iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000005699.16	ENSMUST00000098444.8	ENSMUSP00000096043.2
ENSMUSG00000005699.16	ENSMUST00000212352.1	ENSMUSP00000148508.1
ENSMUSG00000005699.16	ENSMUST00000211888.1	ENSMUSP00000148821.1
ENSMUSG00000005699.16	ENSMUST00000212430.1	ENSMUSP00000148603.1
ENSMUSG00000005699.16	ENSMUST00000093195.6	ENSMUSP00000090886.6

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
microRNA	TRANSFAC	RepTar	miRNAMap
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	Mentha
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM	Phospho.ELM
UniProt	PHOSIDA	BioGRID
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
ULD/UDP/UFD/PB1	4.80e-16	59.8	16	94

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

ULD/UDP/UFD/PB1

   S: 2    vrvkvsykgeirsfaldlekpgkfedLlkavrtltelknsevalkYeDedGDlvtlksDedldkavsllaskksllrlliqk 83
           v+vk+++++e+r+fal + ++ +f+++ +++  ++++++ +v l+Y+D++GDl++l++D+ l+ a+    s  + lrll+qk
   Q: 16   VEVKSKFDAEFRRFALPRTSVRGFQEFSRLLCVVHQIPGLDVLLGYTDAHGDLLPLTNDDSLHRALA---SGPPPLRLLVQK 94
           79*****************************************************************...**********98 PP

Organism

Mus musculus

Functional Description
(View)

Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in the formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins (PubMed:15761148). Regulates centrosome organization and function. Essential for the centrosomal recruitment of key proteins that control centrosomal microtubule organization (By similarity).

Protein Sequence
(Fasta)

MARPQRTPAR SPDSIVEVKS KFDAEFRRFA LPRTSVRGFQ EFSRLLCVVH QIPGLDVLLG 60
YTDAHGDLLP LTNDDSLHRA LASGPPPLRL LVQKRAEGDS SGLAFASNSL QRRKKGLLLR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGTTCTGCGC CTGCGCAAGC TCTTCCCGGG TCCTGCTGAC TGACCTAGCT GCTGGCTGAT 60
GACAGTTTAT TCTTACCGGG GCATCTCTCT GAGCCCGTGA GCTGTTCCTC AGTACAACTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0131--Cell cycle
KW-0132--Cell division
KW-0965--Cell junction
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0796--Tight junction

Interpro

IPR000270--PB1_dom
IPR001478--PDZ

PROSITE

PS51745--PB1
PS50106--PDZ

Pfam

PF00564--PB1
PF00595--PDZ

SMART

SM00666--PB1
SM00228--PDZ

Gene Ontology

GO:0045177--C:apical part of cell
GO:0005923--C:bicellular tight junction
GO:0005938--C:cell cortex
GO:0030054--C:cell junction
GO:0034451--C:centriolar satellite
GO:0005813--C:centrosome
GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0043234--C:protein complex
GO:0030742--F:GTP-dependent protein binding
GO:0005080--F:protein kinase C binding
GO:0017048--F:Rho GTPase binding
GO:0007049--P:cell cycle
GO:0051301--P:cell division
GO:0045217--P:cell-cell junction maintenance
GO:0051297--P:centrosome organization
GO:0030010--P:establishment of cell polarity
GO:0001933--P:negative regulation of protein phosphorylation
GO:1904781--P:positive regulation of protein localization to centrosome

KEGG

mmu:56513

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001436	Ailuropoda melanoleuca	92.77	4.00e-178	616.00
IUUC-Apl-004064	Anas platyrhynchos	71.60	1.00e-102	366.00
IUUC-Bta-012518	Bos taurus	90.46	3.00e-160	557.00
IUUC-Cja-019906	Callithrix jacchus	91.91	3.00e-166	577.00
IUUC-Cfa-020182	Canis familiaris	93.06	2.00e-177	615.00
IUUC-Cpo-021341	Cavia porcellus	92.49	1.00e-169	588.00
IUUC-Csa-023165	Chlorocebus sabaeus	93.06	5.00e-170	590.00
IUUC-Dre-027395	Danio rerio	66.40	2.00e-87	316.00
IUUC-Dno-028998	Dasypus novemcinctus	90.75	2.00e-163	567.00
IUUC-Dor-030206	Dipodomys ordii	91.91	3.00e-167	580.00
IUUC-Ete-032644	Echinops telfairi	74.62	1.00e-115	409.00
IUUC-Eca-033390	Equus caballus	92.77	2.00e-170	591.00
IUUC-Fca-035382	Felis catus	92.49	3.00e-164	570.00
IUUC-Gga-040804	Gallus gallus	75.88	4.00e-112	397.00
IUUC-Ggo-044974	Gorilla gorilla	93.06	2.00e-171	594.00
IUUC-Hsa-045815	Homo sapiens	93.06	3.00e-171	594.00
IUUC-Itr-047959	Ictidomys tridecemlineatus	92.51	6.00e-174	603.00
IUUC-Loc-051759	Lepisosteus oculatus	70.61	2.00e-107	382.00
IUUC-Laf-054157	Loxodonta africana	88.44	1.00e-166	578.00
IUUC-Mcc-054932	Macaca mulatta	92.20	5.00e-167	580.00
IUUC-Meu-056725	Macropus eugenii	73.27	1.00e-119	422.00
IUUC-Mpo-057356	Magnaporthe poae	47.37	2.10e-02	36.20
IUUC-Mvi-060532	Microbotryum violaceum	31.25	2.50e-01	30.80
IUUC-Mmr-061600	Microcebus murinus	93.94	8.00e-170	589.00
IUUC-Mdo-062981	Monodelphis domestica	75.14	8.00e-137	479.00
IUUC-Mpu-066720	Mustela putorius furo	92.49	7.00e-177	612.00
IUUC-Mlu-067104	Myotis lucifugus	90.86	3.00e-166	577.00
IUUC-Nle-070003	Nomascus leucogenys	92.20	7.00e-174	602.00
IUUC-Opr-070932	Ochotona princeps	82.71	7.00e-145	506.00
IUUC-Ont-072310	Oreochromis niloticus	66.03	2.00e-93	335.00
IUUC-Oan-073018	Ornithorhynchus anatinus	78.84	8.00e-117	413.00
IUUC-Ocu-074524	Oryctolagus cuniculus	93.01	9.00e-158	549.00
IUUC-Oga-089103	Otolemur garnettii	90.46	1.00e-168	585.00
IUUC-Oar-090055	Ovis aries	91.33	1.00e-163	568.00
IUUC-Ptr-090840	Pan troglodytes	92.20	9.00e-168	582.00
IUUC-Pan-092904	Papio anubis	92.77	1.00e-169	588.00
IUUC-Psi-093762	Pelodiscus sinensis	71.88	5.00e-86	310.00
IUUC-Pfo-096234	Poecilia formosa	64.75	8.00e-90	323.00
IUUC-Pab-097709	Pongo abelii	92.49	1.00e-170	592.00
IUUC-Pca-100345	Procavia capensis	89.36	9.00e-157	546.00
IUUC-Pva-102267	Pteropus vampyrus	91.33	1.00e-164	572.00
IUUC-Rno-105067	Rattus norvegicus	98.84	3.00e-171	594.00
IUUC-Smo-109040	Selaginella moellendorffii	27.50	3.00e-03	37.00
IUUC-Sar-113091	Sorex araneus	79.19	9.00e-137	479.00
IUUC-Tgu-117416	Taeniopygia guttata	76.37	3.00e-105	374.00
IUUC-Tni-120748	Tetraodon nigroviridis	61.01	4.00e-92	330.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence