iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-046117

UUCD1 version

UUC-HoS-00170

Ensembl Protein ID

ENSP00000318944.6

UniProt Accession

Q6Q0C0; Q9H073; TRAF7_HUMAN

Genbank Protein ID

AAS68363.1; CAB66855.1

Protein Name

E3 ubiquitin-protein ligase TRAF7; RING finger and WD repeat-containing protein 1; RING finger protein 119; RING-type E3 ubiquitin transferase TRAF7; TNF receptor-associated factor 7

Genbank Nucleotide ID

AY569455; AL136921

Gene Name

TRAF7; RFWD1; RNF119

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000131653.12	ENST00000565383.5	ENSP00000479297.1
ENSG00000131653.12	ENST00000326181.10	ENSP00000318944.6
ENSG00000131653.12	ENST00000567653.5	ENSP00000478515.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	circBase	CircNet	miRTarBase
microRNA	TRANSFAC	TargetScan	RepTar
miRNAMap	SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Information
OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	BioGRID
mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	20948544; 23404503
E3 adaptor/Cullin RING/DCX/DWD	WD_repeat	20948544; 23404503

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	0.0047	19.1	131	164
E3 adaptor/Cullin RING/DCX/DWD	5.20e-30	103.8	394	425
UBD/Beta-Prp	5.00e-48	165.5	392	670

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlC 45
           C +C++ fkd p+++ CgH+f++ C          + k+ +CP++
   Q: 131  CQLCCSVFKD-PVITTCGHTFCRRC----------ALKSEKCPVD 164
           99********.999***********..........5577778886 PP

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDl 30
           gH+++v+cl+  s  +ll sGs D+tikvWD+
   Q: 394  GHQGPVWCLCVySMgDLLFSGSSDKTIKVWDT 425
           8*********778889***************6 PP

UBD/Beta-Prp

   S: 5    lkghhksvitcvkfspdksllatgsrdgtikvwdv.ttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghed 95
           + gh+   + c+++   ++ll++gs d+tikvwd+ tt k+ ++l+gh++ v a++++     l +gs D ti vwd+++ + v t+++h++
   Q: 392  FVGHQGP-VWCLCVYSMGDLLFSGSSDKTIKVWDTcTTYKCQKTLEGHDGIVLALCIQGC--KLYSGSADCTIIVWDIQNLQKVNTIRAHDN 480
           5556655.5559999*******************846678899***************99..6***************************** PP
   S: 96   svlslsfspsgdklvsGshdrtirvwdl.etgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvysl 186
            v++l +s   ++l sGs  + i+vwd+  t+ +l++ l+g +++v+ +v  +  ++l sGs+ +t+++Wd++t ++++ l+    +svys+
   Q: 481  PVCTLVSSH--NVLFSGS-LKAIKVWDIvGTELKLKKELTGLNHWVRALVAAQ--SYLYSGSY-QTIKIWDIRTLDCIHVLQT-SGGSVYSI 565
           ****99999..9******.9*******7368888888**************99..*******9.79***************99.******** PP
   S: 187  sfdsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfs..pnderlvsgssDgsiriWdlrsgdllktlqlhnssvisvavlsfg 276
           +++    ++v g + + + +wd++++e vrtl+gh  +v+ +++   p+++ + s+s D+s+r+W +++  +++tl +h+ sv++ av   +
   Q: 566  AVTN--HHIVCGTYENLIHVWDIESKEQVRTLTGHVGTVYALAVIstPDQTKVFSASYDRSLRVWSMDNMICTQTLLRHQGSVTALAV---S 652
           ***9..8***********************************99888****************************************9...* PP
   S: 277  dnvlvlgsedskvniwkl 294
           +  l++g+ ds+v++w +
   Q: 653  RGRLFSGAVDSTVKVWTC 670
           ****************86 PP

Organism

Homo sapiens

Functional Description
(View)

E3 ubiquitin ligase capable of auto-ubiquitination, following phosphorylation by MAP3K3. Potentiates MEKK3-mediated activation of the NF-kappa-B, JUN/AP1 and DDIT3 transcriptional regulators. Induces apoptosis when overexpressed.

Protein Sequence
(Fasta)

MSSGKSARYN RFSGGPSNLP TPDVTTGTRM ETTFGPAFSA VTTITKADGT STYKQHCRTP 60
SSSSTLAYSP RDEEDSMPPI STPRRSDSAI SVRSLHSESS MSLRSTFSLP EEEEEPEPLV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGCAGCCGTC CGGGCCCGGA GAGGCGGGGA ACTACACGTC CCGGCGGGCG CAGCGGCCTG 60
GCGCTTCCGG CTCGCGCGTC TAGTCCCTTT CCCGGCCGGC GGCCGAGGGG GCATCATGAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0053--Apoptosis
KW-0181--Complete proteome
KW-0968--Cytoplasmic vesicle
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001370--BIR_rpt
IPR020472--G-protein_beta_WD-40_rep
IPR008974--TRAF-like
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
IPR027370--Znf-RING_LisH
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
IPR001293--Znf_TRAF

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
PS00518--ZF_RING_1
PS50089--ZF_RING_2
PS50145--ZF_TRAF

Pfam

PF00400--WD40
PF13445--zf-RING_UBOX

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00184--RING
SM00320--WD40

Gene Ontology

GO:0031410--C:cytoplasmic vesicle
GO:0043231--C:intracellular membrane-bounded organelle
GO:0005886--C:plasma membrane
GO:0000151--C:ubiquitin ligase complex
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0000185--P:activation of MAPKKK activity
GO:0006915--P:apoptotic process
GO:2001235--P:positive regulation of apoptotic signaling pathway
GO:0043410--P:positive regulation of MAPK cascade
GO:0016567--P:protein ubiquitination
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated

KEGG

hsa:84231

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001971	Ailuropoda melanoleuca	97.33	0.00e+00	1257.00
IUUC-Apl-004098	Anas platyrhynchos	94.85	0.00e+00	1198.00
IUUC-Aca-004852	Anolis carolinensis	87.82	0.00e+00	976.00
IUUC-Ame-011275	Astyanax mexicanus	82.86	0.00e+00	934.00
IUUC-Bta-013153	Bos taurus	97.76	0.00e+00	1274.00
IUUC-Cja-019243	Callithrix jacchus	97.71	0.00e+00	1249.00
IUUC-Cfa-020036	Canis familiaris	98.21	0.00e+00	1292.00
IUUC-Cpo-022194	Cavia porcellus	97.45	0.00e+00	1273.00
IUUC-Csa-023363	Chlorocebus sabaeus	99.25	0.00e+00	1303.00
IUUC-Cin-025279	Ciona intestinalis	58.98	0.00e+00	797.00
IUUC-Csv-026163	Ciona savignyi	64.73	0.00e+00	771.00
IUUC-Dre-027998	Danio rerio	90.48	0.00e+00	1108.00
IUUC-Dno-029356	Dasypus novemcinctus	94.64	5.00e-129	453.00
IUUC-Dor-030750	Dipodomys ordii	94.93	0.00e+00	1231.00
IUUC-Eca-033671	Equus caballus	82.20	0.00e+00	988.00
IUUC-Eeu-034765	Erinaceus europaeus	97.37	3.00e-165	575.00
IUUC-Fca-035843	Felis catus	98.06	0.00e+00	1289.00
IUUC-Fal-037237	Ficedula albicollis	93.28	0.00e+00	1236.00
IUUC-Gmo-038779	Gadus morhua	81.07	0.00e+00	1002.00
IUUC-Gga-040579	Gallus gallus	92.84	0.00e+00	1228.00
IUUC-Gac-042233	Gasterosteus aculeatus	85.67	0.00e+00	1114.00
IUUC-Gma-044293	Glycine max	26.81	3.00e-19	89.40
IUUC-Ggo-045147	Gorilla gorilla	99.85	0.00e+00	1309.00
IUUC-Itr-048899	Ictidomys tridecemlineatus	97.91	0.00e+00	1290.00
IUUC-Lch-050593	Latimeria chalumnae	91.06	0.00e+00	1185.00
IUUC-Loc-052444	Lepisosteus oculatus	90.07	0.00e+00	1212.00
IUUC-Laf-053499	Loxodonta africana	90.82	0.00e+00	1170.00
IUUC-Mcc-055038	Macaca mulatta	99.40	0.00e+00	1304.00
IUUC-Meu-056610	Macropus eugenii	95.01	0.00e+00	945.00
IUUC-Mtr-057641	Medicago truncatula	27.73	3.00e-19	90.10
IUUC-Mga-060183	Meleagris gallopavo	92.56	0.00e+00	1224.00
IUUC-Mmr-061133	Microcebus murinus	96.45	0.00e+00	1215.00
IUUC-Mdo-062312	Monodelphis domestica	95.98	0.00e+00	1263.00
IUUC-Mmu-063844	Mus musculus	96.57	0.00e+00	1239.00
IUUC-Mpu-066552	Mustela putorius furo	97.46	0.00e+00	1254.00
IUUC-Mlu-067719	Myotis lucifugus	97.16	0.00e+00	1248.00
IUUC-Nle-070045	Nomascus leucogenys	99.20	0.00e+00	1210.00
IUUC-Opr-070927	Ochotona princeps	94.93	0.00e+00	1224.00
IUUC-Ont-072680	Oreochromis niloticus	85.59	0.00e+00	1137.00
IUUC-Oan-073521	Ornithorhynchus anatinus	94.00	3.00e-52	196.00
IUUC-Ogu-077987	Oryza glumaepatula	25.86	4.00e-19	89.70
IUUC-Oru-085210	Oryza rufipogon	25.60	2.00e-19	90.10
IUUC-Ola-087454	Oryzias latipes	86.68	0.00e+00	1176.00
IUUC-Oga-088380	Otolemur garnettii	97.91	0.00e+00	1286.00
IUUC-Oar-089558	Ovis aries	80.06	0.00e+00	1009.00
IUUC-Ptr-091606	Pan troglodytes	99.85	0.00e+00	1309.00
IUUC-Pan-092227	Papio anubis	99.40	0.00e+00	1304.00
IUUC-Psi-093853	Pelodiscus sinensis	86.15	0.00e+00	1017.00
IUUC-Pma-094541	Petromyzon marinus	81.33	1.00e-153	535.00
IUUC-Pfo-096237	Poecilia formosa	88.38	0.00e+00	1124.00
IUUC-Pab-097589	Pongo abelii	99.70	0.00e+00	1308.00
IUUC-Pca-100375	Procavia capensis	93.84	0.00e+00	1179.00
IUUC-Pva-102434	Pteropus vampyrus	98.06	0.00e+00	1285.00
IUUC-Rno-105443	Rattus norvegicus	97.01	0.00e+00	1244.00
IUUC-Sha-106517	Sarcophilus harrisii	95.68	0.00e+00	1257.00
IUUC-Ssc-115990	Sus scrofa	97.01	0.00e+00	1272.00
IUUC-Tgu-117222	Taeniopygia guttata	93.10	0.00e+00	1226.00
IUUC-Tru-118392	Takifugu rubripes	88.13	0.00e+00	1134.00
IUUC-Tni-120220	Tetraodon nigroviridis	87.20	0.00e+00	1127.00
IUUC-Tca-121793	Theobroma cacao	27.11	1.00e-20	94.40
IUUC-Tbe-128045	Tupaia belangeri	99.65	1.00e-161	563.00
IUUC-Ttr-128203	Tursiops truncatus	94.63	0.00e+00	1223.00
IUUC-Xtr-132043	Xenopus tropicalis	91.64	0.00e+00	1240.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence