iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000213983.11	ENST00000308724.9	ENSP00000312442.5
ENSG00000213983.11	ENST00000554477.1	ENSP00000450805.1
ENSG00000213983.11	ENST00000557162.1	ENSP00000450588.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
circBase	circRNADb	CircNet	microRNA
TRANSFAC	TargetScan	RepTar	miRNAMap
miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
UBD/Alpha-Helix/UIM	UIM	16867982

Organism

Homo sapiens

Functional Description
(View)

May function in protein sorting in late endosomes or multivesucular bodies (MVBs). Involved in MVB-assisted maturation of hepatitis B virus (HBV).

Protein Sequence
(Fasta)

MVVPSLKLQD LIEEIRGAKT QAQEREVIQK ECAHIRASFR DGDPVHRHRQ LAKLLYVHML 60
GYPAHFGQME CLKLIASSRF TDKRVGYLGA MLLLDERHDA HLLITNSIKN DLSQGIQPVQ 120

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Nucleotide Sequence
(Fasta)

AAAAAAAATA TATTAATAAA AAAGTTCAAA AAAGGGGGGG GATTGTCATC TCCTTTGGGG 60
TGCGATGGCT TCAAATCCAA ACTGAGGCTC TCCGGGTGGT AAGGATGTGC GAGGAGGCCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0968--Cytoplasmic vesicle
KW-0967--Endosome
KW-0333--Golgi apparatus
KW-0945--Host-virus interaction
KW-0472--Membrane
KW-0621--Polymorphism
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0813--Transport

Interpro

IPR017107--AP1_complex_gsu
IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR002553--Clathrin/coatomer_adapt-like_N
IPR008152--Clathrin_a/b/g-adaptin_app_Ig
IPR008153--Clathrin_g-adaptin_app
IPR013041--Coatomer/clathrin_app_Ig-like

PROSITE

PS50180--GAE

Pfam

PF01602--Adaptin_N
PF02883--Alpha_adaptinC2

SMART

SM00809--Alpha_adaptinC2

Gene Ontology

GO:0030121--C:AP-1 adaptor complex
GO:0010008--C:endosome membrane
GO:0005794--C:Golgi apparatus
GO:0000139--C:Golgi membrane
GO:0005798--C:Golgi-associated vesicle
GO:0016020--C:membrane
GO:0030133--C:transport vesicle
GO:0008565--F:protein transporter activity
GO:0006886--P:intracellular protein transport
GO:0016192--P:vesicle-mediated transport
GO:0016032--P:viral process

KEGG

hsa:8906

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001927	Ailuropoda melanoleuca	87.35	0.00e+00	1260.00
IUUC-Bta-012396	Bos taurus	89.02	0.00e+00	1059.00
IUUC-Cja-019267	Callithrix jacchus	86.61	0.00e+00	1058.00
IUUC-Cfa-020381	Canis familiaris	89.61	0.00e+00	1248.00
IUUC-Cpo-021411	Cavia porcellus	86.01	0.00e+00	1177.00
IUUC-Csa-023574	Chlorocebus sabaeus	96.94	0.00e+00	1336.00
IUUC-Dre-028339	Danio rerio	58.43	0.00e+00	896.00
IUUC-Dno-030066	Dasypus novemcinctus	88.40	0.00e+00	1295.00
IUUC-Dor-031086	Dipodomys ordii	86.31	0.00e+00	926.00
IUUC-Eca-033211	Equus caballus	91.97	0.00e+00	1332.00
IUUC-Eeu-034574	Erinaceus europaeus	81.27	0.00e+00	1146.00
IUUC-Ggo-044758	Gorilla gorilla	99.24	0.00e+00	1372.00
IUUC-Itr-048524	Ictidomys tridecemlineatus	92.24	0.00e+00	1296.00
IUUC-Laf-054160	Loxodonta africana	90.32	0.00e+00	1265.00
IUUC-Mcc-055299	Macaca mulatta	97.07	0.00e+00	1341.00
IUUC-Meu-056526	Macropus eugenii	81.71	0.00e+00	1125.00
IUUC-Mmr-061441	Microcebus murinus	92.10	0.00e+00	1293.00
IUUC-Mdo-062443	Monodelphis domestica	78.50	0.00e+00	1118.00
IUUC-Mmu-063539	Mus musculus	86.73	0.00e+00	1267.00
IUUC-Mpu-065857	Mustela putorius furo	90.32	0.00e+00	1268.00
IUUC-Mlu-067650	Myotis lucifugus	89.81	0.00e+00	1236.00
IUUC-Nle-069751	Nomascus leucogenys	97.96	0.00e+00	1314.00
IUUC-Opr-071071	Ochotona princeps	86.91	0.00e+00	1125.00
IUUC-Ocu-074118	Oryctolagus cuniculus	87.69	0.00e+00	1185.00
IUUC-Oga-087949	Otolemur garnettii	90.70	0.00e+00	1269.00
IUUC-Oar-090094	Ovis aries	90.06	0.00e+00	1309.00
IUUC-Ptr-091184	Pan troglodytes	99.62	0.00e+00	1379.00
IUUC-Pan-092405	Papio anubis	97.20	0.00e+00	1328.00
IUUC-Pab-097941	Pongo abelii	98.73	0.00e+00	1369.00
IUUC-Pca-100934	Procavia capensis	86.24	0.00e+00	1208.00
IUUC-Pva-102188	Pteropus vampyrus	88.45	0.00e+00	809.00
IUUC-Rno-105192	Rattus norvegicus	87.39	0.00e+00	1254.00
IUUC-Tbe-127973	Tupaia belangeri	88.89	2.00e-136	479.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence