iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	microRNA	TRANSFAC	TargetScan
RepTar	miRNAMap	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	Mentha
InWeb_IM
Disease-associated Information
OMIM
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	SOCS	16325183

Organism

Homo sapiens

Functional Description
(View)

Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Protein Sequence
(Fasta)

MRIVLQLAKM NLMDITKIFS LLQPDKEEED TDTEEKQALN QAVYDNDSYT LDQLLRQERY 60
KRFINSRSGW GVPGTPLRLA ASYGHLSCLQ VLLAHGADVD SLDVKAQTPL FTAVSHGHLD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACTGACTCCT AGTCTTTCAA CGGCATTGTT AACAGTGGGA AACGAGAGCC CCAGCTGCTC 60
CAGGTTGGGG CCGTGGGGGC TCCCTAAGGA GGGGACACCA GGGCCCCAAT GTTTCACAGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0040--ANK repeat
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway

Interpro

IPR002110--Ankyrin_rpt
IPR020683--Ankyrin_rpt-contain_dom
IPR001496--SOCS_box

PROSITE

PS50297--ANK_REP_REGION
PS50088--ANK_REPEAT

Pfam

PF00023--Ank
PF12796--Ank_2
PF07525--SOCS_box

SMART

SM00248--ANK
SM00969--SOCS_box

Gene Ontology

GO:0005622--C:intracellular
GO:0035556--P:intracellular signal transduction
GO:0016567--P:protein ubiquitination

KEGG

hsa:142689

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001687	Ailuropoda melanoleuca	91.22	4.00e-159	553.00
IUUC-Apl-003316	Anas platyrhynchos	64.38	1.00e-115	409.00
IUUC-Aca-004677	Anolis carolinensis	62.78	3.00e-110	391.00
IUUC-Ame-011686	Astyanax mexicanus	62.74	2.00e-108	385.00
IUUC-Bta-013050	Bos taurus	90.20	1.00e-156	545.00
IUUC-Cfa-020331	Canis familiaris	92.16	8.00e-162	562.00
IUUC-Cpo-021837	Cavia porcellus	89.34	2.00e-161	561.00
IUUC-Csa-023302	Chlorocebus sabaeus	98.74	4.00e-175	607.00
IUUC-Dre-028542	Danio rerio	59.61	3.00e-104	371.00
IUUC-Dno-029108	Dasypus novemcinctus	93.73	3.00e-167	580.00
IUUC-Eca-033539	Equus caballus	92.79	5.00e-163	566.00
IUUC-Fca-035885	Felis catus	92.48	2.00e-161	561.00
IUUC-Fal-036760	Ficedula albicollis	65.37	8.00e-111	393.00
IUUC-Gmo-038774	Gadus morhua	58.96	8.00e-105	373.00
IUUC-Gga-040432	Gallus gallus	65.52	2.00e-120	425.00
IUUC-Gac-042345	Gasterosteus aculeatus	59.09	3.00e-94	338.00
IUUC-Ggo-044738	Gorilla gorilla	98.71	2.00e-169	587.00
IUUC-Itr-048720	Ictidomys tridecemlineatus	89.62	3.00e-161	560.00
IUUC-Lch-050001	Latimeria chalumnae	59.37	4.00e-113	400.00
IUUC-Laf-053954	Loxodonta africana	96.10	1.00e-165	575.00
IUUC-Meu-056024	Macropus eugenii	77.47	3.00e-113	401.00
IUUC-Mga-059306	Meleagris gallopavo	65.83	3.00e-122	431.00
IUUC-Mmr-060921	Microcebus murinus	93.73	9.00e-166	575.00
IUUC-Mdo-062338	Monodelphis domestica	74.05	4.00e-128	451.00
IUUC-Mmu-063534	Mus musculus	88.64	7.00e-155	539.00
IUUC-Mpu-066393	Mustela putorius furo	91.22	8.00e-161	559.00
IUUC-Mlu-067956	Myotis lucifugus	82.65	7.00e-151	527.00
IUUC-Nle-069144	Nomascus leucogenys	98.74	4.00e-175	607.00
IUUC-Opr-071120	Ochotona princeps	76.49	7.00e-126	443.00
IUUC-Ont-072016	Oreochromis niloticus	61.94	7.00e-101	360.00
IUUC-Ocu-074678	Oryctolagus cuniculus	94.04	4.00e-167	580.00
IUUC-Ola-086912	Oryzias latipes	60.71	2.00e-100	358.00
IUUC-Oga-087915	Otolemur garnettii	92.48	3.00e-163	567.00
IUUC-Ptr-091446	Pan troglodytes	98.74	9.00e-175	605.00
IUUC-Pan-092113	Papio anubis	98.73	3.00e-173	600.00
IUUC-Psi-093998	Pelodiscus sinensis	67.21	8.00e-121	426.00
IUUC-Pfo-097085	Poecilia formosa	60.06	7.00e-106	377.00
IUUC-Pab-098363	Pongo abelii	98.43	7.00e-175	606.00
IUUC-Pca-100842	Procavia capensis	90.28	2.00e-163	568.00
IUUC-Rno-105361	Rattus norvegicus	88.96	7.00e-156	542.00
IUUC-Sar-113567	Sorex araneus	66.14	2.00e-103	369.00
IUUC-Tgu-117142	Taeniopygia guttata	60.00	1.00e-61	229.00
IUUC-Tru-118185	Takifugu rubripes	60.19	1.00e-108	385.00
IUUC-Tni-120054	Tetraodon nigroviridis	59.62	7.00e-105	373.00
IUUC-Ttr-129120	Tursiops truncatus	93.42	3.00e-164	570.00
IUUC-Xtr-131874	Xenopus tropicalis	54.48	4.00e-81	294.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence