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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Dme-031938
UUCD1 version UUC-DrM-00261
Ensembl Protein ID FBpp0085255
UniProt Accession Q9V9R2; Q95RE8; Q9V9R2_DROME
Genbank Protein ID AAF57224.3; AAG22124.2; AAL28982.1
Protein Name Cullin 2, isoform A; Cullin 2, isoform B; LD36177p
Genbank Nucleotide ID AE014134; AE014134; AY061434
Gene Name Cul2; Cul-2; cul-2; CG1512; Dmel_CG1512
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
FBgn0032956 FBtr0085900 FBpp0085255
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpress
DNA & RNA Element
microRNARAID2
Protein-protein Interaction
IIDiRefIndexPINAMentha
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/Cullin 9.00e-150 500.3 20 649
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/Cullin
   S: 5    avkkilrqesv.kkeyeelytavynlclsk...vgaklYkklkevleefikqv.kkkv......eesedeq.lLktynreWekfreqlkvlrkifayl 90
           + + + + ++v ++ +++ +++vy+lc+++   ++++lY ++k++le++++++  kkv       +s++   lL+ y   W ++++++k+l++++ yl
   Q: 20   IAESVITLTKVeRSVWNTSFSDVYTLCVAQpepMADRLYGETKHFLEQHVQEMlAKKVliegecSHSNGGPdLLQRYYITWMEYSQGIKYLHQLYIYL 117
           56778888999999************************************6652444422222145555556************************** PP
   S: 91   drtyvkk................skkvsevrkLaldlwrkeivedikkrllelllklieaeRkge.avdr...rllsgvveslveLslnk....laiy 164
           +++ +kk                  + +e+ +L+ld+wr  ++e+++++l++ +l+ i+a+R  + ++d+   ++++gv++s+ve++ +k    l++y
   Q: 118  NQQHIKKqkitdtesfygnlssdAAEQMEIGELGLDIWRLYMIEYLSSELVRHILEGIAADRASNgTLDHhrvQIINGVIHSFVEVQDYKktgsLKLY 215
           *******78877777777665554455***********************************75424554333899**********98889******* PP
   S: 165  kesFEakfleatqefykaesaeflqenevdeYlkkvearlneeeeraaryleestetkLlevvekeliakhlesllaelvallrdkktedlsrmykLl 262
           +e FE + lea+  +y+ e++++l+ ++v+eY+++v   l+ e++ra+++l++s++ kL +++e++ i++ l ++++e+ +++ +++++dl++my +l
   Q: 216  QELFEGPMLEASGAYYTDEANKLLHRCSVSEYMQEVIRILEYESRRAQKFLHVSSLPKLRKECEEKFINDRLGFIYSECREMVSEERRQDLRNMYVVL 313
           ************************************************************************************************** PP
   S: 263  srvlngl.eellkeleshikeqgkaaltaeekekdpkkyVerllelknklqklvseaFnndakFlkaldkafetfvnknsvlka.akspEllAryiDq 358
           + +++ l +el+ ++  hik++g++ ++a + e+    +Ve++l++++k+q+l+  +F+nd  Fl+aldka+++++n+++  +  ++s+E++A+y+D 
   Q: 314  KPIPDNLkSELITTFLDHIKSEGLQTVSALKGENIHIAFVENMLKVHHKYQELIADVFENDSLFLSALDKACASVINRRPTERQpCRSAEYVAKYCDT 411
           *****66169************************999******************************************998878************* PP
   S: 359  lLrksskglteeeleaqldkvllvfkyisekdvFekyYkkhLakRLlsgksasseaEesviekLkeecgaeftskLerMfqdlkvSedlnrqFkeeke 456
           lL+ks  ++ e+e++++l++ +++fkyi++kdv++k+Y ++LakRL++++s s++aEe +i++Lk++cg+eft+kL+rMf+d++vS dln++F+++ +
   Q: 412  LLKKS--KTCEAEIDQKLTNNITIFKYIEDKDVYQKFYSRLLAKRLIHEQSQSMDAEEGMINRLKQACGYEFTNKLHRMFTDISVSVDLNNKFNTHLK 507
           *****..899**************************************************************************************** PP
   S: 457  nteesesvelsvlvLsagaWptaset.ekvsLPaelektiekfeefYlekhsgRkLqWqhtlgraelkaelkkgkyelqVstfQmavLLafnnsekvs 553
           +++ + +++l ++vL+agaWp  s++   +++P+e+ek+i++fe +Y + +sgRkL+W+h+++++elk    k+ y+++  t+Qma++L+f + +++s
   Q: 508  DSNVDLGINLAIKVLQAGAWPLGSTQvIPFAVPQEFEKSIKMFEDYYHKLFSGRKLTWLHHMCHGELKLSHLKKSYIVTMQTYQMAIILLFETCDSLS 605
           **********************9655545********************************************************************* PP
   S: 554  veelkkatelpeeeLrrtlqsLvsskkqvlkkepeskeieeedlfsvN 601
             e+++  +l++e  ++ +q++++sk  +l++++e  +++ e+ + +N
   Q: 606  CREIQNTLQLNDETFQKHMQPIIESK--LLNASSE--NLAGETRIELN 649
           *************************9..7766655..56666666666 PP
   
Organism Drosophila melanogaster
Protein Sequence
(Fasta)
MSLKPKIVEF VDVWPRLRCI AESVITLTKV ERSVWNTSFS DVYTLCVAQP EPMADRLYGE 60
TKHFLEQHVQ EMLAKKVLIE GECSHSNGGP DLLQRYYITW MEYSQGIKYL HQLYIYLNQQ 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Dme-031938|E3,Cullin|Drosophila melanogaster
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CGATAGATTA TATCGATATC GTCTTCGTCT GACAAACCAT TTCACGATAC CAAAAAAAAA 60
GTGCAAAAAT AACTAAATTC TCGGCGTAAT TATTTAGTAA ATAGCGTAGC TAAGCAGCAG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Dme-031938|E3,Cullin|Drosophila melanogaster
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-1267--Proteomics identification
KW-1185--Reference proteome
Interpro

IPR016157--Cullin_CS
IPR016158--Cullin_homology
IPR001373--Cullin_N
IPR019559--Cullin_neddylation_domain
IPR016159--Cullin_repeat-like_dom
IPR011991--WHTH_DNA-bd_dom
PROSITE

PS01256--CULLIN_1
PS50069--CULLIN_2
Pfam

PF00888--Cullin
PF10557--Cullin_Nedd8
SMART

SM00182--CULLIN
SM00884--Cullin_Nedd8
Gene Ontology

GO:0031462--C:Cul2-RING ubiquitin ligase complex
GO:0048471--C:perinuclear region of cytoplasm
GO:0031625--F:ubiquitin protein ligase binding
GO:0007281--P:germ cell development
GO:0007295--P:growth of a germarium-derived egg chamber
GO:0048140--P:male germ-line cyst encapsulation
GO:0030514--P:negative regulation of BMP signaling pathway
GO:0022008--P:neurogenesis
GO:0016567--P:protein ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0008582--P:regulation of synaptic growth at neuromuscular junction
KEGG dme:Dmel_CG1512
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001969 Ailuropoda melanoleuca 50.66 0.00e+00 759.00
IUUC-Apl-004067 Anas platyrhynchos 50.39 0.00e+00 751.00
IUUC-Aca-004534 Anolis carolinensis 49.10 0.00e+00 751.00
IUUC-Ame-011695 Astyanax mexicanus 50.66 0.00e+00 760.00
IUUC-Bta-013074 Bos taurus 50.66 0.00e+00 758.00
IUUC-Cel-018431 Caenorhabditis elegans 39.26 5.00e-159 554.00
IUUC-Cja-019371 Callithrix jacchus 50.53 0.00e+00 756.00
IUUC-Cfa-020508 Canis familiaris 50.66 0.00e+00 758.00
IUUC-Cpo-021851 Cavia porcellus 50.39 0.00e+00 757.00
IUUC-Csa-023583 Chlorocebus sabaeus 50.53 0.00e+00 754.00
IUUC-Cho-024308 Choloepus hoffmanni 40.11 3.00e-65 242.00
IUUC-Cin-025350 Ciona intestinalis 40.79 1.00e-168 585.00
IUUC-Csv-026096 Ciona savignyi 35.15 6.00e-150 523.00
IUUC-Dre-028828 Danio rerio 49.74 0.00e+00 743.00
IUUC-Dno-029709 Dasypus novemcinctus 50.53 0.00e+00 753.00
IUUC-Dor-030319 Dipodomys ordii 46.77 1.00e-135 476.00
IUUC-Ete-032945 Echinops telfairi 44.40 2.00e-112 398.00
IUUC-Eca-034019 Equus caballus 50.53 0.00e+00 756.00
IUUC-Eeu-034914 Erinaceus europaeus 47.11 7.00e-138 483.00
IUUC-Fca-035926 Felis catus 50.66 0.00e+00 758.00
IUUC-Fal-037627 Ficedula albicollis 50.53 0.00e+00 753.00
IUUC-Gmo-038728 Gadus morhua 50.72 0.00e+00 753.00
IUUC-Gga-040820 Gallus gallus 48.66 0.00e+00 744.00
IUUC-Gac-041293 Gasterosteus aculeatus 50.66 0.00e+00 750.00
IUUC-Ggo-045235 Gorilla gorilla 49.08 0.00e+00 726.00
IUUC-Hsa-046819 Homo sapiens 50.53 0.00e+00 757.00
IUUC-Lch-049443 Latimeria chalumnae 50.39 0.00e+00 752.00
IUUC-Loc-052798 Lepisosteus oculatus 50.66 0.00e+00 759.00
IUUC-Laf-053379 Loxodonta africana 50.66 0.00e+00 756.00
IUUC-Mcc-055702 Macaca mulatta 50.53 0.00e+00 756.00
IUUC-Meu-056223 Macropus eugenii 36.93 9.00e-121 426.00
IUUC-Mga-060034 Meleagris gallopavo 50.26 0.00e+00 748.00
IUUC-Mmr-061090 Microcebus murinus 50.66 0.00e+00 758.00
IUUC-Mdo-062530 Monodelphis domestica 49.74 0.00e+00 746.00
IUUC-Mmu-063857 Mus musculus 50.39 0.00e+00 740.00
IUUC-Mpu-065915 Mustela putorius furo 50.66 0.00e+00 759.00
IUUC-Mlu-068049 Myotis lucifugus 50.53 0.00e+00 758.00
IUUC-Nle-069102 Nomascus leucogenys 48.80 1.00e-152 532.00
IUUC-Opr-071197 Ochotona princeps 46.42 3.00e-166 577.00
IUUC-Ont-071902 Oreochromis niloticus 50.59 0.00e+00 755.00
IUUC-Oan-073307 Ornithorhynchus anatinus 48.35 0.00e+00 738.00
IUUC-Ocu-074703 Oryctolagus cuniculus 50.66 0.00e+00 759.00
IUUC-Ola-086789 Oryzias latipes 50.59 0.00e+00 754.00
IUUC-Oga-088480 Otolemur garnettii 50.26 0.00e+00 754.00
IUUC-Oar-089899 Ovis aries 50.66 0.00e+00 759.00
IUUC-Ptr-090965 Pan troglodytes 50.39 0.00e+00 756.00
IUUC-Pan-092920 Papio anubis 48.95 0.00e+00 718.00
IUUC-Psi-093122 Pelodiscus sinensis 50.13 0.00e+00 757.00
IUUC-Pma-094656 Petromyzon marinus 50.99 0.00e+00 761.00
IUUC-Pfo-096342 Poecilia formosa 50.46 0.00e+00 753.00
IUUC-Pab-097544 Pongo abelii 50.53 0.00e+00 758.00
IUUC-Pca-100564 Procavia capensis 56.62 2.00e-134 472.00
IUUC-Rno-105439 Rattus norvegicus 50.39 0.00e+00 739.00
IUUC-Sha-106654 Sarcophilus harrisii 49.61 0.00e+00 746.00
IUUC-Sar-113138 Sorex araneus 47.50 0.00e+00 696.00
IUUC-Ssc-115543 Sus scrofa 52.54 3.00e-160 557.00
IUUC-Tgu-117095 Taeniopygia guttata 50.59 0.00e+00 749.00
IUUC-Tru-118593 Takifugu rubripes 45.42 0.00e+00 704.00
IUUC-Tsy-119621 Tarsius syrichta 50.88 1.00e-147 516.00
IUUC-Tni-119697 Tetraodon nigroviridis 50.85 0.00e+00 757.00
IUUC-Tbe-127831 Tupaia belangeri 45.43 6.00e-167 580.00
IUUC-Ttr-129108 Tursiops truncatus 50.66 0.00e+00 759.00
IUUC-Vpa-130414 Vicugna pacos 55.83 6.00e-95 340.00
IUUC-Xtr-132054 Xenopus tropicalis 49.74 0.00e+00 754.00
Created Date 25-Jun-2017

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