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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-047022
UUCD1 version UUC-HoS-00164
Ensembl Protein ID ENSP00000293303.4
UniProt Accession Q6JEL2; Q6NW28; Q96MC0; KLH10_HUMAN
Genbank Protein ID AAS91792.1; BAB71387.1
Protein Name Kelch-like protein 10
Genbank Nucleotide ID AY495339; AK057224
Gene Name KLHL10
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000161594.6 ENST00000293303.4 ENSP00000293303.4
ENSG00000161594.6 ENST00000438813.1 ENSP00000416221.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitemicroRNATRANSFAC
TargetScanRepTarmiRNAMapSomamiR
miRcodeRAID2
Protein-protein Interaction
IIDiRefIndexHINTMentha
InWeb_IM
Disease-associated Information
ClinVarOMIM
Post-translational Modifications (PTMs)
dbPAFPhosphositePlus
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/BCR/BTB_3-box BTB_3-box 16162871
Classification
Family E-value Score Start End
E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB 7.20e-18 66.4 39 104
E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box 1.30e-11 43.5 138 169
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB
   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmeleesksklmveikdvqpevfrallkFlYtgklde 67
           +Dv+++v+g ef+ahk +L+++Ss+F+alf++++++++ k+ ++i +++p+ ++ ++++ Yt ++++
   Q: 39   CDVVIKVNGFEFSAHKNILCSCSSYFRALFTSGWNNTE-KKVYNIPGISPDMMKLIIEYAYTRTVPI 104
           8**********************************998.***********************99986 PP
   

   E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box
   S: 1    leNclgilrfAdlydcpdLkdaaldfilkhFk 32
           l+Nc+gi+ f d y cp+L+++a +fil++F+
   Q: 138  LDNCIGICKFTDYYYCPELRQKAYMFILHNFE 169
           69*****************************5 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Self-associates (Probable). Interacts with CUL3; indicative for the participation in an E3 ubiquitin ligase complex (By similarity).
 Self-associates (Probable). Interacts with CUL3; indicative for the participation in an E3 ubiquitin ligase complex (By similarity).
Protein Sequence
(Fasta)
MEMESAAAST RFHQPHMERK MSAMACEIFN ELRLEGKLCD VVIKVNGFEF SAHKNILCSC 60
SSYFRALFTS GWNNTEKKVY NIPGISPDMM KLIIEYAYTR TVPITPDNVE KLLAAADQFN 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-047022|E3,BTB_3-box|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GAAATTTGGG TTTTAGGACA GGCGAACCAA CCCGCTCTCC TTCAAGCTCC CGGCCATTTC 60
TTGGGGCAGA GAGCTAGGAG GGGTCCGCGG CAGAGCAAAG CGGGAAGGCC CAATGGGCAG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-047022|E3,BTB_3-box|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0221--Differentiation
KW-0225--Disease mutation
KW-0880--Kelch repeat
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0744--Spermatogenesis
KW-0833--Ubl conjugation pathway
Interpro

IPR011705--BACK
IPR017096--BTB-kelch_protein
IPR000210--BTB/POZ_dom
IPR015915--Kelch-typ_b-propeller
IPR006652--Kelch_1
IPR011333--SKP1/BTB/POZ
PROSITE

PS50097--BTB
Pfam

PF07707--BACK
PF00651--BTB
PF01344--Kelch_1
SMART

SM00875--BACK
SM00225--BTB
SM00612--Kelch
Gene Ontology

GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0005737--C:cytoplasm
GO:0000902--P:cell morphogenesis
GO:0009566--P:fertilization
GO:0048873--P:homeostasis of number of cells within a tissue
GO:0048808--P:male genitalia morphogenesis
GO:0008584--P:male gonad development
GO:0016567--P:protein ubiquitination
GO:0007286--P:spermatid development
KEGG hsa:317719
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001576 Ailuropoda melanoleuca 98.85 0.00e+00 1263.00
IUUC-Apl-003525 Anas platyrhynchos 82.15 0.00e+00 1048.00
IUUC-Aca-005295 Anolis carolinensis 88.12 0.00e+00 954.00
IUUC-Ang-009879 Aspergillus niger 27.56 4.00e-09 55.80
IUUC-Ate-010500 Aspergillus terreus 25.56 3.00e-19 89.70
IUUC-Ame-010953 Astyanax mexicanus 48.25 1.00e-164 573.00
IUUC-Bta-013447 Bos taurus 98.85 0.00e+00 1263.00
IUUC-Cja-019472 Callithrix jacchus 98.68 0.00e+00 788.00
IUUC-Cfa-020332 Canis familiaris 98.68 0.00e+00 1260.00
IUUC-Cpo-021949 Cavia porcellus 97.53 0.00e+00 1248.00
IUUC-Csa-023573 Chlorocebus sabaeus 99.67 0.00e+00 1271.00
IUUC-Cho-024451 Choloepus hoffmanni 97.61 0.00e+00 1090.00
IUUC-Cin-025680 Ciona intestinalis 51.40 1.00e-173 602.00
IUUC-Csv-026085 Ciona savignyi 50.17 7.00e-173 600.00
IUUC-Dre-028799 Danio rerio 57.66 0.00e+00 691.00
IUUC-Dno-029608 Dasypus novemcinctus 98.85 0.00e+00 1264.00
IUUC-Dor-030200 Dipodomys ordii 99.26 0.00e+00 1132.00
IUUC-Dme-031964 Drosophila melanogaster 45.63 2.00e-153 536.00
IUUC-Ete-032475 Echinops telfairi 95.23 0.00e+00 1211.00
IUUC-Eca-034237 Equus caballus 99.01 0.00e+00 1265.00
IUUC-Eeu-035104 Erinaceus europaeus 88.68 4.00e-167 580.00
IUUC-Fca-036271 Felis catus 98.68 0.00e+00 1263.00
IUUC-Fal-037352 Ficedula albicollis 68.41 0.00e+00 851.00
IUUC-Ggr-040046 Gaeumannomyces graminis 29.73 6.00e-07 49.30
IUUC-Gga-040205 Gallus gallus 80.14 0.00e+00 1013.00
IUUC-Gac-041982 Gasterosteus aculeatus 54.20 0.00e+00 641.00
IUUC-Ggo-045241 Gorilla gorilla 99.67 0.00e+00 1272.00
IUUC-Itr-048079 Ictidomys tridecemlineatus 98.85 0.00e+00 1263.00
IUUC-Lch-050637 Latimeria chalumnae 87.13 0.00e+00 1135.00
IUUC-Loc-052412 Lepisosteus oculatus 74.88 0.00e+00 959.00
IUUC-Laf-054118 Loxodonta africana 98.68 0.00e+00 1262.00
IUUC-Mcc-055476 Macaca mulatta 91.61 0.00e+00 1143.00
IUUC-Meu-056158 Macropus eugenii 98.85 0.00e+00 1263.00
IUUC-Mpo-057379 Magnaporthe poae 32.88 4.00e-07 48.50
IUUC-Mga-059634 Meleagris gallopavo 81.05 0.00e+00 1003.00
IUUC-Mmr-061217 Microcebus murinus 89.47 0.00e+00 1113.00
IUUC-Mdo-062138 Monodelphis domestica 98.85 0.00e+00 1261.00
IUUC-Mmu-063769 Mus musculus 98.85 0.00e+00 1263.00
IUUC-Mpu-066045 Mustela putorius furo 99.01 0.00e+00 1265.00
IUUC-Mlu-067348 Myotis lucifugus 98.36 0.00e+00 1258.00
IUUC-Nfi-068435 Neosartorya fischeri 30.65 1.00e-06 46.20
IUUC-Nle-069331 Nomascus leucogenys 99.34 0.00e+00 1267.00
IUUC-Opr-071203 Ochotona princeps 96.05 0.00e+00 1218.00
IUUC-Ont-071882 Oreochromis niloticus 49.32 4.00e-158 551.00
IUUC-Ocu-073757 Oryctolagus cuniculus 98.68 0.00e+00 1257.00
IUUC-Ola-086791 Oryzias latipes 49.08 5.00e-152 531.00
IUUC-Oga-088676 Otolemur garnettii 98.68 0.00e+00 1261.00
IUUC-Oar-089804 Ovis aries 98.68 0.00e+00 1260.00
IUUC-Ptr-090767 Pan troglodytes 99.67 0.00e+00 1272.00
IUUC-Pan-092856 Papio anubis 99.67 0.00e+00 1271.00
IUUC-Psi-094041 Pelodiscus sinensis 92.26 0.00e+00 1196.00
IUUC-Pfo-096673 Poecilia formosa 58.17 0.00e+00 664.00
IUUC-Pab-097694 Pongo abelii 99.34 0.00e+00 1268.00
IUUC-Pca-100693 Procavia capensis 91.53 0.00e+00 988.00
IUUC-Pva-102153 Pteropus vampyrus 99.00 0.00e+00 839.00
IUUC-Rno-105012 Rattus norvegicus 98.85 0.00e+00 1264.00
IUUC-Sha-106593 Sarcophilus harrisii 98.85 0.00e+00 1264.00
IUUC-Ssl-108429 Sclerotinia sclerotiorum 25.18 1.00e-07 50.80
IUUC-Sar-113188 Sorex araneus 97.95 0.00e+00 1189.00
IUUC-Tgu-116852 Taeniopygia guttata 70.60 0.00e+00 842.00
IUUC-Tru-118098 Takifugu rubripes 49.00 4.00e-161 561.00
IUUC-Tsy-119581 Tarsius syrichta 85.03 0.00e+00 1052.00
IUUC-Tni-120002 Tetraodon nigroviridis 52.05 4.00e-163 568.00
IUUC-Tbe-127778 Tupaia belangeri 91.61 0.00e+00 1145.00
IUUC-Ttr-128966 Tursiops truncatus 92.60 0.00e+00 1162.00
IUUC-Vpa-130421 Vicugna pacos 98.95 0.00e+00 792.00
IUUC-Xtr-131853 Xenopus tropicalis 59.13 0.00e+00 683.00
IUUC-Xma-133112 Xiphophorus maculatus 58.53 0.00e+00 667.00
Created Date 25-Jun-2017

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