iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Cancer Mutation
ICGC	COSMIC
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
AREsite	microRNA	TRANSFAC
Protein-protein Interaction
IID	PINA	HINT	Mentha
Post-translational Modifications (PTMs)
PhosphositePlus
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	1.00e-07	34.0	16	61

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkw.pglknssskefrCPlCr 46
           C +C  +++d  ++ pCgH+f++ Cl ++ +   +ss k  +CPlC+
   Q: 16   CTLCAGPLED-AVTIPCGHTFCRLCLPALsQMGAQSSGKILLCPLCQ 61
           9*********.999************6663334445666668****7 PP

Organism

Homo sapiens

Protein Sequence
(Fasta)

MPATPSLKVV HELPACTLCA GPLEDAVTIP CGHTFCRLCL PALSQMGAQS SGKILLCPLC 60
QEEEQAETPM APVPLGPLGE TYCEEHGEKI YFFCENDAEF LCTSECRTTD GFGCA 115

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACTTTGATGC TGTGGGCACG CCTCAGAGCC AGAAGTTTAT GGCTCCCACC TGCTCAATCT 60
GACAGGAAGC TTCTGCTCCC CAGTTCTCCC CAGCCACTGT GGTCTACAGA TTCCAGGAAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001870--B30.2/SPRY
IPR003879--Butyrophylin
IPR013320--ConA-like_dom
IPR006574--PRY
IPR003877--SPRY_dom
IPR000315--Znf_B-box
IPR018957--Znf_C3HC4_RING-type
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50188--B302_SPRY
PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF13765--PRY
PF00622--SPRY
PF00643--zf-B_box
PF00097--zf-C3HC4

PRINTS

PR01407--BUTYPHLNCDUF

SMART

SM00336--BBOX
SM00589--PRY
SM00184--RING
SM00449--SPRY

Gene Ontology

GO:0005622--C:intracellular
GO:0008270--F:zinc ion binding
GO:0045087--P:innate immune response
GO:0007500--P:mesodermal cell fate determination
GO:1901253--P:negative regulation of intracellular transport of viral material
GO:1902187--P:negative regulation of viral release from host cell
GO:0051092--P:positive regulation of NF-kappaB transcription factor activity
GO:1900246--P:positive regulation of RIG-I signaling pathway
GO:0051091--P:positive regulation of sequence-specific DNA binding transcription factor activity
GO:0032481--P:positive regulation of type I interferon production

KEGG

hsa:89870

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence