iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
microRNA	RAID2
Protein-protein Interaction
iRefIndex	Mentha
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
UBD/Other/Other	51.38	2.00e-24	108.00	IUUC-Hsa-046921

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Caenorhabditis elegans

Functional Description
(View)

Promotes the biosynthesis of heme as well as the assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathways. May play a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe(2+) to Fe(3+). May be able to store large amounts of the metal in the form of a ferrihydrite mineral by oligomerization.

Protein Sequence
(Fasta)

MLSTILRNNF VRRSFSSRIF SQNEYETAAD STLERLSDYF DQIADSFPVS EQFDVSHAMG 60
VLTVNVSKSV GTYVINKQSP NKQIWLSSPM SGPKRYDLEE EGKWTYAHDG EQLDSLLNRE 120

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Nucleotide Sequence
(Fasta)

ATGCTCTCCA CTATTCTACG AAACAATTTT GTACGTCGCT CATTTTCGTC CCGGATTTTC 60
AGTCAAAATG AGTACGAAAC AGCAGCTGAT TCAACATTAG AAAGATTATC AGACTATTTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0350--Heme biosynthesis
KW-0406--Ion transport
KW-0408--Iron
KW-0409--Iron storage
KW-0410--Iron transport
KW-0496--Mitochondrion
KW-0560--Oxidoreductase
KW-1185--Reference proteome
KW-0809--Transit peptide
KW-0813--Transport

Interpro

IPR017789--Frataxin
IPR002908--Frataxin/CyaY
IPR020895--Frataxin_CS

PROSITE

PS01344--FRATAXIN_1
PS50810--FRATAXIN_2

Pfam

PF01491--Frataxin_Cyay

PRINTS

PR00904--FRATAXIN

SMART

SM01219--Frataxin_Cyay

Gene Ontology

GO:0005739--C:mitochondrion
GO:0051537--F:2 iron, 2 sulfur cluster binding
GO:0008199--F:ferric iron binding
GO:0008198--F:ferrous iron binding
GO:0004322--F:ferroxidase activity
GO:0034986--F:iron chaperone activity
GO:0006879--P:cellular iron ion homeostasis
GO:0034599--P:cellular response to oxidative stress
GO:0008340--P:determination of adult lifespan
GO:0009792--P:embryo development ending in birth or egg hatching
GO:0040007--P:growth
GO:0006783--P:heme biosynthetic process
GO:0006811--P:ion transport
GO:0018283--P:iron incorporation into metallo-sulfur cluster
GO:0016226--P:iron-sulfur cluster assembly
GO:0007005--P:mitochondrion organization
GO:0002119--P:nematode larval development
GO:0042542--P:response to hydrogen peroxide
GO:0000303--P:response to superoxide

KEGG

cel:CELE_F59G1.7

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002122	Ailuropoda melanoleuca	50.89	8.00e-27	112.00
IUUC-Apl-003853	Anas platyrhynchos	48.21	2.00e-25	106.00
IUUC-Aca-005026	Anolis carolinensis	56.00	2.00e-28	116.00
IUUC-Aly-006200	Arabidopsis lyrata	37.29	1.00e-15	74.70
IUUC-Ath-007033	Arabidopsis thaliana	35.09	6.00e-15	72.40
IUUC-Ago-007707	Ashbya gossypii	43.86	1.00e-19	86.70
IUUC-Acl-008146	Aspergillus clavatus	38.10	3.00e-16	77.40
IUUC-Afl-008501	Aspergillus flavus	47.95	1.00e-13	68.20
IUUC-Afu-008851	Aspergillus fumigatus	46.15	2.00e-16	77.80
IUUC-Ani-009129	Aspergillus nidulans	41.86	7.00e-13	65.90
IUUC-Ang-009557	Aspergillus niger	43.96	5.00e-16	76.30
IUUC-Ate-010486	Aspergillus terreus	45.05	2.00e-16	77.40
IUUC-Bgr-012108	Blumeria graminis	41.82	8.00e-17	78.60
IUUC-Bta-013437	Bos taurus	50.46	2.00e-25	107.00
IUUC-Bci-013810	Botrytis cinerea	50.00	4.00e-15	73.20
IUUC-Bdi-014226	Brachypodium distachyon	36.70	1.00e-16	78.20
IUUC-Bol-015092	Brassica oleracea	37.50	4.00e-15	73.20
IUUC-Bra-017945	Brassica rapa	39.33	5.00e-15	72.40
IUUC-Cja-019306	Callithrix jacchus	53.26	7.00e-24	102.00
IUUC-Cfa-020063	Canis familiaris	51.96	4.00e-26	109.00
IUUC-Cpo-021325	Cavia porcellus	50.00	7.00e-27	112.00
IUUC-Cre-022889	Chlamydomonas reinhardtii	43.33	4.00e-17	79.70
IUUC-Csa-023739	Chlorocebus sabaeus	51.38	3.00e-26	110.00
IUUC-Cho-024324	Choloepus hoffmanni	52.17	3.00e-22	97.10
IUUC-Cgl-026402	Colletotrichum gloeosporioides	43.86	2.00e-19	87.80
IUUC-Cne-027094	Cryptococcus neoformans	35.29	2.00e-11	60.50
IUUC-Cme-027112	Cyanidioschyzon merolae	40.00	4.00e-14	69.30
IUUC-Dre-028813	Danio rerio	50.86	1.00e-26	111.00
IUUC-Dno-029949	Dasypus novemcinctus	47.22	3.00e-24	102.00
IUUC-Dse-031482	Dothistroma septosporum	38.33	1.00e-17	81.60
IUUC-Dme-031608	Drosophila melanogaster	45.80	2.00e-28	117.00
IUUC-Ete-032937	Echinops telfairi	73.33	2.00e-09	53.50
IUUC-Eca-033899	Equus caballus	52.17	7.00e-24	101.00
IUUC-Fca-036579	Felis catus	55.06	4.00e-24	103.00
IUUC-Fox-037940	Fusarium oxysporum	40.35	1.00e-17	81.60
IUUC-Fso-038465	Fusarium solani	41.46	6.00e-18	82.80
IUUC-Ggr-040089	Gaeumannomyces graminis	44.55	1.00e-17	82.00
IUUC-Gga-040910	Gallus gallus	48.21	2.00e-25	107.00
IUUC-Gma-044349	Glycine max	38.98	4.00e-18	83.20
IUUC-Ggo-044854	Gorilla gorilla	52.13	9.00e-24	102.00
IUUC-Hsa-046921	Homo sapiens	52.13	9.00e-24	102.00
IUUC-Hvu-047142	Hordeum vulgare	37.07	8.00e-16	75.50
IUUC-Kpa-049187	Komagataella pastoris	42.31	1.00e-16	77.40
IUUC-Lch-050614	Latimeria chalumnae	50.91	5.00e-28	115.00
IUUC-Lpe-051184	Leersia perrieri	37.61	2.00e-18	84.00
IUUC-Loc-052083	Lepisosteus oculatus	50.43	4.00e-29	118.00
IUUC-Lma-053209	Leptosphaeria maculans	34.68	2.00e-14	70.10
IUUC-Laf-054090	Loxodonta africana	48.25	3.00e-26	110.00
IUUC-Meu-056814	Macropus eugenii	53.85	1.00e-27	114.00
IUUC-Mor-057169	Magnaporthe oryzae	42.11	5.00e-18	82.80
IUUC-Mpo-057483	Magnaporthe poae	44.55	7.00e-18	82.40
IUUC-Mtr-058166	Medicago truncatula	36.70	3.00e-13	66.60
IUUC-Mla-059015	Melampsora laricipopulina	41.13	1.00e-19	87.40
IUUC-Mvi-060356	Microbotryum violaceum	48.60	5.00e-20	89.40
IUUC-Mdo-062658	Monodelphis domestica	48.70	2.00e-26	110.00
IUUC-Mmu-063470	Mus musculus	49.12	6.00e-27	112.00
IUUC-Mac-065327	Musa acuminata	37.61	3.00e-16	77.00
IUUC-Mpu-065761	Mustela putorius furo	54.35	2.00e-24	103.00
IUUC-Mlu-067175	Myotis lucifugus	47.32	2.00e-25	107.00
IUUC-Nfi-068535	Neosartorya fischeri	46.15	1.00e-16	78.20
IUUC-Ncr-068966	Neurospora crassa	42.64	2.00e-20	90.50
IUUC-Opr-070533	Ochotona princeps	53.70	4.00e-12	62.40
IUUC-Oan-073024	Ornithorhynchus anatinus	58.43	1.00e-25	108.00
IUUC-Ocu-074451	Oryctolagus cuniculus	51.09	3.00e-23	100.00
IUUC-Oba-075540	Oryza barthii	38.53	4.00e-18	83.20
IUUC-Obr-076285	Oryza brachyantha	37.61	4.00e-17	80.10
IUUC-Ogl-077827	Oryza glaberrima	38.53	4.00e-18	83.20
IUUC-Ogu-078491	Oryza glumaepatula	38.53	4.00e-18	83.20
IUUC-Oin-080149	Oryza indica	38.53	5.00e-18	82.80
IUUC-Olo-080318	Oryza longistaminata	36.52	3.00e-16	75.90
IUUC-Oni-083037	Oryza nivara	38.53	5.00e-18	82.80
IUUC-Opu-083448	Oryza punctata	38.53	4.00e-18	83.20
IUUC-Oru-084793	Oryza rufipogon	39.45	2.00e-18	84.30
IUUC-Osa-086032	Oryza sativa	38.53	5.00e-18	82.80
IUUC-Ola-086956	Oryzias latipes	53.33	6.00e-27	112.00
IUUC-Olu-087806	Ostreococcus lucimarinus	36.75	9.00e-16	75.10
IUUC-Oga-089029	Otolemur garnettii	53.93	1.00e-23	101.00
IUUC-Oar-089471	Ovis aries	51.38	3.00e-26	110.00
IUUC-Pan-092091	Papio anubis	51.38	2.00e-26	110.00
IUUC-Psi-093193	Pelodiscus sinensis	48.44	9.00e-27	111.00
IUUC-Pma-094540	Petromyzon marinus	51.89	6.00e-30	120.00
IUUC-Pno-094873	Phaeosphaeria nodorum	37.72	3.00e-15	73.60
IUUC-Ppa-095343	Physcomitrella patens	39.13	1.00e-14	72.00
IUUC-Pfo-097093	Poecilia formosa	54.81	2.00e-28	117.00
IUUC-Pab-098781	Pongo abelii	66.67	3.00e-18	82.80
IUUC-Pop-098983	Populus trichocarpa	35.45	4.00e-17	79.70
IUUC-Pca-100872	Procavia capensis	47.78	6.00e-20	89.40
IUUC-Ppe-101711	Prunus persica	40.45	6.00e-16	75.90
IUUC-Pva-102256	Pteropus vampyrus	49.11	9.00e-25	105.00
IUUC-Pgr-103607	Puccinia graminis	42.45	6.00e-19	85.90
IUUC-Pte-104220	Pyrenophora teres	34.68	3.00e-13	66.20
IUUC-Pyt-104562	Pyrenophora triticirepentis	35.96	1.00e-13	67.80
IUUC-Rno-105021	Rattus norvegicus	41.41	3.00e-22	97.10
IUUC-Sce-106182	Saccharomyces cerevisiae	46.05	2.00e-15	73.90
IUUC-Sha-107279	Sarcophilus harrisii	49.57	1.00e-26	111.00
IUUC-Sja-107819	Schizosaccharomyces japonicus	39.32	9.00e-17	78.20
IUUC-Spo-108197	Schizosaccharomyces pombe	42.57	2.00e-16	77.40
IUUC-Smo-108810	Selaginella moellendorffii	45.88	7.00e-18	80.90
IUUC-Sit-110256	Setaria italica	37.61	4.00e-17	80.10
IUUC-Sly-111448	Solanum lycopersicum	38.53	4.00e-18	83.20
IUUC-Stu-112702	Solanum tuberosum	38.53	5.00e-18	82.80
IUUC-Sbi-113956	Sorghum bicolor	39.62	4.00e-17	79.70
IUUC-Sre-115024	Sporisorium reilianum	31.03	2.00e-13	67.80
IUUC-Ssc-116034	Sus scrofa	50.46	9.00e-26	108.00
IUUC-Tgu-117503	Taeniopygia guttata	47.71	6.00e-25	105.00
IUUC-Tsy-119166	Tarsius syrichta	25.83	2.00e-05	40.80
IUUC-Tni-120703	Tetraodon nigroviridis	35.54	6.00e-13	65.90
IUUC-Tca-121473	Theobroma cacao	39.33	1.00e-14	71.20
IUUC-Tre-122241	Trichoderma reesei	41.67	6.00e-19	85.10
IUUC-Tvi-122347	Trichoderma virens	41.67	6.00e-18	82.40
IUUC-Tae-124560	Triticum aestivum	38.46	1.00e-15	75.10
IUUC-Tur-126452	Triticum urartu	35.29	7.00e-17	79.00
IUUC-Tme-127205	Tuber melanosporum	44.90	9.00e-16	73.60
IUUC-Ttr-128186	Tursiops truncatus	48.62	6.00e-24	102.00
IUUC-Uma-129523	Ustilago maydis	45.24	8.00e-14	68.90
IUUC-Vda-129793	Verticillium dahliae	43.64	8.00e-19	85.50
IUUC-Vpa-130040	Vicugna pacos	51.38	8.00e-26	108.00
IUUC-Vvi-131588	Vitis vinifera	40.66	2.00e-17	80.90
IUUC-Yli-134631	Yarrowia lipolytica	47.13	3.00e-17	79.70
IUUC-Zma-135478	Zea mays	38.89	2.00e-17	80.50

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence