iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-046029

UUCD1 version

UUC-HoS-00055

Ensembl Protein ID

ENSP00000392787.2

UniProt Accession

P14373; A2BE15; Q5RJA8; Q5ST26; Q6LA73; Q6NXR9; Q9BZY6; Q9UJL3; TRI27_HUMAN

Genbank Protein ID

AAA36564.1; AAG50172.1; AAG50173.1; CAI17553.1; CAI18381.1; CAI18618.1; CAI18618.1; CAI18619.1; CAI18619.1; CAI18645.1; CAI18645.1; CAI18646.1; CAI18646.1; CAM24901.1; CAM25659.1; CAM25871.1; CAM25871.1; CAM25872.1; CAM25872.1; CAM26230.1; CAM26230.1; CAM26231.1; CAM26231.1; CAQ07942.1; CAQ07943.1; CAB06480.2; CAB06480.2; CAI19959.1; CAI19959.1; EAX03176.1; EAX03177.1; AAH13580.1; AAH66924.1

Protein Name

Zinc finger protein RFP; RING finger protein 76; RING-type E3 ubiquitin transferase TRIM27; Ret finger protein; Tripartite motif-containing protein 27

Genbank Nucleotide ID

J03407; AF230393; AF230394; AL662859; AL662871; BX000360; BX537153; BX000360; BX537153; BX537153; BX000360; BX537153; BX000360; AL662859; AL662871; BX005144; BX119924; BX005144; BX119924; BX119924; BX005144; BX119924; BX005144; CR759942; CR759942; Z84474; Z84476; Z84476; Z84474; CH471081; CH471081; BC013580; BC066924

Gene Name

TRIM27; RFP; RNF76

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000234495.7	ENST00000437160.6	ENSP00000392787.2
ENSG00000234495.7	ENST00000412687.6	ENSP00000416281.2
ENSG00000234495.7	ENST00000417993.1	ENSP00000398020.1

Annotation

Cancer Mutation
TCGA	COSMIC	CGAP	IntOGen
mRNA Expression
ArrayExpress	TCGA	ICGC	COSMIC
THPA	HPM
DNA & RNA Element
UTRdb	CircNet	RepTar	SomamiR
miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	Mentha
Disease-associated Information
GWASdb
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	PHOSIDA	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	20145714; 23404503

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	0.00016	23.7	16	57

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadCl.qkwpglknssskefrCPlCr 46
           C++Cl+ f + p+ l+CgH ++  Cl  +w      + ++ +CP Cr
   Q: 16   CPVCLQYFAE-PMMLDCGHNICCACLaRCW----GTAETNVSCPQCR 57
           ********99.999****************....99**********8 PP

Organism

Homo sapiens

Functional Description
(View)

E3 ubiquitin-protein ligase that mediates ubiquitination of PIK3C2B and inhibits its activity; mediates the formation of 'Lys-48'-linked polyubiquitin chains; the function inhibits CD4 T-cell activation. Acts as a regulator of retrograde transport: together with MAGEL2, mediates the formation of 'Lys-63'-linked polyubiquitin chains at 'Lys-220' of WASHC1, leading to promote endosomal F-actin assembly (PubMed:23452853). Has a transcriptional repressor activity by cooperating with EPC1. Induces apoptosis by activating Jun N-terminal kinase and p38 kinase and also increases caspase-3-like activity independently of mitochondrial events. May function in male germ cell development. Has DNA-binding activity and preferentially bound to double-stranded DNA.

Protein Sequence
(Fasta)

MASGSVAECL QQETTCPVCL QYFAEPMMLD CGHNICCACL ARCWGTAETN VSCPQCRETF 60
PQRHMRPNRH LANVTQLVKQ LRTERPSGPG GEMGVCEKHR EPLKLYCEED QMPICVVCDR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTTTACGCTG CCGCCGGCAT CCGCTCGGAC GCGGCCACGT TGTCTTGCGC GCTTTGCCCG 60
CCTGGCCCTG GGACTCTGAC CCTCGGCTAC CCTTTCCTGC CCCACTAGCG TGGCCGCGAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0160--Chromosomal rearrangement
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0238--DNA-binding
KW-0967--Endosome
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0656--Proto-oncogene
KW-1185--Reference proteome
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase
KW-0813--Transport
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001870--B30.2/SPRY
IPR003879--Butyrophylin
IPR013320--ConA-like_dom
IPR006574--PRY
IPR003877--SPRY_dom
IPR000315--Znf_B-box
IPR020457--Znf_B-box_chordata
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50188--B302_SPRY
PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF13765--PRY
PF00622--SPRY
PF00643--zf-B_box

PRINTS

PR01406--BBOXZNFINGER
PR01407--BUTYPHLNCDUF

SMART

SM00336--BBOX
SM00589--PRY
SM00184--RING
SM00449--SPRY

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005769--C:early endosome
GO:0005768--C:endosome
GO:0001650--C:fibrillar center
GO:0005887--C:integral component of plasma membrane
GO:0016020--C:membrane
GO:0031965--C:nuclear membrane
GO:0005730--C:nucleolus
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0016605--C:PML body
GO:0003677--F:DNA binding
GO:0042802--F:identical protein binding
GO:0046872--F:metal ion binding
GO:0003676--F:nucleic acid binding
GO:0004714--F:transmembrane receptor protein tyrosine kinase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0034314--P:Arp2/3 complex-mediated actin nucleation
GO:0008283--P:cell proliferation
GO:0045087--P:innate immune response
GO:0072643--P:interferon-gamma secretion
GO:0002820--P:negative regulation of adaptive immune response
GO:0090281--P:negative regulation of calcium ion import
GO:0045814--P:negative regulation of gene expression, epigenetic
GO:1900041--P:negative regulation of interleukin-2 secretion
GO:0006469--P:negative regulation of protein kinase activity
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0032720--P:negative regulation of tumor necrosis factor production
GO:1902187--P:negative regulation of viral release from host cell
GO:0032897--P:negative regulation of viral transcription
GO:0051127--P:positive regulation of actin nucleation
GO:0051091--P:positive regulation of sequence-specific DNA binding transcription factor activity
GO:0070534--P:protein K63-linked ubiquitination
GO:0070206--P:protein trimerization
GO:0042147--P:retrograde transport, endosome to Golgi
GO:0007283--P:spermatogenesis
GO:0006351--P:transcription, DNA-templated

KEGG

hsa:5987

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001890	Ailuropoda melanoleuca	98.62	0.00e+00	971.00
IUUC-Apl-003609	Anas platyrhynchos	40.29	6.00e-97	347.00
IUUC-Ame-011639	Astyanax mexicanus	34.42	2.00e-69	256.00
IUUC-Bta-013520	Bos taurus	99.42	0.00e+00	985.00
IUUC-Cja-019557	Callithrix jacchus	97.47	0.00e+00	967.00
IUUC-Cfa-020583	Canis familiaris	98.57	0.00e+00	924.00
IUUC-Cpo-021738	Cavia porcellus	90.25	0.00e+00	879.00
IUUC-Csa-023502	Chlorocebus sabaeus	100.00	0.00e+00	990.00
IUUC-Cho-024563	Choloepus hoffmanni	95.84	3.00e-179	621.00
IUUC-Dno-029747	Dasypus novemcinctus	96.59	0.00e+00	910.00
IUUC-Dor-030243	Dipodomys ordii	96.88	0.00e+00	935.00
IUUC-Ete-032749	Echinops telfairi	84.55	0.00e+00	796.00
IUUC-Eca-034246	Equus caballus	99.47	0.00e+00	694.00
IUUC-Eeu-034481	Erinaceus europaeus	88.50	0.00e+00	867.00
IUUC-Fca-036152	Felis catus	98.66	0.00e+00	688.00
IUUC-Gac-042288	Gasterosteus aculeatus	37.58	2.00e-75	276.00
IUUC-Ggo-044987	Gorilla gorilla	90.25	0.00e+00	875.00
IUUC-Itr-048438	Ictidomys tridecemlineatus	99.42	0.00e+00	960.00
IUUC-Laf-054488	Loxodonta africana	99.61	0.00e+00	980.00
IUUC-Mcc-055352	Macaca mulatta	100.00	0.00e+00	990.00
IUUC-Mmr-060883	Microcebus murinus	99.61	0.00e+00	985.00
IUUC-Mmu-064242	Mus musculus	98.83	0.00e+00	981.00
IUUC-Mpu-065958	Mustela putorius furo	99.03	0.00e+00	982.00
IUUC-Mlu-068005	Myotis lucifugus	85.54	0.00e+00	654.00
IUUC-Nle-069710	Nomascus leucogenys	99.72	0.00e+00	644.00
IUUC-Opr-071200	Ochotona princeps	99.03	0.00e+00	976.00
IUUC-Ocu-074081	Oryctolagus cuniculus	98.02	0.00e+00	846.00
IUUC-Ola-087166	Oryzias latipes	33.58	5.00e-70	258.00
IUUC-Oga-088784	Otolemur garnettii	99.61	0.00e+00	986.00
IUUC-Oar-089433	Ovis aries	99.42	0.00e+00	985.00
IUUC-Ptr-090595	Pan troglodytes	100.00	0.00e+00	990.00
IUUC-Pan-092027	Papio anubis	100.00	0.00e+00	990.00
IUUC-Psi-093179	Pelodiscus sinensis	47.36	4.00e-116	411.00
IUUC-Pfo-096858	Poecilia formosa	33.77	8.00e-69	254.00
IUUC-Pab-098331	Pongo abelii	100.00	0.00e+00	990.00
IUUC-Pca-101091	Procavia capensis	99.61	0.00e+00	986.00
IUUC-Pva-103141	Pteropus vampyrus	99.48	0.00e+00	715.00
IUUC-Rno-105507	Rattus norvegicus	98.44	0.00e+00	976.00
IUUC-Sar-113713	Sorex araneus	90.23	0.00e+00	897.00
IUUC-Ssc-115594	Sus scrofa	99.41	0.00e+00	983.00
IUUC-Tru-118630	Takifugu rubripes	34.27	8.00e-72	264.00
IUUC-Tsy-119235	Tarsius syrichta	99.22	0.00e+00	702.00
IUUC-Tni-120295	Tetraodon nigroviridis	37.37	7.00e-75	274.00
IUUC-Tbe-127796	Tupaia belangeri	88.64	6.00e-139	487.00
IUUC-Ttr-128738	Tursiops truncatus	99.46	0.00e+00	692.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence