iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000028952.12	ENSMUST00000155389.7	ENSMUSP00000114726.1
ENSMUSG00000028952.12	ENSMUST00000066715.10	ENSMUSP00000067521.4
ENSMUSG00000028952.12	ENSMUST00000156748.1	ENSMUSP00000117079.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
microRNA	TRANSFAC	RepTar	miRNAMap
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha
Protein 3D Structure
PDB	MMDB
Post-translational Modifications (PTMs)
dbPAF
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB	3.20e-06	28.5	26	87

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_Other: BTB

   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmeleesksklmveikdvqpevfrallkFlYtgklde 67
           +D +l vgg +f+ah +vLa +S++F++       +++ ++ v++    +e f  ll+F Ytg l +
   Q: 26   CDATLDVGGLVFKAHWSVLACCSHFFQRIY----GDGT-GGSVVLPAGFAEIFGLLLDFFYTGHLAL 87
           89**************************99....4666.899*********************9976 PP

Organism

Mus musculus

Functional Description
(View)

Telomere-binding protein that acts as a regulator of telomere length. Directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat. Preferentially binds to long telomeres that have a low concentration of shelterin complex and acts as a regulator of telomere length by initiating telomere trimming, a process that prevents the accumulation of aberrantly long telomeres. Also acts as a transcription regulator that binds to promoter regions. Regulates expression the J and/or S elements in MHC II promoter. Acts as a negative regulator of cell proliferation by specifically activating expression of ARF, a tumor suppressor isoform of CDKN2A.

Protein Sequence
(Fasta)

MDGSFVQHSV RVLQELNKQR EKGQYCDATL DVGGLVFKAH WSVLACCSHF FQRIYGDGTG 60
GSVVLPAGFA EIFGLLLDFF YTGHLALTSG NRDQVLLAAK ELRVPEAVEL CQSFQPQTSV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTATGTCACA TCCGGCGCGG CGGCGGTGGC GTCTCCGCGC TGTGGGCCGG GCAGTAGTTA 60
GTCTTGTGGG CGGTGGAAGT GGTCTAGGCC GGAGCAGTGA AGCCGGTGTG AGCCGGGAGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0010--Activator
KW-0025--Alternative splicing
KW-0158--Chromosome
KW-0181--Complete proteome
KW-0238--DNA-binding
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0779--Telomere
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR000210--BTB/POZ_dom
IPR011333--SKP1/BTB/POZ
IPR013087--Znf_C2H2_type
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50097--BTB
PS00028--ZINC_FINGER_C2H2_1
PS50157--ZINC_FINGER_C2H2_2

Pfam

PF00651--BTB

SMART

SM00225--BTB
SM00355--ZnF_C2H2

Gene Ontology

GO:0000781--C:chromosome, telomeric region
GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:0003691--F:double-stranded telomeric DNA binding
GO:0042802--F:identical protein binding
GO:0046872--F:metal ion binding
GO:0006355--P:regulation of transcription, DNA-templated
GO:0010833--P:telomere maintenance via telomere lengthening
GO:0006351--P:transcription, DNA-templated

KEGG

mmu:100090

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001731	Ailuropoda melanoleuca	88.23	0.00e+00	1180.00
IUUC-Bta-012521	Bos taurus	87.16	0.00e+00	1156.00
IUUC-Cja-019221	Callithrix jacchus	82.85	0.00e+00	1079.00
IUUC-Cfa-020921	Canis familiaris	85.67	0.00e+00	1136.00
IUUC-Cpo-021758	Cavia porcellus	88.66	0.00e+00	1164.00
IUUC-Csa-023497	Chlorocebus sabaeus	90.55	0.00e+00	1215.00
IUUC-Dno-029919	Dasypus novemcinctus	86.57	0.00e+00	1158.00
IUUC-Dor-030586	Dipodomys ordii	88.76	0.00e+00	1194.00
IUUC-Ete-032430	Echinops telfairi	83.82	0.00e+00	1096.00
IUUC-Eca-033442	Equus caballus	89.53	0.00e+00	1169.00
IUUC-Eeu-034922	Erinaceus europaeus	85.59	0.00e+00	778.00
IUUC-Fca-035486	Felis catus	88.23	0.00e+00	1175.00
IUUC-Gmo-039194	Gadus morhua	55.30	0.00e+00	627.00
IUUC-Gga-040361	Gallus gallus	90.25	0.00e+00	734.00
IUUC-Ggo-045193	Gorilla gorilla	90.55	0.00e+00	1186.00
IUUC-Hsa-046618	Homo sapiens	90.84	0.00e+00	1223.00
IUUC-Itr-048576	Ictidomys tridecemlineatus	90.26	0.00e+00	1208.00
IUUC-Lch-049869	Latimeria chalumnae	59.57	0.00e+00	800.00
IUUC-Laf-053873	Loxodonta africana	85.05	0.00e+00	1124.00
IUUC-Mcc-055703	Macaca mulatta	90.70	0.00e+00	1217.00
IUUC-Meu-056339	Macropus eugenii	79.51	0.00e+00	1059.00
IUUC-Mmr-061354	Microcebus murinus	90.55	0.00e+00	1203.00
IUUC-Mdo-062372	Monodelphis domestica	68.95	4.00e-137	482.00
IUUC-Mpu-066260	Mustela putorius furo	87.79	0.00e+00	1184.00
IUUC-Mlu-067675	Myotis lucifugus	80.81	0.00e+00	996.00
IUUC-Nle-069672	Nomascus leucogenys	90.84	0.00e+00	1225.00
IUUC-Opr-070357	Ochotona princeps	84.92	0.00e+00	1135.00
IUUC-Oan-072874	Ornithorhynchus anatinus	78.86	0.00e+00	1021.00
IUUC-Ocu-073872	Oryctolagus cuniculus	87.79	0.00e+00	1169.00
IUUC-Oga-088469	Otolemur garnettii	89.39	0.00e+00	1234.00
IUUC-Oar-090081	Ovis aries	79.39	0.00e+00	1016.00
IUUC-Ptr-090537	Pan troglodytes	90.84	0.00e+00	1193.00
IUUC-Pan-092530	Papio anubis	90.70	0.00e+00	1217.00
IUUC-Psi-093837	Pelodiscus sinensis	74.07	0.00e+00	997.00
IUUC-Pab-097987	Pongo abelii	89.24	0.00e+00	1186.00
IUUC-Pca-100921	Procavia capensis	84.01	0.00e+00	1114.00
IUUC-Rno-105597	Rattus norvegicus	96.49	0.00e+00	1326.00
IUUC-Sha-107605	Sarcophilus harrisii	90.32	0.00e+00	663.00
IUUC-Sar-113191	Sorex araneus	61.29	2.00e-100	360.00
IUUC-Ssc-115656	Sus scrofa	88.42	0.00e+00	1188.00
IUUC-Tsy-119603	Tarsius syrichta	96.26	3.00e-98	352.00
IUUC-Tni-120741	Tetraodon nigroviridis	72.37	8.00e-146	510.00
IUUC-Ttr-129274	Tursiops truncatus	86.77	0.00e+00	1145.00
IUUC-Vpa-130774	Vicugna pacos	71.28	0.00e+00	863.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence