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Basic Information Integrated Annotations

Tag Content
iUUCD ID IUUC-Hsa-136375
UUCD1 version UUC-HoS-01124
Ensembl Protein ID ENSP00000339389.2
UniProt Accession Q7L8S5; B2RPB7; OTU6A_HUMAN
Genbank Protein ID AK098697; CH471132; BC137355; BC137356
Protein Name OTU domain-containing protein 6A;DUBA-2
Genbank Nucleotide ID BAC05384.1; EAX05357.1; AAI37356.1; AAI37357.1
Gene Name OTUD6A;DUBA2
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000189401.2 ENST00000338352.2 ENSP00000339389.2
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
ArrayExpressTCGAICGCCOSMIC
THPAHPM
DNA & RNA Element
miRTarBasemicroRNATRANSFACTargetScan
RepTarmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Information
OMIM
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTMHPRD
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
DUB/OTU OTU 23827681
Organism Homo sapiens
Functional Description
(View)

Functional Description



     Deubiquitinating enzyme that hydrolyzes 'Lys-27'-, 'Lys-29'- and 'Lys-33'-linked polyubiquitin chains. Also able to hydrolyze 'Lys-11'-linked ubiquitin chains.
Deubiquitinating enzyme that hydrolyzes 'Lys-27'-, 'Lys-29'- and 'Lys-33'-linked polyubiquitin chains. Also able to hydrolyze 'Lys-11'-linked ubiquitin chains.
Protein Sequence
(Fasta)
MDDPKSEQQR ILRRHQRERQ ELQAQIRSLK NSVPKTDKTK RKQLLQDVAR MEAEMAQKHR 60
QELEKFQDDS SIESVVEDLA KMNLENRPPR SSKAHRKRER MESEERERQE SIFQAEMSEH 120
It may take some time, please wait.

Protein Fasta Sequence



>IUUC-Hsa-136375|DUB,OTU|Homo sapiens
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Nucleotide Sequence
(Fasta)
AGCAAATTTC AACTCCCGCT TGCCATTCAA CATCATGGAT GATCCGAAGA GTGAACAGCA 60
GCGCATACTG CGCCGCCACC AACGCGAGAG GCAGGAGCTG CAGGCCCAGA TCCGGAGCTT 120
It may take some time, please wait.

Nucleotide Fasta Sequence



>IUUC-Hsa-136375|DUB,OTU|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR003323--OTU_dom

PROSITE

PS50802--OTU

Pfam

PF02338--OTU

Gene Ontology

GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0035871--P:protein K11-linked deubiquitination
GO:1990167--P:protein K27-linked deubiquitination
GO:0035523--P:protein K29-linked deubiquitination
GO:1990168--P:protein K33-linked deubiquitination

KEGG hsa:139562
Created Date 25-Jun-2017

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