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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Rno-105309
Ensembl Protein ID ENSRNOP00000012432.6
UniProt Accession P50545; Q64647; Q6AYV7; HCK_RAT
Genbank Protein ID AAA41312.1; AAB20754.1; CAA44218.1; AAH78890.2
Protein Name Tyrosine-protein kinase HCK; Hematopoietic cell kinase; Hemopoietic cell kinase; p56-HCK; p56Hck; p59Hck
Genbank Nucleotide ID M83666; S74141; X62345; BC078890
Gene Name Hck
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSRNOG00000009331.6 ENSRNOT00000012432.6 ENSRNOP00000012432.6
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpress
DNA & RNA Element
microRNATRANSFACmiRNAMapRAID2
Protein-protein Interaction
IID
Drug and target
GRAC
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTM
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
UBD/SH3 9.70e-17 61.1 57 114
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/SH3
   S: 3    kekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           +  v +lydyea + ++L+++kGd++ v+   e++++W+k+ + +++k+G +P+n+v++++
   Q: 57   DTIVVALYDYEAIHREDLSFQKGDQMVVL---EESGEWWKARSLATKKEGYIPSNYVARVN 114
           56899************************...99*************************97 PP
   
Organism Rattus norvegicus
Functional Description
(View)

Functional Description


     Non-receptor tyrosine-protein kinase found in hematopoietic cells that transmits signals from cell surface receptors and plays an important role in the regulation of innate immune responses, including neutrophil, monocyte, macrophage and mast cell functions, phagocytosis, cell survival and proliferation, cell adhesion and migration. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as FCGR1A and FCGR2A, but also CSF3R, PLAUR, the receptors for IFNG, IL2, IL6 and IL8, and integrins, such as ITGB1 and ITGB2. During the phagocytic process, mediates mobilization of secretory lysosomes, degranulation, and activation of NADPH oxidase to bring about the respiratory burst. Plays a role in the release of inflammatory molecules. Promotes reorganization of the actin cytoskeleton and actin polymerization, formation of podosomes and cell protrusions. Inhibits TP73-mediated transcription activation and TP73-mediated apoptosis. Phosphorylates CBL in response to activation of immunoglobulin gamma Fc region receptors. Phosphorylates ADAM15, BCR, ELMO1, FCGR2A, GAB1, GAB2, RAPGEF1, STAT5B, TP73, VAV1 and WAS (By similarity).
 Non-receptor tyrosine-protein kinase found in hematopoietic cells that transmits signals from cell surface receptors and plays an important role in the regulation of innate immune responses, including neutrophil, monocyte, macrophage and mast cell functions, phagocytosis, cell survival and proliferation, cell adhesion and migration. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as FCGR1A and FCGR2A, but also CSF3R, PLAUR, the receptors for IFNG, IL2, IL6 and IL8, and integrins, such as ITGB1 and ITGB2. During the phagocytic process, mediates mobilization of secretory lysosomes, degranulation, and activation of NADPH oxidase to bring about the respiratory burst. Plays a role in the release of inflammatory molecules. Promotes reorganization of the actin cytoskeleton and actin polymerization, formation of podosomes and cell protrusions. Inhibits TP73-mediated transcription activation and TP73-mediated apoptosis. Phosphorylates CBL in response to activation of immunoglobulin gamma Fc region receptors. Phosphorylates ADAM15, BCR, ELMO1, FCGR2A, GAB1, GAB2, RAPGEF1, STAT5B, TP73, VAV1 and WAS (By similarity).
Protein Sequence
(Fasta)
MGCVKSRFLR EGSKASKIEP NANQKGPVYV PDPTSPKKLG PNSINSLPPG VVEGSEDTIV 60
VALYDYEAIH REDLSFQKGD QMVVLEESGE WWKARSLATK KEGYIPSNYV ARVNSLETEE 120
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Protein Fasta Sequence


>IUUC-Rno-105309|UBD,SH3|Rattus norvegicus
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Nucleotide Sequence
(Fasta)
GGCCAGTGAG CACCACCGGG TTGCCGCTCC CCGCTTGCAC TTTACGGTTG CGGCTCTCAG 60
ACGGGTGGGA GGGAACCAAA GTCGCCGGTA AAGGCGGCTC TGACCCGCTC GGAGCGCCAA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Rno-105309|UBD,SH3|Rattus norvegicus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0024--Alternative initiation
KW-0067--ATP-binding
KW-0965--Cell junction
KW-1003--Cell membrane
KW-0966--Cell projection
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0968--Cytoplasmic vesicle
KW-0206--Cytoskeleton
KW-0268--Exocytosis
KW-0333--Golgi apparatus
KW-0391--Immunity
KW-0395--Inflammatory response
KW-0399--Innate immunity
KW-0418--Kinase
KW-0449--Lipoprotein
KW-0458--Lysosome
KW-0472--Membrane
KW-0519--Myristate
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-0564--Palmitate
KW-0581--Phagocytosis
KW-0597--Phosphoprotein
KW-0656--Proto-oncogene
KW-1185--Reference proteome
KW-0727--SH2 domain
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase
KW-0832--Ubl conjugation
Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom
PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3
Pfam

PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1
PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00109--TYRKINASE
SMART

SM00252--SH2
SM00326--SH3
SM00219--TyrKc
Gene Ontology

GO:0005901--C:caveola
GO:0042995--C:cell projection
GO:0005856--C:cytoskeleton
GO:0005829--C:cytosol
GO:0031234--C:extrinsic component of cytoplasmic side of plasma membrane
GO:0005925--C:focal adhesion
GO:0005794--C:Golgi apparatus
GO:0005764--C:lysosome
GO:0005654--C:nucleoplasm
GO:0030133--C:transport vesicle
GO:0005524--F:ATP binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0004713--F:protein tyrosine kinase activity
GO:0005102--F:receptor binding
GO:0030154--P:cell differentiation
GO:0016477--P:cell migration
GO:0006887--P:exocytosis
GO:0006954--P:inflammatory response
GO:0045087--P:innate immune response
GO:0038083--P:peptidyl-tyrosine autophosphorylation
GO:0018108--P:peptidyl-tyrosine phosphorylation
GO:0006909--P:phagocytosis
GO:2000251--P:positive regulation of actin cytoskeleton reorganization
GO:0008284--P:positive regulation of cell proliferation
GO:0046777--P:protein autophosphorylation
GO:0042127--P:regulation of cell proliferation
GO:0008360--P:regulation of cell shape
GO:0050764--P:regulation of phagocytosis
GO:0071801--P:regulation of podosome assembly
GO:0007169--P:transmembrane receptor protein tyrosine kinase signaling pathway
KEGG rno:25734
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001284 Ailuropoda melanoleuca 87.52 0.00e+00 921.00
IUUC-Apl-003285 Anas platyrhynchos 77.36 0.00e+00 806.00
IUUC-Aca-004724 Anolis carolinensis 76.73 0.00e+00 789.00
IUUC-Ame-011954 Astyanax mexicanus 74.11 0.00e+00 763.00
IUUC-Bta-013060 Bos taurus 90.26 0.00e+00 955.00
IUUC-Cja-019817 Callithrix jacchus 90.30 0.00e+00 929.00
IUUC-Cfa-020511 Canis familiaris 88.27 0.00e+00 936.00
IUUC-Cpo-022538 Cavia porcellus 89.48 0.00e+00 947.00
IUUC-Csa-024143 Chlorocebus sabaeus 90.08 0.00e+00 943.00
IUUC-Dre-028157 Danio rerio 73.81 0.00e+00 783.00
IUUC-Dno-029761 Dasypus novemcinctus 88.49 0.00e+00 934.00
IUUC-Eca-034090 Equus caballus 87.48 0.00e+00 917.00
IUUC-Fca-035937 Felis catus 86.08 0.00e+00 888.00
IUUC-Fal-036624 Ficedula albicollis 77.65 0.00e+00 810.00
IUUC-Gmo-039009 Gadus morhua 71.68 0.00e+00 756.00
IUUC-Gga-040296 Gallus gallus 75.25 0.00e+00 789.00
IUUC-Gac-042362 Gasterosteus aculeatus 72.98 0.00e+00 776.00
IUUC-Ggo-044570 Gorilla gorilla 89.50 0.00e+00 932.00
IUUC-Hsa-046378 Homo sapiens 89.70 0.00e+00 940.00
IUUC-Itr-048695 Ictidomys tridecemlineatus 91.47 0.00e+00 962.00
IUUC-Loc-052904 Lepisosteus oculatus 77.56 0.00e+00 825.00
IUUC-Laf-053654 Loxodonta africana 88.67 0.00e+00 942.00
IUUC-Mcc-055317 Macaca mulatta 90.48 0.00e+00 951.00
IUUC-Mga-060194 Meleagris gallopavo 80.85 0.00e+00 773.00
IUUC-Mmr-061510 Microcebus murinus 89.48 0.00e+00 944.00
IUUC-Mdo-062035 Monodelphis domestica 83.53 0.00e+00 890.00
IUUC-Mmu-064037 Mus musculus 97.42 0.00e+00 1025.00
IUUC-Mpu-066874 Mustela putorius furo 88.10 0.00e+00 939.00
IUUC-Mlu-068202 Myotis lucifugus 85.29 0.00e+00 887.00
IUUC-Nle-069222 Nomascus leucogenys 90.08 0.00e+00 941.00
IUUC-Opr-070705 Ochotona princeps 87.13 0.00e+00 929.00
IUUC-Ont-072347 Oreochromis niloticus 81.03 0.00e+00 763.00
IUUC-Ocu-074490 Oryctolagus cuniculus 88.07 0.00e+00 937.00
IUUC-Ola-086521 Oryzias latipes 79.24 0.00e+00 768.00
IUUC-Oga-088153 Otolemur garnettii 88.89 0.00e+00 937.00
IUUC-Oar-090184 Ovis aries 90.12 0.00e+00 954.00
IUUC-Ptr-090505 Pan troglodytes 85.74 0.00e+00 880.00
IUUC-Pan-092260 Papio anubis 90.28 0.00e+00 950.00
IUUC-Pma-094311 Petromyzon marinus 69.94 0.00e+00 739.00
IUUC-Pfo-096566 Poecilia formosa 74.66 0.00e+00 797.00
IUUC-Pva-103021 Pteropus vampyrus 88.89 0.00e+00 942.00
IUUC-Sha-107099 Sarcophilus harrisii 82.05 0.00e+00 879.00
IUUC-Tgu-116912 Taeniopygia guttata 76.97 0.00e+00 798.00
IUUC-Tru-118449 Takifugu rubripes 78.24 0.00e+00 751.00
IUUC-Tae-123706 Triticum aestivum 31.40 1.00e-22 102.00
IUUC-Tur-126022 Triticum urartu 31.40 1.00e-22 102.00
IUUC-Tbe-128144 Tupaia belangeri 86.00 0.00e+00 796.00
IUUC-Xma-133902 Xiphophorus maculatus 74.16 0.00e+00 789.00
Created Date 25-Jun-2017

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