iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	microRNA	TRANSFAC	RepTar
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha
Protein 3D Structure
PDB	MMDB
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
UniProt	PHOSIDA
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/SCF/F-box	F-box	17494702

Classification

Family	E-value	Score	Start	End
E3 adaptor/Cullin RING/SCF/F-box	0.031	15.5	42	92

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/SCF/F-box

   S: 94   peegpdaglldrlpeeilveilklldkee.llraarvcrrwqelasqkalw 143
            ee    + l +lpe +l+++l  l+++e ++++++vc rw+el +   lw
   Q: 42   EEEAEAVEYLAELPEPLLLRVLAELPATElVQACRLVCLRWKELVDGAPLW 92
           45556678899**************9988688899*******998866665 PP

Organism

Mus musculus

Functional Description
(View)

Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Involved in the endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranslocated into the cytosol and promoting their ubiquitination and subsequent degradation. Prevents formation of cytosolic aggregates of unfolded glycoproteins that have been retrotranslocated into the cytosol. Able to recognize and bind denatured glycoproteins, preferentially those of the high-mannose type.

Protein Sequence
(Fasta)

MDGDGDPESV SHPEEASPEE QPEEAGAEAS AEEEQLREAE EEEEAEAVEY LAELPEPLLL 60
RVLAELPATE LVQACRLVCL RWKELVDGAP LWLLKCQQEG LVPEGSADEE RDHWQQFYFL 120

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Nucleotide Sequence
(Fasta)

TGACGCGGGC AGCTCCAGGA CTCGCCACCC GCAGCGCTCA GGCTCTTCTC TCTTGACAGC 60
ACCGCAGCGA TGGATGGAGA TGGTGATCCA GGTATCCGCT GCTGGCCCCG CTAGATACAG 120

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Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0256--Endoplasmic reticulum
KW-0430--Lectin
KW-0472--Membrane
KW-0492--Microsome
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR007397--F-box-assoc_dom
IPR001810--F-box_dom
IPR008979--Galactose-bd-like

PROSITE

PS51114--FBA
PS50181--FBOX

Pfam

PF00646--F-box
PF04300--FBA

SMART

SM01198--FBA

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0043197--C:dendritic spine
GO:0005783--C:endoplasmic reticulum
GO:0070062--C:extracellular exosome
GO:0031090--C:organelle membrane
GO:0019005--C:SCF ubiquitin ligase complex
GO:0001540--F:beta-amyloid binding
GO:0030246--F:carbohydrate binding
GO:0001948--F:glycoprotein binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0006516--P:glycoprotein catabolic process
GO:0008285--P:negative regulation of cell proliferation
GO:0016567--P:protein ubiquitination
GO:0031396--P:regulation of protein ubiquitination
GO:0031146--P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0030433--P:ubiquitin-dependent ERAD pathway
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

mmu:230904

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001683	Ailuropoda melanoleuca	81.00	1.00e-119	422.00
IUUC-Apl-003298	Anas platyrhynchos	68.62	6.00e-98	350.00
IUUC-Aca-005151	Anolis carolinensis	64.85	2.00e-87	315.00
IUUC-Ame-011216	Astyanax mexicanus	50.92	6.00e-57	213.00
IUUC-Bta-013523	Bos taurus	87.92	6.00e-123	433.00
IUUC-Cja-019449	Callithrix jacchus	91.15	3.00e-120	424.00
IUUC-Cfa-021011	Canis familiaris	89.58	7.00e-125	439.00
IUUC-Cpo-021870	Cavia porcellus	76.74	3.00e-119	421.00
IUUC-Csa-024225	Chlorocebus sabaeus	91.15	7.00e-121	426.00
IUUC-Dno-029067	Dasypus novemcinctus	87.50	9.00e-92	329.00
IUUC-Dor-030945	Dipodomys ordii	90.04	2.00e-121	428.00
IUUC-Ete-032537	Echinops telfairi	88.94	2.00e-111	395.00
IUUC-Eca-033888	Equus caballus	89.82	3.00e-118	417.00
IUUC-Eeu-034498	Erinaceus europaeus	89.93	3.00e-76	277.00
IUUC-Fca-035793	Felis catus	88.44	2.00e-116	411.00
IUUC-Fal-037415	Ficedula albicollis	68.62	2.00e-92	331.00
IUUC-Gmo-039430	Gadus morhua	57.23	6.00e-48	183.00
IUUC-Gga-040818	Gallus gallus	69.46	2.00e-99	355.00
IUUC-Ggo-045653	Gorilla gorilla	91.59	1.00e-114	405.00
IUUC-Hsa-045945	Homo sapiens	91.15	4.00e-114	404.00
IUUC-Itr-048593	Ictidomys tridecemlineatus	91.23	7.00e-121	426.00
IUUC-Lch-049839	Latimeria chalumnae	52.30	2.00e-77	281.00
IUUC-Laf-053956	Loxodonta africana	87.07	9.00e-119	419.00
IUUC-Mcc-054799	Macaca mulatta	91.59	3.00e-121	427.00
IUUC-Mtr-057935	Medicago truncatula	27.94	2.10e-01	29.60
IUUC-Mga-059915	Meleagris gallopavo	69.46	1.00e-99	355.00
IUUC-Mdo-062296	Monodelphis domestica	71.55	1.00e-101	362.00
IUUC-Mpu-066032	Mustela putorius furo	88.31	8.00e-120	422.00
IUUC-Mlu-066950	Myotis lucifugus	71.43	2.00e-107	382.00
IUUC-Nle-069626	Nomascus leucogenys	90.83	3.00e-120	424.00
IUUC-Opr-070783	Ochotona princeps	90.52	2.00e-122	431.00
IUUC-Oan-073742	Ornithorhynchus anatinus	73.95	5.00e-92	330.00
IUUC-Oga-088822	Otolemur garnettii	89.04	3.00e-117	414.00
IUUC-Oar-089801	Ovis aries	88.31	3.00e-119	421.00
IUUC-Ptr-091637	Pan troglodytes	91.15	4.00e-114	404.00
IUUC-Pan-092330	Papio anubis	91.59	2.00e-121	428.00
IUUC-Psi-093974	Pelodiscus sinensis	66.95	2.00e-95	341.00
IUUC-Ppa-095869	Physcomitrella patens	23.02	8.00e-13	67.80
IUUC-Pab-097688	Pongo abelii	92.04	2.00e-121	428.00
IUUC-Pca-100828	Procavia capensis	92.62	1.00e-78	285.00
IUUC-Pva-102795	Pteropus vampyrus	89.96	2.00e-120	424.00
IUUC-Rno-106103	Rattus norvegicus	96.51	2.00e-129	455.00
IUUC-Smo-108894	Selaginella moellendorffii	21.28	2.00e-08	53.50
IUUC-Stu-112556	Solanum tuberosum	36.17	1.40e-02	33.10
IUUC-Ssc-115796	Sus scrofa	88.70	8.00e-120	422.00
IUUC-Tgu-116848	Taeniopygia guttata	68.20	2.00e-90	324.00
IUUC-Tre-121870	Trichoderma reesei	51.85	2.80e-01	29.60
IUUC-Tvi-122582	Trichoderma virens	25.00	3.60e-01	29.30
IUUC-Tbe-127621	Tupaia belangeri	87.88	2.00e-81	295.00
IUUC-Ttr-128809	Tursiops truncatus	86.40	1.00e-106	379.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence