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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Mmu-063493
UUCD1 version UUC-MuM-01060
Ensembl Protein ID ENSMUSP00000028398.7
UniProt Accession P52483; O09180; Q3TI00; Q91X63; UB2E3_MOUSE
Genbank Protein ID CAA63352.1; AAB60948.1; BAC36118.1; BAE40046.1; AAH11477.1
Protein Name Ubiquitin-conjugating enzyme E2 E3; E2 ubiquitin-conjugating enzyme E3; UbcM2; Ubiquitin carrier protein E3; Ubiquitin-conjugating enzyme E2-23 kDa; Ubiquitin-protein ligase E3
Genbank Nucleotide ID X92664; AF003346; AK076011; AK168072; BC011477
Gene Name Ube2e3; Ubce4; Ubcm2
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000027011.14 ENSMUST00000028398.13 ENSMUSP00000028398.7
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
miRTarBasemicroRNATRANSFACRepTar
miRNAMapRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
Mentha
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTMPHOSIDA
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E2/UBC E2_UBC 19256485
Classification
Family E-value Score Start End
E2/UBC 6.90e-50 169.5 65 200
Active Site
Position(s) Description Evidence
145 Glycyl thioester intermediate N/A
Domain Profile

   E2/UBC
   S: 1    RlkkelkelekdppegisakpvdesdltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltkifhPnvyenGkvClsilkee 89
           R++kel+e++ dpp+++sa+p+ + +++ew+ +ilGp++++YeggvF l+i+f++dYPfkPPkv+f t+i+h+n++++G +Cl+ilk  
   Q: 65   RIQKELAEITLDPPPNCSAGPKGD-NIYEWRSTILGPPGSVYEGGVFFLDITFSSDYPFKPPKVTFRTRIYHCNINSQGVICLDILK-- 150
           9***********************.9************************************************************9.. PP
   S: 90   ekWspalsvesvllsiqsllaepnpesplneeaaellkknreeykkkvre 139
           ++Wspal++++vllsi+sll+++np++pl  ++a+++ +nr+e+++++r+
   Q: 151  DNWSPALTISKVLLSICSLLTDCNPADPLVGSIATQYLTNRAEHDRIARQ 200
           ********************************************999875 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-, as well as 'Lys-63'-linked polyubiquitination (By similarity). Participates in the regulation of transepithelial sodium transport in renal cells. May be involved in cell growth arrest.
 Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-, as well as 'Lys-63'-linked polyubiquitination (By similarity). Participates in the regulation of transepithelial sodium transport in renal cells. May be involved in cell growth arrest.
Protein Sequence
(Fasta)
MSSDRQRSDD ESPSTSSGSS DADQRDPAAP EPEEQEERKP SATQQKKNTK LSSKTTAKLS 60
TSAKRIQKEL AEITLDPPPN CSAGPKGDNI YEWRSTILGP PGSVYEGGVF FLDITFSSDY 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063493|E2,E2/UBC|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GGCTTCTCTA TCCAGAAGTG GTCTCTCTCT CTCTCTCTCT CTCTCTCTCT CTCTCTCTCT 60
CTCTCTCTCT CTCTCTCTCT CTCTCTCTCT CTCTCTCGCA AAGCAGAGCC CGCCGCCAGA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063493|E2,E2/UBC|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0341--Growth regulation
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
Interpro

IPR000608--UBQ-conjugat_E2
IPR023313--UBQ-conjugating_AS
IPR016135--UBQ-conjugating_enzyme/RWD
PROSITE

PS00183--UBIQUITIN_CONJUGAT_1
PS50127--UBIQUITIN_CONJUGAT_2
Pfam

PF00179--UQ_con
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0005524--F:ATP binding
GO:0061631--F:ubiquitin conjugating enzyme activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0070979--P:protein K11-linked ubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0070534--P:protein K63-linked ubiquitination
GO:0040008--P:regulation of growth
KEGG mmu:22193
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000463 Aegilops tauschii 64.34 6.00e-53 202.00
IUUC-Apl-003415 Anas platyrhynchos 99.52 2.00e-89 321.00
IUUC-Aca-005276 Anolis carolinensis 99.52 6.00e-90 323.00
IUUC-Bta-012796 Bos taurus 98.55 2.00e-86 311.00
IUUC-Cja-019670 Callithrix jacchus 100.00 2.00e-89 321.00
IUUC-Cfa-021171 Canis familiaris 100.00 2.00e-89 321.00
IUUC-Csa-023464 Chlorocebus sabaeus 99.52 4.00e-89 320.00
IUUC-Cme-027286 Cyanidioschyzon merolae 72.62 2.00e-70 258.00
IUUC-Dre-027376 Danio rerio 100.00 5.00e-84 303.00
IUUC-Ete-032812 Echinops telfairi 100.00 6.00e-84 302.00
IUUC-Eca-033312 Equus caballus 100.00 2.00e-89 321.00
IUUC-Eeu-035232 Erinaceus europaeus 100.00 6.00e-84 302.00
IUUC-Fal-036688 Ficedula albicollis 99.52 2.00e-89 321.00
IUUC-Gga-040613 Gallus gallus 99.52 2.00e-89 321.00
IUUC-Ggo-045068 Gorilla gorilla 96.14 1.00e-83 301.00
IUUC-Hsa-046464 Homo sapiens 100.00 2.00e-89 321.00
IUUC-Itr-048624 Ictidomys tridecemlineatus 100.00 3.00e-74 269.00
IUUC-Loc-052492 Lepisosteus oculatus 96.17 3.00e-87 314.00
IUUC-Laf-054416 Loxodonta africana 100.00 2.00e-89 321.00
IUUC-Mcc-055754 Macaca mulatta 99.52 4.00e-89 320.00
IUUC-Mtr-058214 Medicago truncatula 60.26 1.00e-54 205.00
IUUC-Mga-059436 Meleagris gallopavo 99.52 2.00e-89 321.00
IUUC-Mmr-060893 Microcebus murinus 99.03 1.00e-92 332.00
IUUC-Mdo-063010 Monodelphis domestica 100.00 2.00e-89 321.00
IUUC-Mpu-065789 Mustela putorius furo 100.00 2.00e-89 321.00
IUUC-Mlu-066934 Myotis lucifugus 99.52 3.00e-89 320.00
IUUC-Nle-069930 Nomascus leucogenys 100.00 2.00e-89 321.00
IUUC-Opr-070917 Ochotona princeps 94.74 8.00e-60 221.00
IUUC-Ocu-074769 Oryctolagus cuniculus 97.10 2.00e-85 308.00
IUUC-Olu-087783 Ostreococcus lucimarinus 77.86 2.00e-65 240.00
IUUC-Oga-088760 Otolemur garnettii 100.00 2.00e-89 321.00
IUUC-Oar-090077 Ovis aries 100.00 1.00e-89 322.00
IUUC-Ptr-091596 Pan troglodytes 97.10 3.00e-84 304.00
IUUC-Pan-092142 Papio anubis 99.52 4.00e-89 320.00
IUUC-Psi-093471 Pelodiscus sinensis 99.52 2.00e-89 321.00
IUUC-Ppa-095789 Physcomitrella patens 78.38 4.00e-69 253.00
IUUC-Pab-098675 Pongo abelii 100.00 2.00e-89 321.00
IUUC-Pop-099024 Populus trichocarpa 65.03 9.00e-58 215.00
IUUC-Pca-100467 Procavia capensis 100.00 2.00e-89 321.00
IUUC-Ppe-101314 Prunus persica 59.72 1.00e-53 202.00
IUUC-Pva-103205 Pteropus vampyrus 100.00 2.00e-89 321.00
IUUC-Rno-105806 Rattus norvegicus 87.50 4.00e-86 310.00
IUUC-Smo-109298 Selaginella moellendorffii 69.74 5.00e-63 233.00
IUUC-Sly-111200 Solanum lycopersicum 61.54 1.00e-54 205.00
IUUC-Sar-113672 Sorex araneus 100.00 2.00e-89 321.00
IUUC-Tgu-116892 Taeniopygia guttata 99.52 2.00e-89 321.00
IUUC-Tsy-119046 Tarsius syrichta 99.52 6.00e-89 319.00
IUUC-Tca-121777 Theobroma cacao 63.19 1.00e-55 209.00
IUUC-Tbe-127690 Tupaia belangeri 100.00 3.00e-86 310.00
IUUC-Ttr-128849 Tursiops truncatus 100.00 2.00e-89 321.00
IUUC-Vvi-131190 Vitis vinifera 61.84 6.00e-56 209.00
Created Date 25-Jun-2017

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