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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Rno-105406
UUCD1 version UUC-RaN-00813
Ensembl Protein ID ENSRNOP00000019167.4
UniProt Accession Q4V8B2; DCNL3_RAT
Genbank Protein ID AAH97462.1
Protein Name DCN1-like protein 3; DCUN1 domain-containing protein 3; Defective in cullin neddylation protein 1-like protein 3
Genbank Nucleotide ID BC097462
Gene Name Dcun1d3
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSRNOG00000014037.4 ENSRNOT00000019167.4 ENSRNOP00000019167.4
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
microRNATRANSFACRAID2
Protein-protein Interaction
IID
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/DCUN1 1.20e-84 283.5 87 278
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/DCUN1
   S: 2    skkkleelferYkdpqedligieglekfcedlgvdpediavLvlawkleaatlcefsreefldgltalgcdsieklqeklktleselkd 90
           s ++leelf+rYkd++ed+i++eg+e+fc+dl+vdp++++vL+lawk++aat+c+f+r+ef+dg++a+++dsi+++++++++l +e+k+
   Q: 87   SLQRLEELFRRYKDEREDAILEEGMERFCNDLCVDPTEFRVLLLAWKFQAATMCKFTRKEFFDGCKAISADSIDGICARFPSLLTEAKQ 175
           679************************************************************************************** PP
   S: 91   eqkfkdiYrfafnfakd..kgqksldldtaialwkLllaerefklldawlkfLeee..kkksiskDtWnllLefskviakdlsnYdeeg 175
           e+kfkd+Yrf+f+f++d  +gq+sl++++aialwkL+++++++++ld+wl+fL+e+  ++k+is+DtWn++L+f++vi +dlsnY+e++
   Q: 176  EDKFKDLYRFTFQFGLDseEGQRSLHREIAIALWKLVFTQNNPPVLDQWLNFLTENpsGIKGISRDTWNMFLNFTQVIGPDLSNYSEDE 264
           ***************998899**********************************9889****************************** PP
   S: 176  aWPvliDefveylk 189
           aWP+l+D+fve+++
   Q: 265  AWPSLFDTFVEWEM 278
           ************85 PP
   
Organism Rattus norvegicus
Functional Description
(View)

Functional Description


     Antagonizes DCUN1D1-mediated CUL1 neddylation by sequestering CUL1 at the cell membrane.
 Antagonizes DCUN1D1-mediated CUL1 neddylation by sequestering CUL1 at the cell membrane.
Protein Sequence
(Fasta)
MGQCVTKCKN PSSTLGSKNG DRDPSSKSHS RRGASHREEQ VPPCGKPAGD ILVNGTKKAE 60
AATEACQLPT SSGDAGRESK TNAEESSLQR LEELFRRYKD EREDAILEEG MERFCNDLCV 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Rno-105406|E3,DCUN1|Rattus norvegicus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CCAGTCCCCC GCGACCGGAG CCGGCTTCTC CATCCTTACA CTCACTCAGC GTCACTCCTG 60
CCTTCCCCCA CCCACAGGAG TCGGCTGGGA AGAGGCGGTG CCAGGAGCTC TGCCGAGCCT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Rno-105406|E3,DCUN1|Rattus norvegicus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0449--Lipoprotein
KW-0472--Membrane
KW-0519--Myristate
KW-1185--Reference proteome
Interpro

IPR014764--DCN-prot
IPR005176--PONY_dom
PROSITE

PS51229--DCUN1
Pfam

PF03556--Cullin_binding
Gene Ontology

GO:0005737--C:cytoplasm
GO:0048471--C:perinuclear region of cytoplasm
GO:0005886--C:plasma membrane
GO:0000151--C:ubiquitin ligase complex
GO:0097602--F:cullin family protein binding
GO:0031624--F:ubiquitin conjugating enzyme binding
GO:0032182--F:ubiquitin-like protein binding
GO:0030308--P:negative regulation of cell growth
GO:0043065--P:positive regulation of apoptotic process
GO:0051443--P:positive regulation of ubiquitin-protein transferase activity
GO:0045116--P:protein neddylation
GO:0010332--P:response to gamma radiation
GO:0009314--P:response to radiation
GO:0010225--P:response to UV-C
KEGG rno:309035
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001689 Ailuropoda melanoleuca 96.38 8.00e-166 575.00
IUUC-Apl-003497 Anas platyrhynchos 82.24 1.00e-143 501.00
IUUC-Aca-004961 Anolis carolinensis 79.93 1.00e-145 508.00
IUUC-Aor-009902 Aspergillus oryzae 33.33 2.00e-11 61.20
IUUC-Ame-011413 Astyanax mexicanus 64.39 2.00e-100 358.00
IUUC-Bta-013338 Bos taurus 97.04 1.00e-167 582.00
IUUC-Cja-019458 Callithrix jacchus 98.03 5.00e-170 590.00
IUUC-Cfa-020160 Canis familiaris 96.71 2.00e-166 578.00
IUUC-Cpo-021835 Cavia porcellus 97.37 8.00e-159 552.00
IUUC-Csa-023328 Chlorocebus sabaeus 98.36 1.00e-170 592.00
IUUC-Cho-024888 Choloepus hoffmanni 95.03 2.00e-164 570.00
IUUC-Cin-025134 Ciona intestinalis 55.61 5.00e-60 224.00
IUUC-Csv-025904 Ciona savignyi 50.41 2.00e-32 130.00
IUUC-Dre-027780 Danio rerio 64.75 9.00e-98 349.00
IUUC-Dno-028866 Dasypus novemcinctus 96.38 4.00e-165 573.00
IUUC-Dor-030387 Dipodomys ordii 96.71 3.00e-167 580.00
IUUC-Dme-032081 Drosophila melanogaster 45.61 3.00e-48 185.00
IUUC-Eca-033857 Equus caballus 96.71 1.00e-167 582.00
IUUC-Eeu-034825 Erinaceus europaeus 88.49 4.00e-150 523.00
IUUC-Fca-036130 Felis catus 97.04 2.00e-167 581.00
IUUC-Fal-037296 Ficedula albicollis 82.89 4.00e-143 500.00
IUUC-Gmo-039626 Gadus morhua 65.12 2.00e-98 352.00
IUUC-Ggr-039959 Gaeumannomyces graminis 26.64 4.00e-15 76.60
IUUC-Gga-040741 Gallus gallus 81.58 3.00e-140 491.00
IUUC-Gac-042271 Gasterosteus aculeatus 64.75 1.00e-92 332.00
IUUC-Ggo-044727 Gorilla gorilla 98.36 1.00e-170 592.00
IUUC-Hsa-046288 Homo sapiens 98.03 4.00e-170 590.00
IUUC-Itr-049054 Ictidomys tridecemlineatus 98.36 7.00e-179 619.00
IUUC-Lch-050289 Latimeria chalumnae 78.22 9.00e-133 466.00
IUUC-Loc-052455 Lepisosteus oculatus 71.22 1.00e-108 385.00
IUUC-Laf-054369 Loxodonta africana 94.74 3.00e-157 547.00
IUUC-Mcc-055413 Macaca mulatta 79.22 2.00e-123 434.00
IUUC-Meu-056535 Macropus eugenii 86.84 9.00e-153 532.00
IUUC-Mga-059290 Meleagris gallopavo 82.24 1.00e-142 498.00
IUUC-Mmr-060689 Microcebus murinus 98.03 6.00e-170 589.00
IUUC-Mdo-062128 Monodelphis domestica 86.18 7.00e-147 513.00
IUUC-Mmu-064396 Mus musculus 99.01 4.00e-180 623.00
IUUC-Mpu-065926 Mustela putorius furo 96.38 8.00e-166 575.00
IUUC-Mlu-067044 Myotis lucifugus 94.41 3.00e-171 593.00
IUUC-Nle-069346 Nomascus leucogenys 98.36 1.00e-170 592.00
IUUC-Opr-070682 Ochotona princeps 97.70 2.00e-157 548.00
IUUC-Ont-071772 Oreochromis niloticus 68.46 1.00e-101 362.00
IUUC-Oan-072765 Ornithorhynchus anatinus 84.21 2.00e-145 508.00
IUUC-Ocu-074272 Oryctolagus cuniculus 92.05 1.00e-119 422.00
IUUC-Ola-087561 Oryzias latipes 69.44 7.00e-108 383.00
IUUC-Oga-088440 Otolemur garnettii 78.38 1.00e-124 439.00
IUUC-Oar-089403 Ovis aries 97.37 1.00e-168 585.00
IUUC-Ptr-091384 Pan troglodytes 98.36 1.00e-170 592.00
IUUC-Pan-092650 Papio anubis 98.36 1.00e-170 592.00
IUUC-Psi-093806 Pelodiscus sinensis 82.89 6.00e-135 473.00
IUUC-Pma-094196 Petromyzon marinus 63.83 1.00e-87 315.00
IUUC-Pfo-096584 Poecilia formosa 70.00 2.00e-105 375.00
IUUC-Pab-098605 Pongo abelii 98.36 1.00e-170 592.00
IUUC-Pca-100933 Procavia capensis 78.95 7.00e-116 410.00
IUUC-Pva-102172 Pteropus vampyrus 92.18 3.00e-161 560.00
IUUC-Sha-106531 Sarcophilus harrisii 86.18 2.00e-152 531.00
IUUC-Sar-113051 Sorex araneus 75.66 1.00e-115 409.00
IUUC-Ssc-115555 Sus scrofa 96.71 2.00e-167 581.00
IUUC-Tgu-117178 Taeniopygia guttata 82.89 2.00e-144 504.00
IUUC-Tru-117876 Takifugu rubripes 67.48 8.00e-106 376.00
IUUC-Tsy-118790 Tarsius syrichta 96.20 6.00e-136 476.00
IUUC-Tni-119673 Tetraodon nigroviridis 66.23 1.00e-107 382.00
IUUC-Tbe-127429 Tupaia belangeri 98.03 3.00e-170 590.00
IUUC-Ttr-128467 Tursiops truncatus 97.04 4.00e-168 583.00
IUUC-Vpa-130376 Vicugna pacos 67.27 4.00e-96 343.00
IUUC-Xtr-132134 Xenopus tropicalis 80.00 1.00e-123 435.00
Created Date 25-Jun-2017

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