iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000055994.15	ENSMUST00000109634.2	ENSMUSP00000105262.2
ENSMUSG00000055994.15	ENSMUST00000054324.14	ENSMUSP00000050538.8

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	microRNA	TRANSFAC	RepTar
RAID2
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
Drug and target
GRAC
Post-translational Modifications (PTMs)
dbPAF
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/CARD	7.10e-13	50.0	141	182

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/CARD

   S: 3    eeyrlllstlqdrvrklLdvtdvldkylseflleeekelila 44
           ee+rl+++t ++r+r+lLd++ v++++l++fll+++ el+++
   Q: 141  EEIRLPIFTSSQRARRLLDLAAVKANGLAAFLLQHVRELPAP 182
           8*************************************9875 PP

Organism

Mus musculus

Functional Description
(View)

Involved in gastrointestinal immunity. Upon stimulation by muramyl dipeptide (MDP), a fragment of bacterial peptidoglycan, binds the proximal adapter receptor-interacting RIPK2, which recruits ubiquitin ligases as XIAP, BIRC2, BIRC3 and the LUBAC complex, triggering activation of MAP kinases and activation of NF-kappa-B signaling. This in turn leads to the transcriptional activation of hundreds of genes involved in immune response (PubMed:22607974). Required for MDP-induced NLRP1-dependent CASP1 activation and IL1B release in macrophages (PubMed:18511561).

Protein Sequence
(Fasta)

MCSQEEFQAQ RSQLVALLIS GSLEGFESIL DWLLSWDVLS REDYEGLSLP GQPLSHSARR 60
LLDTVWNKGV WGCQKLLEAV QEAQANSHTF ELYGSWDTHS LHPTRDLQSH RPAIVRRLYN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGTGGGTGGG GCGATGGGCG GGAGTAGATC ACTGAGGGAG TCCTAGTGTG GAGTCACCGC 60
AAAACTGGCG AGGGATCCCC ACGCTGCAGC TGGCGGTGAG TGCTTGCTTT CTGGTTCTGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0067--ATP-binding
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0391--Immunity
KW-0399--Innate immunity
KW-0433--Leucine-rich repeat
KW-0472--Membrane
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0677--Repeat
KW-0832--Ubl conjugation

Interpro

IPR001315--CARD
IPR011029--DEATH-like_dom
IPR018228--DNase_TatD-rel_CS
IPR032675--L_dom-like
IPR001611--Leu-rich_rpt
IPR007111--NACHT_NTPase
IPR027417--P-loop_NTPase

PROSITE

PS50209--CARD
PS50837--NACHT

Pfam

PF00619--CARD
PF13516--LRR_6

Gene Ontology

GO:0016323--C:basolateral plasma membrane
GO:0009986--C:cell surface
GO:0005737--C:cytoplasm
GO:0005856--C:cytoskeleton
GO:0005829--C:cytosol
GO:0005794--C:Golgi apparatus
GO:0005886--C:plasma membrane
GO:0043234--C:protein complex
GO:0031982--C:vesicle
GO:0003779--F:actin binding
GO:0005524--F:ATP binding
GO:0050700--F:CARD domain binding
GO:0016888--F:endodeoxyribonuclease activity, producing 5'-phosphomonoesters
GO:0019899--F:enzyme binding
GO:0030544--F:Hsp70 protein binding
GO:0051879--F:Hsp90 protein binding
GO:0032500--F:muramyl dipeptide binding
GO:0042834--F:peptidoglycan binding
GO:0019901--F:protein kinase binding
GO:0002253--P:activation of immune response
GO:0035419--P:activation of MAPK activity involved in innate immune response
GO:0071225--P:cellular response to muramyl dipeptide
GO:0071224--P:cellular response to peptidoglycan
GO:0002367--P:cytokine production involved in immune response
GO:0002374--P:cytokine secretion involved in immune response
GO:0006952--P:defense response
GO:0042742--P:defense response to bacterium
GO:0050830--P:defense response to Gram-positive bacterium
GO:0016045--P:detection of bacterium
GO:0009595--P:detection of biotic stimulus
GO:0032498--P:detection of muramyl dipeptide
GO:0002381--P:immunoglobulin production involved in immunoglobulin mediated immune response
GO:0006954--P:inflammatory response
GO:0045087--P:innate immune response
GO:0002227--P:innate immune response in mucosa
GO:0035556--P:intracellular signal transduction
GO:0071608--P:macrophage inflammatory protein-1 alpha production
GO:0030277--P:maintenance of gastrointestinal epithelium
GO:0044130--P:negative regulation of growth of symbiont in host
GO:0002862--P:negative regulation of inflammatory response to antigenic stimulus
GO:0032689--P:negative regulation of interferon-gamma production
GO:0032695--P:negative regulation of interleukin-12 production
GO:0032701--P:negative regulation of interleukin-18 production
GO:0032703--P:negative regulation of interleukin-2 production
GO:2000110--P:negative regulation of macrophage apoptotic process
GO:0032088--P:negative regulation of NF-kappaB transcription factor activity
GO:0002710--P:negative regulation of T cell mediated immunity
GO:0034136--P:negative regulation of toll-like receptor 2 signaling pathway
GO:0032720--P:negative regulation of tumor necrosis factor production
GO:0070431--P:nucleotide-binding oligomerization domain containing 2 signaling pathway
GO:0070423--P:nucleotide-binding oligomerization domain containing signaling pathway
GO:0006963--P:positive regulation of antibacterial peptide biosynthetic process
GO:0050871--P:positive regulation of B cell activation
GO:0006965--P:positive regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria
GO:1900017--P:positive regulation of cytokine production involved in inflammatory response
GO:0002606--P:positive regulation of dendritic cell antigen processing and presentation
GO:0050679--P:positive regulation of epithelial cell proliferation
GO:0070374--P:positive regulation of ERK1 and ERK2 cascade
GO:0002925--P:positive regulation of humoral immune response mediated by circulating immunoglobulin
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045089--P:positive regulation of innate immune response
GO:0032731--P:positive regulation of interleukin-1 beta production
GO:0050718--P:positive regulation of interleukin-1 beta secretion
GO:0032733--P:positive regulation of interleukin-10 production
GO:0032735--P:positive regulation of interleukin-12 production
GO:0032740--P:positive regulation of interleukin-17 production
GO:0032755--P:positive regulation of interleukin-6 production
GO:0032757--P:positive regulation of interleukin-8 production
GO:0046330--P:positive regulation of JNK cascade
GO:0043410--P:positive regulation of MAPK cascade
GO:0071639--P:positive regulation of monocyte chemotactic protein-1 production
GO:0051092--P:positive regulation of NF-kappaB transcription factor activity
GO:1901224--P:positive regulation of NIK/NF-kappaB signaling
GO:0051770--P:positive regulation of nitric-oxide synthase biosynthetic process
GO:0045747--P:positive regulation of Notch signaling pathway
GO:0051353--P:positive regulation of oxidoreductase activity
GO:0050731--P:positive regulation of peptidyl-tyrosine phosphorylation
GO:0050766--P:positive regulation of phagocytosis
GO:0043552--P:positive regulation of phosphatidylinositol 3-kinase activity
GO:2000363--P:positive regulation of prostaglandin-E synthase activity
GO:0060585--P:positive regulation of prostaglandin-endoperoxide synthase activity
GO:0031398--P:positive regulation of protein ubiquitination
GO:0032874--P:positive regulation of stress-activated MAPK cascade
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0032760--P:positive regulation of tumor necrosis factor production
GO:0002830--P:positive regulation of type 2 immune response
GO:1904417--P:positive regulation of xenophagy
GO:0051259--P:protein oligomerization
GO:0050727--P:regulation of inflammatory response
GO:0090022--P:regulation of neutrophil chemotaxis
GO:0043330--P:response to exogenous dsRNA
GO:0032496--P:response to lipopolysaccharide
GO:0032495--P:response to muramyl dipeptide
GO:0032494--P:response to peptidoglycan
GO:0007165--P:signal transduction

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001822	Ailuropoda melanoleuca	74.69	0.00e+00	1359.00
IUUC-Ame-011021	Astyanax mexicanus	45.11	0.00e+00	862.00
IUUC-Bta-013241	Bos taurus	74.30	0.00e+00	1477.00
IUUC-Cja-019633	Callithrix jacchus	74.17	0.00e+00	1125.00
IUUC-Cfa-020039	Canis familiaris	74.30	0.00e+00	1457.00
IUUC-Cpo-022337	Cavia porcellus	77.37	0.00e+00	1451.00
IUUC-Csa-023906	Chlorocebus sabaeus	78.07	0.00e+00	1525.00
IUUC-Dre-027568	Danio rerio	46.39	0.00e+00	823.00
IUUC-Dno-029098	Dasypus novemcinctus	74.13	0.00e+00	1352.00
IUUC-Dor-031102	Dipodomys ordii	78.88	7.00e-170	591.00
IUUC-Ete-032943	Echinops telfairi	72.09	0.00e+00	1032.00
IUUC-Eca-034310	Equus caballus	77.49	0.00e+00	1465.00
IUUC-Eeu-034589	Erinaceus europaeus	67.74	1.00e-149	524.00
IUUC-Fca-036252	Felis catus	72.85	0.00e+00	741.00
IUUC-Gac-041442	Gasterosteus aculeatus	45.03	0.00e+00	809.00
IUUC-Ggo-044861	Gorilla gorilla	77.78	0.00e+00	1474.00
IUUC-Hsa-046093	Homo sapiens	77.39	0.00e+00	1469.00
IUUC-Itr-048543	Ictidomys tridecemlineatus	76.01	0.00e+00	1392.00
IUUC-Lch-049454	Latimeria chalumnae	52.32	0.00e+00	906.00
IUUC-Laf-053553	Loxodonta africana	75.94	0.00e+00	1363.00
IUUC-Mcc-055772	Macaca mulatta	77.58	0.00e+00	1494.00
IUUC-Meu-056785	Macropus eugenii	67.38	8.00e-114	405.00
IUUC-Mmr-060596	Microcebus murinus	76.14	0.00e+00	1442.00
IUUC-Mdo-062983	Monodelphis domestica	62.36	0.00e+00	1041.00
IUUC-Mpu-066412	Mustela putorius furo	74.69	0.00e+00	1454.00
IUUC-Mlu-067601	Myotis lucifugus	73.69	0.00e+00	1330.00
IUUC-Nle-069913	Nomascus leucogenys	77.51	0.00e+00	1237.00
IUUC-Opr-070999	Ochotona princeps	75.68	0.00e+00	888.00
IUUC-Ont-072512	Oreochromis niloticus	45.40	0.00e+00	863.00
IUUC-Oan-073564	Ornithorhynchus anatinus	57.46	0.00e+00	1049.00
IUUC-Ocu-074837	Oryctolagus cuniculus	77.68	0.00e+00	1486.00
IUUC-Ola-086555	Oryzias latipes	43.60	0.00e+00	787.00
IUUC-Oga-088909	Otolemur garnettii	75.07	0.00e+00	1431.00
IUUC-Oar-089315	Ovis aries	73.65	0.00e+00	1426.00
IUUC-Ptr-090542	Pan troglodytes	78.07	0.00e+00	1479.00
IUUC-Pan-092545	Papio anubis	77.49	0.00e+00	1491.00
IUUC-Pma-094167	Petromyzon marinus	33.92	1.00e-65	244.00
IUUC-Ppa-095344	Physcomitrella patens	24.62	4.00e-05	43.50
IUUC-Pfo-096976	Poecilia formosa	44.31	0.00e+00	806.00
IUUC-Pab-098481	Pongo abelii	77.58	0.00e+00	1473.00
IUUC-Pca-100135	Procavia capensis	74.57	0.00e+00	1054.00
IUUC-Pva-102127	Pteropus vampyrus	73.53	0.00e+00	1311.00
IUUC-Rno-105783	Rattus norvegicus	91.50	0.00e+00	1766.00
IUUC-Sar-113448	Sorex araneus	68.56	0.00e+00	863.00
IUUC-Tru-118708	Takifugu rubripes	43.94	0.00e+00	758.00
IUUC-Tni-120172	Tetraodon nigroviridis	37.09	1.00e-33	137.00
IUUC-Tbe-127661	Tupaia belangeri	79.02	0.00e+00	745.00
IUUC-Ttr-128318	Tursiops truncatus	70.05	0.00e+00	1277.00
IUUC-Vpa-130502	Vicugna pacos	75.66	1.00e-78	288.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence