iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Bta-012778

Ensembl Protein ID

ENSBTAP00000008224.4

UniProt Accession

Q95KU9; A2VDM3; Q5E9T0; Q5EA16; NEMO_BOVIN

Genbank Protein ID

CAC93688.1; AAX08857.1; AAX08770.1; AAX08784.1; AAX08889.1; AAI33307.1

Protein Name

NF-kappa-B essential modulator; IkB kinase-associated protein 1; Inhibitor of nuclear factor kappa-B kinase subunit gamma; NF-kappa-B essential modifier

Genbank Nucleotide ID

AJ414557; BT020840; BT020753; BT020767; BT020872; BC133306

Gene Name

IKBKG; NEMO

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSBTAG00000006268.5	ENSBTAT00000008224.4	ENSBTAP00000008224.4

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/Alpha-Helix/UBAN	6.90e-26	90.1	291	350

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/UBAN

   S: 1    keelletvevLkqQveiYkeDFqaERadRErlneekeeLqeqveklqkqvsklndslkas 60
           +++++etv+vLk+Q++iYk+DFqaER++RE+l+e+ke Lqeq+e+lq+++s+l+ s+++s
   Q: 291  HKIVMETVPVLKAQADIYKADFQAERQAREKLAEKKEFLQEQLEQLQREYSRLKTSCQES 350
           899*******************************************************98 PP

Organism

Bos taurus

Functional Description
(View)

Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Its binding to scaffolding polyubiquitin seems to play a role in IKK activation by multiple signaling receptor pathways. Also considered to be a mediator for TAX activation of NF-kappa-B. Could be implicated in NF-kappa-B-mediated protection from cytokine toxicity. Essential for viral activation of IRF3. Involved in TLR3- and IFIH1-mediated antiviral innate response; this function requires 'Lys-27'-linked polyubiquitination (By similarity).

Protein Sequence
(Fasta)

MSRPPWKSPL CEMVQPSGSP AGDQDMLGEE SSLGKPAMLH VPSEQGTPET FQRCLEENQE 60
LRDAIRQSNQ MLRERCEELQ HFQGNQREEK AFLMQKFQEA RDLVVRLSLE KRELRQQREQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGCCGGAGCA GGTCAAACCA GCCCTATTAG ATAATAGCCT CGTTGTGGTT CCAACCCTAG 60
CGGGAGGGGG GACGGCCCTG CCGGAGAGAC AAGAGGGAAT GCAGGTCGCA ACGCTAATTA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-1015--Disulfide bond
KW-0227--DNA damage
KW-1017--Isopeptide bond
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR032419--CC2-LZ_dom
IPR021063--NEMO_N
IPR034735--ZF_CCHC_NOA

PROSITE

PS51801--ZF_CCHC_NOA

Pfam

PF16516--CC2-LZ
PF11577--NEMO

Gene Ontology

GO:0008385--C:IkappaB kinase complex
GO:0072686--C:mitotic spindle
GO:0005634--C:nucleus
GO:0000922--C:spindle pole
GO:0000151--C:ubiquitin ligase complex
GO:0070530--F:K63-linked polyubiquitin binding
GO:0046872--F:metal ion binding
GO:0046982--F:protein heterodimerization activity
GO:0042803--F:protein homodimerization activity
GO:0006974--P:cellular response to DNA damage stimulus
GO:0051650--P:establishment of vesicle localization
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0051092--P:positive regulation of NF-kappaB transcription factor activity
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0006351--P:transcription, DNA-templated

KEGG

bta:281855

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002336	Ailuropoda melanoleuca	89.74	0.00e+00	630.00
IUUC-Aca-004653	Anolis carolinensis	57.11	2.00e-94	338.00
IUUC-Cja-018954	Callithrix jacchus	85.92	2.00e-174	605.00
IUUC-Cfa-020778	Canis familiaris	88.31	0.00e+00	683.00
IUUC-Cpo-022327	Cavia porcellus	81.86	6.00e-143	500.00
IUUC-Csa-023340	Chlorocebus sabaeus	86.86	2.00e-150	525.00
IUUC-Dre-028819	Danio rerio	49.14	6.00e-55	208.00
IUUC-Dno-029566	Dasypus novemcinctus	82.90	2.00e-161	561.00
IUUC-Dor-031122	Dipodomys ordii	86.30	3.00e-30	125.00
IUUC-Eca-033895	Equus caballus	82.10	1.00e-149	522.00
IUUC-Eeu-034478	Erinaceus europaeus	77.33	3.00e-140	491.00
IUUC-Fca-035990	Felis catus	89.20	1.00e-128	453.00
IUUC-Gmo-038622	Gadus morhua	44.60	6.00e-61	228.00
IUUC-Gac-041917	Gasterosteus aculeatus	45.66	8.00e-61	228.00
IUUC-Ggo-045478	Gorilla gorilla	85.92	1.00e-158	553.00
IUUC-Hsa-046243	Homo sapiens	85.68	3.00e-158	551.00
IUUC-Itr-048520	Ictidomys tridecemlineatus	85.20	3.00e-174	604.00
IUUC-Lch-050187	Latimeria chalumnae	56.60	1.00e-99	356.00
IUUC-Loc-052627	Lepisosteus oculatus	54.05	2.00e-59	223.00
IUUC-Laf-054387	Loxodonta africana	82.42	3.00e-138	484.00
IUUC-Mcc-054611	Macaca mulatta	86.40	7.00e-160	556.00
IUUC-Meu-056530	Macropus eugenii	61.33	8.00e-91	327.00
IUUC-Mmr-061028	Microcebus murinus	84.36	4.00e-173	600.00
IUUC-Mdo-062520	Monodelphis domestica	62.84	7.00e-116	410.00
IUUC-Mmu-063925	Mus musculus	83.05	3.00e-153	534.00
IUUC-Mpu-066392	Mustela putorius furo	85.68	9.00e-163	566.00
IUUC-Mlu-067374	Myotis lucifugus	84.11	2.00e-163	568.00
IUUC-Nle-069085	Nomascus leucogenys	83.24	6.00e-77	279.00
IUUC-Ont-071385	Oreochromis niloticus	45.03	1.00e-56	214.00
IUUC-Oan-073347	Ornithorhynchus anatinus	70.74	3.00e-149	521.00
IUUC-Ocu-074929	Oryctolagus cuniculus	82.34	2.00e-172	598.00
IUUC-Ola-086340	Oryzias latipes	48.00	3.00e-65	243.00
IUUC-Oga-088042	Otolemur garnettii	86.16	1.00e-175	609.00
IUUC-Oar-090051	Ovis aries	94.92	0.00e+00	641.00
IUUC-Ptr-090498	Pan troglodytes	84.96	7.00e-156	543.00
IUUC-Psi-093840	Pelodiscus sinensis	55.58	6.00e-84	305.00
IUUC-Pfo-097140	Poecilia formosa	43.41	7.00e-51	195.00
IUUC-Pab-097707	Pongo abelii	86.16	5.00e-159	553.00
IUUC-Pca-100427	Procavia capensis	72.41	1.00e-129	456.00
IUUC-Pva-102328	Pteropus vampyrus	82.58	1.00e-143	503.00
IUUC-Rno-105231	Rattus norvegicus	82.82	2.00e-173	601.00
IUUC-Sha-106676	Sarcophilus harrisii	71.66	5.00e-150	523.00
IUUC-Sar-113027	Sorex araneus	77.58	2.00e-70	258.00
IUUC-Ssc-116284	Sus scrofa	89.50	4.00e-160	557.00
IUUC-Tru-117790	Takifugu rubripes	42.47	2.00e-50	193.00
IUUC-Tbe-127949	Tupaia belangeri	88.78	8.00e-66	244.00
IUUC-Ttr-128663	Tursiops truncatus	91.13	0.00e+00	634.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence