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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-063801
UUCD1 version UUC-MuM-00758
Ensembl Protein ID ENSMUSP00000021617.7
UniProt Accession Q8K0L0; Q9CTH4; Q9WV73; ASB2_MOUSE
Genbank Protein ID AAD38809.2; AAH31161.1; BAB22862.1
Protein Name Ankyrin repeat and SOCS box protein 2
Genbank Nucleotide ID AF155353; BC031161; AK003566
Gene Name Asb2
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000021200.14 ENSMUST00000021617.13 ENSMUSP00000021617.7
ENSMUSG00000021200.14 ENSMUST00000149431.1 ENSMUSP00000117595.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
microRNATRANSFACRepTarRAID2
Protein-protein Interaction
IIDiRefIndexHINTMentha
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
mUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box 1.20e-17 64.6 582 633
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box
   S: 1    lsklwllrseprSLqhLCRlaIrrclgsqrlkaidkLPLPksLkdYLlyedy 52
           ++ +++  + pr+L hLCRl++r+++g++r+k++d+LPLP +L++YL+ye++
   Q: 582  WAVIKEKAEPPRPLAHLCRLRVRKAIGKYRIKLLDTLPLPGRLIRYLKYENT 633
           567899999*****************************************86 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
 Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Protein Sequence
(Fasta)
MATEISTRGR QRAIGHEEYS LYSSLSEEEL LQMAIEQSLA DKTRGPTPAE ASASSQTNHQ 60
PGHFHPWTRS PSSPENPPAR APLGLFQGVM QKYSSNLFKT SQMAAMDPVL KAIKEGDEEA 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063801|E3,SOCS|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
TGCTCTCTGA AGCGGGAGCC TGTCTCCCGT GCCCTCGGAG GAGTGGAGGG CGGAATCACG 60
GCTTCCTTAG TGCGATCTTC AGAAGGGAAA TCTGAGAGTC ATAACGTCTT ATAGCTTGGC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063801|E3,SOCS|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0040--ANK repeat
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway
Interpro

IPR002110--Ankyrin_rpt
IPR020683--Ankyrin_rpt-contain_dom
IPR001496--SOCS_box
IPR003903--UIM_dom
PROSITE

PS50297--ANK_REP_REGION
PS50088--ANK_REPEAT
PS50225--SOCS
PS50330--UIM
Pfam

PF12796--Ank_2
PF13606--Ank_3
PF07525--SOCS_box
PRINTS

PR01415--ANKYRIN
SMART

SM00248--ANK
SM00253--SOCS
SM00969--SOCS_box
Gene Ontology

GO:0031466--C:Cul5-RING ubiquitin ligase complex
GO:0035556--P:intracellular signal transduction
GO:0045445--P:myoblast differentiation
GO:0000209--P:protein polyubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0035914--P:skeletal muscle cell differentiation
KEGG mmu:65256
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002426 Ailuropoda melanoleuca 88.23 0.00e+00 1117.00
IUUC-Apl-003289 Anas platyrhynchos 68.40 0.00e+00 898.00
IUUC-Aca-004685 Anolis carolinensis 67.13 0.00e+00 885.00
IUUC-Ame-011522 Astyanax mexicanus 51.53 0.00e+00 669.00
IUUC-Bta-012533 Bos taurus 87.09 0.00e+00 1112.00
IUUC-Cja-018887 Callithrix jacchus 89.45 0.00e+00 1124.00
IUUC-Cfa-020241 Canis familiaris 86.93 0.00e+00 1051.00
IUUC-Cpo-021586 Cavia porcellus 87.50 0.00e+00 1071.00
IUUC-Csa-024206 Chlorocebus sabaeus 90.24 0.00e+00 1138.00
IUUC-Csv-025944 Ciona savignyi 38.46 5.00e-90 325.00
IUUC-Dre-028150 Danio rerio 51.19 0.00e+00 654.00
IUUC-Dno-029859 Dasypus novemcinctus 87.28 0.00e+00 1077.00
IUUC-Dor-030375 Dipodomys ordii 83.00 0.00e+00 882.00
IUUC-Ete-032832 Echinops telfairi 90.30 0.00e+00 943.00
IUUC-Eca-033752 Equus caballus 87.40 0.00e+00 1108.00
IUUC-Eeu-034810 Erinaceus europaeus 82.02 1.00e-130 460.00
IUUC-Fca-036306 Felis catus 86.52 0.00e+00 1094.00
IUUC-Fal-037401 Ficedula albicollis 67.03 0.00e+00 853.00
IUUC-Gga-040683 Gallus gallus 68.41 0.00e+00 870.00
IUUC-Gac-041891 Gasterosteus aculeatus 49.36 4.00e-156 544.00
IUUC-Ggo-044676 Gorilla gorilla 90.24 0.00e+00 1169.00
IUUC-Hsa-046276 Homo sapiens 91.20 0.00e+00 1083.00
IUUC-Itr-048291 Ictidomys tridecemlineatus 88.85 0.00e+00 1135.00
IUUC-Lch-050470 Latimeria chalumnae 61.16 0.00e+00 813.00
IUUC-Loc-052826 Lepisosteus oculatus 61.00 0.00e+00 706.00
IUUC-Laf-053868 Loxodonta africana 88.21 0.00e+00 1128.00
IUUC-Mcc-054926 Macaca mulatta 90.39 0.00e+00 1140.00
IUUC-Meu-056671 Macropus eugenii 76.18 0.00e+00 908.00
IUUC-Mla-059173 Melampsora laricipopulina 38.18 1.50e-01 30.00
IUUC-Mga-059782 Meleagris gallopavo 67.80 0.00e+00 891.00
IUUC-Mmr-061793 Microcebus murinus 89.29 0.00e+00 1122.00
IUUC-Mdo-062521 Monodelphis domestica 77.47 0.00e+00 1047.00
IUUC-Mpu-066868 Mustela putorius furo 87.72 0.00e+00 1102.00
IUUC-Mlu-067101 Myotis lucifugus 85.71 0.00e+00 1026.00
IUUC-Nle-069551 Nomascus leucogenys 90.39 0.00e+00 1167.00
IUUC-Opr-071102 Ochotona princeps 93.31 0.00e+00 1068.00
IUUC-Ont-071648 Oreochromis niloticus 55.82 8.00e-173 600.00
IUUC-Oan-073719 Ornithorhynchus anatinus 74.03 0.00e+00 1013.00
IUUC-Ocu-074019 Oryctolagus cuniculus 85.49 0.00e+00 1043.00
IUUC-Oga-088029 Otolemur garnettii 88.38 0.00e+00 1103.00
IUUC-Oar-090209 Ovis aries 71.36 0.00e+00 841.00
IUUC-Ptr-090635 Pan troglodytes 90.55 0.00e+00 1142.00
IUUC-Pan-092406 Papio anubis 90.39 0.00e+00 1140.00
IUUC-Psi-093322 Pelodiscus sinensis 69.11 0.00e+00 918.00
IUUC-Pma-094270 Petromyzon marinus 46.57 3.00e-147 515.00
IUUC-Pfo-096482 Poecilia formosa 44.43 1.00e-138 486.00
IUUC-Pab-097967 Pongo abelii 92.59 0.00e+00 1070.00
IUUC-Pca-100765 Procavia capensis 88.41 0.00e+00 1009.00
IUUC-Pva-102807 Pteropus vampyrus 89.69 0.00e+00 1001.00
IUUC-Rno-104953 Rattus norvegicus 97.32 0.00e+00 1232.00
IUUC-Sha-107217 Sarcophilus harrisii 77.81 0.00e+00 1046.00
IUUC-Ssc-116227 Sus scrofa 84.66 0.00e+00 1095.00
IUUC-Tgu-116733 Taeniopygia guttata 69.34 0.00e+00 880.00
IUUC-Tru-117954 Takifugu rubripes 51.90 2.00e-177 615.00
IUUC-Tbe-127564 Tupaia belangeri 91.30 0.00e+00 1035.00
IUUC-Ttr-128996 Tursiops truncatus 88.73 0.00e+00 1033.00
IUUC-Xtr-132772 Xenopus tropicalis 62.97 0.00e+00 788.00
Created Date 25-Jun-2017

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