iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000017119.19	ENSMUST00000103099.7	ENSMUSP00000099388.1
ENSMUSG00000017119.19	ENSMUST00000107213.7	ENSMUSP00000102831.1
ENSMUSG00000017119.19	ENSMUST00000123558.7	ENSMUSP00000133619.1
ENSMUSG00000017119.19	ENSMUST00000107208.7	ENSMUSP00000102826.1
ENSMUSG00000017119.19	ENSMUST00000107212.7	ENSMUSP00000102830.1
ENSMUSG00000017119.19	ENSMUST00000136185.1	ENSMUSP00000134500.1
ENSMUSG00000017119.19	ENSMUST00000149019.1	ENSMUSP00000119900.1
ENSMUSG00000017119.19	ENSMUST00000071537.12	ENSMUSP00000071467.6

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	miRTarBase	microRNA	TRANSFAC
RepTar	RAID2
Protein-protein Interaction
IID	PINA	HINT	Mentha
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM	mUbiSiDa
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
UBD/Alpha-Helix/UBA	UBA	19427866; 20814249

Classification

Family	E-value	Score	Start	End
UBD/Alpha-Helix/UBA	0.00014	23.0	941	977
ULD/UDP/UFD/PB1	6.00e-18	65.9	4	85

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/UBA

   S: 5    dkleqlveMGF.dreealqaLraa.nnnleaAveyLl 39
            +++ l eMGF dr+++l+ Lr + +n l++++e+L 
   Q: 941  ALMAHLFEMGFcDRQLNLRLLRKHnYNILQVVTELLQ 977
           5788999*****************9999999999985 PP

ULD/UDP/UFD/PB1

   S: 1    tvrvkvsykgeirsfaldlekpgkfedLlkavrtltelknsevalkYeDedGDlvtlksDedldkavslla.skksllrlliqk 83
           +v+++v++k+e++sf ++ +++++++d++++v+   +++ +++++kY De+++ ++++s+ ++++a+++++ ++ ++l++++++
   Q: 4    QVTLNVTFKNETQSFLVSDPENTTWADVEAMVKV--SFDLNTIQIKYLDEENEEISINSQGEYEEALKMANiKQGNQLQMQVHE 85
           6899******************************..**********************************************97 PP

Organism

Mus musculus

Functional Description
(View)

Acts probably as a receptor for selective autophagosomal degradation of ubiquitinated targets.

Protein Sequence
(Fasta)

MEPQVTLNVT FKNETQSFLV SDPENTTWAD VEAMVKVSFD LNTIQIKYLD EENEEISINS 60
QGEYEEALKM ANIKQGNQLQ MQVHEGYHVV DEALPKNVVE NQAAARTGKK PLAHYSSLVR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGTCACAGTA GTTCTGTACA AAGGGTGGGA ATCGCTCCCT GAGGCCGGAA TATGAGCGCA 60
AGGTAGTGCC CAAAGCAGTT GCAAAACGAG GTCTCATCCC TCCCTCAGCC TTCCTGCCAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0968--Cytoplasmic vesicle
KW-0458--Lysosome
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR032350--N_BRCA1_central
IPR033513--NBR1
IPR000270--PB1_dom
IPR015940--UBA
IPR009060--UBA-like
IPR000433--Znf_ZZ

PROSITE

PS51745--PB1
PS50030--UBA
PS01357--ZF_ZZ_1
PS50135--ZF_ZZ_2

Pfam

PF16158--N_BRCA1_IG
PF00564--PB1
PF00569--ZZ

SMART

SM00666--PB1
SM00291--ZnF_ZZ

Gene Ontology

GO:0005776--C:autophagosome
GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0043231--C:intracellular membrane-bounded organelle
GO:0005770--C:late endosome
GO:0005764--C:lysosome
GO:0031430--C:M band
GO:0016020--C:membrane
GO:0005739--C:mitochondrion
GO:0016604--C:nuclear body
GO:0005654--C:nucleoplasm
GO:0000407--C:pre-autophagosomal structure
GO:0051019--F:mitogen-activated protein kinase binding
GO:0043130--F:ubiquitin binding
GO:0008270--F:zinc ion binding
GO:0016236--P:macroautophagy
GO:0045668--P:negative regulation of osteoblast differentiation
GO:0051259--P:protein oligomerization
GO:0030500--P:regulation of bone mineralization
GO:0032872--P:regulation of stress-activated MAPK cascade

KEGG

mmu:17966

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002028	Ailuropoda melanoleuca	78.29	0.00e+00	1431.00
IUUC-Atr-003106	Amborella trichopoda	36.64	2.00e-14	75.10
IUUC-Apl-003851	Anas platyrhynchos	56.92	0.00e+00	932.00
IUUC-Aca-005281	Anolis carolinensis	52.84	0.00e+00	846.00
IUUC-Acl-008033	Aspergillus clavatus	26.28	1.00e-15	79.00
IUUC-Afl-008503	Aspergillus flavus	25.68	2.00e-14	75.10
IUUC-Afu-008992	Aspergillus fumigatus	26.91	6.00e-16	79.70
IUUC-Ani-009220	Aspergillus nidulans	23.73	7.00e-15	76.30
IUUC-Aor-010141	Aspergillus oryzae	25.34	2.00e-14	75.10
IUUC-Ate-010391	Aspergillus terreus	26.88	6.00e-15	77.00
IUUC-Ame-010904	Astyanax mexicanus	43.21	1.00e-134	474.00
IUUC-Bgr-011970	Blumeria graminis	30.08	6.00e-09	56.60
IUUC-Bta-013030	Bos taurus	82.56	0.00e+00	1566.00
IUUC-Bol-015840	Brassica oleracea	33.80	1.00e-14	75.10
IUUC-Bra-017383	Brassica rapa	38.26	9.00e-15	75.50
IUUC-Cja-019576	Callithrix jacchus	78.30	0.00e+00	1505.00
IUUC-Cfa-021030	Canis familiaris	78.85	0.00e+00	1482.00
IUUC-Cpo-021386	Cavia porcellus	62.48	0.00e+00	1045.00
IUUC-Cre-022856	Chlamydomonas reinhardtii	30.91	1.00e-02	37.70
IUUC-Csa-023265	Chlorocebus sabaeus	83.25	0.00e+00	1551.00
IUUC-Cho-024901	Choloepus hoffmanni	64.09	5.00e-161	560.00
IUUC-Cne-027045	Cryptococcus neoformans	43.94	1.00e-10	62.80
IUUC-Dre-028204	Danio rerio	41.91	4.00e-135	476.00
IUUC-Dno-028885	Dasypus novemcinctus	78.56	0.00e+00	1506.00
IUUC-Dse-031315	Dothistroma septosporum	27.48	9.00e-11	62.80
IUUC-Eca-033409	Equus caballus	82.64	0.00e+00	1580.00
IUUC-Fca-035407	Felis catus	78.41	0.00e+00	1501.00
IUUC-Fal-037400	Ficedula albicollis	55.68	0.00e+00	946.00
IUUC-Gmo-039454	Gadus morhua	37.69	1.00e-100	361.00
IUUC-Gga-040430	Gallus gallus	61.64	0.00e+00	795.00
IUUC-Gac-042114	Gasterosteus aculeatus	41.58	6.00e-179	621.00
IUUC-Gma-044280	Glycine max	36.84	8.00e-17	82.80
IUUC-Ggo-045643	Gorilla gorilla	86.88	0.00e+00	1212.00
IUUC-Hsa-045869	Homo sapiens	81.64	0.00e+00	1543.00
IUUC-Itr-048172	Ictidomys tridecemlineatus	84.73	0.00e+00	1588.00
IUUC-Lch-050238	Latimeria chalumnae	53.64	0.00e+00	933.00
IUUC-Loc-052860	Lepisosteus oculatus	47.87	2.00e-117	417.00
IUUC-Lma-053158	Leptosphaeria maculans	28.24	1.00e-11	65.10
IUUC-Laf-054460	Loxodonta africana	80.73	0.00e+00	1561.00
IUUC-Mcc-055768	Macaca mulatta	83.22	0.00e+00	1549.00
IUUC-Meu-056136	Macropus eugenii	65.34	0.00e+00	751.00
IUUC-Mor-057101	Magnaporthe oryzae	24.24	2.00e-15	78.20
IUUC-Mtr-058592	Medicago truncatula	39.66	1.00e-14	75.10
IUUC-Mga-059507	Meleagris gallopavo	62.37	0.00e+00	806.00
IUUC-Mvi-060452	Microbotryum violaceum	37.07	7.00e-14	73.20
IUUC-Mmr-060796	Microcebus murinus	82.88	0.00e+00	1430.00
IUUC-Mdo-062214	Monodelphis domestica	70.70	0.00e+00	1362.00
IUUC-Mpu-066809	Mustela putorius furo	79.22	0.00e+00	1468.00
IUUC-Mlu-067887	Myotis lucifugus	82.68	0.00e+00	1543.00
IUUC-Nfi-068336	Neosartorya fischeri	26.91	3.00e-17	84.00
IUUC-Nle-069230	Nomascus leucogenys	82.35	0.00e+00	1543.00
IUUC-Opr-070848	Ochotona princeps	84.28	0.00e+00	719.00
IUUC-Ont-071913	Oreochromis niloticus	43.34	0.00e+00	676.00
IUUC-Oan-073479	Ornithorhynchus anatinus	47.23	6.00e-176	611.00
IUUC-Ocu-074112	Oryctolagus cuniculus	82.32	0.00e+00	1582.00
IUUC-Ola-087486	Oryzias latipes	38.85	5.00e-146	511.00
IUUC-Oga-088832	Otolemur garnettii	82.83	0.00e+00	1517.00
IUUC-Oar-090088	Ovis aries	82.28	0.00e+00	1548.00
IUUC-Ptr-090790	Pan troglodytes	82.11	0.00e+00	1546.00
IUUC-Pan-092523	Papio anubis	83.15	0.00e+00	1548.00
IUUC-Psi-093398	Pelodiscus sinensis	56.96	0.00e+00	992.00
IUUC-Pno-095009	Phaeosphaeria nodorum	25.45	5.00e-15	77.00
IUUC-Pfo-097491	Poecilia formosa	40.18	4.00e-143	502.00
IUUC-Pab-098775	Pongo abelii	82.23	0.00e+00	1509.00
IUUC-Pca-100690	Procavia capensis	81.84	0.00e+00	775.00
IUUC-Ppe-101351	Prunus persica	40.00	1.00e-16	81.60
IUUC-Pva-102582	Pteropus vampyrus	84.34	0.00e+00	825.00
IUUC-Pgr-103390	Puccinia graminis	40.00	6.00e-11	63.90
IUUC-Ptt-103754	Puccinia triticina	38.68	7.00e-14	72.80
IUUC-Pte-104190	Pyrenophora teres	25.36	3.00e-15	77.40
IUUC-Pyt-104763	Pyrenophora triticirepentis	25.36	3.00e-16	80.90
IUUC-Rno-105543	Rattus norvegicus	91.30	0.00e+00	1680.00
IUUC-Sha-106861	Sarcophilus harrisii	70.41	0.00e+00	1357.00
IUUC-Sly-111749	Solanum lycopersicum	38.21	1.00e-16	81.60
IUUC-Stu-111924	Solanum tuberosum	40.16	8.00e-18	85.90
IUUC-Sar-113740	Sorex araneus	73.61	0.00e+00	1286.00
IUUC-Ssc-116108	Sus scrofa	83.55	0.00e+00	1588.00
IUUC-Tgu-117185	Taeniopygia guttata	55.50	0.00e+00	941.00
IUUC-Tru-117624	Takifugu rubripes	43.58	0.00e+00	654.00
IUUC-Tsy-119265	Tarsius syrichta	86.64	0.00e+00	819.00
IUUC-Tni-120728	Tetraodon nigroviridis	44.51	9.00e-142	498.00
IUUC-Tca-120994	Theobroma cacao	33.86	6.00e-15	76.60
IUUC-Tre-122001	Trichoderma reesei	23.33	6.00e-14	73.20
IUUC-Tme-127010	Tuber melanosporum	26.79	2.00e-09	58.50
IUUC-Tbe-127236	Tupaia belangeri	82.41	0.00e+00	1553.00
IUUC-Ttr-128229	Tursiops truncatus	88.73	0.00e+00	838.00
IUUC-Vpa-130650	Vicugna pacos	81.53	6.00e-124	437.00
IUUC-Vvi-131325	Vitis vinifera	38.94	7.00e-18	86.30
IUUC-Xtr-132375	Xenopus tropicalis	48.10	0.00e+00	813.00
IUUC-Xma-134007	Xiphophorus maculatus	39.72	2.00e-140	493.00
IUUC-Zma-134921	Zea mays	38.40	5.00e-17	83.20

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence