iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000274229.2	ENST00000631692.1	ENSP00000488601.1
ENSG00000274229.2	ENST00000615473.2	ENSP00000480736.1
ENSG00000274229.2	ENST00000632687.1	ENSP00000487855.1

Annotation

Cancer Mutation
TCGA	CGAP	IntOGen
mRNA Expression
TCGA	ICGC	THPA	HPM
DNA & RNA Element
UTRdb	circRNADb	CircNet	miRWalk
RepTar	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	Mentha
InWeb_IM
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus
DNA Methylation
TCGA	ICGC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	SOCS	12052866

Classification

Family	E-value	Score	Start	End
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	1.50e-13	52.0	506	553

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box

   S: 2    sklwllrseprSLqhLCRlaIrrclgsqrlkaidkLPLPksLkdYLlyedy 52
           +++ +++s++ SLqhLCR++Ir++++++++   + LPLPk L++Y++++ y
   Q: 506  LYPVSRFSNVKSLQHLCRFRIRQLVRIDHI---PDLPLPKPLISYIRKFYY 553
           567899*********************998...*************99976 PP

Organism

Homo sapiens

Functional Description
(View)

Regulates signaling cascades probably through protein ubiquitination and/or sequestration. Functions in insulin signaling and glucose homeostasis through IRS1 ubiquitination and subsequent proteasomal degradation. Inhibits also prolactin, growth hormone and leptin signaling by preventing STAT3 and STAT5 activation, sequestering them in the cytoplasm and reducing their binding to DNA. May be a substrate recognition component of a SCF-like E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity).

Protein Sequence
(Fasta)

MVFRNVGRPP EEEDVEAAPE PGPSELLCPR HRCALDPKAL PPGLALERTW GPAAGLEAQL 60
AALGLGQPAG PGVKTVGGGC CPCPCPPQPP PPQPQPPAAA PQAGEDPTET SDALLVLEGL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCCGGCCGCC GCAGCTGATG GTGTTCCGCA ACGTGGGTCG GCCGCCGGAG GAGGAGGACG 60
TGGAGGCGGC CCCGGAGCCG GGACCCTCGG AACTGCTGTG TCCCCGGCAC CGCTGTGCCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0341--Growth regulation
KW-0472--Membrane
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0727--SH2 domain
KW-0734--Signal transduction inhibitor
KW-0833--Ubl conjugation pathway

Interpro

IPR000980--SH2
IPR028423--SOCS7
IPR001496--SOCS_box

PROSITE

PS50001--SH2
PS50225--SOCS

Pfam

PF00017--SH2
PF07525--SOCS_box

SMART

SM00252--SH2
SM00253--SOCS
SM00969--SOCS_box

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0004860--F:protein kinase inhibitor activity
GO:0017124--F:SH3 domain binding
GO:0019221--P:cytokine-mediated signaling pathway
GO:0045444--P:fat cell differentiation
GO:0008286--P:insulin receptor signaling pathway
GO:0035556--P:intracellular signal transduction
GO:0021819--P:layer formation in cerebral cortex
GO:0046426--P:negative regulation of JAK-STAT cascade
GO:0006469--P:negative regulation of protein kinase activity
GO:0016567--P:protein ubiquitination
GO:0021942--P:radial glia guided migration of Purkinje cell
GO:0040008--P:regulation of growth

KEGG

hsa:30837

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001668	Ailuropoda melanoleuca	91.19	0.00e+00	662.00
IUUC-Apl-003277	Anas platyrhynchos	91.78	5.00e-73	266.00
IUUC-Aca-004639	Anolis carolinensis	97.28	3.00e-108	383.00
IUUC-Ame-011301	Astyanax mexicanus	70.00	2.00e-130	459.00
IUUC-Bta-013483	Bos taurus	96.39	0.00e+00	740.00
IUUC-Cja-019765	Callithrix jacchus	99.69	8.00e-164	569.00
IUUC-Cfa-020109	Canis familiaris	98.41	0.00e+00	652.00
IUUC-Cpo-021555	Cavia porcellus	96.29	7.00e-179	620.00
IUUC-Csa-023580	Chlorocebus sabaeus	99.48	0.00e+00	733.00
IUUC-Cho-024431	Choloepus hoffmanni	99.21	3.00e-72	265.00
IUUC-Dre-028183	Danio rerio	70.45	1.00e-139	490.00
IUUC-Dno-028858	Dasypus novemcinctus	94.49	0.00e+00	722.00
IUUC-Dor-031071	Dipodomys ordii	79.25	4.00e-114	404.00
IUUC-Dme-031876	Drosophila melanogaster	43.65	3.00e-43	171.00
IUUC-Ete-032928	Echinops telfairi	70.86	2.00e-101	362.00
IUUC-Eca-033250	Equus caballus	93.67	1.00e-177	615.00
IUUC-Eeu-034946	Erinaceus europaeus	84.41	6.00e-52	198.00
IUUC-Fca-036589	Felis catus	94.98	0.00e+00	645.00
IUUC-Fal-037316	Ficedula albicollis	93.07	3.00e-112	397.00
IUUC-Gmo-038552	Gadus morhua	91.26	1.00e-53	201.00
IUUC-Gga-041248	Gallus gallus	96.76	3.00e-108	383.00
IUUC-Gac-041469	Gasterosteus aculeatus	83.47	9.00e-57	211.00
IUUC-Ggo-045282	Gorilla gorilla	100.00	1.00e-163	568.00
IUUC-Itr-048411	Ictidomys tridecemlineatus	95.97	6.00e-166	577.00
IUUC-Lch-049768	Latimeria chalumnae	71.08	4.00e-153	534.00
IUUC-Loc-051949	Lepisosteus oculatus	74.30	3.00e-129	456.00
IUUC-Laf-053410	Loxodonta africana	93.94	0.00e+00	714.00
IUUC-Mcc-054605	Macaca mulatta	92.03	0.00e+00	698.00
IUUC-Meu-056773	Macropus eugenii	79.87	1.00e-106	379.00
IUUC-Mmr-060927	Microcebus murinus	96.90	0.00e+00	717.00
IUUC-Mdo-061892	Monodelphis domestica	88.36	2.00e-175	609.00
IUUC-Mmu-064246	Mus musculus	93.99	0.00e+00	719.00
IUUC-Mpu-065995	Mustela putorius furo	95.18	0.00e+00	639.00
IUUC-Mlu-067526	Myotis lucifugus	91.22	0.00e+00	719.00
IUUC-Nle-069317	Nomascus leucogenys	91.67	1.00e-169	589.00
IUUC-Ont-072258	Oreochromis niloticus	66.75	2.00e-117	416.00
IUUC-Oan-073703	Ornithorhynchus anatinus	80.49	1.00e-36	144.00
IUUC-Ocu-074577	Oryctolagus cuniculus	89.44	0.00e+00	745.00
IUUC-Oga-088426	Otolemur garnettii	95.18	0.00e+00	708.00
IUUC-Oar-089407	Ovis aries	96.23	0.00e+00	664.00
IUUC-Ptr-091327	Pan troglodytes	100.00	0.00e+00	640.00
IUUC-Pan-092064	Papio anubis	99.47	0.00e+00	651.00
IUUC-Psi-093834	Pelodiscus sinensis	94.04	1.00e-153	535.00
IUUC-Pfo-097100	Poecilia formosa	62.50	1.00e-115	410.00
IUUC-Pab-097695	Pongo abelii	90.71	0.00e+00	698.00
IUUC-Pca-100569	Procavia capensis	90.13	2.00e-170	592.00
IUUC-Pva-102784	Pteropus vampyrus	95.70	0.00e+00	702.00
IUUC-Ptt-103775	Puccinia triticina	38.46	1.90e+00	28.10
IUUC-Rno-105485	Rattus norvegicus	95.35	0.00e+00	721.00
IUUC-Sha-106720	Sarcophilus harrisii	93.40	9.00e-173	600.00
IUUC-Sar-112975	Sorex araneus	84.28	3.00e-128	451.00
IUUC-Ssc-116369	Sus scrofa	97.08	0.00e+00	722.00
IUUC-Tgu-116867	Taeniopygia guttata	86.83	8.00e-125	439.00
IUUC-Tru-117562	Takifugu rubripes	80.56	8.00e-101	360.00
IUUC-Tsy-118999	Tarsius syrichta	93.40	4.00e-146	510.00
IUUC-Tni-120793	Tetraodon nigroviridis	68.62	3.00e-129	455.00
IUUC-Tbe-127671	Tupaia belangeri	99.07	8.00e-129	453.00
IUUC-Ttr-128491	Tursiops truncatus	81.95	2.00e-131	462.00
IUUC-Vpa-130104	Vicugna pacos	88.97	2.00e-175	608.00
IUUC-Xtr-132507	Xenopus tropicalis	80.05	2.00e-144	505.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence