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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046926
UUCD1 version UUC-HoS-00427
Ensembl Protein ID ENSP00000394394.3
UniProt Accession Q9UJX3; Q96AC4; Q96GF4; Q9BU24; Q9NT16; APC7_HUMAN
Genbank Protein ID AAF05754.1; AAH02941.2; AAH09498.2; AAH17316.2; CAB70828.1
Protein Name Anaphase-promoting complex subunit 7; Cyclosome subunit 7
Genbank Nucleotide ID AF191340; BC002941; BC009498; BC017316; AL137586
Gene Name ANAPC7; APC7
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000196510.12 ENST00000455511.7 ENSP00000394394.3
ENSG00000196510.12 ENST00000552087.1 ENSP00000450293.1
ENSG00000196510.12 ENST00000450008.2 ENSP00000402314.2
ENSG00000196510.12 ENST00000552170.1 ENSP00000450405.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbcircBasecircRNADbCircNet
miRTarBasemicroRNATRANSFACmiRWalk
TargetScanSomamiRmiRcodeRAID2
Protein-protein Interaction
IIDPINAHINTMentha
InWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
OMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMPHOSIDABioGRID
mUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/APC_C/APC_C APC_C 21107322; 16763193
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
 Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
Protein Sequence
(Fasta)
MDPGDAAILE SSLRILYRLF ESVLPPLPAA LQSRMNVIDH VRDMAAAGLH SNVRLLSSLL 60
LTMSNNNPEL FSPPQKYQLL VYHADSLFHD KEYRNAVSKY TMALQQKKAL SKTSKVRPST 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046926|E3,APC_C|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GATGGACCCC GGCGACGCCG CCATTTTGGA GTCTTCCCTA AGGATCCTCT ACCGGCTTTT 60
CGAGTCAGTG CTGCCGCCGC TGCCCGCGGC TTTGCAGAGC AGGATGAATG TGATAGACCA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046926|E3,APC_C|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0498--Mitosis
KW-1185--Reference proteome
KW-0677--Repeat
KW-0802--TPR repeat
KW-0833--Ubl conjugation pathway
Interpro

IPR013026--TPR-contain_dom
IPR011990--TPR-like_helical_dom
IPR019734--TPR_repeat
PROSITE

PS50005--TPR
PS50293--TPR_REGION
Pfam

PF13181--TPR_8
SMART

SM00028--TPR
Gene Ontology

GO:0005680--C:anaphase-promoting complex
GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0019903--F:protein phosphatase binding
GO:0031145--P:anaphase-promoting complex-dependent catabolic process
GO:0051301--P:cell division
GO:0007067--P:mitotic nuclear division
GO:0051436--P:negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051437--P:positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0070979--P:protein K11-linked ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0051439--P:regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
KEGG hsa:51434
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002083 Ailuropoda melanoleuca 97.49 0.00e+00 1056.00
IUUC-Atr-003140 Amborella trichopoda 28.87 4.00e-53 202.00
IUUC-Apl-003343 Anas platyrhynchos 96.06 0.00e+00 1017.00
IUUC-Aca-005258 Anolis carolinensis 95.80 0.00e+00 1053.00
IUUC-Aly-005478 Arabidopsis lyrata 27.00 9.00e-38 151.00
IUUC-Ath-007040 Arabidopsis thaliana 27.38 2.00e-42 167.00
IUUC-Ame-010782 Astyanax mexicanus 88.85 0.00e+00 976.00
IUUC-Bdi-014872 Brachypodium distachyon 27.05 5.00e-45 175.00
IUUC-Bol-016501 Brassica oleracea 26.91 3.00e-44 173.00
IUUC-Bra-018097 Brassica rapa 26.71 4.00e-44 172.00
IUUC-Cja-018884 Callithrix jacchus 99.65 0.00e+00 1040.00
IUUC-Cfa-020235 Canis familiaris 97.33 0.00e+00 1062.00
IUUC-Cpo-021616 Cavia porcellus 98.69 0.00e+00 1010.00
IUUC-Cho-024848 Choloepus hoffmanni 83.24 1.00e-159 556.00
IUUC-Csv-026317 Ciona savignyi 35.05 6.00e-88 318.00
IUUC-Dre-028548 Danio rerio 89.22 0.00e+00 997.00
IUUC-Dno-029381 Dasypus novemcinctus 99.40 0.00e+00 942.00
IUUC-Dor-030225 Dipodomys ordii 90.21 0.00e+00 900.00
IUUC-Dme-031693 Drosophila melanogaster 25.95 3.00e-41 163.00
IUUC-Eca-033603 Equus caballus 99.47 0.00e+00 1033.00
IUUC-Eeu-035107 Erinaceus europaeus 69.35 6.00e-90 325.00
IUUC-Fca-036408 Felis catus 97.66 0.00e+00 1066.00
IUUC-Fal-036872 Ficedula albicollis 96.81 0.00e+00 1048.00
IUUC-Gmo-039212 Gadus morhua 89.56 0.00e+00 974.00
IUUC-Gga-040183 Gallus gallus 92.39 0.00e+00 972.00
IUUC-Gac-041690 Gasterosteus aculeatus 89.91 0.00e+00 991.00
IUUC-Gma-042697 Glycine max 29.14 2.00e-50 194.00
IUUC-Ggo-045188 Gorilla gorilla 77.21 0.00e+00 766.00
IUUC-Hvu-047507 Hordeum vulgare 36.49 1.00e-21 96.70
IUUC-Itr-048217 Ictidomys tridecemlineatus 98.58 0.00e+00 1031.00
IUUC-Lch-050119 Latimeria chalumnae 89.52 0.00e+00 966.00
IUUC-Lpe-050905 Leersia perrieri 28.34 2.00e-48 186.00
IUUC-Loc-052439 Lepisosteus oculatus 90.11 0.00e+00 989.00
IUUC-Laf-054340 Loxodonta africana 98.94 0.00e+00 1024.00
IUUC-Meu-056210 Macropus eugenii 96.81 0.00e+00 1043.00
IUUC-Mtr-058264 Medicago truncatula 29.32 3.00e-52 199.00
IUUC-Mga-059761 Meleagris gallopavo 97.32 0.00e+00 1041.00
IUUC-Mmr-061752 Microcebus murinus 88.41 0.00e+00 927.00
IUUC-Mdo-063053 Monodelphis domestica 98.05 0.00e+00 1029.00
IUUC-Mmu-064183 Mus musculus 98.23 0.00e+00 1026.00
IUUC-Mac-064710 Musa acuminata 28.06 4.00e-51 196.00
IUUC-Mpu-065854 Mustela putorius furo 98.00 0.00e+00 1081.00
IUUC-Mlu-067159 Myotis lucifugus 97.16 0.00e+00 1057.00
IUUC-Nle-069297 Nomascus leucogenys 97.83 0.00e+00 1080.00
IUUC-Opr-070794 Ochotona princeps 83.19 0.00e+00 846.00
IUUC-Ont-071802 Oreochromis niloticus 89.59 0.00e+00 991.00
IUUC-Oan-073628 Ornithorhynchus anatinus 97.18 0.00e+00 957.00
IUUC-Ocu-074743 Oryctolagus cuniculus 99.47 0.00e+00 1038.00
IUUC-Oba-075920 Oryza barthii 28.28 1.00e-46 181.00
IUUC-Obr-076650 Oryza brachyantha 26.26 2.00e-44 174.00
IUUC-Ogl-077604 Oryza glaberrima 28.28 1.00e-46 181.00
IUUC-Ogu-078587 Oryza glumaepatula 28.28 1.00e-46 181.00
IUUC-Oin-079624 Oryza indica 28.28 1.00e-46 181.00
IUUC-Ome-081464 Oryza meridionalis 28.28 1.00e-46 181.00
IUUC-Oni-082743 Oryza nivara 28.28 2.00e-46 181.00
IUUC-Opu-083895 Oryza punctata 28.48 4.00e-43 169.00
IUUC-Oru-085274 Oryza rufipogon 28.48 5.00e-47 182.00
IUUC-Osa-085306 Oryza sativa 28.28 1.00e-46 181.00
IUUC-Ola-086494 Oryzias latipes 88.89 0.00e+00 998.00
IUUC-Olu-087678 Ostreococcus lucimarinus 24.18 7.00e-23 102.00
IUUC-Oga-088978 Otolemur garnettii 99.47 0.00e+00 1038.00
IUUC-Oar-089894 Ovis aries 96.51 0.00e+00 1065.00
IUUC-Pan-091984 Papio anubis 93.19 0.00e+00 1022.00
IUUC-Psi-094087 Pelodiscus sinensis 97.59 0.00e+00 929.00
IUUC-Ppa-095620 Physcomitrella patens 27.64 7.00e-54 205.00
IUUC-Pfo-097117 Poecilia formosa 89.03 0.00e+00 962.00
IUUC-Pop-098940 Populus trichocarpa 28.43 1.00e-51 197.00
IUUC-Ppe-101732 Prunus persica 28.63 1.00e-46 181.00
IUUC-Pva-103096 Pteropus vampyrus 99.12 0.00e+00 1033.00
IUUC-Rno-104947 Rattus norvegicus 98.41 0.00e+00 1027.00
IUUC-Sha-107198 Sarcophilus harrisii 97.70 0.00e+00 1026.00
IUUC-Smo-109520 Selaginella moellendorffii 29.59 6.00e-52 199.00
IUUC-Sit-110721 Setaria italica 26.87 1.00e-46 181.00
IUUC-Sly-111676 Solanum lycopersicum 29.26 5.00e-52 199.00
IUUC-Sar-113646 Sorex araneus 99.65 0.00e+00 1040.00
IUUC-Sbi-114239 Sorghum bicolor 25.50 6.00e-41 162.00
IUUC-Ssc-115401 Sus scrofa 98.94 0.00e+00 1035.00
IUUC-Tgu-116712 Taeniopygia guttata 96.99 0.00e+00 1050.00
IUUC-Tru-117766 Takifugu rubripes 88.30 0.00e+00 974.00
IUUC-Tni-119801 Tetraodon nigroviridis 87.10 0.00e+00 956.00
IUUC-Tca-121284 Theobroma cacao 28.23 4.00e-48 186.00
IUUC-Tae-123683 Triticum aestivum 27.44 3.00e-45 176.00
IUUC-Tur-126825 Triticum urartu 22.42 5.00e-31 129.00
IUUC-Tbe-127885 Tupaia belangeri 98.02 2.00e-129 456.00
IUUC-Ttr-128641 Tursiops truncatus 98.58 0.00e+00 1023.00
IUUC-Vpa-130810 Vicugna pacos 87.79 0.00e+00 901.00
IUUC-Vvi-131044 Vitis vinifera 28.63 4.00e-53 202.00
IUUC-Xtr-132617 Xenopus tropicalis 93.54 0.00e+00 999.00
IUUC-Xma-133575 Xiphophorus maculatus 88.85 0.00e+00 960.00
Created Date 25-Jun-2017

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