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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Hsa-047037
UUCD1 version UUC-HoS-00894
Ensembl Protein ID ENSP00000371355.3
UniProt Accession Q96PQ7; A8K170; B7WP68; E9PCF4; F8WAE7; G3XA92; Q6Y881; Q86XW0; Q9NUK3; Q9NV27; Q9NVA9; Q9Y2X2; KLHL5_HUMAN
Genbank Protein ID AAL08584.1; AAO39710.1; BAA91845.1; BAA91933.1; BAA92121.1; BAF82474.1; EAW92908.1; EAW92911.1; AAH48262.1; AAD32565.1
Protein Name Kelch-like protein 5
Genbank Nucleotide ID AF272976; AY172948; AK001698; AK001836; AK002174; AK289785; AC079921; CH471069; BC048262; AF123320
Gene Name KLHL5
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000109790.16 ENST00000504108.5 ENSP00000423897.1
ENSG00000109790.16 ENST00000381930.7 ENSP00000371355.3
ENSG00000109790.16 ENST00000261426.9 ENSP00000261426.5
ENSG00000109790.16 ENST00000514399.1 ENSP00000426949.1
ENSG00000109790.16 ENST00000515612.1 ENSP00000425512.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarmiRNAMapSomamiR
miRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Variation
GWASdbOMIM
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusBioGRID
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB 6.60e-19 69.7 220 287
E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box 7.80e-09 34.7 319 349
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB
   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmeleesksklmveikdvqpevfrallkFlYtgkldene 69
           +Dvilv g+++++ah++vL++ S++F a+f+++ +e + ++++++++v+p ++  l+++ Ytg+l+++e
   Q: 220  CDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREAR-QEEIKMEGVEPNSLWSLIQYAYTGRLELKE 287
           9************************************9.**************************9986 PP
   

   E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box
   S: 1    leNclgilrfAdlydcpdLkdaaldfilkhF 31
           ++Nclgi++fAd+ +c+dL+++a++++  hF
   Q: 319  PSNCLGIRSFADAQGCTDLHKVAHNYTMEHF 349
           89************************98777 PP
   
Organism Homo sapiens
Protein Sequence
(Fasta)
MNVIYFPLHI FVVYSRAYTS LVLVGCTNLC AVLFARCLDD HLVSLRMSGS RKEFDVKQIL 60
KIRWRWFGHQ ASSPNSTVDS QQGEFWNRGQ TGANGGRKFL DPCSLQLPLA SIGYRRSSQL 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-047037|E3,BTB_3-box|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CTCCCGCCTG GCCGCCCCGG CCCGCCGTGA CCCACGGCCG CCTCCGGAGC CCGACGCGGT 60
AAGTGCGACT TCCTTCTCGG CATCGGGGAG GGGGCCGCCT CGGGCAGGGC CCGCTTCCCG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-047037|E3,BTB_3-box|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0009--Actin-binding
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0880--Kelch repeat
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
Interpro

IPR011705--BACK
IPR000210--BTB/POZ_dom
IPR015915--Kelch-typ_b-propeller
IPR006652--Kelch_1
IPR011333--SKP1/BTB/POZ
PROSITE

PS50097--BTB
Pfam

PF07707--BACK
PF00651--BTB
PF01344--Kelch_1
SMART

SM00875--BACK
SM00225--BTB
SM00612--Kelch
Gene Ontology

GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0005737--C:cytoplasm
GO:0005856--C:cytoskeleton
GO:0016567--P:protein ubiquitination
KEGG hsa:51088
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000220 Aegilops tauschii 33.19 1.00e-37 152.00
IUUC-Aml-001239 Ailuropoda melanoleuca 98.76 0.00e+00 1169.00
IUUC-Apl-003930 Anas platyrhynchos 89.71 0.00e+00 1226.00
IUUC-Aca-004826 Anolis carolinensis 87.38 0.00e+00 1320.00
IUUC-Ame-011037 Astyanax mexicanus 80.81 0.00e+00 839.00
IUUC-Bta-013448 Bos taurus 97.71 0.00e+00 1458.00
IUUC-Cja-019953 Callithrix jacchus 98.52 0.00e+00 1475.00
IUUC-Cfa-020335 Canis familiaris 98.76 0.00e+00 1446.00
IUUC-Cpo-021385 Cavia porcellus 98.62 0.00e+00 1441.00
IUUC-Csa-023109 Chlorocebus sabaeus 98.85 0.00e+00 1392.00
IUUC-Cho-024402 Choloepus hoffmanni 98.73 0.00e+00 1405.00
IUUC-Csv-026377 Ciona savignyi 65.81 0.00e+00 751.00
IUUC-Dre-028618 Danio rerio 82.37 0.00e+00 967.00
IUUC-Dme-032222 Drosophila melanogaster 58.11 0.00e+00 660.00
IUUC-Eca-034002 Equus caballus 99.03 0.00e+00 1446.00
IUUC-Fca-035953 Felis catus 91.50 0.00e+00 1345.00
IUUC-Fal-037331 Ficedula albicollis 92.85 0.00e+00 1165.00
IUUC-Gmo-039309 Gadus morhua 75.94 0.00e+00 881.00
IUUC-Gga-041137 Gallus gallus 95.86 0.00e+00 1130.00
IUUC-Gac-042162 Gasterosteus aculeatus 77.56 0.00e+00 865.00
IUUC-Ggo-044697 Gorilla gorilla 97.63 0.00e+00 1493.00
IUUC-Lch-050568 Latimeria chalumnae 85.60 0.00e+00 1273.00
IUUC-Loc-052139 Lepisosteus oculatus 78.65 0.00e+00 1137.00
IUUC-Laf-054213 Loxodonta africana 98.42 0.00e+00 1387.00
IUUC-Mcc-054988 Macaca mulatta 98.92 0.00e+00 1485.00
IUUC-Mga-059394 Meleagris gallopavo 84.48 0.00e+00 1258.00
IUUC-Mmr-061186 Microcebus murinus 98.40 0.00e+00 1029.00
IUUC-Mdo-062687 Monodelphis domestica 96.99 0.00e+00 1362.00
IUUC-Mmu-063695 Mus musculus 96.70 0.00e+00 1361.00
IUUC-Mpu-065886 Mustela putorius furo 93.70 0.00e+00 1373.00
IUUC-Mlu-067820 Myotis lucifugus 97.44 0.00e+00 1466.00
IUUC-Nle-069647 Nomascus leucogenys 99.06 0.00e+00 1489.00
IUUC-Opr-070814 Ochotona princeps 96.90 0.00e+00 1449.00
IUUC-Ont-071631 Oreochromis niloticus 77.17 0.00e+00 877.00
IUUC-Oan-073455 Ornithorhynchus anatinus 91.04 0.00e+00 1157.00
IUUC-Oga-088236 Otolemur garnettii 97.58 0.00e+00 1459.00
IUUC-Oar-089243 Ovis aries 97.71 0.00e+00 1466.00
IUUC-Ptr-090722 Pan troglodytes 98.92 0.00e+00 1486.00
IUUC-Pan-092727 Papio anubis 98.57 0.00e+00 1389.00
IUUC-Psi-093068 Pelodiscus sinensis 90.53 0.00e+00 1300.00
IUUC-Pma-094371 Petromyzon marinus 78.99 0.00e+00 947.00
IUUC-Ppa-095209 Physcomitrella patens 30.04 1.00e-20 94.00
IUUC-Pfo-096355 Poecilia formosa 77.96 0.00e+00 875.00
IUUC-Pab-097795 Pongo abelii 99.02 0.00e+00 1049.00
IUUC-Pva-103111 Pteropus vampyrus 97.32 0.00e+00 1460.00
IUUC-Rno-105085 Rattus norvegicus 97.13 0.00e+00 1358.00
IUUC-Sha-107240 Sarcophilus harrisii 96.13 0.00e+00 1348.00
IUUC-Sit-109883 Setaria italica 25.00 4.00e-17 83.60
IUUC-Sar-113739 Sorex araneus 96.71 0.00e+00 1188.00
IUUC-Ssc-115542 Sus scrofa 98.97 0.00e+00 953.00
IUUC-Tgu-116703 Taeniopygia guttata 91.63 0.00e+00 1315.00
IUUC-Tru-117551 Takifugu rubripes 67.75 0.00e+00 907.00
IUUC-Tsy-118944 Tarsius syrichta 92.95 0.00e+00 1384.00
IUUC-Tni-120665 Tetraodon nigroviridis 77.36 0.00e+00 869.00
IUUC-Ttr-128501 Tursiops truncatus 97.83 0.00e+00 1463.00
IUUC-Vpa-130295 Vicugna pacos 89.74 0.00e+00 1319.00
IUUC-Xtr-132607 Xenopus tropicalis 82.00 0.00e+00 1189.00
Created Date 25-Jun-2017

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