iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
AREsite	CircNet	miRTarBase	microRNA
TRANSFAC	miRWalk	TargetScan	RepTar
miRcode	RAID2	LncRNADisease
Protein-protein Interaction
IID	iRefIndex	Mentha
Disease-associated Information
ClinVar	GWASdb	GWAS Central	OMIM
Post-translational Modifications (PTMs)
PhosphositePlus
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/BCR/BTB_Other	BTB_Other	20081843; 21237243

Classification

Family	E-value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB	0.0048	18.9	15	48

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_Other: BTB

   S: 35   e.esksklmveikdvqpevfrallkFlYtgklden 68
           + +s+ ++ + i+ ++ ++fr++l+Fl+ g+ld++
   Q: 15   NlNSQGGGHYFID-RDGKAFRHILNFLRLGRLDLP 48
           4456778999999.*******************86 PP

Organism

Homo sapiens

Functional Description
(View)

Plays a role as a marker and a regulator of neuronal differentiation; Up-regulated by a variety of neurogenic signals, such as retinoic acid, epidermal growth factor/EGF and NGFB/nerve growth factor. Induces apoptosis, growth arrest and the expression of cyclin-dependent kinase inhibitor CDKN1B. Plays a role as a tumor repressor and inhibits cell growth and tumorigenicity of medulloblastoma (MDB). Acts as an E3 ubiquitin-protein ligase towards HDAC1, leading to its proteasomal degradation. Functions as antagonist of the Hedgehog pathway on cell proliferation and differentiation by affecting the nuclear transfer of transcription factor GLI1, thus maintaining cerebellar granule cells in undifferentiated state, this effect probably occurs via HDAC1 down-regulation, keeping GLI1 acetylated and inactive. When knock-down, Hedgehog antagonism is impaired and proliferation of granule cells is sustained. Activates the caspase cascade.

Protein Sequence
(Fasta)

MLGAMFRAGT PMPPNLNSQG GGHYFIDRDG KAFRHILNFL RLGRLDLPRG YGETALLRAE 60
ADFYQIRPLL DALRELEASQ GTPAPTAALL HADVDVSPRL VHFSARRGPH HYELSSVQVD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATTAGAGGCT CCAGCCCCGC CGACTTGCAG ACGTGAGATC GGGCACACCT GAGCGGCGGC 60
GGGGCGGTCG TGGCCACATC CGGGGCGACG TGCCTGAGTC ACCCCGTCCC GCCAGCGTCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0024--Alternative initiation
KW-0131--Cell cycle
KW-0181--Complete proteome
KW-0217--Developmental protein
KW-0341--Growth regulation
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0808--Transferase
KW-0043--Tumor suppressor
KW-0833--Ubl conjugation pathway

Interpro

IPR011333--SKP1/BTB/POZ
IPR003131--T1-type_BTB

Pfam

PF02214--BTB_2

Gene Ontology

GO:0005737--C:cytoplasm
GO:0042802--F:identical protein binding
GO:0016740--F:transferase activity
GO:0007049--P:cell cycle
GO:0007406--P:negative regulation of neuroblast proliferation
GO:0045879--P:negative regulation of smoothened signaling pathway
GO:0045666--P:positive regulation of neuron differentiation
GO:0051260--P:protein homooligomerization
GO:0016567--P:protein ubiquitination
GO:0040008--P:regulation of growth

KEGG

hsa:147040

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Bta-013452	Bos taurus	93.10	3.00e-122	430.00
IUUC-Cja-019887	Callithrix jacchus	96.12	6.00e-126	442.00
IUUC-Cpo-021439	Cavia porcellus	92.21	4.00e-122	430.00
IUUC-Csa-023123	Chlorocebus sabaeus	96.98	1.00e-128	451.00
IUUC-Dor-031091	Dipodomys ordii	91.42	2.00e-121	427.00
IUUC-Eca-033975	Equus caballus	93.97	3.00e-125	440.00
IUUC-Ggo-044499	Gorilla gorilla	100.00	1.00e-132	465.00
IUUC-Itr-048770	Ictidomys tridecemlineatus	93.10	1.00e-123	435.00
IUUC-Laf-054335	Loxodonta africana	93.10	1.00e-123	435.00
IUUC-Mcc-055167	Macaca mulatta	97.41	5.00e-129	453.00
IUUC-Meu-056493	Macropus eugenii	81.55	3.00e-106	377.00
IUUC-Mdo-062644	Monodelphis domestica	80.26	7.00e-105	373.00
IUUC-Mmu-064216	Mus musculus	89.66	4.00e-118	417.00
IUUC-Mlu-068062	Myotis lucifugus	90.13	4.00e-119	420.00
IUUC-Nle-069357	Nomascus leucogenys	98.28	6.00e-130	456.00
IUUC-Opr-070353	Ochotona princeps	92.15	2.00e-97	348.00
IUUC-Ocu-074168	Oryctolagus cuniculus	92.67	6.00e-122	429.00
IUUC-Oga-088462	Otolemur garnettii	92.67	1.00e-121	428.00
IUUC-Oar-090451	Ovis aries	92.21	6.00e-120	423.00
IUUC-Ptr-091005	Pan troglodytes	99.57	3.00e-132	463.00
IUUC-Psi-094047	Pelodiscus sinensis	51.46	2.00e-66	246.00
IUUC-Pab-097661	Pongo abelii	99.14	3.00e-131	460.00
IUUC-Rno-105608	Rattus norvegicus	90.95	9.00e-120	422.00
IUUC-Ssc-115986	Sus scrofa	93.53	3.00e-123	434.00
IUUC-Tvi-122274	Trichoderma virens	22.95	9.00e-02	28.90

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence