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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-063622
UUCD1 version UUC-MuM-01059
Ensembl Protein ID ENSMUSP00000141807.1
UniProt Accession Q9Z2X8; Q3U243; Q3U8N7; Q547S3; Q6ZQI6; Q8BQY3; KEAP1_MOUSE
Genbank Protein ID BAA34639.1; AAL84711.1; BAC97871.1; BAC32621.1; BAC36267.1; BAE29559.1; BAE29601.1; BAE30980.1; BAE32581.1; BAE33299.1; BAE35433.1; AAH55732.1
Protein Name Kelch-like ECH-associated protein 1; Cytosolic inhibitor of Nrf2
Genbank Nucleotide ID AB020063; AF454353; AK129061; AK046178; AK076234; AK150437; AK150485; AK152142; AK154430; AK155507; AK159858; BC055732
Gene Name Keap1; Inrf2; Kiaa0132
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000003308.15 ENSMUST00000194542.5 ENSMUSP00000141807.1
ENSMUSG00000003308.15 ENSMUST00000216436.1 ENSMUSP00000149705.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
microRNATRANSFACRepTarRAID2
Protein-protein Interaction
IIDiRefIndexHINTMentha
Protein 3D Structure
PDBMMDB
Drug and target
GRAC
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB 2.30e-16 61.0 77 147
E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box 2.20e-10 39.6 181 211
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB
   S: 1    aDvilvv.....ggeeffahkivLaasSsvFyalflmeleesksklmveikdvqpevfrallkFlYtgklde 67
           +Dv+l+v        +f ahk+vLa+sS+vF+a+f+++l+e+   + v i+++ p+v++ l++F Yt +++ 
   Q: 77   CDVTLQVkyediPAAQFMAHKVVLASSSPVFKAMFTNGLREQG-MEVVSIEGIHPKVMERLIEFAYTASISV 147
           89*****655444999*************************98.***********************98875 PP
   

   E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box
   S: 1    leNclgilrfAdlydcpdLkdaaldfilkhF 31
           ++N++gi  fA++ +c++L+++a+++i  hF
   Q: 181  PSNAIGIANFAEQIGCTELHQRAREYIYMHF 211
           89****************************9 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Acts as a substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1 and targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. Retains NFE2L2/NRF2 and may also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome (By similarity).
 Acts as a substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1 and targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. Retains NFE2L2/NRF2 and may also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome (By similarity).
Protein Sequence
(Fasta)
MQPEPKLSGA PRSSQFLPLW SKCPEGAGDA VMYASTECKA EVTPSQDGNR TFSYTLEDHT 60
KQAFGVMNEL RLSQQLCDVT LQVKYEDIPA AQFMAHKVVL ASSSPVFKAM FTNGLREQGM 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063622|E3,BTB_3-box|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AACCCGGAGG CAGCCTCCTA GGGCCGCCCA GACCCACGCC CTGCTCCCTC CGCCCGGCAC 60
CTGCAGGAAG GGCTGGAACT GCCTCTGCGT ACCCGCCGCC CGTTTCCGCC CTCCCGCTCC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063622|E3,BTB_3-box|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0880--Kelch repeat
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
Interpro

IPR011705--BACK
IPR017096--BTB-kelch_protein
IPR000210--BTB/POZ_dom
IPR015916--Gal_Oxidase_b-propeller
IPR030563--KEAP1
IPR015915--Kelch-typ_b-propeller
IPR006652--Kelch_1
IPR011333--SKP1/BTB/POZ
PROSITE

PS50097--BTB
Pfam

PF07707--BACK
PF00651--BTB
PF01344--Kelch_1
SMART

SM00875--BACK
SM00225--BTB
SM00612--Kelch
Gene Ontology

GO:0005884--C:actin filament
GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005783--C:endoplasmic reticulum
GO:0005815--C:microtubule organizing center
GO:0030496--C:midbody
GO:0005654--C:nucleoplasm
GO:0008134--F:transcription factor binding
GO:0071353--P:cellular response to interleukin-4
GO:0042994--P:cytoplasmic sequestering of transcription factor
GO:0001701--P:in utero embryonic development
GO:0043433--P:negative regulation of sequence-specific DNA binding transcription factor activity
GO:0010499--P:proteasomal ubiquitin-independent protein catabolic process
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0016567--P:protein ubiquitination
GO:0045604--P:regulation of epidermal cell differentiation
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated
KEGG mmu:50868
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001377 Ailuropoda melanoleuca 94.23 0.00e+00 1240.00
IUUC-Aca-005389 Anolis carolinensis 84.49 0.00e+00 1069.00
IUUC-Ame-010749 Astyanax mexicanus 77.89 0.00e+00 966.00
IUUC-Bta-013505 Bos taurus 94.55 0.00e+00 1244.00
IUUC-Cja-018823 Callithrix jacchus 93.91 0.00e+00 1238.00
IUUC-Cfa-021202 Canis familiaris 94.23 0.00e+00 1240.00
IUUC-Cpo-021830 Cavia porcellus 94.17 0.00e+00 826.00
IUUC-Csa-023728 Chlorocebus sabaeus 93.91 0.00e+00 1235.00
IUUC-Cin-025195 Ciona intestinalis 54.66 0.00e+00 674.00
IUUC-Csv-026155 Ciona savignyi 53.59 0.00e+00 627.00
IUUC-Dre-027388 Danio rerio 76.40 0.00e+00 942.00
IUUC-Dno-029066 Dasypus novemcinctus 82.78 0.00e+00 1061.00
IUUC-Dor-030674 Dipodomys ordii 92.94 0.00e+00 817.00
IUUC-Dme-032165 Drosophila melanogaster 49.02 2.00e-158 553.00
IUUC-Ete-032255 Echinops telfairi 92.86 4.00e-98 351.00
IUUC-Eca-034381 Equus caballus 93.43 0.00e+00 1202.00
IUUC-Eeu-034791 Erinaceus europaeus 90.28 0.00e+00 801.00
IUUC-Fca-036067 Felis catus 94.71 0.00e+00 1246.00
IUUC-Gmo-039691 Gadus morhua 76.53 0.00e+00 944.00
IUUC-Gga-040266 Gallus gallus 80.54 0.00e+00 1000.00
IUUC-Gac-041866 Gasterosteus aculeatus 76.44 0.00e+00 948.00
IUUC-Ggo-044719 Gorilla gorilla 94.07 0.00e+00 1239.00
IUUC-Hsa-046255 Homo sapiens 94.07 0.00e+00 1239.00
IUUC-Itr-048457 Ictidomys tridecemlineatus 93.75 0.00e+00 1233.00
IUUC-Lch-049646 Latimeria chalumnae 81.86 0.00e+00 1028.00
IUUC-Loc-052296 Lepisosteus oculatus 57.32 0.00e+00 645.00
IUUC-Laf-054579 Loxodonta africana 93.59 0.00e+00 1234.00
IUUC-Mcc-055315 Macaca mulatta 93.91 0.00e+00 1235.00
IUUC-Meu-056288 Macropus eugenii 85.58 0.00e+00 1097.00
IUUC-Mmr-061639 Microcebus murinus 93.91 0.00e+00 1241.00
IUUC-Mdo-062072 Monodelphis domestica 91.03 0.00e+00 1190.00
IUUC-Mpu-066737 Mustela putorius furo 91.19 0.00e+00 1192.00
IUUC-Mlu-068173 Myotis lucifugus 93.27 0.00e+00 1226.00
IUUC-Nle-069336 Nomascus leucogenys 60.90 0.00e+00 686.00
IUUC-Opr-070432 Ochotona princeps 94.66 0.00e+00 1201.00
IUUC-Ont-072160 Oreochromis niloticus 76.64 0.00e+00 944.00
IUUC-Oan-072691 Ornithorhynchus anatinus 80.00 0.00e+00 972.00
IUUC-Ocu-073798 Oryctolagus cuniculus 93.27 0.00e+00 1233.00
IUUC-Ola-086367 Oryzias latipes 74.20 0.00e+00 911.00
IUUC-Oga-088231 Otolemur garnettii 94.07 0.00e+00 1239.00
IUUC-Oar-089227 Ovis aries 93.27 0.00e+00 1219.00
IUUC-Ptr-091460 Pan troglodytes 94.07 0.00e+00 1239.00
IUUC-Pan-092713 Papio anubis 93.91 0.00e+00 1235.00
IUUC-Pfo-096468 Poecilia formosa 77.76 0.00e+00 953.00
IUUC-Pab-098357 Pongo abelii 94.23 0.00e+00 1242.00
IUUC-Pca-100837 Procavia capensis 92.79 0.00e+00 1220.00
IUUC-Pva-103249 Pteropus vampyrus 91.03 0.00e+00 1168.00
IUUC-Rno-106086 Rattus norvegicus 97.60 0.00e+00 1277.00
IUUC-Sha-107245 Sarcophilus harrisii 90.87 0.00e+00 1189.00
IUUC-Sar-112985 Sorex araneus 92.47 0.00e+00 1221.00
IUUC-Ssc-115756 Sus scrofa 94.55 0.00e+00 1245.00
IUUC-Tgu-116838 Taeniopygia guttata 54.74 2.00e-118 418.00
IUUC-Tru-117644 Takifugu rubripes 77.48 0.00e+00 969.00
IUUC-Tni-120245 Tetraodon nigroviridis 77.34 0.00e+00 956.00
IUUC-Tbe-127472 Tupaia belangeri 96.73 2.00e-147 516.00
IUUC-Ttr-128953 Tursiops truncatus 91.34 0.00e+00 676.00
IUUC-Vpa-130683 Vicugna pacos 91.39 0.00e+00 1073.00
IUUC-Xtr-132827 Xenopus tropicalis 75.26 0.00e+00 942.00
Created Date 25-Jun-2017

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