iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-046774

UUCD1 version

UUC-HoS-01112

Ensembl Protein ID

ENSP00000333329.3

UniProt Accession

Q6R6M4; U17L2_HUMAN

Genbank Protein ID

AAR91701.1; ENSP00000333329

Protein Name

Ubiquitin carboxyl-terminal hydrolase 17; Deubiquitinating enzyme 17-like protein 2; Deubiquitinating protein 3; Ubiquitin carboxyl-terminal hydrolase 17-like protein 2; Ubiquitin thioesterase 17-like protein 2; Ubiquitin-specific-processing protease 17-like protein 2

Genbank Nucleotide ID

AY509884; AC130366

Gene Name

USP17L2; DUB3; USP17; USP17H; USP17I; USP17J; USP17K; USP17L; USP17M

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000223443.2	ENST00000333796.3	ENSP00000333329.3

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA
DNA & RNA Element
TRANSFAC	miRcode
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
InWeb_IM
Disease-associated Information
OMIM
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	BioGRID
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
DUB/USP	USP	16611142; 19615732

Classification

Family	E-value	Score	Start	End
DUB/USP	3.00e-78	265.1	81	374

Active Site

Position(s)	Description	Evidence
89	Nucleophile
334	Proton acceptor	ECO:0000255\|PROSITE-ProRule:PRU10093}

Domain Profile

DUB/USP

   S: 2    GlkNlgNtCYmNSvLQcLsnipelrellle.kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqqDa 92
           Gl+N+gNtCY N+ LQcL+ +p+l++++l+ ++++++     + pk ++l+++q  ++  ++s  ++++p++       +a  f+  +q+Da
   Q: 81   GLQNMGNTCYENASLQCLTYTPPLANYMLSrEHSQTC-----QRPKCCMLCTMQAHITWALHSPGHVIQPSQA------LAAGFHRGKQEDA 161
           9*****************************4444444.....35899*******9998887888888888865......4567999****** PP
   S: 93   qEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkk 184
           +Efl+f +d++++++                  l+ +++ ++++k ++li+++F+g ++sqikcl+c+ +s +++p ld+ l+++  +    
   Q: 162  HEFLMFTVDAMKKAC------------------LPGHKQVDHHSKDTTLIHQIFGGCWRSQIKCLHCHGISDTFDPYLDIALDIQAAQ---- 231
           ***************..................7888899************************************************.... PP
   S: 185  eslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfctspeekqkekk 276
            s++++Le+ +k+eel+gen+y+c  c ++  a+k+l+l++  +vLil LkRf  s      +k+ k+v++p+ Ld++p++++++++   + 
   Q: 232  -SVKQALEQLVKPEELNGENAYHCGLCLQRAPASKTLTLHTSAKVLILVLKRF--S--DVTGNKLAKNVQYPECLDMQPYMSQQNTG---PL 315
           .9***************************************************..3..35778********************8876...89 PP
   S: 277  kYeLiavvvHsG.slssGHYvayvknekgkWllfdDskVtevkeeevleetgstaYvlfYkr 337
            Y L+av+vH G s++ GHY++yvk ++g+W+++dD kVt+++ ++vl+   ++aYvlfY +
   Q: 316  VYVLYAVLVHAGwSCHDGHYFSYVKAQEGQWYKMDDAKVTACSITSVLS---QQAYVLFYIQ 374
           *************************************************...********86 PP

Organism

Homo sapiens

Functional Description
(View)

Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Regulates cell proliferation by deubiquitinating and inhibiting RCE1 thereby controlling the small GTPases NRAS and HRAS localization and activation. In parallel, mediates deubiquitination of CDC25A, preventing CDC25A degradation by the proteasome during the G1/S and G2/M phases promoting cell-cycle progression. Also regulates cell proliferation and apoptosis through deubiquitination of SUDS3 a regulator of histone deacetylation. Through activation of the Rho family GTPases RAC1A, CDC42 and RHOA, regulates cell migration. Through the cleavage of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains of the cytoplasmic innate immune receptors DDX58 and IFIH1 stimulates the cellular response to viral infection.

Protein Sequence
(Fasta)

MEDDSLYLGG EWQFNHFSKL TSSRPDAAFA EIQRTSLPEK SPLSSEARVD LCDDLAPVAR 60
QLAPRKKLPL SSRRPAAVGA GLQNMGNTCY ENASLQCLTY TPPLANYMLS REHSQTCQRP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TATTATATGT GCCTATCACC CTGAGGAGTA ATTTGATTCA GGTGTTCTAG AAGTCATGAT 60
GTGGGCTGTG TCTGTTGAAT TCCCAGCGAT GCAAGGGGAC ACACCCTGTG ACTCATTCCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0053--Apoptosis
KW-0131--Cell cycle
KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0378--Hydrolase
KW-0539--Nucleus
KW-0621--Polymorphism
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

Gene Ontology

GO:0005829--C:cytosol
GO:0005789--C:endoplasmic reticulum membrane
GO:0005634--C:nucleus
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0006915--P:apoptotic process
GO:0071586--P:CAAX-box protein processing
GO:0000075--P:cell cycle checkpoint
GO:0007093--P:mitotic cell cycle checkpoint
GO:0034260--P:negative regulation of GTPase activity
GO:0031064--P:negative regulation of histone deacetylation
GO:0010955--P:negative regulation of protein processing
GO:0090315--P:negative regulation of protein targeting to membrane
GO:0043547--P:positive regulation of GTPase activity
GO:1900245--P:positive regulation of MDA-5 signaling pathway
GO:1900246--P:positive regulation of RIG-I signaling pathway
GO:0016579--P:protein deubiquitination
GO:0071108--P:protein K48-linked deubiquitination
GO:0070536--P:protein K63-linked deubiquitination
GO:0042981--P:regulation of apoptotic process
GO:0030334--P:regulation of cell migration
GO:0042127--P:regulation of cell proliferation
GO:0050691--P:regulation of defense response to virus by host
GO:1900027--P:regulation of ruffle assembly
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

hsa:377630

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Itr-048248	Ictidomys tridecemlineatus	62.88	0.00e+00	631.00
IUUC-Mcc-055191	Macaca mulatta	89.06	0.00e+00	936.00
IUUC-Mmu-063098	Mus musculus	47.04	8.00e-125	440.00
IUUC-Opr-070217	Ochotona princeps	57.33	1.00e-125	443.00
IUUC-Ocu-074058	Oryctolagus cuniculus	59.84	6.00e-166	577.00
IUUC-Pan-092066	Papio anubis	88.49	0.00e+00	927.00
IUUC-Rno-105845	Rattus norvegicus	48.65	3.00e-122	432.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence