iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	HPM
DNA & RNA Element
AREsite	microRNA	TRANSFAC	TargetScan
RepTar	SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Information
ClinVar	OMIM
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	BioGRID
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	19529779; 19171932

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	0.0027	19.9	26	72
E3 adaptor/Cullin RING/DCX/DWD	0.1	14.7	182	202

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledf....kdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C +C+e f    ++ p+ l+CgHv ++ C+ ++  ++     +  CP Cr
   Q: 26   CKVCFEKFghrqQRRPRNLSCGHVVCLACVAAL-AHP--RTLALECPFCR 72
           99******9999555**************9777.444..899999****8 PP

E3 adaptor/Cullin RING/DCX/DWD

   S: 11   f.sd.tllvsGsdDgtikvWD 29
             +d + +v+ ++D +ikv+D
   Q: 182  ItNDcHVVVTDAGDRSIKVFD 202
           26776778************* PP

Organism

Homo sapiens

Functional Description
(View)

E3 ubiquitin-protein ligase. Together with the phosphatase EPM2A/laforin, appears to be involved in the clearance of toxic polyglucosan and protein aggregates via multiple pathways. In complex with EPM2A/laforin and HSP70, suppresses the cellular toxicity of misfolded proteins by promoting their degradation through the ubiquitin-proteasome system (UPS). Ubiquitinates the glycogen-targeting protein phosphatase subunits PPP1R3C/PTG and PPP1R3D in a laforin-dependent manner and targets them for proteasome-dependent degradation, thus decreasing glycogen accumulation. Polyubiquitinates EPM2A/laforin and ubiquitinates AGL and targets them for proteasome-dependent degradation. Also promotes proteasome-independent protein degradation through the macroautophagy pathway.

Protein Sequence
(Fasta)

MAAEASESGP ALHELMREAE ISLLECKVCF EKFGHRQQRR PRNLSCGHVV CLACVAALAH 60
PRTLALECPF CRRACRGCDT SDCLPVLHLI ELLGSALRQS PAAHRAAPSA PGALTCHHTF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCGGCCG AAGCCTCGGA GAGCGGGCCA GCGCTGCATG AGCTCATGCG CGAGGCGGAG 60
ATCAGCCTGC TCGAGTGCAA GGTGTGCTTT GAGAAGTTTG GCCACCGGCA GCAGCGGCGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0072--Autophagy
KW-0181--Complete proteome
KW-0225--Disease mutation
KW-0256--Endoplasmic reticulum
KW-0887--Epilepsy
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR013017--NHL_repeat_subgr
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS51125--NHL
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF14634--zf-RING_5

SMART

SM00184--RING

Gene Ontology

GO:0005829--C:cytosol
GO:0005783--C:endoplasmic reticulum
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0006914--P:autophagy
GO:0005978--P:glycogen biosynthetic process
GO:0031398--P:positive regulation of protein ubiquitination
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0000209--P:protein polyubiquitination

KEGG

hsa:378884

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Apl-003482	Anas platyrhynchos	50.25	6.00e-60	223.00
IUUC-Aca-004781	Anolis carolinensis	55.03	8.00e-133	466.00
IUUC-Ame-011442	Astyanax mexicanus	42.58	3.00e-80	292.00
IUUC-Bta-013205	Bos taurus	87.37	0.00e+00	650.00
IUUC-Cfa-020810	Canis familiaris	88.16	6.00e-174	603.00
IUUC-Cpo-022053	Cavia porcellus	76.34	1.00e-125	442.00
IUUC-Csa-023522	Chlorocebus sabaeus	97.97	0.00e+00	703.00
IUUC-Dno-029008	Dasypus novemcinctus	80.76	2.00e-168	585.00
IUUC-Ete-032878	Echinops telfairi	80.12	2.00e-47	183.00
IUUC-Eca-034419	Equus caballus	90.56	0.00e+00	653.00
IUUC-Eeu-034990	Erinaceus europaeus	79.70	5.00e-168	583.00
IUUC-Fca-035755	Felis catus	90.03	0.00e+00	665.00
IUUC-Fal-036689	Ficedula albicollis	58.46	2.00e-42	164.00
IUUC-Fox-037671	Fusarium oxysporum	43.86	4.00e-06	45.10
IUUC-Gmo-038749	Gadus morhua	39.80	2.00e-65	243.00
IUUC-Gga-040860	Gallus gallus	53.42	4.00e-102	364.00
IUUC-Gac-041602	Gasterosteus aculeatus	41.75	4.00e-75	275.00
IUUC-Ggo-044705	Gorilla gorilla	96.20	0.00e+00	712.00
IUUC-Itr-048387	Ictidomys tridecemlineatus	85.93	8.00e-180	622.00
IUUC-Lch-049978	Latimeria chalumnae	46.63	4.00e-100	358.00
IUUC-Loc-051893	Lepisosteus oculatus	47.63	8.00e-93	333.00
IUUC-Mcc-054648	Macaca mulatta	98.23	0.00e+00	707.00
IUUC-Meu-056176	Macropus eugenii	67.26	3.00e-144	504.00
IUUC-Mvi-060410	Microbotryum violaceum	32.39	1.30e-02	34.70
IUUC-Mmr-061462	Microcebus murinus	92.15	0.00e+00	653.00
IUUC-Mdo-062329	Monodelphis domestica	68.16	5.00e-156	543.00
IUUC-Mmu-063514	Mus musculus	83.55	3.00e-171	594.00
IUUC-Mac-064583	Musa acuminata	25.81	6.80e-02	33.10
IUUC-Mpu-066828	Mustela putorius furo	88.13	1.00e-177	615.00
IUUC-Nle-069194	Nomascus leucogenys	98.48	0.00e+00	736.00
IUUC-Opr-070547	Ochotona princeps	83.46	8.00e-179	619.00
IUUC-Ont-071588	Oreochromis niloticus	40.98	1.00e-72	267.00
IUUC-Oan-073550	Ornithorhynchus anatinus	53.40	2.00e-106	379.00
IUUC-Ocu-074699	Oryctolagus cuniculus	83.42	0.00e+00	631.00
IUUC-Ola-087036	Oryzias latipes	42.06	5.00e-77	281.00
IUUC-Oga-088924	Otolemur garnettii	91.39	0.00e+00	653.00
IUUC-Oar-089939	Ovis aries	82.26	3.00e-117	414.00
IUUC-Ptr-091431	Pan troglodytes	100.00	0.00e+00	721.00
IUUC-Pan-092496	Papio anubis	97.72	0.00e+00	704.00
IUUC-Psi-094079	Pelodiscus sinensis	57.39	6.00e-134	470.00
IUUC-Pab-097605	Pongo abelii	99.24	0.00e+00	714.00
IUUC-Pca-100676	Procavia capensis	79.50	2.00e-178	618.00
IUUC-Pva-102804	Pteropus vampyrus	90.13	0.00e+00	682.00
IUUC-Rno-104999	Rattus norvegicus	83.59	1.00e-173	602.00
IUUC-Sha-107067	Sarcophilus harrisii	68.00	3.00e-150	525.00
IUUC-Tgu-116560	Taeniopygia guttata	51.43	1.00e-40	158.00
IUUC-Tru-117560	Takifugu rubripes	40.67	5.00e-61	228.00
IUUC-Tni-120569	Tetraodon nigroviridis	40.99	1.00e-72	266.00
IUUC-Ttr-129122	Tursiops truncatus	90.38	0.00e+00	648.00
IUUC-Xtr-132226	Xenopus tropicalis	45.71	2.00e-105	375.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence