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Basic Information Integrated Annotations

Tag Content
iUUCD ID IUUC-Hsa-046632
UUCD1 version UUC-HoS-00160
Ensembl Protein ID ENSP00000487542.1
UniProt Accession Q676U5; A3EXK9; A3EXL0; B6ZDH0; Q6IPN1; Q6UXW4; Q6ZVZ5; Q8NCY2; Q96JV5; Q9H619; A16L1_HUMAN
Genbank Protein ID AAR32130.1; ABN48554.1; ABN48555.1; AAQ88549.1; BAB15448.1; BAB55412.1; BAC85713.1; EAW71034.1; AAH71846.1; CAD39182.1
Protein Name Autophagy-related protein 16-1; APG16-like 1
Genbank Nucleotide ID AY398617; EF079889; EF079890; AY358182; AK026330; AK027854; AK123876; AC013726; BC071846; AL834526
Gene Name ATG16L1; APG16L; UNQ9393/PRO34307
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000281089.2 ENST00000625501.2 ENSP00000487542.1
ENSG00000281089.2 ENST00000626623.2 ENSP00000487298.1
ENSG00000281089.2 ENST00000627513.2 ENSP00000486688.1
ENSG00000281089.2 ENST00000630204.2 ENSP00000487455.1
ENSG00000281089.2 ENST00000630596.2 ENSP00000486453.1
ENSG00000281089.2 ENST00000630066.2 ENSP00000487446.1
ENSG00000281089.2 ENST00000626639.1 ENSP00000486603.1
Annotation
Cancer Mutation
TCGACOSMICCGAPIntOGen
mRNA Expression
TCGAICGCCOSMICTHPA
HPM
DNA & RNA Element
UTRdbcircRNADbCircNetRepTar
SomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAMentha
InWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
ClinVarGWASdbGWAS Central
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtPHOSIDA
mUbiSiDa
DNA Methylation
TCGAICGC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/DCX/DWD WD_repeat 17588513
UBD/Beta-Prp Beta-Prp 23300079
Classification
Family E-value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 3.40e-31 107.6 406 445
UBD/Beta-Prp 2.60e-64 219.0 315 606
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf..sdtllvsGsdDgtikvWDlrtgvllks 38
    gH+++v + +f ++ ++vsGs+D t+k+WDlr+ v++k+
   Q: 406 GHSGKVLSAKFllDNARIVSGSHDRTLKLWDLRSKVCIKT 445
    8***********64489********************985 PP
   


   UBD/Beta-Prp

   S: 3    ktlkghhksvitcvkfspdksllatgsrdgtikvwdvttgkl..lrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkg 92
    +++++h++ +++v+fsp+++llatg++d+++k+w+v+ +k+ slsg +a++t+++f++ g++l+ +s+D + ++w ++++ htl+g
   Q: 315 LCVFDAHDGEVNAVQFSPGSRLLATGGMDRRVKLWEVFGEKCefKGSLSGSNAGITSIEFDSAGSYLLAASNDFASRIWTVDDYRLRHTLTG 406
    57899************************************9999*********************************************** PP
   S: 93 hedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvy 184
    h+ +vls +f ++ ++vsGshdrt+++wdl+++ c++++++g + c + +++++++sG+ D+++r+Wd+++++++r+++ ++++
   Q: 407 HSGKVLSAKFLLDNARIVSGSHDRTLKLWDLRSKVCIKTVFAGSS----CNDIVCTEQCVMSGHFDKKIRFWDIRSESIVREME--LLGKIT 492
    **************************************9999988....888888889*************************6..69**** PP
   S: 185 slsfdsngkelvsgsldgtvklwdlqtgecvrtlnght....dnvksvrfspnderlvsgssDgsiriWdlrsgdllktlqlhnssvisvav 272
    l+++++++el+s+s+d +k+ dl+t+ + +t+ + + ++v fsp++ +++ gs++gs++iW + +g++ k+l++++ss+i +
   Q: 493 ALDLNPERTELLSCSRDDLLKVIDLRTNAIKQTFSAPGfkcgSDWTRVVFSPDGSYVAAGSAEGSLYIWSVLTGKVEKVLSKQHSSSINAVA 584
    ******************************99999988888877777********************************************* PP
   S: 273 lsfgdnvlvlgsedskvniwkl 294
    +s++++++v++++ +k+ +w++
   Q: 585 WSPSGSHVVSVDKGCKAVLWAQ 606
    ********************85 PP
   

Organism Homo sapiens
Functional Description
(View)

Functional Description



     Plays an essential role in autophagy: interacts with ATG12-ATG5 to mediate the conjugation of phosphatidylethanolamine (PE) to LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C), to produce a membrane-bound activated form of LC3 named LC3-II. Thereby, controls the elongation of the nascent autophagosomal membrane (PubMed:24553140, PubMed:23376921, PubMed:24954904, PubMed:27273576, PubMed:23392225). Regulates mitochondrial antiviral signaling (MAVS)-dependent type I interferon (IFN-I) production (PubMed:25645662). Negatively regulates NOD1- and NOD2-driven inflammatory cytokine response (PubMed:24238340). Plays a role in regulating morphology and function of Paneth cell (PubMed:18849966).
Plays an essential role in autophagy: interacts with ATG12-ATG5 to mediate the conjugation of phosphatidylethanolamine (PE) to LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C), to produce a membrane-bound activated form of LC3 named LC3-II. Thereby, controls the elongation of the nascent autophagosomal membrane (PubMed:24553140, PubMed:23376921, PubMed:24954904, PubMed:27273576, PubMed:23392225). Regulates mitochondrial antiviral signaling (MAVS)-dependent type I interferon (IFN-I) production (PubMed:25645662). Negatively regulates NOD1- and NOD2-driven inflammatory cytokine response (PubMed:24238340). Plays a role in regulating morphology and function of Paneth cell (PubMed:18849966).
Protein Sequence
(Fasta)
MSSGLRAADF PRWKRHISEQ LRRRDRLQRQ AFEEIILQYN KLLEKSDLHS VLAQKLQAEK 60
HDVPNRHEIS PGHDGTWNDN QLQEMAQLRI KHQEELTELH KKRGELAQLV IDLNNQMQRK 120
It may take some time, please wait.

Protein Fasta Sequence



>IUUC-Hsa-046632|E3,WD_repeat;UBD,Beta-Prp|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
TTTTCTGACG GGCTGGCTGG CCTGCACTGG TGAGTTCTCT CTCAGGTCAC AGCAGACCGA 60
ACCACTAGGC TTACCAGTGA CTAATCTCAC AGCAGGCATA CCCAGCTCAT GCTCTTCCTC 120
It may take some time, please wait.

Nucleotide Fasta Sequence



>IUUC-Hsa-046632|E3,WD_repeat;UBD,Beta-Prp|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0072--Autophagy
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0677--Repeat
KW-0813--Transport
KW-0853--WD repeat

Interpro

IPR013923--Autophagy-rel_prot_16
IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF08614--ATG16
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0005776--C:autophagosome
GO:0000421--C:autophagosome membrane
GO:0005930--C:axoneme
GO:0005829--C:cytosol
GO:0034045--C:pre-autophagosomal structure membrane
GO:0042802--F:identical protein binding
GO:0019787--F:ubiquitin-like protein transferase activity
GO:0000045--P:autophagosome assembly
GO:0016236--P:macroautophagy
GO:0039689--P:negative stranded viral RNA replication
GO:0051260--P:protein homooligomerization
GO:0015031--P:protein transport

KEGG hsa:55054
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000090 Aegilops tauschii 26.22 4.00e-33 135.00
IUUC-Aml-002242 Ailuropoda melanoleuca 86.58 0.00e+00 1040.00
IUUC-Apl-003384 Anas platyrhynchos 87.35 0.00e+00 1052.00
IUUC-Aca-004962 Anolis carolinensis 83.95 0.00e+00 1022.00
IUUC-Aly-005435 Arabidopsis lyrata 29.56 1.00e-46 181.00
IUUC-Ath-006948 Arabidopsis thaliana 35.10 4.00e-46 179.00
IUUC-Ame-010915 Astyanax mexicanus 78.70 1.00e-151 528.00
IUUC-Bta-012388 Bos taurus 91.65 0.00e+00 1139.00
IUUC-Bdi-014231 Brachypodium distachyon 25.43 2.00e-37 150.00
IUUC-Bol-016174 Brassica oleracea 30.02 2.00e-46 179.00
IUUC-Bra-017165 Brassica rapa 28.52 1.00e-46 181.00
IUUC-Cel-018131 Caenorhabditis elegans 30.65 2.00e-62 234.00
IUUC-Cja-018898 Callithrix jacchus 87.28 0.00e+00 1012.00
IUUC-Cfa-020484 Canis familiaris 95.39 0.00e+00 1154.00
IUUC-Cpo-022156 Cavia porcellus 94.21 0.00e+00 1130.00
IUUC-Csa-024019 Chlorocebus sabaeus 95.55 0.00e+00 1140.00
IUUC-Cho-024311 Choloepus hoffmanni 79.33 0.00e+00 953.00
IUUC-Cin-025260 Ciona intestinalis 37.84 2.00e-101 362.00
IUUC-Csv-025836 Ciona savignyi 43.96 7.00e-47 179.00
IUUC-Dre-027702 Danio rerio 73.00 0.00e+00 875.00
IUUC-Dno-029728 Dasypus novemcinctus 90.87 0.00e+00 1140.00
IUUC-Dor-030587 Dipodomys ordii 81.69 5.00e-113 401.00
IUUC-Dme-031595 Drosophila melanogaster 37.99 7.00e-105 374.00
IUUC-Ete-032969 Echinops telfairi 75.70 0.00e+00 775.00
IUUC-Eca-034214 Equus caballus 95.12 0.00e+00 943.00
IUUC-Eeu-034537 Erinaceus europaeus 88.34 0.00e+00 899.00
IUUC-Fca-036005 Felis catus 91.71 0.00e+00 1069.00
IUUC-Fal-037593 Ficedula albicollis 84.46 0.00e+00 984.00
IUUC-Gmo-039042 Gadus morhua 64.71 0.00e+00 671.00
IUUC-Gga-040986 Gallus gallus 84.11 0.00e+00 1053.00
IUUC-Gac-041351 Gasterosteus aculeatus 71.83 0.00e+00 886.00
IUUC-Gma-043452 Glycine max 33.77 8.00e-46 178.00
IUUC-Ggo-045427 Gorilla gorilla 97.12 0.00e+00 1179.00
IUUC-Itr-048504 Ictidomys tridecemlineatus 92.76 0.00e+00 1104.00
IUUC-Lch-049439 Latimeria chalumnae 51.06 3.00e-143 501.00
IUUC-Lpe-051254 Leersia perrieri 25.35 8.00e-40 158.00
IUUC-Loc-052610 Lepisosteus oculatus 73.55 0.00e+00 888.00
IUUC-Laf-053936 Loxodonta africana 89.15 0.00e+00 1106.00
IUUC-Mcc-055504 Macaca mulatta 92.45 0.00e+00 1176.00
IUUC-Meu-056516 Macropus eugenii 82.21 0.00e+00 985.00
IUUC-Mtr-058062 Medicago truncatula 31.68 2.00e-42 166.00
IUUC-Mga-059777 Meleagris gallopavo 84.17 0.00e+00 1040.00
IUUC-Mmr-061298 Microcebus murinus 95.02 0.00e+00 1154.00
IUUC-Mdo-062969 Monodelphis domestica 86.54 0.00e+00 1065.00
IUUC-Mmu-064076 Mus musculus 91.80 0.00e+00 1107.00
IUUC-Mac-065161 Musa acuminata 27.52 8.00e-41 161.00
IUUC-Mpu-066196 Mustela putorius furo 92.78 0.00e+00 1129.00
IUUC-Mlu-067651 Myotis lucifugus 93.26 0.00e+00 1131.00
IUUC-Nle-069853 Nomascus leucogenys 97.53 0.00e+00 1176.00
IUUC-Opr-070350 Ochotona princeps 93.19 4.00e-119 422.00
IUUC-Ont-072489 Oreochromis niloticus 71.71 0.00e+00 871.00
IUUC-Oan-072703 Ornithorhynchus anatinus 80.83 0.00e+00 965.00
IUUC-Ocu-074205 Oryctolagus cuniculus 91.33 0.00e+00 1134.00
IUUC-Oba-075619 Oryza barthii 26.56 8.00e-38 151.00
IUUC-Obr-076632 Oryza brachyantha 29.47 6.00e-37 149.00
IUUC-Ogl-077671 Oryza glaberrima 26.76 8.00e-38 151.00
IUUC-Ogu-078052 Oryza glumaepatula 26.76 9.00e-38 151.00
IUUC-Oin-079611 Oryza indica 26.37 9.00e-36 144.00
IUUC-Olo-080408 Oryza longistaminata 26.74 3.00e-36 146.00
IUUC-Ome-081560 Oryza meridionalis 26.76 7.00e-38 151.00
IUUC-Oni-082145 Oryza nivara 26.56 8.00e-38 151.00
IUUC-Opu-083918 Oryza punctata 26.34 9.00e-36 145.00
IUUC-Oru-084858 Oryza rufipogon 26.37 2.00e-35 144.00
IUUC-Osa-086277 Oryza sativa 26.56 9.00e-36 144.00
IUUC-Ola-086816 Oryzias latipes 68.98 5.00e-98 350.00
IUUC-Olu-087622 Ostreococcus lucimarinus 33.44 1.00e-43 171.00
IUUC-Oga-088765 Otolemur garnettii 93.26 0.00e+00 1065.00
IUUC-Oar-090196 Ovis aries 88.32 0.00e+00 988.00
IUUC-Ptr-091676 Pan troglodytes 99.84 0.00e+00 1203.00
IUUC-Pan-092068 Papio anubis 96.15 0.00e+00 1168.00
IUUC-Psi-093367 Pelodiscus sinensis 86.66 0.00e+00 1037.00
IUUC-Ppa-095699 Physcomitrella patens 28.88 6.00e-42 165.00
IUUC-Pfo-096067 Poecilia formosa 72.77 0.00e+00 859.00
IUUC-Pab-098111 Pongo abelii 96.79 0.00e+00 1174.00
IUUC-Pop-099116 Populus trichocarpa 31.79 5.00e-42 165.00
IUUC-Pca-100680 Procavia capensis 81.21 0.00e+00 926.00
IUUC-Ppe-101790 Prunus persica 26.20 1.00e-44 174.00
IUUC-Pva-102871 Pteropus vampyrus 89.59 0.00e+00 1041.00
IUUC-Rno-106088 Rattus norvegicus 91.64 0.00e+00 1106.00
IUUC-Sha-106984 Sarcophilus harrisii 89.77 0.00e+00 1068.00
IUUC-Smo-109404 Selaginella moellendorffii 26.80 3.00e-42 166.00
IUUC-Sit-110828 Setaria italica 27.42 1.00e-44 174.00
IUUC-Sly-111009 Solanum lycopersicum 26.94 5.00e-48 185.00
IUUC-Stu-112370 Solanum tuberosum 27.33 1.00e-48 187.00
IUUC-Sar-113659 Sorex araneus 63.51 2.00e-92 331.00
IUUC-Sbi-114819 Sorghum bicolor 28.48 9.00e-42 164.00
IUUC-Ssc-116241 Sus scrofa 91.95 0.00e+00 1107.00
IUUC-Tgu-116576 Taeniopygia guttata 87.15 0.00e+00 1081.00
IUUC-Tru-118336 Takifugu rubripes 64.37 0.00e+00 727.00
IUUC-Tsy-119006 Tarsius syrichta 90.53 0.00e+00 1093.00
IUUC-Tni-120300 Tetraodon nigroviridis 74.12 0.00e+00 862.00
IUUC-Tca-121002 Theobroma cacao 28.52 2.00e-49 190.00
IUUC-Tae-124868 Triticum aestivum 30.10 8.00e-34 138.00
IUUC-Tur-126463 Triticum urartu 29.41 4.00e-33 136.00
IUUC-Tbe-127631 Tupaia belangeri 96.65 0.00e+00 926.00
IUUC-Ttr-129005 Tursiops truncatus 84.52 2.00e-163 569.00
IUUC-Vpa-130246 Vicugna pacos 83.39 0.00e+00 837.00
IUUC-Vvi-130878 Vitis vinifera 34.08 2.00e-43 170.00
IUUC-Xtr-132798 Xenopus tropicalis 74.39 0.00e+00 868.00
IUUC-Xma-133264 Xiphophorus maculatus 72.73 0.00e+00 865.00
Created Date 25-Jun-2017

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