iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	TRANSFAC	RAID2
Protein-protein Interaction
IID	HINT
Drug and target
GRAC
Post-translational Modifications (PTMs)
CPLM	PhosphositePlus
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	7.50e-59	193.4	127	166
UBD/Beta-Prp	1.30e-88	297.5	40	332

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvllks 38
           gH++ v+c++f +  +l+vsGs D ++++WD++tg++lk+
   Q: 127  GHSNYVFCCNFnPQsNLIVSGSFDESVRIWDVKTGKCLKT 166
           8***********666**********************986 PP

UBD/Beta-Prp

   S: 4    tlkghhksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkg 92
           tl gh k+v + vkfsp++++la++s+d+ ik+w + +gk+ +++sgh+ ++++v +s+d+++lv++s+D+t+k+wd+s+gkc+ tlkg
   Q: 40   TLAGHTKAVSS-VKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKG 127
           67777776666.***************************************************************************** PP
   S: 93   hedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtd 181
           h+++v +++f+p+++ +vsGs d+ +r+wd++tg+cl+ tl  h++ v+ v+++ dg+l+vs+s+D+ +r+Wd ++g++l+tl  ++++
   Q: 128  HSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLK-TLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNP 215
           **************************************.********************************************999*** PP
   S: 182  svyslsfdsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfs...pnderlvsgssDgsiriWdlrsgdllktlqlhnssv 267
           +v  ++f++ngk+++++ ld+t+klwd+++g+c++t++gh++  +++ +      ++++vsgs+D+ ++iW+l++++++++lq+h + v
   Q: 216  PVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANfsvTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVV 304
           **********************************************98887899*********************************** PP
   S: 268  isvavlsfgdnvlvlgse..dskvniwkl 294
           is a+ ++++n++++++   d+++++wk 
   Q: 305  ISTAC-HPTENIIASAALenDKTIKLWKS 332
           *****.*******9998888*******96 PP

Organism

Rattus norvegicus

Functional Description
(View)

Contributes to histone modification. May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation (By similarity).

Protein Sequence
(Fasta)

MATEEKKPET EAARAQPTPS SSATQSKPTP VKPNYALKFT LAGHTKAVSS VKFSPNGEWL 60
ASSSADKLIK IWGAYDGKFE KTISGHKLGI SDVAWSSDSN LLVSASDDKT LKIWDVSSGK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATCGTCTGCT CTCGCGCGCA GGGCCAGCCG AGGCGACGCC AGAGCGCCCG GCCCCGCCGC 60
CCCGGCCCCG GCAGGTAAGG GAGTGACCCG GTCCTGCGGG CGCGAGGGGG GCGGCGACCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0005671--C:Ada2/Gcn5/Ada3 transcription activator complex
GO:0036064--C:ciliary basal body
GO:0000123--C:histone acetyltransferase complex
GO:0035097--C:histone methyltransferase complex
GO:0071339--C:MLL1 complex
GO:0044666--C:MLL3/4 complex
GO:0005634--C:nucleus
GO:0048188--C:Set1C/COMPASS complex
GO:0046972--F:histone acetyltransferase activity (H4-K16 specific)
GO:0043995--F:histone acetyltransferase activity (H4-K5 specific)
GO:0043996--F:histone acetyltransferase activity (H4-K8 specific)
GO:0042800--F:histone methyltransferase activity (H3-K4 specific)
GO:0060271--P:cilium assembly
GO:0043966--P:histone H3 acetylation
GO:0051568--P:histone H3-K4 methylation
GO:0043984--P:histone H4-K16 acetylation
GO:0043981--P:histone H4-K5 acetylation
GO:0043982--P:histone H4-K8 acetylation
GO:0031175--P:neuron projection development
GO:0035948--P:positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter
GO:0001501--P:skeletal system development
GO:0006351--P:transcription, DNA-templated

KEGG

rno:362093

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000502	Aegilops tauschii	53.02	7.00e-90	323.00
IUUC-Aml-002420	Ailuropoda melanoleuca	100.00	0.00e+00	650.00
IUUC-Atr-002439	Amborella trichopoda	69.51	3.00e-130	457.00
IUUC-Apl-003436	Anas platyrhynchos	89.82	2.00e-168	584.00
IUUC-Aca-004259	Anolis carolinensis	96.11	0.00e+00	637.00
IUUC-Aly-005723	Arabidopsis lyrata	64.45	6.00e-117	413.00
IUUC-Ath-007308	Arabidopsis thaliana	65.45	4.00e-117	414.00
IUUC-Acl-008045	Aspergillus clavatus	45.95	1.00e-83	303.00
IUUC-Afl-008596	Aspergillus flavus	44.66	6.00e-81	294.00
IUUC-Afu-009074	Aspergillus fumigatus	46.75	1.00e-83	303.00
IUUC-Ani-009318	Aspergillus nidulans	50.00	4.00e-83	301.00
IUUC-Ang-009775	Aspergillus niger	45.63	4.00e-83	301.00
IUUC-Aor-010222	Aspergillus oryzae	44.66	6.00e-81	295.00
IUUC-Ate-010583	Aspergillus terreus	48.75	7.00e-81	294.00
IUUC-Ame-011349	Astyanax mexicanus	99.02	5.00e-179	619.00
IUUC-Bgr-011968	Blumeria graminis	50.33	9.00e-85	307.00
IUUC-Bta-013016	Bos taurus	99.68	0.00e+00	628.00
IUUC-Bci-013948	Botrytis cinerea	50.96	2.00e-85	310.00
IUUC-Bdi-014263	Brachypodium distachyon	62.46	1.00e-120	425.00
IUUC-Bol-015900	Brassica oleracea	62.50	1.00e-113	402.00
IUUC-Bra-017143	Brassica rapa	62.17	1.00e-114	405.00
IUUC-Cel-018355	Caenorhabditis elegans	72.24	3.00e-132	464.00
IUUC-Cja-019936	Callithrix jacchus	100.00	0.00e+00	650.00
IUUC-Cfa-020596	Canis familiaris	100.00	0.00e+00	650.00
IUUC-Cpo-021318	Cavia porcellus	100.00	0.00e+00	650.00
IUUC-Cre-022935	Chlamydomonas reinhardtii	48.76	2.00e-79	289.00
IUUC-Csa-023053	Chlorocebus sabaeus	100.00	0.00e+00	650.00
IUUC-Cin-025495	Ciona intestinalis	86.96	1.00e-169	588.00
IUUC-Csv-025988	Ciona savignyi	91.86	4.00e-164	570.00
IUUC-Cne-027025	Cryptococcus neoformans	32.13	4.00e-53	201.00
IUUC-Cme-027119	Cyanidioschyzon merolae	50.43	5.00e-106	377.00
IUUC-Dre-027521	Danio rerio	95.81	0.00e+00	633.00
IUUC-Dno-029739	Dasypus novemcinctus	100.00	4.00e-179	620.00
IUUC-Dor-030966	Dipodomys ordii	100.00	0.00e+00	627.00
IUUC-Dse-031189	Dothistroma septosporum	48.91	7.00e-86	310.00
IUUC-Dme-031613	Drosophila melanogaster	94.72	4.00e-172	597.00
IUUC-Eca-033790	Equus caballus	100.00	0.00e+00	650.00
IUUC-Eeu-034805	Erinaceus europaeus	83.18	2.00e-154	538.00
IUUC-Fca-035901	Felis catus	100.00	0.00e+00	650.00
IUUC-Fal-037413	Ficedula albicollis	97.01	0.00e+00	639.00
IUUC-Fox-037876	Fusarium oxysporum	46.45	3.00e-58	218.00
IUUC-Gmo-039131	Gadus morhua	93.71	3.00e-179	620.00
IUUC-Ggr-040071	Gaeumannomyces graminis	40.27	1.00e-64	241.00
IUUC-Gga-040789	Gallus gallus	97.01	0.00e+00	639.00
IUUC-Gac-042634	Gasterosteus aculeatus	91.32	3.00e-177	613.00
IUUC-Gma-043692	Glycine max	66.34	2.00e-127	448.00
IUUC-Ggo-044443	Gorilla gorilla	100.00	0.00e+00	650.00
IUUC-Hsa-046290	Homo sapiens	100.00	0.00e+00	650.00
IUUC-Hvu-047077	Hordeum vulgare	57.73	8.00e-80	289.00
IUUC-Itr-048954	Ictidomys tridecemlineatus	100.00	0.00e+00	650.00
IUUC-Kpa-049404	Komagataella pastoris	45.42	1.00e-65	243.00
IUUC-Lch-049539	Latimeria chalumnae	98.75	0.00e+00	643.00
IUUC-Lpe-051082	Leersia perrieri	61.67	2.00e-119	421.00
IUUC-Loc-051743	Lepisosteus oculatus	99.02	5.00e-179	619.00
IUUC-Lma-053188	Leptosphaeria maculans	46.73	8.00e-86	310.00
IUUC-Laf-054432	Loxodonta africana	95.22	0.00e+00	639.00
IUUC-Mcc-055603	Macaca mulatta	100.00	0.00e+00	650.00
IUUC-Meu-056440	Macropus eugenii	92.13	3.00e-156	544.00
IUUC-Mor-056965	Magnaporthe oryzae	36.71	5.00e-69	255.00
IUUC-Mpo-057333	Magnaporthe poae	41.16	3.00e-61	229.00
IUUC-Mtr-057951	Medicago truncatula	65.58	1.00e-122	432.00
IUUC-Mla-058896	Melampsora laricipopulina	43.60	3.00e-72	265.00
IUUC-Mga-060046	Meleagris gallopavo	96.71	0.00e+00	638.00
IUUC-Mvi-060453	Microbotryum violaceum	48.02	1.00e-88	320.00
IUUC-Mmr-061020	Microcebus murinus	92.51	9.00e-178	615.00
IUUC-Mdo-062204	Monodelphis domestica	95.92	0.00e+00	629.00
IUUC-Mmu-063917	Mus musculus	100.00	0.00e+00	650.00
IUUC-Mac-065310	Musa acuminata	66.22	1.00e-122	432.00
IUUC-Mpu-066072	Mustela putorius furo	100.00	0.00e+00	650.00
IUUC-Mlu-068209	Myotis lucifugus	100.00	0.00e+00	650.00
IUUC-Nfi-068538	Neosartorya fischeri	46.43	6.00e-83	301.00
IUUC-Ncr-068651	Neurospora crassa	41.36	1.00e-72	267.00
IUUC-Opr-070937	Ochotona princeps	83.96	7.00e-143	499.00
IUUC-Ont-071458	Oreochromis niloticus	92.22	2.00e-179	621.00
IUUC-Oan-073597	Ornithorhynchus anatinus	100.00	2.00e-180	624.00
IUUC-Oba-075292	Oryza barthii	54.09	1.00e-99	356.00
IUUC-Obr-076723	Oryza brachyantha	54.90	8.00e-97	346.00
IUUC-Ogl-077251	Oryza glaberrima	60.39	4.00e-117	414.00
IUUC-Ogu-078882	Oryza glumaepatula	49.86	4.00e-103	368.00
IUUC-Oin-079601	Oryza indica	54.55	2.00e-112	398.00
IUUC-Olo-080976	Oryza longistaminata	62.95	1.00e-102	365.00
IUUC-Ome-081430	Oryza meridionalis	60.78	2.00e-117	414.00
IUUC-Oni-082182	Oryza nivara	49.45	1.00e-102	366.00
IUUC-Opu-083880	Oryza punctata	60.13	2.00e-116	411.00
IUUC-Oru-084935	Oryza rufipogon	53.65	8.00e-99	353.00
IUUC-Osa-085706	Oryza sativa	60.39	4.00e-117	414.00
IUUC-Ola-087134	Oryzias latipes	94.31	2.00e-179	620.00
IUUC-Olu-087660	Ostreococcus lucimarinus	42.50	3.00e-40	157.00
IUUC-Oga-088672	Otolemur garnettii	99.40	0.00e+00	644.00
IUUC-Oar-089860	Ovis aries	86.25	7.00e-158	549.00
IUUC-Ptr-091513	Pan troglodytes	100.00	0.00e+00	650.00
IUUC-Pan-092046	Papio anubis	100.00	0.00e+00	650.00
IUUC-Psi-093192	Pelodiscus sinensis	96.71	0.00e+00	639.00
IUUC-Pno-094881	Phaeosphaeria nodorum	48.04	1.00e-89	323.00
IUUC-Ppa-095367	Physcomitrella patens	72.58	4.00e-134	470.00
IUUC-Pfo-097434	Poecilia formosa	91.92	5.00e-179	619.00
IUUC-Pab-097773	Pongo abelii	93.51	4.00e-166	576.00
IUUC-Pop-099778	Populus trichocarpa	64.87	7.00e-122	429.00
IUUC-Pca-100281	Procavia capensis	79.02	7.00e-125	439.00
IUUC-Ppe-101341	Prunus persica	64.56	5.00e-123	433.00
IUUC-Pva-103020	Pteropus vampyrus	99.06	0.00e+00	647.00
IUUC-Pgr-103589	Puccinia graminis	39.27	8.00e-70	257.00
IUUC-Pte-104153	Pyrenophora teres	51.91	7.00e-94	337.00
IUUC-Pyt-104712	Pyrenophora triticirepentis	52.43	5.00e-79	287.00
IUUC-Sce-106243	Saccharomyces cerevisiae	34.47	3.00e-40	158.00
IUUC-Sha-107101	Sarcophilus harrisii	98.43	0.00e+00	640.00
IUUC-Sja-107858	Schizosaccharomyces japonicus	51.17	1.00e-68	253.00
IUUC-Spo-108117	Schizosaccharomyces pombe	47.98	5.00e-64	238.00
IUUC-Smo-109155	Selaginella moellendorffii	71.29	1.00e-132	465.00
IUUC-Sit-110688	Setaria italica	62.00	3.00e-119	421.00
IUUC-Sly-110891	Solanum lycopersicum	68.90	8.00e-127	446.00
IUUC-Stu-112365	Solanum tuberosum	66.13	5.00e-127	446.00
IUUC-Sbi-114284	Sorghum bicolor	62.00	2.00e-118	418.00
IUUC-Sre-115180	Sporisorium reilianum	42.57	1.00e-66	246.00
IUUC-Ssc-116204	Sus scrofa	100.00	2.00e-179	621.00
IUUC-Tgu-117172	Taeniopygia guttata	97.01	0.00e+00	639.00
IUUC-Tru-118320	Takifugu rubripes	91.62	2.00e-178	618.00
IUUC-Tni-120660	Tetraodon nigroviridis	87.84	1.00e-109	388.00
IUUC-Tca-121051	Theobroma cacao	67.53	3.00e-125	441.00
IUUC-Tre-122237	Trichoderma reesei	45.09	1.00e-85	310.00
IUUC-Tvi-122635	Trichoderma virens	46.18	4.00e-85	308.00
IUUC-Tae-125819	Triticum aestivum	60.26	7.00e-121	426.00
IUUC-Tur-126217	Triticum urartu	55.84	1.00e-76	279.00
IUUC-Tme-127061	Tuber melanosporum	55.99	2.00e-112	398.00
IUUC-Ttr-129309	Tursiops truncatus	94.04	4.00e-174	603.00
IUUC-Uma-129585	Ustilago maydis	41.64	1.00e-73	269.00
IUUC-Vda-129907	Verticillium dahliae	44.71	8.00e-79	288.00
IUUC-Vpa-130384	Vicugna pacos	84.68	7.00e-159	552.00
IUUC-Vvi-131269	Vitis vinifera	66.45	6.00e-120	423.00
IUUC-Xtr-131945	Xenopus tropicalis	97.01	0.00e+00	638.00
IUUC-Xma-132997	Xiphophorus maculatus	91.92	5.00e-179	619.00
IUUC-Yli-134418	Yarrowia lipolytica	42.95	1.00e-75	276.00
IUUC-Zma-135765	Zea mays	61.67	3.00e-117	414.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence