iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
AREsite	miRTarBase	microRNA	TRANSFAC
miRWalk	TargetScan	RepTar	miRcode
RAID2
Protein-protein Interaction
IID	PINA	HINT	Mentha
InWeb_IM
Disease-associated Information
ClinVar	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/BCR/BTB_3-box	BTB_3-box	17543862; 15772280

Classification

Family	E-value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB	2.20e-15	58.4	50	118
E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box	6.50e-08	31.8	151	182

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB

   S: 1    aDvilvvg..geeffahkivLaasSsvFyalflmeleesksklmveikdvqpevfrallkFlYtgklden 68
           +Dv+lv g  +e f++h++++a++S++F+a+f+++++e++   ++++++v    ++ +++F+Yt kl++n
   Q: 50   CDVTLVPGdgDEIFPVHRAMMASASDYFKAMFTGGMKEQD-LMCIKLHGVNKVGLKKIIDFIYTAKLSLN 118
           8******998999**************************9.**************************987 PP

E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box

   S: 1    leNclgilrfAdlydcpdLkdaaldfilkhFk 32
           l+Nc+++ r+A++y++ ++ +++++filk+F+
   Q: 151  LDNCVEVGRIANTYNLIEVDKYVNNFILKNFP 182
           69*****************************6 PP

Organism

Homo sapiens

Functional Description
(View)

Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis.

Protein Sequence
(Fasta)

MKVSLGNGEM GVSAHLQPCK AGTTRFFTSN THSSVVLQGF DQLRIEGLLC DVTLVPGDGD 60
EIFPVHRAMM ASASDYFKAM FTGGMKEQDL MCIKLHGVNK VGLKKIIDFI YTAKLSLNMD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGAAGGAGCG GCTCGGTGTT GGGGCTAGGC CGGTATTCTA GGCCCAAGCC CAGGCCCAGG 60
CCTGTGTTCC CGGCCCTTGC TCAAAGACAG GCCGGTGGCC GCTGCGACAC TCTAGGTACA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0880--Kelch repeat
KW-0498--Mitosis
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway

Interpro

IPR011705--BACK
IPR017096--BTB-kelch_protein
IPR000210--BTB/POZ_dom
IPR015915--Kelch-typ_b-propeller
IPR006652--Kelch_1
IPR011333--SKP1/BTB/POZ

PROSITE

PS50097--BTB

Pfam

PF07707--BACK
PF00651--BTB
PF01344--Kelch_1

SMART

SM00875--BACK
SM00225--BTB
SM00612--Kelch

Gene Ontology

GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0030496--C:midbody
GO:0000910--P:cytokinesis
GO:0007067--P:mitotic nuclear division
GO:0016567--P:protein ubiquitination

KEGG

hsa:55958

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Apl-003784	Anas platyrhynchos	95.92	0.00e+00	1217.00
IUUC-Bta-013439	Bos taurus	99.35	0.00e+00	1257.00
IUUC-Cho-024873	Choloepus hoffmanni	99.03	0.00e+00	1259.00
IUUC-Cin-025654	Ciona intestinalis	64.37	0.00e+00	807.00
IUUC-Fca-036091	Felis catus	95.92	0.00e+00	1192.00
IUUC-Gmo-039422	Gadus morhua	84.36	0.00e+00	1048.00
IUUC-Gga-040612	Gallus gallus	95.76	0.00e+00	1213.00
IUUC-Ggo-044475	Gorilla gorilla	96.60	0.00e+00	1210.00
IUUC-Itr-048813	Ictidomys tridecemlineatus	99.51	0.00e+00	1261.00
IUUC-Mcc-054723	Macaca mulatta	99.83	0.00e+00	1236.00
IUUC-Meu-056474	Macropus eugenii	91.52	0.00e+00	1157.00
IUUC-Mor-057229	Magnaporthe oryzae	37.68	3.00e-07	48.90
IUUC-Mmr-061352	Microcebus murinus	99.34	0.00e+00	1229.00
IUUC-Mdo-061869	Monodelphis domestica	90.76	0.00e+00	1174.00
IUUC-Mmu-063519	Mus musculus	98.70	0.00e+00	1254.00
IUUC-Mpu-065703	Mustela putorius furo	99.51	0.00e+00	1262.00
IUUC-Mlu-067082	Myotis lucifugus	98.38	0.00e+00	1248.00
IUUC-Opr-070825	Ochotona princeps	99.18	0.00e+00	1239.00
IUUC-Ont-071620	Oreochromis niloticus	92.01	0.00e+00	1168.00
IUUC-Oan-073694	Ornithorhynchus anatinus	87.72	0.00e+00	1023.00
IUUC-Ocu-074027	Oryctolagus cuniculus	99.68	0.00e+00	1262.00
IUUC-Oga-088341	Otolemur garnettii	99.51	0.00e+00	1251.00
IUUC-Ptr-091283	Pan troglodytes	100.00	0.00e+00	1126.00
IUUC-Pan-092737	Papio anubis	96.57	0.00e+00	1202.00
IUUC-Psi-094003	Pelodiscus sinensis	95.76	0.00e+00	1213.00
IUUC-Pab-098052	Pongo abelii	100.00	0.00e+00	1266.00
IUUC-Rno-105991	Rattus norvegicus	99.19	0.00e+00	1258.00
IUUC-Ssc-116052	Sus scrofa	99.68	0.00e+00	1263.00
IUUC-Tru-117586	Takifugu rubripes	91.22	0.00e+00	1165.00
IUUC-Tsy-119119	Tarsius syrichta	99.51	0.00e+00	1257.00
IUUC-Ttr-128192	Tursiops truncatus	99.68	0.00e+00	1262.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence