iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000198876.12	ENST00000361264.8	ENSP00000355114.3
ENSG00000198876.12	ENST00000396990.6	ENSP00000380187.2
ENSG00000198876.12	ENST00000450964.1	ENSP00000415833.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circRNADb	CircNet
miRTarBase	microRNA	TRANSFAC	TargetScan
RepTar	SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
GWASdb
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	BioGRID
mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/DCX/DWD	WD_repeat	17588513

Classification

Family	E-value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.70e-23	83.3	182	220

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sdtllvsGsdDgtikvWDlrtgvllks 38
           gH+d+++++a+ sdt+ vsGs+Dg++ +W+++++vl+ks
   Q: 182  GHKDWIFSIAWiSDTMAVSGSRDGSMGLWEVTDDVLTKS 220
           8**********************************9986 PP

Organism

Homo sapiens

Functional Description
(View)

May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.

Protein Sequence
(Fasta)

MARKVVSRKR KAPASPGAGS DAQGPQFGWD HSLHKRKRLP PVKRSLVYYL KNREVRLQNE 60
TSYSRVLHGY AAQQLPSLLK EREFHLGTLN KVFASQWLNH RQVVCGTKCN TLFVVDVQTS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TGGAAATCTA AAGGGAATGG TGAAGTTGCA CCGTAAGGGG AAGGTGACTG AGGAGCTGAA 60
ACTGACTGAG GGGCTGAAGC ATTTCGGACA GGAGAAAGGA TCAGGAGGAG ACAGAGCGGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat

Interpro

IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

SMART

SM00320--WD40

Gene Ontology

GO:0005813--C:centrosome
GO:0080008--C:Cul4-RING E3 ubiquitin ligase complex
GO:0005737--C:cytoplasm
GO:0016567--P:protein ubiquitination

KEGG

hsa:25853

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002102	Ailuropoda melanoleuca	98.90	0.00e+00	934.00
IUUC-Apl-003794	Anas platyrhynchos	91.86	0.00e+00	825.00
IUUC-Aca-004264	Anolis carolinensis	85.81	0.00e+00	743.00
IUUC-Ame-011254	Astyanax mexicanus	69.06	0.00e+00	666.00
IUUC-Bta-012923	Bos taurus	98.01	0.00e+00	927.00
IUUC-Cja-019590	Callithrix jacchus	99.42	0.00e+00	709.00
IUUC-Cfa-021123	Canis familiaris	99.34	0.00e+00	937.00
IUUC-Cpo-021733	Cavia porcellus	94.44	0.00e+00	671.00
IUUC-Csa-023339	Chlorocebus sabaeus	99.34	0.00e+00	940.00
IUUC-Cho-024837	Choloepus hoffmanni	77.55	2.00e-149	521.00
IUUC-Dre-027571	Danio rerio	70.14	0.00e+00	671.00
IUUC-Dno-029106	Dasypus novemcinctus	98.46	0.00e+00	897.00
IUUC-Dme-031774	Drosophila melanogaster	39.65	3.00e-81	295.00
IUUC-Ete-033140	Echinops telfairi	73.87	8.00e-117	412.00
IUUC-Eca-034316	Equus caballus	98.01	0.00e+00	928.00
IUUC-Eeu-034641	Erinaceus europaeus	91.81	0.00e+00	647.00
IUUC-Fca-036150	Felis catus	99.30	0.00e+00	890.00
IUUC-Fal-036636	Ficedula albicollis	90.11	0.00e+00	849.00
IUUC-Gmo-038736	Gadus morhua	74.19	0.00e+00	663.00
IUUC-Gga-040896	Gallus gallus	84.87	0.00e+00	766.00
IUUC-Gac-042623	Gasterosteus aculeatus	72.69	0.00e+00	674.00
IUUC-Ggo-044968	Gorilla gorilla	100.00	0.00e+00	713.00
IUUC-Itr-048766	Ictidomys tridecemlineatus	98.90	0.00e+00	937.00
IUUC-Lch-050244	Latimeria chalumnae	81.66	0.00e+00	776.00
IUUC-Loc-052777	Lepisosteus oculatus	75.49	0.00e+00	683.00
IUUC-Laf-054505	Loxodonta africana	97.13	0.00e+00	923.00
IUUC-Mcc-055187	Macaca mulatta	99.30	0.00e+00	888.00
IUUC-Meu-056026	Macropus eugenii	90.87	0.00e+00	806.00
IUUC-Mga-059618	Meleagris gallopavo	57.67	1.00e-127	449.00
IUUC-Mmr-061121	Microcebus murinus	91.67	0.00e+00	836.00
IUUC-Mdo-062823	Monodelphis domestica	94.26	0.00e+00	871.00
IUUC-Mmu-064332	Mus musculus	98.45	0.00e+00	931.00
IUUC-Mpu-066157	Mustela putorius furo	99.34	0.00e+00	937.00
IUUC-Mlu-067146	Myotis lucifugus	97.13	0.00e+00	923.00
IUUC-Nle-069179	Nomascus leucogenys	97.35	0.00e+00	909.00
IUUC-Opr-070970	Ochotona princeps	95.91	0.00e+00	682.00
IUUC-Ont-072013	Oreochromis niloticus	69.78	0.00e+00	635.00
IUUC-Oan-072810	Ornithorhynchus anatinus	84.21	1.00e-61	228.00
IUUC-Ocu-074646	Oryctolagus cuniculus	97.13	0.00e+00	920.00
IUUC-Ola-087062	Oryzias latipes	70.58	0.00e+00	660.00
IUUC-Olu-087756	Ostreococcus lucimarinus	28.01	3.00e-16	79.70
IUUC-Oga-089071	Otolemur garnettii	98.90	0.00e+00	936.00
IUUC-Oar-089522	Ovis aries	97.79	0.00e+00	925.00
IUUC-Ptr-091042	Pan troglodytes	94.92	0.00e+00	890.00
IUUC-Pan-092832	Papio anubis	99.12	0.00e+00	937.00
IUUC-Psi-093131	Pelodiscus sinensis	92.56	0.00e+00	830.00
IUUC-Pma-094151	Petromyzon marinus	57.71	2.00e-60	225.00
IUUC-Pfo-096970	Poecilia formosa	70.14	0.00e+00	665.00
IUUC-Pab-098019	Pongo abelii	100.00	0.00e+00	943.00
IUUC-Pca-100401	Procavia capensis	79.82	8.00e-156	543.00
IUUC-Pva-103128	Pteropus vampyrus	98.68	0.00e+00	936.00
IUUC-Rno-105945	Rattus norvegicus	85.43	0.00e+00	773.00
IUUC-Sha-107518	Sarcophilus harrisii	95.34	0.00e+00	681.00
IUUC-Smo-108742	Selaginella moellendorffii	32.53	5.00e-51	194.00
IUUC-Sar-113026	Sorex araneus	75.94	0.00e+00	669.00
IUUC-Ssc-115446	Sus scrofa	97.89	0.00e+00	860.00
IUUC-Tgu-117240	Taeniopygia guttata	83.20	0.00e+00	661.00
IUUC-Tru-118560	Takifugu rubripes	68.98	0.00e+00	662.00
IUUC-Tsy-119344	Tarsius syrichta	91.61	0.00e+00	854.00
IUUC-Tni-119714	Tetraodon nigroviridis	72.28	0.00e+00	676.00
IUUC-Tbe-127634	Tupaia belangeri	99.40	4.00e-97	348.00
IUUC-Ttr-128503	Tursiops truncatus	98.45	0.00e+00	931.00
IUUC-Vpa-130126	Vicugna pacos	97.21	4.00e-166	577.00
IUUC-Xtr-132744	Xenopus tropicalis	51.21	6.00e-109	387.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence