/POZ
IPR013087--Znf_C2H2_type

PROSITE

PS50097--BTB
PS00028--ZINC_FINGER_C2H2_1
PS50157--ZINC_FINGER_C2H2_2

Pfam

PF00651--BTB

SMART

SM00225--BTB
SM00355--ZnF_C2H2

Gene Ontology

GO:0005739--C:mitochondrion
GO:0005634--C:nucleus
GO:0003677--F:DNA binding
GO:0046872--F:metal ion binding
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated

KEGG

hsa:10773

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ame-011016	Astyanax mexicanus	52.89	9.00e-32	131.00
IUUC-Bta-012441	Bos taurus	94.58	0.00e+00	832.00
IUUC-Cja-019851	Callithrix jacchus	98.35	0.00e+00	863.00
IUUC-Cfa-020328	Canis familiaris	95.99	0.00e+00	843.00
IUUC-Cpo-022027	Cavia porcellus	94.10	0.00e+00	822.00
IUUC-Csa-024130	Chlorocebus sabaeus	99.29	0.00e+00	872.00
IUUC-Cho-024568	Choloepus hoffmanni	95.05	0.00e+00	811.00
IUUC-Dno-029716	Dasypus novemcinctus	95.23	0.00e+00	790.00
IUUC-Ete-032272	Echinops telfairi	91.75	0.00e+00	807.00
IUUC-Eca-033644	Equus caballus	95.99	0.00e+00	840.00
IUUC-Eeu-034904	Erinaceus europaeus	93.16	0.00e+00	819.00
IUUC-Fal-036710	Ficedula albicollis	76.28	0.00e+00	637.00
IUUC-Gmo-039610	Gadus morhua	52.03	2.00e-27	116.00
IUUC-Ggo-044541	Gorilla gorilla	100.00	0.00e+00	878.00
IUUC-Itr-048653	Ictidomys tridecemlineatus	94.10	0.00e+00	830.00
IUUC-Loc-052329	Lepisosteus oculatus	36.96	8.00e-77	280.00
IUUC-Laf-053344	Loxodonta africana	93.40	0.00e+00	821.00
IUUC-Mcc-055428	Macaca mulatta	99.06	0.00e+00	869.00
IUUC-Meu-055915	Macropus eugenii	79.58	6.00e-112	396.00
IUUC-Mmr-061556	Microcebus murinus	97.41	0.00e+00	858.00
IUUC-Mmu-063464	Mus musculus	92.45	0.00e+00	810.00
IUUC-Mlu-067440	Myotis lucifugus	94.66	0.00e+00	808.00
IUUC-Nle-069279	Nomascus leucogenys	100.00	0.00e+00	878.00
IUUC-Ont-071841	Oreochromis niloticus	33.41	3.00e-54	206.00
IUUC-Oga-088944	Otolemur garnettii	95.75	0.00e+00	838.00
IUUC-Oar-090101	Ovis aries	93.63	0.00e+00	829.00
IUUC-Ptr-091369	Pan troglodytes	100.00	0.00e+00	878.00
IUUC-Pan-092903	Papio anubis	99.06	0.00e+00	870.00
IUUC-Psi-093807	Pelodiscus sinensis	78.93	0.00e+00	664.00
IUUC-Pfo-096344	Poecilia formosa	48.84	6.00e-31	129.00
IUUC-Pab-097901	Pongo abelii	99.76	0.00e+00	875.00
IUUC-Pva-102743	Pteropus vampyrus	94.34	0.00e+00	816.00
IUUC-Rno-104922	Rattus norvegicus	90.09	0.00e+00	790.00
IUUC-Sar-113512	Sorex araneus	91.27	0.00e+00	797.00
IUUC-Ssc-116018	Sus scrofa	91.27	0.00e+00	793.00
IUUC-Tgu-117513	Taeniopygia guttata	77.22	0.00e+00	634.00
IUUC-Tsy-119311	Tarsius syrichta	96.99	0.00e+00	734.00
IUUC-Tni-120696	Tetraodon nigroviridis	52.00	2.00e-31	130.00
IUUC-Ttr-128586	Tursiops truncatus	95.05	0.00e+00	835.00
IUUC-Vpa-130665	Vicugna pacos	93.38	0.00e+00	817.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence