iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	miRTarBase	microRNA	TRANSFAC
RepTar	RAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/U-box	2.90e-06	28.4	29	90
E3 activity/RING/RING	3.80e-06	28.4	33	73

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 4    eeflCpIslelMrdPvvlp.sGitydrssIekwlasggktcPvtrqplteedl.vPnltlrr 63
           ++f CpI le+ + Pv +  +G+t+  ++++ +l+     cP++r p++++++ +  ++ ++
   Q: 29   AQFSCPICLEVYHRPVAIGsCGHTFCGECLQPCLQVPSPLCPLCRLPFDPKKVdKATHVEKQ 90
           58**************9877****************************99988666666555 PP

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C+iCle + +++ +++CgH+f+ +Clq       ++ ++ +CPlCr
   Q: 33   CPICLEVYHRPVAIGSCGHTFCGECLQPC-----LQVPSPLCPLCR 73
           **********999************9444.....799********8 PP

Organism

Mus musculus

Protein Sequence
(Fasta)

MAMFRSLVAS AQQRQPPAGP AGGDSGLEAQ FSCPICLEVY HRPVAIGSCG HTFCGECLQP 60
CLQVPSPLCP LCRLPFDPKK VDKATHVEKQ LSSYKAPCRG CNKKVTLAKM RAHISSCLKV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGTCTGCCGG CCTGGATAGG GGGCGGCGGC GGCGGCCTGC CCCGGGGATG GCGATGTTCC 60
GCAGCCTGGT GGCCTCGGCG CAGCAGCGGC AGCCGCCGGC TGGGCCCGCG GGCGGCGACA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR008598--Di19_Zn_binding_dom
IPR034734--ZF_C2HC_RNF
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS51803--ZF_C2HC_RNF
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF05605--zf-Di19

SMART

SM00184--RING

Gene Ontology

GO:0005622--C:intracellular
GO:0031624--F:ubiquitin conjugating enzyme binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0000209--P:protein polyubiquitination

KEGG

mmu:68718

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002042	Ailuropoda melanoleuca	67.33	2.00e-66	244.00
IUUC-Apl-003816	Anas platyrhynchos	70.98	5.00e-75	273.00
IUUC-Aca-005379	Anolis carolinensis	88.72	9.00e-105	372.00
IUUC-Acl-008013	Aspergillus clavatus	45.45	1.00e-05	45.40
IUUC-Ame-011339	Astyanax mexicanus	89.35	3.00e-91	327.00
IUUC-Bta-012575	Bos taurus	93.67	3.00e-115	407.00
IUUC-Cja-019772	Callithrix jacchus	82.84	5.00e-78	283.00
IUUC-Cfa-021271	Canis familiaris	94.12	7.00e-116	409.00
IUUC-Cpo-022471	Cavia porcellus	98.19	2.00e-129	454.00
IUUC-Csa-023435	Chlorocebus sabaeus	98.64	7.00e-130	456.00
IUUC-Dre-027458	Danio rerio	82.67	1.00e-109	388.00
IUUC-Dor-030798	Dipodomys ordii	97.44	2.00e-66	243.00
IUUC-Eca-033686	Equus caballus	95.86	7.00e-96	342.00
IUUC-Eeu-035051	Erinaceus europaeus	93.67	6.00e-125	439.00
IUUC-Fca-035399	Felis catus	88.42	1.00e-99	355.00
IUUC-Fal-036707	Ficedula albicollis	89.60	5.00e-93	333.00
IUUC-Gga-040346	Gallus gallus	89.74	2.00e-106	377.00
IUUC-Gac-042409	Gasterosteus aculeatus	57.95	7.00e-49	186.00
IUUC-Ggo-045264	Gorilla gorilla	98.64	7.00e-130	456.00
IUUC-Hsa-046649	Homo sapiens	98.64	7.00e-130	456.00
IUUC-Itr-048243	Ictidomys tridecemlineatus	97.63	2.00e-96	344.00
IUUC-Loc-052767	Lepisosteus oculatus	73.41	1.00e-103	369.00
IUUC-Laf-053402	Loxodonta africana	96.38	1.00e-127	448.00
IUUC-Mcc-055236	Macaca mulatta	86.49	3.00e-105	374.00
IUUC-Mga-059430	Meleagris gallopavo	89.71	2.00e-94	338.00
IUUC-Mmr-061214	Microcebus murinus	96.83	1.00e-127	448.00
IUUC-Mdo-062112	Monodelphis domestica	86.38	4.00e-116	410.00
IUUC-Mpu-066881	Mustela putorius furo	93.49	2.00e-94	337.00
IUUC-Mlu-067382	Myotis lucifugus	94.67	3.00e-95	340.00
IUUC-Nle-069388	Nomascus leucogenys	92.76	5.00e-119	420.00
IUUC-Oan-072786	Ornithorhynchus anatinus	91.81	7.00e-80	289.00
IUUC-Ola-087498	Oryzias latipes	80.58	8.00e-101	359.00
IUUC-Oga-088354	Otolemur garnettii	88.51	9.00e-123	432.00
IUUC-Oar-090300	Ovis aries	93.52	6.00e-112	396.00
IUUC-Ptr-090594	Pan troglodytes	98.64	7.00e-130	456.00
IUUC-Pan-091714	Papio anubis	98.64	7.00e-130	456.00
IUUC-Psi-093536	Pelodiscus sinensis	91.12	5.00e-93	333.00
IUUC-Pma-094178	Petromyzon marinus	46.43	2.00e-51	194.00
IUUC-Pfo-096266	Poecilia formosa	77.63	6.00e-105	373.00
IUUC-Pab-098752	Pongo abelii	99.41	3.00e-98	350.00
IUUC-Pca-101015	Procavia capensis	95.73	1.00e-65	241.00
IUUC-Pva-102695	Pteropus vampyrus	95.02	6.00e-116	409.00
IUUC-Rno-104836	Rattus norvegicus	100.00	6.00e-131	459.00
IUUC-Sha-106920	Sarcophilus harrisii	81.05	2.00e-115	408.00
IUUC-Tgu-117434	Taeniopygia guttata	90.53	2.00e-92	330.00
IUUC-Tru-118479	Takifugu rubripes	76.27	1.00e-104	372.00
IUUC-Tni-119994	Tetraodon nigroviridis	55.04	6.00e-67	246.00
IUUC-Ttr-129306	Tursiops truncatus	79.19	4.00e-90	323.00
IUUC-Xtr-132746	Xenopus tropicalis	86.28	4.00e-112	396.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence