iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000052656.12	ENSMUST00000064637.10	ENSMUSP00000066324.4
ENSMUSG00000052656.12	ENSMUST00000114178.7	ENSMUSP00000109816.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	miRTarBase	microRNA	TRANSFAC
RepTar	miRNAMap	RAID2
Post-translational Modifications (PTMs)
PhosphositePlus	PHOSIDA
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	4.20e-07	31.5	619	661

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplv..lpCgHvfhadClqkwpglknssskefrCPlCr 46
           C +Cle f++g l+  lpCgHvfh++C+ +w     ++ ++  CP+Cr
   Q: 619  CVVCLENFENGCLLmgLPCGHVFHQNCIVMW-----LAGGRHCCPVCR 661
           **********87776688*************.....89*********8 PP

Organism

Mus musculus

Functional Description
(View)

Acts as an E2-dependent E3 ubiquitin-protein ligase, probably involved in the ER-associated protein degradation pathway.

Protein Sequence
(Fasta)

MWLKLFFLLL YFLVLFVLAR FFEAIVWYET GIFATQLVDP VALSFKKLKT ILECRGLGYS 60
GLPEKKDVRE LVEKSGDLME GELYSALKEE EASESVSSTN FSGEMHFYEL VEDTKDGIWL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGGCTACAGC GGGTCCAGTG CTCTGGGGGC GACGGCCGCG GCCTGCAGAG GCGGCAGGGA 60
CGGTGGCCGC GGTTGGCGCG GCGCGTCCGC ACGGGGCTGG GCACCGCGCG GCTACGCAGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0472--Membrane
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR012336--Thioredoxin-like_fold
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50089--ZF_RING_2

Pfam

PF13639--zf-RING_2

SMART

SM00184--RING

Gene Ontology

GO:0005783--C:endoplasmic reticulum
GO:0005789--C:endoplasmic reticulum membrane
GO:0016021--C:integral component of membrane
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0016567--P:protein ubiquitination
GO:0030433--P:ubiquitin-dependent ERAD pathway

KEGG

mmu:22644

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002130	Ailuropoda melanoleuca	94.57	0.00e+00	1208.00
IUUC-Apl-004099	Anas platyrhynchos	84.16	0.00e+00	1099.00
IUUC-Aca-004500	Anolis carolinensis	84.38	0.00e+00	1115.00
IUUC-Ame-011513	Astyanax mexicanus	70.62	0.00e+00	926.00
IUUC-Bta-012824	Bos taurus	94.12	0.00e+00	1234.00
IUUC-Bdi-014038	Brachypodium distachyon	49.12	2.00e-10	58.90
IUUC-Bol-015892	Brassica oleracea	51.11	4.00e-10	58.20
IUUC-Cja-019429	Callithrix jacchus	93.97	0.00e+00	1231.00
IUUC-Cfa-020110	Canis familiaris	94.42	0.00e+00	1242.00
IUUC-Cpo-021413	Cavia porcellus	82.41	0.00e+00	1051.00
IUUC-Csa-023111	Chlorocebus sabaeus	94.40	0.00e+00	1125.00
IUUC-Dre-027675	Danio rerio	71.25	0.00e+00	935.00
IUUC-Dno-029645	Dasypus novemcinctus	92.23	0.00e+00	1111.00
IUUC-Dor-030871	Dipodomys ordii	92.08	0.00e+00	773.00
IUUC-Ete-032670	Echinops telfairi	89.34	1.00e-172	599.00
IUUC-Eca-033322	Equus caballus	94.42	0.00e+00	1207.00
IUUC-Eeu-035071	Erinaceus europaeus	96.77	3.00e-150	525.00
IUUC-Fca-036356	Felis catus	94.42	0.00e+00	1239.00
IUUC-Fal-036861	Ficedula albicollis	84.55	0.00e+00	1117.00
IUUC-Gmo-039251	Gadus morhua	61.09	0.00e+00	751.00
IUUC-Gga-040659	Gallus gallus	86.06	0.00e+00	1118.00
IUUC-Gac-042187	Gasterosteus aculeatus	62.97	0.00e+00	782.00
IUUC-Ggo-044883	Gorilla gorilla	95.17	0.00e+00	1279.00
IUUC-Hsa-045756	Homo sapiens	95.17	0.00e+00	1251.00
IUUC-Hvu-047185	Hordeum vulgare	51.06	3.00e-10	57.80
IUUC-Itr-048705	Ictidomys tridecemlineatus	86.34	0.00e+00	1107.00
IUUC-Lch-049872	Latimeria chalumnae	78.79	0.00e+00	979.00
IUUC-Lpe-051679	Leersia perrieri	60.00	9.00e-11	62.40
IUUC-Loc-051795	Lepisosteus oculatus	75.08	0.00e+00	950.00
IUUC-Laf-053807	Loxodonta africana	93.67	0.00e+00	1227.00
IUUC-Mcc-054842	Macaca mulatta	93.36	0.00e+00	1225.00
IUUC-Meu-056570	Macropus eugenii	86.72	0.00e+00	1054.00
IUUC-Mga-059758	Meleagris gallopavo	86.11	0.00e+00	986.00
IUUC-Mvi-060247	Microbotryum violaceum	52.27	1.00e-10	62.00
IUUC-Mmr-061620	Microcebus murinus	91.30	2.00e-171	595.00
IUUC-Mdo-062398	Monodelphis domestica	83.43	0.00e+00	1092.00
IUUC-Mpu-065770	Mustela putorius furo	94.72	0.00e+00	1214.00
IUUC-Mlu-067764	Myotis lucifugus	91.28	0.00e+00	1208.00
IUUC-Nle-069363	Nomascus leucogenys	94.57	0.00e+00	1244.00
IUUC-Opr-070664	Ochotona princeps	92.75	0.00e+00	1215.00
IUUC-Ont-072466	Oreochromis niloticus	62.41	0.00e+00	809.00
IUUC-Oan-073047	Ornithorhynchus anatinus	92.43	0.00e+00	838.00
IUUC-Ocu-074240	Oryctolagus cuniculus	91.16	0.00e+00	1214.00
IUUC-Obr-076086	Oryza brachyantha	48.15	3.00e-10	57.80
IUUC-Olo-080618	Oryza longistaminata	49.06	3.00e-11	61.60
IUUC-Ome-081159	Oryza meridionalis	48.94	4.00e-11	58.90
IUUC-Ola-086352	Oryzias latipes	62.14	0.00e+00	754.00
IUUC-Oga-088582	Otolemur garnettii	94.42	0.00e+00	1238.00
IUUC-Oar-090324	Ovis aries	93.12	0.00e+00	1224.00
IUUC-Pan-092792	Papio anubis	94.72	0.00e+00	1243.00
IUUC-Psi-092964	Pelodiscus sinensis	88.67	0.00e+00	1130.00
IUUC-Pma-094186	Petromyzon marinus	52.78	0.00e+00	685.00
IUUC-Pfo-097169	Poecilia formosa	60.58	0.00e+00	785.00
IUUC-Pab-098549	Pongo abelii	94.87	0.00e+00	1244.00
IUUC-Pca-100113	Procavia capensis	87.34	0.00e+00	1038.00
IUUC-Pva-102543	Pteropus vampyrus	92.83	0.00e+00	777.00
IUUC-Rno-105676	Rattus norvegicus	98.20	0.00e+00	1243.00
IUUC-Sha-106596	Sarcophilus harrisii	91.56	0.00e+00	716.00
IUUC-Sly-111354	Solanum lycopersicum	46.67	2.00e-12	64.30
IUUC-Sar-113147	Sorex araneus	94.08	0.00e+00	1100.00
IUUC-Ssc-115585	Sus scrofa	93.21	0.00e+00	1196.00
IUUC-Tgu-117258	Taeniopygia guttata	84.55	0.00e+00	1117.00
IUUC-Tsy-119127	Tarsius syrichta	92.11	0.00e+00	1073.00
IUUC-Tur-126354	Triticum urartu	37.50	2.00e-09	54.70
IUUC-Tbe-128054	Tupaia belangeri	94.07	0.00e+00	1019.00
IUUC-Ttr-128931	Tursiops truncatus	97.32	0.00e+00	847.00
IUUC-Vpa-130826	Vicugna pacos	93.62	0.00e+00	1115.00
IUUC-Xtr-132828	Xenopus tropicalis	80.54	0.00e+00	1078.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence