iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	CircNet	microRNA
TRANSFAC	TargetScan	RepTar	miRNAMap
miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Information
ClinVar	GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/BCR/BTB_3-box	BTB_3-box	15983046

Classification

Family	E-value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB	6.00e-17	63.4	34	100
E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box	2.10e-10	39.7	132	162

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB

   S: 2    DvilvvggeeffahkivLaasSsvFyalflmeleesksklmveikdvqpevfrallkFlYtgkldene 69
           D++l+ g++  ++h+++L+a+S++F+  fl+e +e k k++v+++ v+p  +  ++k+lY+ ++d+n+
   Q: 34   DCTLKAGDKSLPCHRLILSACSPYFREYFLSEIDEAK-KKEVVLDNVDPAILDLIIKYLYSASIDLND 100
           9***********************************9.***************************986 PP

E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box

   S: 1    leNclgilrfAdlydcpdLkdaaldfilkhF 31
           + Ncl+ilr++ l+dcp+L+ +a++f+++ F
   Q: 132  PGNCLAILRLGLLLDCPRLAISAREFVSDRF 162
           56***************************99 PP

Organism

Homo sapiens

Functional Description
(View)

Involved in skeletal muscle development and differentiation. Regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils. Required for pseudopod elongation in transformed cells.

Protein Sequence
(Fasta)

MDSQRELAEE LRLYQSTLLQ DGLKDLLDEK KFIDCTLKAG DKSLPCHRLI LSACSPYFRE 60
YFLSEIDEAK KKEVVLDNVD PAILDLIIKY LYSASIDLND GNVQDIFALA SRFQIPSVFT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTTTTTACAG CTAGACCTGT GTGCTGCAAG GAGCTAAGGC CTTCAGTGTC CCCTTCCTTA 60
CCCAGGTTTC TCACAGAATG GATTCCCAGC GGGAACTTGC AGAGGAACTG CGGCTTTACC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0966--Cell projection
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0225--Disease mutation
KW-0256--Endoplasmic reticulum
KW-0880--Kelch repeat
KW-0472--Membrane
KW-1057--Nemaline myopathy
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0703--Sarcoplasmic reticulum
KW-0832--Ubl conjugation

Interpro

IPR011705--BACK
IPR017096--BTB-kelch_protein
IPR000210--BTB/POZ_dom
IPR015915--Kelch-typ_b-propeller
IPR006652--Kelch_1
IPR030571--KLHL41
IPR011333--SKP1/BTB/POZ

PROSITE

PS50097--BTB

Pfam

PF07707--BACK
PF00651--BTB
PF01344--Kelch_1

SMART

SM00875--BACK
SM00225--BTB
SM00612--Kelch

Gene Ontology

GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0005737--C:cytoplasm
GO:0005856--C:cytoskeleton
GO:0005829--C:cytosol
GO:0005789--C:endoplasmic reticulum membrane
GO:0031430--C:M band
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0031143--C:pseudopodium
GO:0001726--C:ruffle
GO:0033017--C:sarcoplasmic reticulum membrane
GO:0030239--P:myofibril assembly
GO:0016567--P:protein ubiquitination
GO:0031275--P:regulation of lateral pseudopodium assembly
GO:0045661--P:regulation of myoblast differentiation
GO:2000291--P:regulation of myoblast proliferation
GO:2001014--P:regulation of skeletal muscle cell differentiation
GO:0045214--P:sarcomere organization
GO:0035914--P:skeletal muscle cell differentiation
GO:0048741--P:skeletal muscle fiber development
GO:0006941--P:striated muscle contraction

KEGG

hsa:10324

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002167	Ailuropoda melanoleuca	97.03	0.00e+00	1181.00
IUUC-Apl-003866	Anas platyrhynchos	86.14	0.00e+00	1040.00
IUUC-Ame-011172	Astyanax mexicanus	61.86	0.00e+00	753.00
IUUC-Bta-012925	Bos taurus	97.52	0.00e+00	1187.00
IUUC-Bci-013875	Botrytis cinerea	29.58	1.00e-18	87.00
IUUC-Bdi-014115	Brachypodium distachyon	24.05	6.00e-11	62.00
IUUC-Cja-019348	Callithrix jacchus	98.35	0.00e+00	1194.00
IUUC-Cfa-020782	Canis familiaris	97.85	0.00e+00	1188.00
IUUC-Cpo-021825	Cavia porcellus	93.23	0.00e+00	1136.00
IUUC-Csa-023184	Chlorocebus sabaeus	99.04	0.00e+00	1026.00
IUUC-Cin-025237	Ciona intestinalis	29.45	1.00e-70	260.00
IUUC-Dre-028278	Danio rerio	60.43	0.00e+00	775.00
IUUC-Dno-029516	Dasypus novemcinctus	95.54	0.00e+00	1169.00
IUUC-Dor-030850	Dipodomys ordii	92.96	0.00e+00	759.00
IUUC-Ete-032697	Echinops telfairi	94.39	0.00e+00	1134.00
IUUC-Eca-033714	Equus caballus	97.36	0.00e+00	1188.00
IUUC-Eeu-035245	Erinaceus europaeus	94.90	0.00e+00	1070.00
IUUC-Gmo-039392	Gadus morhua	57.47	0.00e+00	731.00
IUUC-Ggr-040041	Gaeumannomyces graminis	27.78	6.00e-08	52.00
IUUC-Gga-041106	Gallus gallus	85.48	0.00e+00	1055.00
IUUC-Gac-042252	Gasterosteus aculeatus	60.53	0.00e+00	772.00
IUUC-Ggo-044817	Gorilla gorilla	99.83	0.00e+00	1205.00
IUUC-Lch-050477	Latimeria chalumnae	69.80	0.00e+00	859.00
IUUC-Loc-051955	Lepisosteus oculatus	70.46	0.00e+00	912.00
IUUC-Laf-053500	Loxodonta africana	96.53	0.00e+00	1174.00
IUUC-Mcc-055316	Macaca mulatta	99.34	0.00e+00	1199.00
IUUC-Mor-057181	Magnaporthe oryzae	26.35	2.00e-10	60.10
IUUC-Mmr-061444	Microcebus murinus	98.35	0.00e+00	1191.00
IUUC-Mmu-064147	Mus musculus	95.38	0.00e+00	1164.00
IUUC-Mlu-067481	Myotis lucifugus	94.72	0.00e+00	1162.00
IUUC-Ncr-068938	Neurospora crassa	30.10	1.00e-07	52.00
IUUC-Nle-069339	Nomascus leucogenys	99.83	0.00e+00	1205.00
IUUC-Opr-070703	Ochotona princeps	96.37	0.00e+00	1130.00
IUUC-Ont-072420	Oreochromis niloticus	60.70	0.00e+00	793.00
IUUC-Oan-073476	Ornithorhynchus anatinus	92.74	0.00e+00	1136.00
IUUC-Ocu-074248	Oryctolagus cuniculus	96.86	0.00e+00	1186.00
IUUC-Ola-086361	Oryzias latipes	61.50	0.00e+00	780.00
IUUC-Oar-090349	Ovis aries	97.36	0.00e+00	1187.00
IUUC-Pan-092069	Papio anubis	99.50	0.00e+00	1201.00
IUUC-Psi-093671	Pelodiscus sinensis	88.45	0.00e+00	1054.00
IUUC-Pfo-096122	Poecilia formosa	61.79	0.00e+00	809.00
IUUC-Pab-098711	Pongo abelii	99.83	0.00e+00	1206.00
IUUC-Pca-100495	Procavia capensis	88.45	0.00e+00	1055.00
IUUC-Pva-102401	Pteropus vampyrus	97.03	0.00e+00	1184.00
IUUC-Rno-105969	Rattus norvegicus	95.21	0.00e+00	1161.00
IUUC-Sar-113405	Sorex araneus	93.07	0.00e+00	1125.00
IUUC-Tgu-116725	Taeniopygia guttata	85.81	0.00e+00	1075.00
IUUC-Tru-117743	Takifugu rubripes	59.04	0.00e+00	763.00
IUUC-Tsy-119225	Tarsius syrichta	90.43	0.00e+00	1081.00
IUUC-Tni-120547	Tetraodon nigroviridis	61.96	0.00e+00	791.00
IUUC-Ttr-128645	Tursiops truncatus	97.03	0.00e+00	1181.00
IUUC-Vpa-130714	Vicugna pacos	97.36	0.00e+00	1186.00
IUUC-Xtr-132144	Xenopus tropicalis	76.40	0.00e+00	945.00
IUUC-Xma-133860	Xiphophorus maculatus	61.96	0.00e+00	810.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence