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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Hsa-047035
Ensembl Protein ID ENSP00000294008.3
UniProt Accession Q8IY92; Q69YT8; Q8TF15; Q96JP1; SLX4_HUMAN
Genbank Protein ID BAB85573.1; BAB47413.1; CAH10659.1
Protein Name Structure-specific endonuclease subunit SLX4; BTB/POZ domain-containing protein 12
Genbank Nucleotide ID AC006111; AB058687; AL442083
Gene Name SLX4; BTBD12; KIAA1784; KIAA1987
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000188827.10 ENST00000294008.3 ENSP00000294008.3
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
THPAHPM
DNA & RNA Element
UTRdbAREsiteCircNetmiRTarBase
microRNATRANSFACTargetScanRepTar
miRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
ClinVarGWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDUniProtBioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
UBD/ZnF/UBZ UBZ 23093618; 21464321
Classification
Family E-value Score Start End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB 0.00022 23.2 691 759
UBD/ZnF/UBZ 2.30e-10 42.1 294 319
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/BCR/BTB_Other: BTB
   S: 1    aDvilvvg.geeffahkivLaasSsvFyalf.lmele...esksklmveikdvqpevfrallkFlYtgk 64
           +Dv+++ + ge+  ahk vL a+++ +     + +++   ++  + +v + dv+ e+ r++l++lYt  
   Q: 691  SDVQFQTDsGEVLYAHKFVLYARCPLLIQYVnNEGFSaveDGVLTQRVLLGDVSTEAARTFLHYLYTAD 759
           69***************************9953444431144557888888****************75 PP
   

   UBD/ZnF/UBZ
   S: 2    lvCPvCqkm...vdqtdfeeHlDeCl 24
           ++C++Cqk    +++t++e+H+++Cl
   Q: 294  FFCQICQKNlsaMNVTRREQHVNRCL 319
           89***********************8 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Regulatory subunit that interacts with and increases the activity of different structure-specific endonucleases. Has several distinct roles in protecting genome stability by resolving diverse forms of deleterious DNA structures originating from replication and recombination intermediates and from DNA damage. Component of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. Interacts with the structure-specific ERCC4-ERCC1 endonuclease and promotes the cleavage of bubble structures. Interacts with the structure-specific MUS81-EME1 endonuclease and promotes the cleavage of 3'-flap and replication fork-like structures. SLX4 is required for recovery from alkylation-induced DNA damage and is involved in the resolution of DNA double-strand breaks.
 Regulatory subunit that interacts with and increases the activity of different structure-specific endonucleases. Has several distinct roles in protecting genome stability by resolving diverse forms of deleterious DNA structures originating from replication and recombination intermediates and from DNA damage. Component of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. Interacts with the structure-specific ERCC4-ERCC1 endonuclease and promotes the cleavage of bubble structures. Interacts with the structure-specific MUS81-EME1 endonuclease and promotes the cleavage of 3'-flap and replication fork-like structures. SLX4 is required for recovery from alkylation-induced DNA damage and is involved in the resolution of DNA double-strand breaks.
Protein Sequence
(Fasta)
MKLSVNEAQL GFYLGSLSHL SACPGIDPRS SEDQPESLKT GQMMDESDED FKELCASFFQ 60
RVKKHGIKEV SGERKTQKAA SNGTQIRSKL KRTKQTATKT KTLQGPAEKK PPSGSQAPRT 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-047035|UBD,UBZ;E3,BTB_Other|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GCGAGTCTCC GTTAAGAAGG TGCCGCGGCG GCGCCGGAGG TAGGAGGAGC CGGGCTGTGG 60
GGCTGGGAGT CGGCACCCGG GAGGCGGAGG TCCTGTCATT TCGGGCCGTT CTCTCTTTCC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-047035|UBD,UBZ;E3,BTB_Other|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0233--DNA recombination
KW-0234--DNA repair
KW-0923--Fanconi anemia
KW-1017--Isopeptide bond
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0832--Ubl conjugation
Interpro

IPR000210--BTB/POZ_dom
IPR011333--SKP1/BTB/POZ
IPR018574--Structure-sp_endonuc_su_Slx4
PROSITE

PS50097--BTB
Pfam

PF00651--BTB
PF09494--Slx4
SMART

SM00225--BTB
Gene Ontology

GO:0030054--C:cell junction
GO:0000781--C:chromosome, telomeric region
GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:0033557--C:Slx1-Slx4 complex
GO:0017108--F:5'-flap endonuclease activity
GO:0004520--F:endodeoxyribonuclease activity
GO:0008047--F:enzyme activator activity
GO:0010792--P:DNA double-strand break processing involved in repair via single-strand annealing
GO:0006281--P:DNA repair
GO:0006260--P:DNA replication
GO:0000724--P:double-strand break repair via homologous recombination
GO:0036297--P:interstrand cross-link repair
GO:0000706--P:meiotic DNA double-strand break processing
GO:1904357--P:negative regulation of telomere maintenance via telomere lengthening
GO:0006289--P:nucleotide-excision repair
GO:1904431--P:positive regulation of t-circle formation
GO:0000712--P:resolution of meiotic recombination intermediates
GO:0072429--P:response to intra-S DNA damage checkpoint signaling
GO:0090656--P:t-circle formation
GO:0061820--P:telomeric D-loop disassembly
KEGG hsa:84464
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001225 Ailuropoda melanoleuca 62.56 0.00e+00 1423.00
IUUC-Apl-003261 Anas platyrhynchos 41.26 1.00e-146 514.00
IUUC-Aca-004455 Anolis carolinensis 59.65 1.00e-15 73.90
IUUC-Acl-008026 Aspergillus clavatus 25.51 1.10e-02 35.80
IUUC-Ame-010993 Astyanax mexicanus 36.03 9.00e-11 60.10
IUUC-Bta-013472 Bos taurus 60.94 0.00e+00 1483.00
IUUC-Bci-013652 Botrytis cinerea 27.27 9.80e-02 32.70
IUUC-Bdi-014556 Brachypodium distachyon 35.16 7.00e-06 45.10
IUUC-Cel-018663 Caenorhabditis elegans 38.64 5.00e-03 36.60
IUUC-Cja-019406 Callithrix jacchus 84.38 0.00e+00 2440.00
IUUC-Cfa-020129 Canis familiaris 62.02 0.00e+00 1551.00
IUUC-Cpo-021944 Cavia porcellus 60.46 0.00e+00 920.00
IUUC-Csa-023941 Chlorocebus sabaeus 88.66 0.00e+00 1321.00
IUUC-Cho-024847 Choloepus hoffmanni 70.36 3.00e-171 596.00
IUUC-Cin-025405 Ciona intestinalis 44.23 2.00e-07 50.40
IUUC-Csv-025916 Ciona savignyi 37.29 3.00e-08 52.40
IUUC-Dre-027764 Danio rerio 34.03 3.00e-78 287.00
IUUC-Dno-030083 Dasypus novemcinctus 58.42 0.00e+00 1383.00
IUUC-Dor-031129 Dipodomys ordii 52.35 0.00e+00 1063.00
IUUC-Dse-031510 Dothistroma septosporum 38.89 2.50e-02 35.00
IUUC-Ete-032536 Echinops telfairi 45.25 4.00e-122 433.00
IUUC-Eca-033407 Equus caballus 64.98 0.00e+00 1392.00
IUUC-Eeu-034473 Erinaceus europaeus 52.11 8.00e-60 226.00
IUUC-Fca-035730 Felis catus 61.73 0.00e+00 1485.00
IUUC-Fal-036850 Ficedula albicollis 43.27 6.00e-136 479.00
IUUC-Gmo-038677 Gadus morhua 43.78 1.00e-39 158.00
IUUC-Gga-041088 Gallus gallus 38.17 2.00e-129 457.00
IUUC-Gac-041824 Gasterosteus aculeatus 76.32 1.00e-12 66.20
IUUC-Ggo-045642 Gorilla gorilla 97.66 0.00e+00 2497.00
IUUC-Hvu-047552 Hordeum vulgare 34.23 2.00e-06 46.60
IUUC-Itr-049010 Ictidomys tridecemlineatus 64.48 0.00e+00 1737.00
IUUC-Kpa-049328 Komagataella pastoris 29.41 1.00e-03 38.10
IUUC-Lch-050364 Latimeria chalumnae 41.98 5.00e-79 290.00
IUUC-Loc-052423 Lepisosteus oculatus 36.62 5.00e-47 184.00
IUUC-Lma-053057 Leptosphaeria maculans 29.17 1.20e-01 32.00
IUUC-Laf-053910 Loxodonta africana 58.17 0.00e+00 1372.00
IUUC-Mcc-055883 Macaca mulatta 90.02 0.00e+00 2769.00
IUUC-Meu-056224 Macropus eugenii 52.51 3.00e-91 330.00
IUUC-Mga-059880 Meleagris gallopavo 44.44 3.00e-133 470.00
IUUC-Mvi-060510 Microbotryum violaceum 32.73 1.00e-03 39.30
IUUC-Mmr-061715 Microcebus murinus 69.44 0.00e+00 1961.00
IUUC-Mdo-062426 Monodelphis domestica 43.15 0.00e+00 1029.00
IUUC-Mmu-063947 Mus musculus 56.32 0.00e+00 1379.00
IUUC-Mpu-066184 Mustela putorius furo 66.03 0.00e+00 962.00
IUUC-Mlu-067533 Myotis lucifugus 63.61 0.00e+00 1529.00
IUUC-Nle-069204 Nomascus leucogenys 93.20 0.00e+00 2880.00
IUUC-Opr-070377 Ochotona princeps 63.89 0.00e+00 937.00
IUUC-Ont-072551 Oreochromis niloticus 32.54 6.00e-63 236.00
IUUC-Oan-073350 Ornithorhynchus anatinus 49.72 5.00e-102 365.00
IUUC-Ocu-074915 Oryctolagus cuniculus 62.58 0.00e+00 942.00
IUUC-Ola-087360 Oryzias latipes 78.72 2.00e-17 82.40
IUUC-Oga-089106 Otolemur garnettii 62.01 0.00e+00 1385.00
IUUC-Oar-089289 Ovis aries 60.26 0.00e+00 1022.00
IUUC-Ptr-091469 Pan troglodytes 98.09 0.00e+00 2964.00
IUUC-Pan-091841 Papio anubis 90.12 0.00e+00 2166.00
IUUC-Psi-093842 Pelodiscus sinensis 47.28 4.00e-92 334.00
IUUC-Pma-094732 Petromyzon marinus 57.69 3.00e-09 55.10
IUUC-Pfo-097299 Poecilia formosa 37.44 2.00e-30 128.00
IUUC-Pab-098271 Pongo abelii 94.67 0.00e+00 2862.00
IUUC-Pca-100721 Procavia capensis 56.48 0.00e+00 928.00
IUUC-Pva-102276 Pteropus vampyrus 66.69 0.00e+00 1745.00
IUUC-Rno-105619 Rattus norvegicus 57.94 0.00e+00 1484.00
IUUC-Sha-106722 Sarcophilus harrisii 44.62 0.00e+00 1049.00
IUUC-Sar-113673 Sorex araneus 50.93 1.00e-72 269.00
IUUC-Sre-115039 Sporisorium reilianum 33.90 2.00e-04 40.00
IUUC-Ssc-115383 Sus scrofa 58.49 0.00e+00 1285.00
IUUC-Tgu-117243 Taeniopygia guttata 49.50 7.00e-93 334.00
IUUC-Tru-118092 Takifugu rubripes 39.10 2.00e-26 112.00
IUUC-Tsy-119362 Tarsius syrichta 68.25 0.00e+00 738.00
IUUC-Tni-120380 Tetraodon nigroviridis 66.13 1.00e-17 83.20
IUUC-Tbe-127404 Tupaia belangeri 51.54 0.00e+00 726.00
IUUC-Ttr-128317 Tursiops truncatus 66.77 0.00e+00 1645.00
IUUC-Uma-129640 Ustilago maydis 33.96 3.00e-03 36.20
IUUC-Vda-129851 Verticillium dahliae 28.00 4.20e-02 33.50
IUUC-Xtr-132533 Xenopus tropicalis 39.08 7.00e-92 333.00
IUUC-Xma-134059 Xiphophorus maculatus 40.85 5.00e-33 137.00
Created Date 25-Jun-2017

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