iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	CircNet	miRTarBase
microRNA	TRANSFAC	TargetScan	RepTar
miRNAMap	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
InWeb_IM
Disease-associated Information
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	21455683; 19753093

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	5.50e-07	31.7	621	663

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplv..lpCgHvfhadClqkwpglknssskefrCPlCr 46
           C +Cle f++g l+  lpCgHvfh++C+ +w     ++ ++  CP+Cr
   Q: 621  CVVCLENFENGCLLmgLPCGHVFHQNCIVMW-----LAGGRHCCPVCR 663
           **********87776688*************.....89*********8 PP

Organism

Homo sapiens

Functional Description
(View)

Acts as an E2-dependent E3 ubiquitin-protein ligase, probably involved in the ER-associated protein degradation pathway.

Protein Sequence
(Fasta)

MWLKLFFLLL YFLVLFVLAR FFEAIVWYET GIFATQLVDP VALSFKKLKT ILECRGLGYS 60
GLPEKKDVRE LVEKSGDLME GELYSALKEE EASESVSSTN FSGEMHFYEL VEDTKDGIWL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TGTTATGTCT CGGCTCCGGC CGCGGCCGCC GCTGATACAC GGTTGTGGAG GGTACGGCCG 60
CGGTCTCCGG AGGTGGCGGG GGTGTTGGGG ACGGGTGCTG CGACCGGCAC TGCCCATCCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0472--Membrane
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR012336--Thioredoxin-like_fold
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50089--ZF_RING_2

Pfam

PF13639--zf-RING_2

SMART

SM00184--RING

Gene Ontology

GO:0005783--C:endoplasmic reticulum
GO:0005789--C:endoplasmic reticulum membrane
GO:0044322--C:endoplasmic reticulum quality control compartment
GO:0016021--C:integral component of membrane
GO:1904264--F:ubiquitin protein ligase activity involved in ERAD pathway
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0007417--P:central nervous system development
GO:1904380--P:endoplasmic reticulum mannose trimming
GO:0016567--P:protein ubiquitination
GO:0030433--P:ubiquitin-dependent ERAD pathway

KEGG

hsa:7844

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002130	Ailuropoda melanoleuca	97.59	0.00e+00	1262.00
IUUC-Apl-004099	Anas platyrhynchos	86.85	0.00e+00	1102.00
IUUC-Aca-004500	Anolis carolinensis	85.16	0.00e+00	1106.00
IUUC-Ame-011513	Astyanax mexicanus	70.69	0.00e+00	920.00
IUUC-Bta-012824	Bos taurus	97.29	0.00e+00	1264.00
IUUC-Bdi-014038	Brachypodium distachyon	54.35	3.00e-10	58.50
IUUC-Cja-019429	Callithrix jacchus	97.89	0.00e+00	1296.00
IUUC-Cfa-020110	Canis familiaris	97.74	0.00e+00	1299.00
IUUC-Cpo-021413	Cavia porcellus	83.21	0.00e+00	1050.00
IUUC-Csa-023111	Chlorocebus sabaeus	99.34	0.00e+00	1176.00
IUUC-Dre-027675	Danio rerio	71.71	0.00e+00	925.00
IUUC-Dno-029645	Dasypus novemcinctus	94.55	0.00e+00	1148.00
IUUC-Dor-030871	Dipodomys ordii	95.06	0.00e+00	801.00
IUUC-Ete-032670	Echinops telfairi	94.52	0.00e+00	649.00
IUUC-Eca-033322	Equus caballus	97.74	0.00e+00	1261.00
IUUC-Eeu-035071	Erinaceus europaeus	96.77	9.00e-151	527.00
IUUC-Fca-036356	Felis catus	97.29	0.00e+00	1272.00
IUUC-Fal-036861	Ficedula albicollis	85.91	0.00e+00	1130.00
IUUC-Gmo-039251	Gadus morhua	60.85	0.00e+00	740.00
IUUC-Gga-040659	Gallus gallus	86.97	0.00e+00	1142.00
IUUC-Gac-042187	Gasterosteus aculeatus	63.25	0.00e+00	777.00
IUUC-Ggo-044883	Gorilla gorilla	99.70	0.00e+00	1377.00
IUUC-Hvu-047185	Hordeum vulgare	47.17	3.00e-10	57.40
IUUC-Itr-048705	Ictidomys tridecemlineatus	87.46	0.00e+00	1101.00
IUUC-Lch-049872	Latimeria chalumnae	80.76	0.00e+00	976.00
IUUC-Lpe-051679	Leersia perrieri	60.00	9.00e-11	62.40
IUUC-Loc-051795	Lepisosteus oculatus	76.35	0.00e+00	963.00
IUUC-Laf-053807	Loxodonta africana	96.68	0.00e+00	1282.00
IUUC-Mcc-054842	Macaca mulatta	98.04	0.00e+00	1280.00
IUUC-Meu-056570	Macropus eugenii	87.38	0.00e+00	1068.00
IUUC-Mga-059758	Meleagris gallopavo	87.42	0.00e+00	1014.00
IUUC-Mvi-060247	Microbotryum violaceum	52.27	1.00e-10	61.60
IUUC-Mmr-061620	Microcebus murinus	94.51	0.00e+00	637.00
IUUC-Mdo-062398	Monodelphis domestica	84.64	0.00e+00	1111.00
IUUC-Mmu-064279	Mus musculus	95.32	0.00e+00	1230.00
IUUC-Mac-064686	Musa acuminata	37.50	1.00e-11	62.40
IUUC-Mpu-065770	Mustela putorius furo	98.04	0.00e+00	1269.00
IUUC-Mlu-067764	Myotis lucifugus	93.84	0.00e+00	1254.00
IUUC-Nle-069363	Nomascus leucogenys	99.40	0.00e+00	1317.00
IUUC-Opr-070664	Ochotona princeps	95.17	0.00e+00	1243.00
IUUC-Ont-072466	Oreochromis niloticus	63.44	0.00e+00	815.00
IUUC-Oan-073047	Ornithorhynchus anatinus	92.98	0.00e+00	836.00
IUUC-Ocu-074240	Oryctolagus cuniculus	93.30	0.00e+00	1240.00
IUUC-Oba-075208	Oryza barthii	49.06	3.00e-11	61.60
IUUC-Ogl-077486	Oryza glaberrima	49.06	3.00e-11	61.60
IUUC-Olo-080618	Oryza longistaminata	49.06	3.00e-11	61.60
IUUC-Ome-081540	Oryza meridionalis	45.45	3.00e-11	61.20
IUUC-Oru-084388	Oryza rufipogon	49.06	3.00e-11	61.60
IUUC-Osa-086245	Oryza sativa	49.06	3.00e-11	61.60
IUUC-Ola-086352	Oryzias latipes	62.16	0.00e+00	750.00
IUUC-Oga-088582	Otolemur garnettii	98.04	0.00e+00	1302.00
IUUC-Oar-090324	Ovis aries	96.26	0.00e+00	1255.00
IUUC-Pan-092792	Papio anubis	99.10	0.00e+00	1311.00
IUUC-Psi-092964	Pelodiscus sinensis	90.50	0.00e+00	1147.00
IUUC-Pma-094186	Petromyzon marinus	52.85	0.00e+00	671.00
IUUC-Pfo-097169	Poecilia formosa	61.85	0.00e+00	792.00
IUUC-Pab-098549	Pongo abelii	99.70	0.00e+00	1318.00
IUUC-Pca-100113	Procavia capensis	91.63	0.00e+00	1045.00
IUUC-Pva-102543	Pteropus vampyrus	93.83	0.00e+00	786.00
IUUC-Rno-105676	Rattus norvegicus	95.50	0.00e+00	1193.00
IUUC-Sha-106596	Sarcophilus harrisii	91.84	0.00e+00	710.00
IUUC-Sit-109739	Setaria italica	50.00	2.00e-09	55.10
IUUC-Sly-111354	Solanum lycopersicum	52.17	2.00e-12	64.30
IUUC-Sar-113147	Sorex araneus	97.04	0.00e+00	1145.00
IUUC-Ssc-115585	Sus scrofa	96.38	0.00e+00	1247.00
IUUC-Tgu-117258	Taeniopygia guttata	86.21	0.00e+00	1129.00
IUUC-Tsy-119127	Tarsius syrichta	95.23	0.00e+00	1125.00
IUUC-Tbe-128054	Tupaia belangeri	97.03	0.00e+00	1068.00
IUUC-Ttr-128931	Tursiops truncatus	98.88	0.00e+00	857.00
IUUC-Vpa-130826	Vicugna pacos	96.50	0.00e+00	1155.00
IUUC-Xtr-132828	Xenopus tropicalis	81.74	0.00e+00	1087.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence