iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000197705.9	ENST00000359358.8	ENSP00000352314.4
ENSG00000197705.9	ENST00000358095.4	ENSP00000350808.4
ENSG00000197705.9	ENST00000583263.1	ENSP00000463803.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	CircNet	miRTarBase
microRNA	TRANSFAC	TargetScan	RepTar
miRNAMap	SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
InWeb_IM
Disease-associated Variation
GWASdb	OMIM
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB	1.90e-11	45.8	33	148

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_Other: BTB

   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmelees..................................................ksklm 42
           +Dv+l  +g++f++hk+vLa++S++F++lf+++ + +                                                  +  + 
   Q: 33   CDVTLTAQGQQFHCHKAVLASCSQYFRSLFSSHPPLGggvggqdglgapkdqqqppqqqpsqqqqpppqeepgtpssspddklltspRAINN 124
           9*********************************9777***********************************************9977999 PP
   S: 43   veikdvqpevfrallkFlYtgkld 66
            ++++ +   +r +l++lYt  ++
   Q: 125  LVLQGCSSIGLRLVLEYLYTANVT 148
           9999****************9876 PP

Organism

Homo sapiens

Protein Sequence
(Fasta)

MSRSGDRTST FDPSHSDNLL HGLNLLWRKQ LFCDVTLTAQ GQQFHCHKAV LASCSQYFRS 60
LFSSHPPLGG GVGGQDGLGA PKDQQQPPQQ QPSQQQQPPP QEEPGTPSSS PDDKLLTSPR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGCACGACCG TTTCTCTCCC CAACCGTGGA TTTCCTATTA CTCTCGTTAC GACTCACTGA 60
GCCCCAGGCC CAAGGATAAT GATGTGTTGT TTCTTGGTAG CATAATTTGT CACACGTACA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0256--Endoplasmic reticulum
KW-0880--Kelch repeat
KW-0472--Membrane
KW-1185--Reference proteome
KW-0677--Repeat

Interpro

IPR011705--BACK
IPR000210--BTB/POZ_dom
IPR015915--Kelch-typ_b-propeller
IPR006652--Kelch_1
IPR030584--KLHL14
IPR011333--SKP1/BTB/POZ

PROSITE

PS50097--BTB

Pfam

PF07707--BACK
PF00651--BTB
PF01344--Kelch_1

SMART

SM00875--BACK
SM00225--BTB
SM00612--Kelch

Gene Ontology

GO:0015629--C:actin cytoskeleton
GO:0016235--C:aggresome
GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0005829--C:cytosol
GO:0005783--C:endoplasmic reticulum
GO:0005789--C:endoplasmic reticulum membrane
GO:0043005--C:neuron projection
GO:0043025--C:neuronal cell body
GO:0016567--P:protein ubiquitination

KEGG

hsa:57565

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001196	Ailuropoda melanoleuca	96.91	1.00e-177	615.00
IUUC-Bta-012869	Bos taurus	96.82	0.00e+00	1185.00
IUUC-Cja-018731	Callithrix jacchus	97.45	0.00e+00	1194.00
IUUC-Cfa-020355	Canis familiaris	98.25	0.00e+00	1192.00
IUUC-Cpo-021612	Cavia porcellus	98.09	0.00e+00	1167.00
IUUC-Csa-023993	Chlorocebus sabaeus	99.52	0.00e+00	1172.00
IUUC-Dre-027629	Danio rerio	86.46	0.00e+00	1077.00
IUUC-Dno-029185	Dasypus novemcinctus	97.46	0.00e+00	1190.00
IUUC-Fca-036303	Felis catus	97.77	0.00e+00	1186.00
IUUC-Fal-037175	Ficedula albicollis	93.15	0.00e+00	1148.00
IUUC-Gmo-038807	Gadus morhua	85.69	0.00e+00	1061.00
IUUC-Gga-040750	Gallus gallus	93.98	0.00e+00	1139.00
IUUC-Gac-041372	Gasterosteus aculeatus	85.35	0.00e+00	1065.00
IUUC-Ggo-044702	Gorilla gorilla	95.24	0.00e+00	1161.00
IUUC-Lch-049564	Latimeria chalumnae	91.26	0.00e+00	1145.00
IUUC-Loc-051831	Lepisosteus oculatus	89.81	0.00e+00	1128.00
IUUC-Laf-054353	Loxodonta africana	98.09	0.00e+00	1191.00
IUUC-Mcc-055080	Macaca mulatta	99.16	1.00e-171	595.00
IUUC-Meu-056733	Macropus eugenii	85.74	0.00e+00	819.00
IUUC-Mmr-061263	Microcebus murinus	99.21	0.00e+00	1167.00
IUUC-Mdo-061930	Monodelphis domestica	88.58	0.00e+00	1058.00
IUUC-Mmu-064251	Mus musculus	97.62	0.00e+00	1192.00
IUUC-Mpu-066871	Mustela putorius furo	98.09	0.00e+00	1194.00
IUUC-Mlu-067725	Myotis lucifugus	83.33	0.00e+00	808.00
IUUC-Nle-069427	Nomascus leucogenys	97.14	0.00e+00	1171.00
IUUC-Ont-072429	Oreochromis niloticus	86.78	0.00e+00	1088.00
IUUC-Ocu-074635	Oryctolagus cuniculus	97.46	0.00e+00	1189.00
IUUC-Ola-086870	Oryzias latipes	88.39	0.00e+00	1089.00
IUUC-Oga-088397	Otolemur garnettii	98.10	0.00e+00	1192.00
IUUC-Oar-089280	Ovis aries	99.21	0.00e+00	1020.00
IUUC-Ptr-091356	Pan troglodytes	94.90	0.00e+00	1091.00
IUUC-Pan-092718	Papio anubis	99.52	0.00e+00	1172.00
IUUC-Psi-093970	Pelodiscus sinensis	92.26	0.00e+00	1085.00
IUUC-Pfo-096550	Poecilia formosa	87.12	0.00e+00	1085.00
IUUC-Pab-097802	Pongo abelii	98.89	0.00e+00	1162.00
IUUC-Pca-101125	Procavia capensis	93.16	0.00e+00	1110.00
IUUC-Pva-102888	Pteropus vampyrus	99.48	0.00e+00	1103.00
IUUC-Rno-105007	Rattus norvegicus	97.46	0.00e+00	1192.00
IUUC-Sar-113671	Sorex araneus	96.03	0.00e+00	1157.00
IUUC-Ssc-116060	Sus scrofa	97.46	0.00e+00	1193.00
IUUC-Tgu-116795	Taeniopygia guttata	86.01	0.00e+00	1016.00
IUUC-Tru-118216	Takifugu rubripes	88.24	0.00e+00	1110.00
IUUC-Tsy-118816	Tarsius syrichta	96.02	0.00e+00	632.00
IUUC-Tni-120281	Tetraodon nigroviridis	80.19	0.00e+00	956.00
IUUC-Tbe-128057	Tupaia belangeri	93.81	0.00e+00	1115.00
IUUC-Ttr-128618	Tursiops truncatus	84.71	0.00e+00	1022.00
IUUC-Vpa-130468	Vicugna pacos	98.06	0.00e+00	731.00
IUUC-Xtr-132753	Xenopus tropicalis	89.21	0.00e+00	1102.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence