iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000243667.6	ENST00000295121.10	ENSP00000295121.6
ENSG00000243667.6	ENST00000457114.5	ENSP00000410301.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
TargetScan	RepTar	SomamiR	miRcode
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Variation
GWASdb	GWAS Central	OMIM
Post-translational Modifications (PTMs)
CPLM	PhosphositePlus	BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.80e-26	92.7	109	152

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.......sd.tllvsGsdDgtikvWDlrtgvll 36
           gH++ +++++         + + +v+Gs+Dgt+kvWD+r+ +++
   Q: 109  GHKEIINAIDGigglgigEGaPEIVTGSRDGTVKVWDPRQKDDP 152
           78888888886688888644679**************9987765 PP

Organism

Homo sapiens

Functional Description
(View)

Seems to act as a modulator of apoptosis.

Protein Sequence
(Fasta)

MSAFEKPQII AHIQKGFNYT VFDCKWVPCS AKFVTMGNFA RGTGVIQLYE IQHGDLKLLR 60
EIEKAKPIKC GTFGATSLQQ RYLATGDFGG NLHIWNLEAP EMPVYSVKGH KEIINAIDGI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGGGCAGAAT ACGGAAAGCG GGAGGGACAA ATTGCCAATG TTTGGAGTCT GGTTTCCAGG 60
TTGCCGTTTT TGGGGGCTCT GGGTGTGGCG GTTGCCGTAG CTGAAATTGG CTGCACCATG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0053--Apoptosis
KW-0181--Complete proteome
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom

PROSITE

PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

SMART

SM00320--WD40

Gene Ontology

GO:0006915--P:apoptotic process

KEGG

hsa:116143

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001641	Ailuropoda melanoleuca	96.08	0.00e+00	702.00
IUUC-Apl-003566	Anas platyrhynchos	72.47	1.00e-145	510.00
IUUC-Aca-004379	Anolis carolinensis	85.96	0.00e+00	634.00
IUUC-Ame-011892	Astyanax mexicanus	79.89	2.00e-174	605.00
IUUC-Bta-013172	Bos taurus	94.96	0.00e+00	694.00
IUUC-Cja-019636	Callithrix jacchus	98.88	0.00e+00	714.00
IUUC-Cfa-020693	Canis familiaris	96.36	0.00e+00	702.00
IUUC-Cpo-022505	Cavia porcellus	95.52	0.00e+00	678.00
IUUC-Cre-022581	Chlamydomonas reinhardtii	58.10	3.00e-124	437.00
IUUC-Csa-023448	Chlorocebus sabaeus	99.16	0.00e+00	716.00
IUUC-Cho-025072	Choloepus hoffmanni	85.02	2.00e-144	504.00
IUUC-Cin-025477	Ciona intestinalis	66.67	2.00e-137	481.00
IUUC-Csv-026095	Ciona savignyi	61.75	2.00e-114	404.00
IUUC-Dre-028504	Danio rerio	83.71	1.00e-180	625.00
IUUC-Dno-028991	Dasypus novemcinctus	95.80	0.00e+00	694.00
IUUC-Dor-030198	Dipodomys ordii	88.80	0.00e+00	640.00
IUUC-Dme-031855	Drosophila melanogaster	55.76	1.00e-118	419.00
IUUC-Ete-032891	Echinops telfairi	93.28	0.00e+00	663.00
IUUC-Eca-033980	Equus caballus	96.36	0.00e+00	701.00
IUUC-Eeu-035248	Erinaceus europaeus	85.99	7.00e-176	610.00
IUUC-Fca-035816	Felis catus	96.64	0.00e+00	703.00
IUUC-Fal-037423	Ficedula albicollis	84.27	0.00e+00	626.00
IUUC-Gmo-039717	Gadus morhua	80.35	6.00e-166	577.00
IUUC-Gga-040937	Gallus gallus	83.43	1.00e-175	608.00
IUUC-Gac-042520	Gasterosteus aculeatus	81.14	4.00e-174	605.00
IUUC-Ggo-045335	Gorilla gorilla	99.72	0.00e+00	721.00
IUUC-Itr-048758	Ictidomys tridecemlineatus	96.92	0.00e+00	686.00
IUUC-Lch-050048	Latimeria chalumnae	85.67	3.00e-179	621.00
IUUC-Loc-052214	Lepisosteus oculatus	83.72	4.00e-176	610.00
IUUC-Laf-054161	Loxodonta africana	96.08	0.00e+00	700.00
IUUC-Mcc-055366	Macaca mulatta	99.44	0.00e+00	717.00
IUUC-Meu-056555	Macropus eugenii	76.56	1.00e-105	375.00
IUUC-Mga-059823	Meleagris gallopavo	87.59	9.00e-140	490.00
IUUC-Mmr-061739	Microcebus murinus	97.20	0.00e+00	685.00
IUUC-Mdo-061852	Monodelphis domestica	91.88	0.00e+00	677.00
IUUC-Mmu-063204	Mus musculus	93.56	0.00e+00	682.00
IUUC-Mpu-065991	Mustela putorius furo	96.36	0.00e+00	703.00
IUUC-Mlu-067191	Myotis lucifugus	96.08	0.00e+00	699.00
IUUC-Nle-069750	Nomascus leucogenys	99.44	0.00e+00	718.00
IUUC-Opr-070193	Ochotona princeps	96.36	0.00e+00	701.00
IUUC-Ont-071758	Oreochromis niloticus	80.34	5.00e-167	581.00
IUUC-Oan-072776	Ornithorhynchus anatinus	91.14	1.00e-78	285.00
IUUC-Ocu-074633	Oryctolagus cuniculus	94.12	0.00e+00	689.00
IUUC-Ola-086652	Oryzias latipes	79.49	6.00e-174	604.00
IUUC-Olu-087833	Ostreococcus lucimarinus	49.71	6.00e-94	337.00
IUUC-Oga-088666	Otolemur garnettii	95.80	0.00e+00	676.00
IUUC-Oar-089500	Ovis aries	93.56	0.00e+00	672.00
IUUC-Ptr-090681	Pan troglodytes	99.72	0.00e+00	719.00
IUUC-Pan-092588	Papio anubis	99.16	0.00e+00	717.00
IUUC-Psi-093562	Pelodiscus sinensis	90.10	7.00e-113	399.00
IUUC-Pma-094744	Petromyzon marinus	78.03	3.00e-122	431.00
IUUC-Ppa-095392	Physcomitrella patens	55.89	1.00e-118	419.00
IUUC-Pfo-096229	Poecilia formosa	82.54	4.00e-179	621.00
IUUC-Pab-097848	Pongo abelii	99.72	0.00e+00	721.00
IUUC-Pca-100296	Procavia capensis	76.75	1.00e-150	526.00
IUUC-Pva-102495	Pteropus vampyrus	86.83	3.00e-179	620.00
IUUC-Rno-105437	Rattus norvegicus	93.28	0.00e+00	661.00
IUUC-Sha-107141	Sarcophilus harrisii	91.88	0.00e+00	655.00
IUUC-Smo-108897	Selaginella moellendorffii	60.00	4.00e-123	434.00
IUUC-Sar-113523	Sorex araneus	95.61	6.00e-164	571.00
IUUC-Ssc-116433	Sus scrofa	96.36	0.00e+00	699.00
IUUC-Tgu-116611	Taeniopygia guttata	83.94	2.00e-177	615.00
IUUC-Tru-118356	Takifugu rubripes	78.65	1.00e-172	600.00
IUUC-Tsy-119597	Tarsius syrichta	97.48	0.00e+00	683.00
IUUC-Tni-120540	Tetraodon nigroviridis	78.93	3.00e-172	597.00
IUUC-Tbe-127572	Tupaia belangeri	96.58	2.00e-81	297.00
IUUC-Ttr-128590	Tursiops truncatus	94.12	0.00e+00	679.00
IUUC-Vpa-130158	Vicugna pacos	96.64	0.00e+00	703.00
IUUC-Xtr-131856	Xenopus tropicalis	81.89	6.00e-122	429.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence