iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	TRANSFAC	RAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/PHD	1.90e-09	37.9	364	411

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/PHD

   S: 2    kvClvCgeggedekslveCek..Cr.ewfHpaClklsveeelpnsekwiCpkCrs 53
           ++C +C + + +e  +v C++  C  ewfH++C++l+   e p+ + w+Cp+C++
   Q: 364  RYC-ICNQVSYGE--MVGCDNqdCPiEWFHYGCVGLT---EAPKGK-WFCPQCTA 411
           69*.*******99..*****999*99***********...999997.******86 PP

Organism

Rattus norvegicus

Functional Description
(View)

Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome (By similarity).

Protein Sequence
(Fasta)

MLYLEDYLEM IEQLPMDLRD RFTEMREMDL QVQNAMDQLE QRVSEFFMNA KKNKPEWREE 60
QMASIKKDYY KALEDADEKV QLANQIYDLV DRHLRKLDQE LAKFKMELEA DNAGITEILE 120

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Nucleotide Sequence
(Fasta)

CTCCGGCGAC AGCGAGTGAC ACAAATAAAC CCCTGGACCC GTTCGTCTCC GCAGCACTCA 60
GGGCCGCGAT GTTGTACCTA GAAGACTATT TGGAAAGTGA GTGCGCGGCG CCGGCAACGC 120

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Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0341--Growth regulation
KW-1017--Isopeptide bond
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR028651--ING_fam
IPR024610--ING_N_histone_binding
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS01359--ZF_PHD_1
PS50016--ZF_PHD_2

Pfam

PF12998--ING

SMART

SM01408--ING
SM00249--PHD

Gene Ontology

GO:0035267--C:NuA4 histone acetyltransferase complex
GO:0032777--C:Piccolo NuA4 histone acetyltransferase complex
GO:0000812--C:Swr1 complex
GO:0004402--F:histone acetyltransferase activity
GO:0008270--F:zinc ion binding
GO:0043968--P:histone H2A acetylation
GO:0043967--P:histone H4 acetylation
GO:0043065--P:positive regulation of apoptotic process
GO:0040008--P:regulation of growth
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated

KEGG

rno:312154

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002275	Ailuropoda melanoleuca	94.06	0.00e+00	682.00
IUUC-Apl-003660	Anas platyrhynchos	85.43	9.00e-155	539.00
IUUC-Aca-005206	Anolis carolinensis	83.14	1.00e-161	562.00
IUUC-Ate-010297	Aspergillus terreus	60.38	1.00e-18	88.60
IUUC-Ame-011952	Astyanax mexicanus	81.09	2.00e-156	545.00
IUUC-Bta-012562	Bos taurus	93.11	0.00e+00	681.00
IUUC-Cja-019646	Callithrix jacchus	92.40	0.00e+00	671.00
IUUC-Cfa-020874	Canis familiaris	94.06	0.00e+00	684.00
IUUC-Cpo-022530	Cavia porcellus	93.59	0.00e+00	666.00
IUUC-Csa-024232	Chlorocebus sabaeus	93.11	0.00e+00	676.00
IUUC-Cho-025039	Choloepus hoffmanni	91.69	0.00e+00	656.00
IUUC-Cin-025233	Ciona intestinalis	58.29	5.00e-52	198.00
IUUC-Csv-025900	Ciona savignyi	62.42	2.00e-52	199.00
IUUC-Dre-027397	Danio rerio	77.54	2.00e-147	515.00
IUUC-Dno-029289	Dasypus novemcinctus	93.59	0.00e+00	680.00
IUUC-Dse-031323	Dothistroma septosporum	54.24	8.00e-18	85.50
IUUC-Ete-032510	Echinops telfairi	84.32	1.00e-154	539.00
IUUC-Eca-033770	Equus caballus	94.30	0.00e+00	684.00
IUUC-Fca-035661	Felis catus	93.35	0.00e+00	677.00
IUUC-Fal-037051	Ficedula albicollis	82.22	2.00e-149	521.00
IUUC-Gmo-039123	Gadus morhua	77.07	2.00e-160	558.00
IUUC-Gga-040794	Gallus gallus	86.22	5.00e-171	593.00
IUUC-Gac-042167	Gasterosteus aculeatus	80.94	2.00e-110	392.00
IUUC-Ggo-044586	Gorilla gorilla	97.71	7.00e-114	403.00
IUUC-Hsa-046035	Homo sapiens	93.59	0.00e+00	677.00
IUUC-Itr-048783	Ictidomys tridecemlineatus	94.30	0.00e+00	684.00
IUUC-Lch-049419	Latimeria chalumnae	81.95	3.00e-177	614.00
IUUC-Loc-052246	Lepisosteus oculatus	84.16	2.00e-165	575.00
IUUC-Lma-053234	Leptosphaeria maculans	52.31	7.00e-17	82.80
IUUC-Laf-053617	Loxodonta africana	95.49	0.00e+00	655.00
IUUC-Mcc-055192	Macaca mulatta	90.50	0.00e+00	641.00
IUUC-Meu-056848	Macropus eugenii	77.91	1.00e-140	492.00
IUUC-Mga-059899	Meleagris gallopavo	84.79	1.00e-149	522.00
IUUC-Mmr-061435	Microcebus murinus	90.02	0.00e+00	647.00
IUUC-Mmu-064032	Mus musculus	98.81	0.00e+00	709.00
IUUC-Mpu-066530	Mustela putorius furo	93.59	0.00e+00	684.00
IUUC-Mlu-067790	Myotis lucifugus	94.06	0.00e+00	682.00
IUUC-Nle-070171	Nomascus leucogenys	93.59	0.00e+00	677.00
IUUC-Opr-070865	Ochotona princeps	74.65	2.00e-75	276.00
IUUC-Ont-072045	Oreochromis niloticus	80.47	2.00e-158	551.00
IUUC-Oan-073641	Ornithorhynchus anatinus	81.40	2.00e-150	525.00
IUUC-Ocu-074613	Oryctolagus cuniculus	93.82	0.00e+00	682.00
IUUC-Oga-088624	Otolemur garnettii	93.60	0.00e+00	669.00
IUUC-Oar-089442	Ovis aries	92.64	0.00e+00	674.00
IUUC-Ptr-091208	Pan troglodytes	93.59	0.00e+00	677.00
IUUC-Pan-092715	Papio anubis	93.35	0.00e+00	676.00
IUUC-Psi-093455	Pelodiscus sinensis	84.56	2.00e-168	585.00
IUUC-Pma-094144	Petromyzon marinus	78.65	4.00e-44	169.00
IUUC-Pfo-096573	Poecilia formosa	80.85	8.00e-159	553.00
IUUC-Pab-097549	Pongo abelii	93.59	0.00e+00	677.00
IUUC-Pca-100198	Procavia capensis	91.45	0.00e+00	659.00
IUUC-Pva-102440	Pteropus vampyrus	92.64	0.00e+00	674.00
IUUC-Pte-104284	Pyrenophora teres	52.54	8.00e-17	82.80
IUUC-Pyt-104787	Pyrenophora triticirepentis	54.24	6.00e-17	83.20
IUUC-Sha-107475	Sarcophilus harrisii	85.51	3.00e-178	617.00
IUUC-Sar-113193	Sorex araneus	91.69	0.00e+00	660.00
IUUC-Ssc-115795	Sus scrofa	93.35	0.00e+00	679.00
IUUC-Tgu-117305	Taeniopygia guttata	87.63	7.00e-152	530.00
IUUC-Tru-117691	Takifugu rubripes	76.89	4.00e-150	524.00
IUUC-Tsy-119035	Tarsius syrichta	86.24	6.00e-95	340.00
IUUC-Tni-120738	Tetraodon nigroviridis	84.12	7.00e-114	403.00
IUUC-Tre-121950	Trichoderma reesei	59.26	8.00e-19	89.40
IUUC-Ttr-128512	Tursiops truncatus	91.45	0.00e+00	682.00
IUUC-Xma-133522	Xiphophorus maculatus	81.09	2.00e-159	555.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence