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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Dme-032166
UUCD1 version UUC-DrM-00041
Ensembl Protein ID FBpp0289746
UniProt Accession Q9VVI3; Q7KUR2; Q8IQR6; Q95R64; Q95TQ0; Q95ZF9; NEDD4_DROME
Genbank Protein ID CAC42101.1; AAF49328.2; AAS64973.1; AAN11694.1; AAN11695.1; AAL29143.1; AAL13848.1
Protein Name E3 ubiquitin-protein ligase Nedd-4; HECT-type E3 ubiquitin transferase NEDD4
Genbank Nucleotide ID AJ278468; AE014296; AE014296; AE014296; AE014296; AY061595; AY058619
Gene Name Nedd4; CG7555
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
FBgn0259174 FBtr0300520 FBpp0289747
FBgn0259174 FBtr0300519 FBpp0289746
FBgn0259174 FBtr0299646 FBpp0288921
FBgn0259174 FBtr0331843 FBpp0304227
FBgn0259174 FBtr0299642 FBpp0288917
FBgn0259174 FBtr0331844 FBpp0304228
FBgn0259174 FBtr0299647 FBpp0288922
FBgn0259174 FBtr0299645 FBpp0288920
FBgn0259174 FBtr0299648 FBpp0288923
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpress
DNA & RNA Element
miRTarBasemicroRNAmiRecordsRAID2
Protein-protein Interaction
IIDiRefIndexMentha
Protein 3D Structure
PDBMMDB
Post-translational Modifications (PTMs)
dbPAFPHOSIDA
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/HECT HECT 17074801
Classification
Family E-value Score Start End
E3 activity/HECT 1.70e-130 435.4 675 1004
Active Site
Position(s) Description Evidence
974 Glycyl thioester intermediate N/A
Domain Profile

   E3 activity/HECT
   S: 4    dlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlplsksfykl 99
            lk +l+vef+gE gld+gG++re+++llske++np++glf+ys+ d++tlq+n+ sgl+n+ehl++F+f+Gr+ g+a+++g+lld+++ ++fyk+
   Q: 675  LLKTKLWVEFEGETGLDYGGLAREWFYLLSKEMFNPYYGLFEYSAMDNYTLQINNGSGLCNEEHLSYFKFIGRIAGMAVYHGKLLDAFFIRPFYKM 770
           6899******************************************************************************************** PP
   S: 100  llgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvveyrlkegikeqveafre 195
           +l+k+++l+d+e+vd e+y+sl++iken   d     l+ltf+ +e+++g+ +++eLkpgG+ni+VtneNk+eY+klv+e+r+  ++keq+ +f +
   Q: 771  MLQKPIDLKDMESVDTEYYNSLMWIKEN---DPRI--LELTFCLDEDVFGQKSQHELKPGGANIDVTNENKDEYIKLVIEWRFVARVKEQMSSFLD 861
           **************************99...5555..7********************************************************** PP
   S: 196  GfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvTgssrlPlgGfaelk....prlf 287
           Gf ++ipl+l+++F+e+elell+cG ++idv+d++++t ykg+y+ ++  iqwFw+++ +fs+e r+++LqFvTg+sr+P++Gf+el     p++f
   Q: 862  GFGSIIPLNLIKIFDEHELELLMCGIQNIDVKDWRENTLYKGDYHMNHIIIQWFWRAVLSFSNEMRSRLLQFVTGTSRVPMNGFKELYgsngPQMF 957
           ************************************************************************************************ PP
   S: 288  virkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFe 334
           +i+k+++++++P+++TCfn+L+LP+Y+ + +lk+kL+ Aie ++gF 
   Q: 958  TIEKWGTPNNFPRAHTCFNRLDLPPYEGYLQLKDKLIKAIEGSQGFA 1004
           ********************************************996 PP
   
Organism Drosophila melanogaster
Functional Description
(View)

Functional Description


     Essential E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Down-regulates Notch/N signaling pathway by promoting Notch ubiquitination, endocytosis and degradation.
 Essential E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Down-regulates Notch/N signaling pathway by promoting Notch ubiquitination, endocytosis and degradation.
Protein Sequence
(Fasta)
MSARSSGLVA AAALPVPSSS SSVAGGDVPR PPPRRRAASV AGQQQTRQEF GNGYTPRRSL 60
AAVNDSGDSC HLRIVVLTGQ SLAKKDIFGA SDPYVRIDLN TINGDINIDS VLTKTKKKTL 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Dme-032166|E3,HECT|Drosophila melanogaster
Please wait for a moment...
Nucleotide Sequence
(Fasta)
TCAGTGCGCG TACACGGTCA CTCTGGCAGT TTTGTTCTCG ATTTTGTCGC CGTTTTGTGC 60
ATTTTTCCCG TCCGGTGTTT AAATTTTATT TAATACTGCG CGTGCGACAT ATATACAGGC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Dme-032166|E3,HECT|Drosophila melanogaster
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0217--Developmental protein
KW-0914--Notch signaling pathway
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom
PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2
Pfam

PF00168--C2
PF00632--HECT
PF00397--WW
PRINTS

PR00360--C2DOMAIN
SMART

SM00239--C2
SM00119--HECTc
SM00456--WW
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005886--C:plasma membrane
GO:0017022--F:myosin binding
GO:0005112--F:Notch binding
GO:0019904--F:protein domain specific binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0007411--P:axon guidance
GO:0016199--P:axon midline choice point recognition
GO:0045746--P:negative regulation of Notch signaling pathway
GO:0007528--P:neuromuscular junction development
GO:0007219--P:Notch signaling pathway
GO:0045807--P:positive regulation of endocytosis
GO:0002092--P:positive regulation of receptor internalization
GO:0051965--P:positive regulation of synapse assembly
GO:0016567--P:protein ubiquitination
GO:0031623--P:receptor internalization
KEGG dme:Dmel_CG42279
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001201 Ailuropoda melanoleuca 67.99 0.00e+00 716.00
IUUC-Apl-003886 Anas platyrhynchos 65.36 0.00e+00 702.00
IUUC-Aca-004744 Anolis carolinensis 64.99 0.00e+00 660.00
IUUC-Aor-010053 Aspergillus oryzae 55.85 5.00e-97 346.00
IUUC-Ame-011138 Astyanax mexicanus 68.97 0.00e+00 696.00
IUUC-Bta-012679 Bos taurus 67.09 0.00e+00 696.00
IUUC-Bci-013785 Botrytis cinerea 50.93 1.00e-143 503.00
IUUC-Cel-018564 Caenorhabditis elegans 58.64 8.00e-180 622.00
IUUC-Cja-019034 Callithrix jacchus 67.43 0.00e+00 717.00
IUUC-Cfa-020258 Canis familiaris 67.43 0.00e+00 713.00
IUUC-Cpo-021671 Cavia porcellus 67.09 0.00e+00 695.00
IUUC-Csa-023334 Chlorocebus sabaeus 67.99 0.00e+00 707.00
IUUC-Cho-024832 Choloepus hoffmanni 69.03 4.00e-155 541.00
IUUC-Cin-025157 Ciona intestinalis 64.99 0.00e+00 721.00
IUUC-Csv-026098 Ciona savignyi 63.21 1.00e-172 598.00
IUUC-Dre-027770 Danio rerio 68.13 0.00e+00 696.00
IUUC-Dno-029466 Dasypus novemcinctus 67.09 0.00e+00 696.00
IUUC-Dor-030138 Dipodomys ordii 65.41 0.00e+00 669.00
IUUC-Ete-033145 Echinops telfairi 61.64 0.00e+00 642.00
IUUC-Eca-033445 Equus caballus 67.09 0.00e+00 694.00
IUUC-Eeu-035247 Erinaceus europaeus 67.09 0.00e+00 694.00
IUUC-Fca-036384 Felis catus 67.71 0.00e+00 710.00
IUUC-Fal-037547 Ficedula albicollis 67.78 0.00e+00 696.00
IUUC-Gmo-039674 Gadus morhua 67.71 0.00e+00 688.00
IUUC-Gga-040703 Gallus gallus 67.71 0.00e+00 699.00
IUUC-Gac-042607 Gasterosteus aculeatus 66.13 0.00e+00 703.00
IUUC-Ggo-045332 Gorilla gorilla 67.30 0.00e+00 695.00
IUUC-Hsa-046479 Homo sapiens 67.63 0.00e+00 715.00
IUUC-Itr-048383 Ictidomys tridecemlineatus 61.80 0.00e+00 679.00
IUUC-Lch-050445 Latimeria chalumnae 70.02 0.00e+00 723.00
IUUC-Loc-052645 Lepisosteus oculatus 68.76 0.00e+00 699.00
IUUC-Laf-053850 Loxodonta africana 67.09 0.00e+00 694.00
IUUC-Mcc-055585 Macaca mulatta 67.63 0.00e+00 714.00
IUUC-Meu-056897 Macropus eugenii 71.78 4.00e-128 451.00
IUUC-Mpo-057442 Magnaporthe poae 51.34 1.00e-143 503.00
IUUC-Mga-059362 Meleagris gallopavo 67.35 0.00e+00 698.00
IUUC-Mvi-060395 Microbotryum violaceum 51.23 7.00e-142 497.00
IUUC-Mmr-061061 Microcebus murinus 65.17 0.00e+00 717.00
IUUC-Mdo-062178 Monodelphis domestica 63.35 0.00e+00 703.00
IUUC-Mmu-064136 Mus musculus 67.09 0.00e+00 696.00
IUUC-Mpu-066765 Mustela putorius furo 67.09 0.00e+00 694.00
IUUC-Mlu-068148 Myotis lucifugus 65.93 0.00e+00 715.00
IUUC-Nle-069225 Nomascus leucogenys 67.99 0.00e+00 714.00
IUUC-Opr-071044 Ochotona princeps 67.09 0.00e+00 692.00
IUUC-Ont-072044 Oreochromis niloticus 68.34 0.00e+00 719.00
IUUC-Oan-073019 Ornithorhynchus anatinus 68.13 0.00e+00 691.00
IUUC-Ocu-074160 Oryctolagus cuniculus 67.09 0.00e+00 694.00
IUUC-Ola-087467 Oryzias latipes 68.13 0.00e+00 694.00
IUUC-Oga-088460 Otolemur garnettii 67.09 0.00e+00 693.00
IUUC-Oar-090198 Ovis aries 67.09 0.00e+00 696.00
IUUC-Ptr-091629 Pan troglodytes 67.63 0.00e+00 716.00
IUUC-Pan-092284 Papio anubis 67.30 0.00e+00 697.00
IUUC-Psi-093618 Pelodiscus sinensis 67.84 0.00e+00 704.00
IUUC-Pma-094364 Petromyzon marinus 67.85 0.00e+00 692.00
IUUC-Pfo-096768 Poecilia formosa 68.62 0.00e+00 694.00
IUUC-Pab-098088 Pongo abelii 67.30 0.00e+00 696.00
IUUC-Pca-100568 Procavia capensis 62.94 0.00e+00 658.00
IUUC-Pva-102354 Pteropus vampyrus 67.09 0.00e+00 694.00
IUUC-Ptt-103806 Puccinia triticina 49.88 8.00e-114 403.00
IUUC-Rno-105318 Rattus norvegicus 67.09 0.00e+00 696.00
IUUC-Sha-107482 Sarcophilus harrisii 66.67 0.00e+00 691.00
IUUC-Ssl-108514 Sclerotinia sclerotiorum 50.93 1.00e-143 503.00
IUUC-Ssc-115950 Sus scrofa 61.36 0.00e+00 656.00
IUUC-Tgu-117130 Taeniopygia guttata 67.01 0.00e+00 699.00
IUUC-Tru-117675 Takifugu rubripes 70.42 0.00e+00 714.00
IUUC-Tsy-119492 Tarsius syrichta 66.88 0.00e+00 687.00
IUUC-Tni-119993 Tetraodon nigroviridis 69.83 0.00e+00 702.00
IUUC-Tre-122203 Trichoderma reesei 51.03 8.00e-141 493.00
IUUC-Tme-126897 Tuber melanosporum 50.31 2.00e-137 482.00
IUUC-Tbe-127408 Tupaia belangeri 62.07 1.00e-178 619.00
IUUC-Ttr-128235 Tursiops truncatus 66.88 0.00e+00 692.00
IUUC-Uma-129332 Ustilago maydis 51.44 3.00e-136 478.00
IUUC-Vpa-130503 Vicugna pacos 67.86 0.00e+00 685.00
IUUC-Xtr-132859 Xenopus tropicalis 67.22 0.00e+00 698.00
IUUC-Xma-133797 Xiphophorus maculatus 68.76 0.00e+00 700.00
Created Date 25-Jun-2017

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