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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Sce-106250
Ensembl Protein ID YML102W
UniProt Accession Q04199; D6W0I2; CAC2_YEAST
Genbank Protein ID CAA56795.1; DAA09796.1
Protein Name Chromatin assembly factor 1 subunit p60; CAF-1 60 kDa subunit
Genbank Nucleotide ID X80835; BK006946
Gene Name CAC2; YML102W
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
YML102W YML102W YML102W
Annotation
mRNA Expression
GEOFFGED
Protein-protein Interaction
IIDiRefIndexHINTMentha
Post-translational Modifications (PTMs)
CPLMBioGRID
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 2.90e-19 66.9 147 178
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 5    svtclaf.sd.tllvsGsdDgtikvWDlrtgv 34
           ++++la+ +d + +v+++ D++i+++D+  g 
   Q: 147  EIYDLAWsPDnRNIVVACMDNSIRLFDVGAGM 178
           79******88788**************97765 PP
   
Organism Saccharomyces cerevisiae
Functional Description
(View)

Functional Description


     Acts as a component of chromatin assembly factor 1 (CAF-1), which assembles histone octamers onto replicating DNA in vitro. It performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer. p50 and p60 form complexes with newly synthesized histones H3 and acetylated H4 in cell extracts (By similarity).
 Acts as a component of chromatin assembly factor 1 (CAF-1), which assembles histone octamers onto replicating DNA in vitro. It performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer. p50 and p60 form complexes with newly synthesized histones H3 and acetylated H4 in cell extracts (By similarity).
Protein Sequence
(Fasta)
MEASHLQIYW HDSQPVYSLT FQKNSANDKL FTAGGDNKVR IWKLNRDENG QNGGVRKIES 60
LDFLGSLTHH EQAINVIRFN SKGDVLASAG DDGQVLLWKQ EDPNTQQESV VRPFGMDAET 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Sce-106250|E3,WD_repeat|Saccharomyces cerevisiae
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATGGAAGCTT CACATTTGCA AATCTACTGG CATGATTCAC AACCCGTTTA CTCGCTCACA 60
TTCCAAAAGA ACAGTGCGAA CGACAAGCTT TTCACCGCTG GTGGTGATAA CAAGGTTAGG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Sce-106250|E3,WD_repeat|Saccharomyces cerevisiae
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat
Interpro

IPR024977--Apc4_WD40_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom
PROSITE

PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF12894--ANAPC4_WD40
PF00400--WD40
SMART

SM00320--WD40
Gene Ontology

GO:0033186--C:CAF-1 complex
GO:0000775--C:chromosome, centromeric region
GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0006335--P:DNA replication-dependent nucleosome assembly
KEGG sce:YML102W
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000474 Aegilops tauschii 34.54 7.00e-62 229.00
IUUC-Aml-001755 Ailuropoda melanoleuca 34.29 1.00e-69 254.00
IUUC-Atr-002674 Amborella trichopoda 30.96 2.00e-61 227.00
IUUC-Apl-003701 Anas platyrhynchos 35.80 3.00e-71 260.00
IUUC-Aca-004692 Anolis carolinensis 35.06 3.00e-72 264.00
IUUC-Aly-006286 Arabidopsis lyrata 36.02 2.00e-68 250.00
IUUC-Ath-007683 Arabidopsis thaliana 35.32 2.00e-69 254.00
IUUC-Ago-007940 Ashbya gossypii 49.10 2.00e-111 394.00
IUUC-Acl-008070 Aspergillus clavatus 42.32 4.00e-47 181.00
IUUC-Afl-008414 Aspergillus flavus 41.67 2.00e-49 188.00
IUUC-Afu-009046 Aspergillus fumigatus 51.19 1.00e-20 92.80
IUUC-Ani-009399 Aspergillus nidulans 42.46 2.00e-47 181.00
IUUC-Ang-009650 Aspergillus niger 40.96 2.00e-45 175.00
IUUC-Aor-009937 Aspergillus oryzae 41.67 2.00e-49 188.00
IUUC-Ate-010505 Aspergillus terreus 36.10 1.00e-30 125.00
IUUC-Ame-011094 Astyanax mexicanus 35.75 3.00e-77 280.00
IUUC-Bgr-012005 Blumeria graminis 35.97 6.00e-43 167.00
IUUC-Bta-013423 Bos taurus 34.72 3.00e-72 264.00
IUUC-Bci-013847 Botrytis cinerea 43.72 4.00e-46 177.00
IUUC-Bdi-014860 Brachypodium distachyon 33.18 1.00e-57 215.00
IUUC-Bol-016603 Brassica oleracea 35.28 3.00e-69 253.00
IUUC-Bra-017175 Brassica rapa 36.14 1.00e-64 238.00
IUUC-Cel-018272 Caenorhabditis elegans 27.10 3.00e-35 140.00
IUUC-Cja-019558 Callithrix jacchus 34.60 2.00e-70 258.00
IUUC-Cfa-020900 Canis familiaris 33.77 5.00e-69 253.00
IUUC-Cpo-022054 Cavia porcellus 33.76 2.00e-61 228.00
IUUC-Csa-023850 Chlorocebus sabaeus 34.49 8.00e-74 269.00
IUUC-Cho-024510 Choloepus hoffmanni 30.03 3.00e-34 137.00
IUUC-Cin-025178 Ciona intestinalis 34.31 2.00e-61 227.00
IUUC-Cgl-026572 Colletotrichum gloeosporioides 45.99 1.00e-43 169.00
IUUC-Cne-027015 Cryptococcus neoformans 33.08 3.00e-33 135.00
IUUC-Cme-027136 Cyanidioschyzon merolae 27.07 1.00e-38 152.00
IUUC-Dre-027879 Danio rerio 35.07 2.00e-74 271.00
IUUC-Dno-029335 Dasypus novemcinctus 34.83 2.00e-74 271.00
IUUC-Dor-030520 Dipodomys ordii 26.68 3.00e-39 154.00
IUUC-Dse-031566 Dothistroma septosporum 40.83 3.00e-46 177.00
IUUC-Dme-031838 Drosophila melanogaster 33.65 8.00e-63 233.00
IUUC-Eca-033563 Equus caballus 35.35 1.00e-73 268.00
IUUC-Fca-036052 Felis catus 34.88 5.00e-72 263.00
IUUC-Fal-037080 Ficedula albicollis 35.33 9.00e-72 262.00
IUUC-Fox-038022 Fusarium oxysporum 45.41 1.00e-47 182.00
IUUC-Fso-038115 Fusarium solani 45.62 4.00e-48 184.00
IUUC-Gmo-039461 Gadus morhua 33.53 9.00e-49 184.00
IUUC-Ggr-040100 Gaeumannomyces graminis 43.32 2.00e-46 178.00
IUUC-Gga-041133 Gallus gallus 36.26 2.00e-72 264.00
IUUC-Gac-041769 Gasterosteus aculeatus 33.41 2.00e-70 258.00
IUUC-Gma-043070 Glycine max 32.43 7.00e-72 262.00
IUUC-Ggo-044561 Gorilla gorilla 34.27 1.00e-73 268.00
IUUC-Hsa-046150 Homo sapiens 34.27 4.00e-74 270.00
IUUC-Hvu-047792 Hordeum vulgare 34.33 3.00e-38 149.00
IUUC-Itr-048630 Ictidomys tridecemlineatus 34.44 6.00e-72 262.00
IUUC-Kpa-049397 Komagataella pastoris 42.75 6.00e-89 318.00
IUUC-Lch-050365 Latimeria chalumnae 28.27 1.00e-36 145.00
IUUC-Lpe-050875 Leersia perrieri 32.86 1.00e-59 221.00
IUUC-Loc-052770 Lepisosteus oculatus 34.53 8.00e-67 246.00
IUUC-Lma-053291 Leptosphaeria maculans 39.00 3.00e-43 167.00
IUUC-Laf-053505 Loxodonta africana 34.88 4.00e-72 263.00
IUUC-Mcc-054803 Macaca mulatta 34.49 8.00e-74 269.00
IUUC-Meu-056578 Macropus eugenii 38.10 1.00e-36 145.00
IUUC-Mor-057211 Magnaporthe oryzae 44.24 4.00e-47 180.00
IUUC-Mpo-057411 Magnaporthe poae 43.18 2.00e-46 178.00
IUUC-Mtr-058066 Medicago truncatula 36.21 2.00e-73 267.00
IUUC-Mga-059735 Meleagris gallopavo 36.90 4.00e-72 263.00
IUUC-Mvi-060288 Microbotryum violaceum 33.97 4.00e-31 128.00
IUUC-Mmr-061343 Microcebus murinus 34.86 1.00e-74 271.00
IUUC-Mdo-062065 Monodelphis domestica 34.53 1.00e-71 261.00
IUUC-Mmu-063501 Mus musculus 33.69 8.00e-73 265.00
IUUC-Mac-064864 Musa acuminata 31.76 5.00e-62 229.00
IUUC-Mpu-066549 Mustela putorius furo 35.31 4.00e-72 263.00
IUUC-Mlu-067121 Myotis lucifugus 34.00 3.00e-72 264.00
IUUC-Nfi-068462 Neosartorya fischeri 41.27 1.00e-48 186.00
IUUC-Ncr-068838 Neurospora crassa 42.01 3.00e-44 171.00
IUUC-Nle-069854 Nomascus leucogenys 34.27 5.00e-74 270.00
IUUC-Opr-070803 Ochotona princeps 34.09 5.00e-67 246.00
IUUC-Ont-071642 Oreochromis niloticus 33.80 3.00e-72 264.00
IUUC-Oan-073675 Ornithorhynchus anatinus 35.82 2.00e-73 268.00
IUUC-Ocu-073863 Oryctolagus cuniculus 35.92 2.00e-71 260.00
IUUC-Oba-075682 Oryza barthii 32.85 2.00e-55 207.00
IUUC-Obr-076039 Oryza brachyantha 34.14 1.00e-61 228.00
IUUC-Ogu-078021 Oryza glumaepatula 33.82 2.00e-59 221.00
IUUC-Oin-079908 Oryza indica 28.37 2.00e-42 164.00
IUUC-Olo-081063 Oryza longistaminata 33.82 1.00e-59 222.00
IUUC-Ome-081930 Oryza meridionalis 33.82 4.00e-60 223.00
IUUC-Oni-082547 Oryza nivara 33.82 2.00e-59 221.00
IUUC-Opu-084089 Oryza punctata 33.82 2.00e-59 221.00
IUUC-Oru-084844 Oryza rufipogon 33.82 2.00e-59 221.00
IUUC-Osa-085582 Oryza sativa 33.82 2.00e-59 221.00
IUUC-Ola-087187 Oryzias latipes 34.72 2.00e-73 267.00
IUUC-Olu-087792 Ostreococcus lucimarinus 33.65 6.00e-60 222.00
IUUC-Oga-088390 Otolemur garnettii 35.23 4.00e-74 270.00
IUUC-Oar-089740 Ovis aries 34.40 3.00e-67 247.00
IUUC-Ptr-091581 Pan troglodytes 34.27 4.00e-74 270.00
IUUC-Pan-092258 Papio anubis 31.83 4.00e-61 227.00
IUUC-Psi-093761 Pelodiscus sinensis 37.12 1.00e-74 271.00
IUUC-Pno-094957 Phaeosphaeria nodorum 34.94 3.00e-34 137.00
IUUC-Ppa-095428 Physcomitrella patens 32.60 9.00e-70 255.00
IUUC-Pfo-097357 Poecilia formosa 33.80 3.00e-73 267.00
IUUC-Pab-098520 Pongo abelii 34.27 7.00e-74 269.00
IUUC-Pop-099331 Populus trichocarpa 31.26 1.00e-67 248.00
IUUC-Ppe-101548 Prunus persica 33.81 3.00e-67 247.00
IUUC-Pva-103243 Pteropus vampyrus 33.09 3.00e-63 233.00
IUUC-Pgr-103591 Puccinia graminis 32.26 3.00e-31 128.00
IUUC-Pte-104247 Pyrenophora teres 39.83 2.00e-44 171.00
IUUC-Pyt-104641 Pyrenophora triticirepentis 39.83 2.00e-44 171.00
IUUC-Rno-105202 Rattus norvegicus 33.62 7.00e-72 262.00
IUUC-Sha-107036 Sarcophilus harrisii 33.54 2.00e-72 264.00
IUUC-Sja-107912 Schizosaccharomyces japonicus 36.98 3.00e-82 296.00
IUUC-Spo-108050 Schizosaccharomyces pombe 40.16 1.00e-44 172.00
IUUC-Ssl-108607 Sclerotinia sclerotiorum 43.72 2.00e-46 178.00
IUUC-Sit-109838 Setaria italica 34.48 7.00e-64 236.00
IUUC-Sly-110872 Solanum lycopersicum 31.84 4.00e-68 249.00
IUUC-Stu-111933 Solanum tuberosum 33.48 4.00e-69 253.00
IUUC-Sbi-114587 Sorghum bicolor 34.81 3.00e-63 233.00
IUUC-Sre-115093 Sporisorium reilianum 30.43 7.00e-32 130.00
IUUC-Ssc-115462 Sus scrofa 34.19 2.00e-72 264.00
IUUC-Tgu-117186 Taeniopygia guttata 36.26 4.00e-72 263.00
IUUC-Tru-118310 Takifugu rubripes 34.34 4.00e-74 270.00
IUUC-Tsy-118927 Tarsius syrichta 29.14 2.00e-38 151.00
IUUC-Tni-120832 Tetraodon nigroviridis 33.56 7.00e-72 262.00
IUUC-Tca-121584 Theobroma cacao 33.26 6.00e-68 249.00
IUUC-Tre-122140 Trichoderma reesei 44.95 1.00e-47 182.00
IUUC-Tvi-122663 Trichoderma virens 45.41 2.00e-47 182.00
IUUC-Tae-123476 Triticum aestivum 34.54 7.00e-62 229.00
IUUC-Tur-126239 Triticum urartu 34.54 6.00e-62 229.00
IUUC-Tme-127108 Tuber melanosporum 38.24 4.00e-76 276.00
IUUC-Ttr-129010 Tursiops truncatus 36.32 4.00e-74 270.00
IUUC-Uma-129499 Ustilago maydis 36.14 2.00e-31 129.00
IUUC-Vda-129825 Verticillium dahliae 44.95 9.00e-48 182.00
IUUC-Vpa-130374 Vicugna pacos 38.07 2.00e-27 115.00
IUUC-Vvi-131136 Vitis vinifera 31.72 2.00e-61 228.00
IUUC-Xtr-132141 Xenopus tropicalis 34.22 5.00e-71 259.00
IUUC-Xma-133980 Xiphophorus maculatus 33.41 1.00e-71 261.00
IUUC-Yli-134457 Yarrowia lipolytica 40.24 1.00e-48 185.00
IUUC-Zma-135321 Zea mays 34.18 2.00e-62 231.00
Created Date 25-Jun-2017

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