iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000213160.9	ENST00000272797.8	ENSP00000272797.4
ENSG00000213160.9	ENST00000437875.1	ENSP00000394732.1
ENSG00000213160.9	ENST00000448589.1	ENSP00000400833.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	HPM
DNA & RNA Element
AREsite	circRNADb	TRANSFAC	RepTar
miRNAMap	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Variation
GWASdb
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB	2.60e-15	58.2	36	102
E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box	2.90e-08	32.9	137	163

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB

   S: 1    aDvilvvg.geeffahkivLaasSsvFyalflmeleesksklmveikdvqpevfrallkFlYtgklde 67
           +D++l++  g  f++h++vLaa+S +F+a+f+ +++e+  k++++++++ ++ ++ l+++ Yt+++++
   Q: 36   TDITLQCPsGIIFHCHRAVLAACSNYFKAMFTADMKEKF-KNKIKLSGIHHDILEGLVNYAYTSQIEI 102
           6999*9999*****************************9.************************9976 PP

E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box

   S: 2    eNclgilrfAdlydcpdLkdaaldfil 28
           +Nc+g+ +fA+ + cp+L +  ++ ++
   Q: 137  DNCIGMHSFAEFHVCPELEKESRRILC 163
           8******************99887555 PP

Organism

Homo sapiens

Protein Sequence
(Fasta)

MALKGQEDYI YLFKDSTHPV DFLDAFRTFY LDGLFTDITL QCPSGIIFHC HRAVLAACSN 60
YFKAMFTADM KEKFKNKIKL SGIHHDILEG LVNYAYTSQI EITKRNVQSL LEAADLLQFL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAGAAGAGAG GCGCCTGCGC TTGCGAGCTG GGCTTGTGAG TGGGGCTGCC GAGAGGGCAG 60
GCGTGGGGCG AGGCCAAAGG ACTGAACCCG CAGGAGCGTC ACGGGCGCCG GGGCGGCTGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0880--Kelch repeat
KW-1185--Reference proteome
KW-0677--Repeat

Interpro

IPR011705--BACK
IPR017096--BTB-kelch_protein
IPR000210--BTB/POZ_dom
IPR015916--Gal_Oxidase_b-propeller
IPR015915--Kelch-typ_b-propeller
IPR006652--Kelch_1
IPR011333--SKP1/BTB/POZ

PROSITE

PS50097--BTB

Pfam

PF07707--BACK
PF00651--BTB
PF01344--Kelch_1

SMART

SM00875--BACK
SM00225--BTB
SM00612--Kelch

Gene Ontology

GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0016567--P:protein ubiquitination

KEGG

hsa:100526832; hsa:151230

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001639	Ailuropoda melanoleuca	98.39	0.00e+00	1150.00
IUUC-Apl-003948	Anas platyrhynchos	77.06	0.00e+00	855.00
IUUC-Aca-005045	Anolis carolinensis	76.88	0.00e+00	932.00
IUUC-Ame-011013	Astyanax mexicanus	62.92	0.00e+00	770.00
IUUC-Bta-013159	Bos taurus	98.21	0.00e+00	1149.00
IUUC-Cja-018886	Callithrix jacchus	99.28	0.00e+00	1159.00
IUUC-Cfa-020205	Canis familiaris	98.57	0.00e+00	1155.00
IUUC-Cpo-022295	Cavia porcellus	97.31	0.00e+00	1135.00
IUUC-Cho-025089	Choloepus hoffmanni	97.80	0.00e+00	934.00
IUUC-Dre-027681	Danio rerio	60.18	0.00e+00	741.00
IUUC-Dno-029078	Dasypus novemcinctus	97.58	0.00e+00	931.00
IUUC-Ete-033011	Echinops telfairi	86.23	0.00e+00	968.00
IUUC-Eca-033213	Equus caballus	98.75	0.00e+00	1156.00
IUUC-Fca-035884	Felis catus	98.39	0.00e+00	1153.00
IUUC-Fal-036897	Ficedula albicollis	77.26	0.00e+00	925.00
IUUC-Gmo-038594	Gadus morhua	57.55	0.00e+00	700.00
IUUC-Gga-040791	Gallus gallus	75.27	0.00e+00	928.00
IUUC-Gac-042512	Gasterosteus aculeatus	60.68	0.00e+00	741.00
IUUC-Ggo-044837	Gorilla gorilla	99.64	0.00e+00	1160.00
IUUC-Itr-048084	Ictidomys tridecemlineatus	99.10	0.00e+00	1155.00
IUUC-Lch-050412	Latimeria chalumnae	72.95	0.00e+00	898.00
IUUC-Loc-052033	Lepisosteus oculatus	68.79	0.00e+00	834.00
IUUC-Laf-053908	Loxodonta africana	98.21	0.00e+00	1150.00
IUUC-Mcc-054734	Macaca mulatta	99.82	0.00e+00	1164.00
IUUC-Meu-055982	Macropus eugenii	89.78	0.00e+00	1068.00
IUUC-Mga-059670	Meleagris gallopavo	74.60	0.00e+00	915.00
IUUC-Mmr-060692	Microcebus murinus	98.57	0.00e+00	1154.00
IUUC-Mdo-062419	Monodelphis domestica	89.96	0.00e+00	1071.00
IUUC-Mmu-063752	Mus musculus	97.13	0.00e+00	1141.00
IUUC-Mpu-066515	Mustela putorius furo	98.39	0.00e+00	1154.00
IUUC-Mlu-068004	Myotis lucifugus	94.97	0.00e+00	1107.00
IUUC-Nle-069163	Nomascus leucogenys	100.00	0.00e+00	1165.00
IUUC-Opr-070823	Ochotona princeps	97.14	0.00e+00	923.00
IUUC-Ont-071629	Oreochromis niloticus	62.10	0.00e+00	751.00
IUUC-Oan-072841	Ornithorhynchus anatinus	84.95	0.00e+00	1019.00
IUUC-Ocu-074300	Oryctolagus cuniculus	98.75	0.00e+00	1156.00
IUUC-Ola-087025	Oryzias latipes	57.65	0.00e+00	713.00
IUUC-Oga-088442	Otolemur garnettii	96.89	0.00e+00	1099.00
IUUC-Oar-089237	Ovis aries	98.21	0.00e+00	1146.00
IUUC-Ptr-091541	Pan troglodytes	99.82	0.00e+00	1163.00
IUUC-Psi-093748	Pelodiscus sinensis	77.60	0.00e+00	942.00
IUUC-Pma-094302	Petromyzon marinus	45.51	1.00e-101	363.00
IUUC-Pfo-097039	Poecilia formosa	61.15	0.00e+00	728.00
IUUC-Pab-098280	Pongo abelii	99.46	0.00e+00	1157.00
IUUC-Pca-100840	Procavia capensis	89.07	0.00e+00	1022.00
IUUC-Pva-102152	Pteropus vampyrus	98.39	0.00e+00	1149.00
IUUC-Rno-105710	Rattus norvegicus	96.94	0.00e+00	1137.00
IUUC-Sha-106991	Sarcophilus harrisii	89.07	0.00e+00	1065.00
IUUC-Sar-112931	Sorex araneus	97.49	0.00e+00	1146.00
IUUC-Ssc-116016	Sus scrofa	97.32	0.00e+00	1139.00
IUUC-Tgu-116999	Taeniopygia guttata	77.06	0.00e+00	930.00
IUUC-Tsy-119071	Tarsius syrichta	98.21	0.00e+00	1147.00
IUUC-Tni-120149	Tetraodon nigroviridis	56.14	0.00e+00	653.00
IUUC-Tbe-127651	Tupaia belangeri	98.92	0.00e+00	1156.00
IUUC-Ttr-128402	Tursiops truncatus	98.57	0.00e+00	1155.00
IUUC-Vpa-130186	Vicugna pacos	96.95	0.00e+00	1135.00
IUUC-Xtr-132379	Xenopus tropicalis	71.15	0.00e+00	880.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence